Cancer Research and Treatment

REVIEW ARTICLE 2022 February 18 Challenges in the Use of Targeted Therapies in Non–Small Cell Lung Cancer
Precision oncology has fundamentally changed how we diagnose and treat cancer. In recent years, there has been a significant change in the management of patients with oncogene-addicted advanced-stage NSCLC. Increasing amounts of identifiable oncogene drivers have led to the deve...

SPECIAL ARTICLE 2022 March 16 Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2019
Purpose The current study provides national cancer statistics and their secular trends in Korea, including incidence, mortality, survival, and prevalence in 2019. Materials and Methods Incidence, survival, and prevalence rates of cancer were calculated using the Korea Nationa...

SPECIAL ARTICLE 2022 March 21 Prediction of Cancer Incidence and Mortality in Korea, 2022
Purpose This study aimed to report the projected cancer incidence and mortality for the year 2022 to estimate Korea’s current cancer burden. Materials and Methods Cancer incidence data from 1999 to 2019 were obtained from the Korea National Cancer Incidence Database, and ca...

ORIGINAL ARTICLE 2021 August 2 Validation of Cancer Diagnosis Based on the National Health Insurance Service Database versus the National Cancer Registry Database in Korea
Purpose This study aimed to assess the feasibility of operational definitions of cancer patients in conducting cancer-related studies using the claims data from the National Health Insurance Service (NHIS). Materials and Methods Cancer incidence data were obtained from the K...

Current Issue

Volume 54(2); Apr 2022

Volume 54(1); January 2022

Volume 53(4); October 2021

Review Article

315

Challenges in the Use of Targeted Therapies in Non–Small Cell Lung Cancer

Joel Rivera-Concepcion, Dipesh Uprety, Alex A. Adjei

Cancer Res Treat. 2022;54(2):315-329. Published online February 18, 2022 DOI: https://doi.org/10.4143/crt.2022.078

Special Articles

330

Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2019

Mee Joo Kang, Young-Joo Won, Jae Jun Lee, Kyu-Won Jung, Hye-Jin Kim, Hyun-Joo Kong, Jeong-Soo Im, Hong Gwan Seo, The Community of Population-Based Regional Cancer Registries

Cancer Res Treat. 2022;54(2):330-344. Published online March 16, 2022 DOI: https://doi.org/10.4143/crt.2022.128

Cited By 1

345

Prediction of Cancer Incidence and Mortality in Korea, 2022

Kyu-Won Jung, Young-Joo Won, Mee Joo Kang, Hyun-Joo Kong, Jeong-Soo Im, Hong Gwan Seo

Cancer Res Treat. 2022;54(2):345-351. Published online March 21, 2022 DOI: https://doi.org/10.4143/crt.2022.179

Original Articles

General

352

Validation of Cancer Diagnosis Based on the National Health Insurance Service Database versus the National Cancer Registry Database in Korea

Min Soo Yang, Minae Park, Joung Hwan Back, Gyeong Hyeon Lee, Ji Hye Shin, Kyuwoong Kim, Hwa Jeong Seo, Young Ae Kim

Cancer Res Treat. 2022;54(2):352-361. Published online August 2, 2021 DOI: https://doi.org/10.4143/crt.2021.044

Cited By 2

362

Engineering a High-Affinity PD-1 Peptide for Optimized Immune Cell-Mediated Tumor Therapy

Yilei Chen, Hongxing Huang, Yin Liu, Zhanghao Wang, Lili Wang, Quanxiao Wang, Yan Zhang, Hua Wang

Cancer Res Treat. 2022;54(2):362-374. Published online August 3, 2021 DOI: https://doi.org/10.4143/crt.2021.424

375

Attitudes toward Risk-Reducing Mastectomy and Risk-Reducing Salpingo-oophorectomy among Young, Unmarried, Healthy Women in Korea

Boyoung Park, Dongwon Kim, Jiyoung Kim, Bom Yi Lee, Junghyun Yoon, Sung-Won Kim

Cancer Res Treat. 2022;54(2):375-382. Published online August 9, 2021 DOI: https://doi.org/10.4143/crt.2021.449

383

Radiation Response Prediction Model Based on Integrated Clinical and Genomic Data Analysis

Bum-Sup Jang, Ji-Hyun Chang, Seung Hyuck Jeon, Myung Geun Song, Kyung-Hun Lee, Seock-Ah Im, Jong-Il Kim, Tae-You Kim, Eui Kyu Chie

Cancer Res Treat. 2022;54(2):383-395. Published online August 24, 2021 DOI: https://doi.org/10.4143/crt.2021.759

CNS cancer

396

Influence of Concurrent and Adjuvant Temozolomide on Health-Related Quality of Life of Patients with Grade III Gliomas: A Secondary Analysis of a Randomized Clinical Trial (KNOG-1101 Study)

Grace S. Ahn, Kihwan Hwang, Tae Min Kim, Chul Kee Park, Jong Hee Chang, Tae-Young Jung, Jin Hee Kim, Do-Hyun Nam, Se-Hyuk Kim, Heon Yoo, Yong-Kil Hong, Eun-Young Kim, Dong-Eun Lee, Jungnam Joo, Yu Jung Kim, Gheeyoung Choe, Byung Se Choi, Seok-Gu Kang, Jeong Hoon Kim, Chae-Yong Kim

Cancer Res Treat. 2022;54(2):396-405. Published online July 6, 2021 DOI: https://doi.org/10.4143/crt.2021.393

Head and Neck cancer

406

Radiotherapy versus Surgery in Early-Stage HPV-Positive Oropharyngeal Cancer

Dong-Yun Kim, Hong-Gyun Wu, Jin Ho Kim, Joo Ho Lee, Soon-Hyun Ahn, Eun-Jae Chung, Keun-Yong Eom, Young Ho Jung, Woo-Jin Jeong, Tack-Kyun Kwon, Suzy Kim, Chan Woo Wee

Cancer Res Treat. 2022;54(2):406-416. Published online June 23, 2021 DOI: https://doi.org/10.4143/crt.2021.441

417

Radiation-Induced Ocular Surface Disorders and Retinopathy: Ocular Structures and Radiation Dose-Volume Effect

Ozlem Ozkaya Akagunduz, Suzan Guven Yilmaz, Emin Tavlayan, Mine Esen Baris, Filiz Afrashi, Mustafa Esassolak

Cancer Res Treat. 2022;54(2):417-423. Published online June 24, 2021 DOI: https://doi.org/10.4143/crt.2021.575

Cited By 2

Lung and Thoracic cancer

424

Comparison of the Predictive Power of a Combination versus Individual Biomarker Testing in Non–Small Cell Lung Cancer Patients Treated with Immune Checkpoint Inhibitors

Hyojin Kim, Hyun Jung Kwon, Eun Sun Kim, Soohyeon Kwon, Kyoung Jin Suh, Se Hyun Kim, Yu Jung Kim, Jong Seok Lee, Jin-Haeng Chung

Cancer Res Treat. 2022;54(2):424-433. Published online July 7, 2021 DOI: https://doi.org/10.4143/crt.2021.583

434

The Clinical Outcomes of Different First-Line EGFR-TKIs Plus Bevacizumab in Advanced EGFR-Mutant Lung Adenocarcinoma

Yen-Hsiang Huang, Kuo-Hsuan Hsu, Chun-Shih Chin, Jeng-Sen Tseng, Tsung-Ying Yang, Kun-Chieh Chen, Kang-Yi Su, Sung-Liang Yu, Jeremy J.W. Chen, Gee-Chen Chang

Cancer Res Treat. 2022;54(2):434-444. Published online August 2, 2021 DOI: https://doi.org/10.4143/crt.2021.671

445

miR-4487 Enhances Gefitinib-Mediated Ubiquitination and Autophagic Degradation of EGFR in Non-Small Cell Lung Cancer Cells by Targeting USP37

Mi Seong Kim, So Hui Kim, Sei Hoon Yang, Min Seuk Kim

Cancer Res Treat. 2022;54(2):445-457. Published online August 3, 2021 DOI: https://doi.org/10.4143/crt.2021.622

458

Histone Deacetylase as a Valuable Predictive Biomarker and Therapeutic Target in Immunotherapy for Non-Small Cell Lung Cancer

Hyun-Seock Shin, Juwhan Choi, Jinhwan Lee, Sung Yong Lee

Cancer Res Treat. 2022;54(2):458-468. Published online September 10, 2021 DOI: https://doi.org/10.4143/crt.2021.425

Cited By 2

Breast cancer

469

Comparison of the Effectiveness and Clinical Outcome of Everolimus Followed by CDK4/6 Inhibitors with the Opposite Treatment Sequence in Hormone Receptor-Positive, HER2-Negative Metastatic Breast Cancer

Hyehyun Jeong, Jae Ho Jeong, Jeong Eun Kim, Jin-Hee Ahn, Kyung Hae Jung, Sung-Bae Kim

Cancer Res Treat. 2022;54(2):469-477. Published online June 23, 2021 DOI: https://doi.org/10.4143/crt.2021.205

Cited By 1

478

Effect of Postoperative Radiotherapy after Primary Tumor Resection in De Novo Stage IV Breast Cancer: A Multicenter Retrospective Study (KROG 19-02)

Yeon Joo Kim, Yeon-Joo Kim, Yong Bae Kim, Ik Jae Lee, Jeanny Kwon, Kyubo Kim, Jihye Cha, Myungsoo Kim, In Young Jo, Jung Hoon Kim, Jaehyeon Park, Jin Hee Kim, Juree Kim, Kyung Hwan Shin, Su Ssan Kim

Cancer Res Treat. 2022;54(2):478-487. Published online July 12, 2021 DOI: https://doi.org/10.4143/crt.2021.632

488

A Real-world Efficacy of Nab-paclitaxel Monotherapy in Metastatic Breast Cancer

Jung Sun Kim, Koung Jin Suh, Dae-Won Lee, Go-un Woo, Miso Kim, Se Hyun Kim, Han Suk Ryu, Kyung-Hun Lee, Tae-Yong Kim, Sae-Won Han, So Yeon Park, In Ae Park, Jee Hyun Kim, Seock-Ah Im

Cancer Res Treat. 2022;54(2):488-496. Published online August 13, 2021 DOI: https://doi.org/10.4143/crt.2021.394

Cited By 2

497

Postmastectomy Radiation Therapy for Node-Negative Breast Cancer of 5 cm or Larger Tumors: A Multicenter Retrospective Analysis (KROG 20-03)

Kyubo Kim, Jinhong Jung, Haeyoung Kim, Wonguen Jung, Kyung Hwan Shin, Ji Hyun Chang, Su Ssan Kim, Won Park, Jee Suk Chang, Yong Bae Kim, Sung Ja Ahn, Ik Jae Lee, Jong Hoon Lee, Hae Jin Park, Jihye Cha, Juree Kim, Jin Hwa Choi, Taeryool Koo, Jeanny Kwon, Jin Hee Kim, Mi Young Kim, Shin-Hyung Park, Yeon-Joo Kim

Cancer Res Treat. 2022;54(2):497-504. Published online August 25, 2021 DOI: https://doi.org/10.4143/crt.2021.933

Cited By 1

Gastrointestinal cancer

505

Real-World Efficacy Data and Predictive Clinical Parameters for Treatment Outcomes in Advanced Esophageal Squamous Cell Carcinoma Treated with Immune Checkpoint Inhibitors

Jwa Hoon Kim, Bokyung Ahn, Seung-Mo Hong, Hwoon-Yong Jung, Do Hoon Kim, Kee Don Choi, Ji Yong Ahn, Jeong Hoon Lee, Hee Kyoung Na, Jong Hoon Kim, Yong-Hee Kim, Hyeong Ryul Kim, Hyun Joo Lee, Sung-Bae Kim, Sook Ryun Park

Cancer Res Treat. 2022;54(2):505-516. Published online June 23, 2021 DOI: https://doi.org/10.4143/crt.2020.1198

Cited By 1

517

Machine Learning Model for Predicting Postoperative Survival of Patients with Colorectal Cancer

Mohamed Hosny Osman, Reham Hosny Mohamed, Hossam Mohamed Sarhan, Eun Jung Park, Seung Hyuk Baik, Kang Young Lee, Jeonghyun Kang

Cancer Res Treat. 2022;54(2):517-524. Published online June 15, 2021 DOI: https://doi.org/10.4143/crt.2021.206

525

A Hypoxia-Induced SCF^FBXL1 E3 Ligase Ubiquitinates and Degrades the MEN1 Tumor Suppressor to Promote Colorectal Cancer Tumorigenesis

Jun Zeng, Xiao-qing Xiao, Zhi-yong Zhou

Cancer Res Treat. 2022;54(2):525-540. Published online June 29, 2021 DOI: https://doi.org/10.4143/crt.2021.373

541

Inhibition of WEE1 Potentiates Sensitivity to PARP Inhibitor in Biliary Tract Cancer

Hye-Rim Seo, Ah-Rong Nam, Ju-Hee Bang, Kyoung-Seok Oh, Jae-Min Kim, Jeesun Yoon, Tae-Yong Kim, Do-Youn Oh

Cancer Res Treat. 2022;54(2):541-553. Published online August 6, 2021 DOI: https://doi.org/10.4143/crt.2021.473

Cited By 1

Gynecologic cancer

554

Effectiveness of Concomitant Chemoradiotherapy with Gemcitabine in Locally Advanced Cervical Cancer Patients with Comorbidities

Hasan Brau-Figueroa, Eder Arango-Bravo, Denisse Castro-Eguiluz, Tatiana Galicia-Carmona, Leopoldo Abraham Lugo-Alferez, Ivette Cruz-Bautista, Roberto Jiménez-Lima, Lucely Cetina-Pérez

Cancer Res Treat. 2022;54(2):554-562. Published online August 10, 2021 DOI: https://doi.org/10.4143/crt.2021.375

Pediatric cancer

563

Vincristine, Irinotecan, and Temozolomide as a Salvage Regimen for Relapsed or Refractory Sarcoma in Children and Young Adults

Hee Young Ju, Meerim Park, Jun Ah Lee, Hyeon Jin Park, Seog Yun Park, June Hyuk Kim, Hyun Guy Kang, Hee Chul Yang, Byung-Kiu Park

Cancer Res Treat. 2022;54(2):563-571. Published online June 14, 2021 DOI: https://doi.org/10.4143/crt.2021.178

Cited By 1

572

Epidemiology of Acute Leukemia among Children with Down Syndrome in Korea

Young Bae Choi, Keon Hee Yoo

Cancer Res Treat. 2022;54(2):572-578. Published online August 10, 2021 DOI: https://doi.org/10.4143/crt.2021.368

Sarcoma

579

Clinicopathologic Characteristics and Clinical Outcome of Localized Liposarcoma: A Single-Center Experience over 25 Years and Evaluation of PD-L1 Expression

Heejung Chae, Jeong Eun Kim, Wanlim Kim, Jong-Seok Lee, Si Yeol Song, Min Hee Lee, Hye Won Chung, Kyung-Ja Cho, Joon Seon Song, Jin-Hee Ahn

Cancer Res Treat. 2022;54(2):579-589. Published online July 6, 2021 DOI: https://doi.org/10.4143/crt.2021.496

590

Incidence Patterns and Outcomes of Ewing Sarcoma in South Korea (1999-2017): A Retrospective Analysis Using Korea Central Cancer Registry Data

Jun Ah Lee, Jiwon Lim, Dayeon Park, Hye Young Jin, Meerim Park, Hyeon Jin Park, Jong Woong Park, June Hyuk Kim, Hyun Guy Kang, Young-Joo Won

Cancer Res Treat. 2022;54(2):590-596. Published online July 20, 2021 DOI: https://doi.org/10.4143/crt.2021.311

Cited By 1

Hematologic malignancy

597

Plasma Circulating Tumor DNA in Patients with Primary Central Nervous System Lymphoma

Sang Eun Yoon, Yeon Jeong Kim, Joon Ho Shim, Donghyun Park, Junhun Cho, Young Hyeh Ko, Woong-Yang Park, Yeung-Chul Mun, Kyoung Eun Lee, Duck Cho, Won Seog Kim, Seok Jin Kim

Cancer Res Treat. 2022;54(2):597-612. Published online July 23, 2021 DOI: https://doi.org/10.4143/crt.2021.752

Cited By 1

613

Predictive Factors of Event-Free Survival at 24 Months in Patients with Peripheral T-Cell Lymphoma: A Retrospective Study

Yu Ri Kim, Soo-Jeong Kim, Hye Sun Lee, Soyoung Jeon, Hyunsoo Cho, Haerim Chung, Ji Eun Jang, June-Won Cheong, Yoo Hong Min, Jin Seok Kim

Cancer Res Treat. 2022;54(2):613-620. Published online August 5, 2021 DOI: https://doi.org/10.4143/crt.2021.270

Cited By 1

Palliative medicine

621

A Prognostic Model to Facilitate Palliative Care Referral in Oncology Outpatients

Yu Jung Kim, Yusuke Hiratsuka, Sang-Yeon Suh, Beodeul Kang, Si Won Lee, Hong-Yup Ahn, Koung Jin Suh, Ji-Won Kim, Se Hyun Kim, Jin Won Kim, Keun-Wook Lee, Jee Hyun Kim, Jong Seok Lee

Cancer Res Treat. 2022;54(2):621-629. Published online July 12, 2021 DOI: https://doi.org/10.4143/crt.2021.483