Cancer Research and Treatment

ORIGINAL ARTICLE 2022 August 16 Role of Local Treatment for Oligometastasis: A Comparability-Based Meta-Analysis
Purpose We intend to investigate the oncological efficacy and feasibility of local consolidative therapy (LCT) through a meta-analysis method. Materials and Methods Four databases including PubMed, MEDLINE, Embase, and Cochrane library were searched. Target studies are controll...

ORIGINAL ARTICLE 2022 January 17 Assessment of Anti-tumor Efficacy of Osimertinib in Non-Small Cell Lung Cancer Patients by Liquid Biopsy Using Bronchoalveolar Lavage Fluid, Plasma, or Pleural Effusion
Purpose This study was to evaluate anti-tumor efficacy of osimertinib in patients positive for acquired epidermal growth factor receptor (EGFR) T790M mutation in liquid biopsy using plasma, bronchoalveolar lavage fluid (BALF) or bronchial washing fluid (BWF), and pleural effusi...

ORIGINAL ARTICLE 2021 November 19 The Value of the Illness-Death Model for Predicting Outcomes in Patients with Non–Small Cell Lung Cancer
Purpose The illness-death model (IDM) is a comprehensive approach to evaluate the relationship between relapse and death. This study aimed to illustrate the value of the IDM for identifying risk factors and evaluating predictive probabilities for relapse and death in patients wi...

Current Issue

Volume 54(4); Oct 2022

Volume 54(3); July 2022

Volume 54(2); April 2022

Editorial

951

Treating Oligometastses, Prelude or Just Hassles of Systemic Treatment

Dae Ho Lee

Cancer Res Treat. 2022;54(4):951-952. Published online October 4, 2022 DOI: https://doi.org/10.4143/crt.2022.1326

Original Articles

General

953

Role of Local Treatment for Oligometastasis: A Comparability-Based Meta-Analysis

Chai Hong Rim, Won Kyung Cho, Jong Hoon Lee, Young Seok Kim, Yang-Gun Suh, Kyung Hwan Kim, Eui Kyu Chie, Yong Chan Ahn, The Oligometastasis Working Group, Korea Cancer Association

Cancer Res Treat. 2022;54(4):953-969. Published online August 16, 2022 DOI: https://doi.org/10.4143/crt.2022.329

Cited By 1

970

Reclassification of Five BRCA1/2 Variants with Unknown Significance Using Complex Functional Study

Anikó Bozsik, János Papp, Vince Kornél Grolmusz, Attila Patócs, Edit Oláh, Henriett Butz

Cancer Res Treat. 2022;54(4):970-984. Published online February 8, 2022 DOI: https://doi.org/10.4143/crt.2021.1078

Lung and Thoracic cancer

985

Assessment of Anti-tumor Efficacy of Osimertinib in Non-Small Cell Lung Cancer Patients by Liquid Biopsy Using Bronchoalveolar Lavage Fluid, Plasma, or Pleural Effusion

Yeon Joo Kim, Won Jun Ji, Jae-Cheol Lee, Sung-Min Chun, Chang-Min Choi

Cancer Res Treat. 2022;54(4):985-995. Published online January 17, 2022 DOI: https://doi.org/10.4143/crt.2021.857

996

The Value of the Illness-Death Model for Predicting Outcomes in Patients with Non–Small Cell Lung Cancer

Kum Ju Chae, Hyemi Choi, Won Gi Jeong, Jinheum Kim

Cancer Res Treat. 2022;54(4):996-1004. Published online November 19, 2021 DOI: https://doi.org/10.4143/crt.2021.902

1005

A Phase I/IIa Randomized Trial Evaluating the Safety and Efficacy of SNK01 Plus Pembrolizumab in Patients with Stage IV Non-Small Cell Lung Cancer

Eo Jin Kim, Yong-Hee Cho, Dong Ha Kim, Dae-Hyun Ko, Eun-Ju Do, Sang-Yeob Kim, Yong Man Kim, Jae Seob Jung, Yoonmi Kang, Wonjun Ji, Myeong Geun Choi, Jae Cheol Lee, Jin Kyung Rho, Chang-Min Choi

Cancer Res Treat. 2022;54(4):1005-1016. Published online December 3, 2021 DOI: https://doi.org/10.4143/crt.2021.986

Cited By 1

1017

The Role of Neutrophil-to-Lymphocyte Ratio in Predicting Pathological Response for Resectable Non–Small Cell Lung Cancer Treated with Neoadjuvant Chemotherapy Combined with PD-1 Checkpoint Inhibitors

Xiaoyan Sun, Yingnan Feng, Bin Zhang, Wuhao Huang, Xiaoliang Zhao, Hua Zhang, Dongsheng Yue, Changli Wang

Cancer Res Treat. 2022;54(4):1017-1029. Published online November 23, 2021 DOI: https://doi.org/10.4143/crt.2021.1007

Cited By 1

1030

Long-term Exposure to PM₁₀ Increases Lung Cancer Risks: A Cohort Analysis

Hyun Woo Lee, Sung-Chan Kang, Sun-Young Kim, Young-Jae Cho, Seungsik Hwang

Cancer Res Treat. 2022;54(4):1030-1037. Published online January 17, 2022 DOI: https://doi.org/10.4143/crt.2021.1030

Cited By 1

Breast cancer

1038

Clinical Evidence of Chemotherapy or Endocrine Therapy Maintenance in Patients with Metastatic Breast Cancer: Meta-Analysis of Randomized Clinical Trials and Propensity Score Matching of Multicenter Cohort Study

Wei Ren, Yunfang Yu, Huangming Hong, Ying Wang, Quanlong Gao, Yongjian Chen, Peixian Chen, Jianli Zhao, Qiyun Ou, Dagui Lin, Tuping Fu, Yujie Tan, Chenchen Li, Xinxin Xie, Guolin Ye, Jun Tang, Herui Yao

Cancer Res Treat. 2022;54(4):1038-1052. Published online February 4, 2022 DOI: https://doi.org/10.4143/crt.2021.698

Cited By 1

1053

Clinical Significance of Major Angiogenesis-Related Effectors in Patients with Metastatic Breast Cancer Treated with Trastuzumab-Based Regimens

Helen P. Kourea, Foteinos-Ioannis Dimitrakopoulos, Georgia-Angeliki Koliou, Anna Batistatou, Kyriaki Papadopoulou, Mattheos Bobos, Anthoula Asimaki-Vlachopoulou, Sofia Chrisafi, Kitty Pavlakis, Kyriakos Chatzopoulos, Eleni Galani, George Pentheroudakis, Dimitrios Pectasides, Dimitrios Bafaloukos, Eleni Res, Pavlos Papakostas, Angelos Koutras, Vassiliki Kotoula, George Fountzilas

Cancer Res Treat. 2022;54(4):1053-1064. Published online November 17, 2021 DOI: https://doi.org/10.4143/crt.2021.748

1065

Fear of Cancer Recurrence and Its Negative Impact on Health-Related Quality of Life in Long-term Breast Cancer Survivors

Thi Xuan Mai Tran, So-Youn Jung, Eun-Gyeong Lee, Heeyoun Cho, Na Yeon Kim, Sungkeun Shim, Ho Young Kim, Danbee Kang, Juhee Cho, Eunsook Lee, Yoon Jung Chang, Hyunsoon Cho

Cancer Res Treat. 2022;54(4):1065-1073. Published online December 8, 2021 DOI: https://doi.org/10.4143/crt.2021.835

Cited By 1

1074

Lobular Carcinoma In Situ during Preoperative Biopsy and the Rate of Upgrade

Jeea Lee, Ga Yoon Ku, Haemin Lee, Hyung Seok Park, Ja Seung Ku, Jee Ye Kim, Seho Park, Byeong-Woo Park

Cancer Res Treat. 2022;54(4):1074-1080. Published online December 21, 2021 DOI: https://doi.org/10.4143/crt.2021.864

1081

Effect of Estrogen Receptor Expression Level and Hormonal Therapy on Prognosis of Early Breast Cancer

Kyung-Hwak Yoon, Yeshong Park, Eunyoung Kang, Eun-Kyu Kim, Jee Hyun Kim, Se Hyun Kim, Koung Jin Suh, Sun Mi Kim, Mijung Jang, Bo La Yun, So Yeon Park, Hee-Chul Shin

Cancer Res Treat. 2022;54(4):1081-1090. Published online November 17, 2021 DOI: https://doi.org/10.4143/crt.2021.890

1091

Real World Evidence of Neoadjuvant Docetaxel/Carboplatin/Trastuzumab/Pertuzumab (TCHP) in Patients with HER2-Positive Early or Locally Advanced Breast Cancer: A Single-Institutional Clinical Experience

Ji-Yeon Kim, Seok Jin Nam, Jeong Eon Lee, Jonghan Yu, Byung Joo Chae, Se Kyung Lee, Jai Min Ryu, Jin Seok Ahn, Young-Hyuck Im, Seok Won Kim, Yeon Hee Park

Cancer Res Treat. 2022;54(4):1091-1098. Published online January 10, 2022 DOI: https://doi.org/10.4143/crt.2021.901

Cited By 1

1099

Implication and Influence of Multigene Panel Testing with Genetic Counseling in Korean Patients with BRCA1/2 Mutation-Negative Breast Cancer

Ji Soo Park, Saeam Shin, Yoon Jung Lee, Seung-Tae Lee, Eun Ji Nam, Jung Woo Han, Sun Hwa Lee, Tae Il Kim, Hyung Seok Park

Cancer Res Treat. 2022;54(4):1099-1110. Published online November 17, 2021 DOI: https://doi.org/10.4143/crt.2021.978

1111

The Association of Estrogen Receptor Activity, Interferon Signaling, and MHC Class I Expression in Breast Cancer

In Hye Song, Young-Ae Kim, Sun-Hee Heo, Won Seon Bang, Hye Seon Park, Yeon ho Choi, Heejae Lee, Jeong-Han Seo, Youngjin Cho, Sung Wook Jung, Hee Jeong Kim, Sei Hyun Ahn, Hee Jin Lee, Gyungyub Gong

Cancer Res Treat. 2022;54(4):1111-1120. Published online December 21, 2021 DOI: https://doi.org/10.4143/crt.2021.1017

1121

The Pattern of Care for Brain Metastasis from Breast Cancer over the Past 10 Years in Korea: A Multicenter Retrospective Study (KROG 16-12)

Jae Sik Kim, Kyubo Kim, Wonguen Jung, Kyung Hwan Shin, Seock-Ah Im, Hee-Jun Kim, Yong Bae Kim, Jee Suk Chang, Jee Hyun Kim, Doo Ho Choi, Yeon Hee Park, Dae Yong Kim, Tae Hyun Kim, Byung Ock Choi, Sea-Won Lee, Suzy Kim, Jeanny Kwon, Ki Mun Kang, Woong-Ki Chung, Kyung Su Kim, Ji Ho Nam, Won Sup Yoon, Jin Hee Kim, Jihye Cha, Yoon Kyeong Oh, In Ah Kim

Cancer Res Treat. 2022;54(4):1121-1129. Published online December 31, 2021 DOI: https://doi.org/10.4143/crt.2021.1083

1130

Real-World Evidence of Trastuzumab, Pertuzumab, and Docetaxel Combination as a First-Line Treatment for Korean Patients with HER2-Positive Metastatic Breast Cancer

Yong-Pyo Lee, Min-Sang Lee, HongSik Kim, Ji-Yeon Kim, Jin Seok Ahn, Young-Hyuck Im, Yeon Hee Park

Cancer Res Treat. 2022;54(4):1130-1137. Published online January 17, 2022 DOI: https://doi.org/10.4143/crt.2021.1103

Cited By 1

Gastrointestinal cancer

1138

Prevalence of Psychological Symptoms in Patients Undergoing Pancreatoduodenectomy and Results of a Distress Management System: A Clinic-Based Study

Mee Joo Kang, Eun-Seung Yu, Young Hwa Kang, Hyeong Min Park, Sang-Jae Park, Sun-Whe Kim, Jong-Heun Kim, Sung-Sik Han

Cancer Res Treat. 2022;54(4):1138-1147. Published online January 4, 2022 DOI: https://doi.org/10.4143/crt.2021.842

1148

Role of Esophagectomy after Chemoradiation Therapy in Patients with Locally Advanced Squamous Cell Carcinoma: A Comparative Analysis Stratified by Clinical Response to Chemoradiation Therapy

Jesang Yu, Jong Hoon Kim, Sung-Bae Kim, Sook Ryun Park, Young-Hee Kim, Hyeong Ryul Kim, Hyun Joo Lee, Ho June Song, Kye Jin Song, Jeong Yun Jang, Yoon Young Jo, Ye Jin Yoo

Cancer Res Treat. 2022;54(4):1148-1156. Published online December 20, 2021 DOI: https://doi.org/10.4143/crt.2021.885

1157

Aberrant DNA Methylation Maker for Predicting Metachronous Recurrence After Endoscopic Resection of Gastric Neoplasms

Cheol Min Shin, Nayoung Kim, Hyuk Yoon, Yoon Jin Choi, Ji Hyun Park, Young Soo Park, Dong Ho Lee

Cancer Res Treat. 2022;54(4):1157-1166. Published online January 18, 2022 DOI: https://doi.org/10.4143/crt.2021.997

1167

Adjuvant Imatinib Treatment for 5 Years versus 3 Years in Patients with Ruptured Localized Gastrointestinal Stromal Tumor: A Retrospective Analysis

Sora Kang, Min-Hee Ryu, Yeong Hak Bang, Hyung-Don Kim, Hyung Eun Lee, Yoon-Koo Kang

Cancer Res Treat. 2022;54(4):1167-1174. Published online December 6, 2011 DOI: https://doi.org/10.4143/crt.2021.1040

Cited By 3

1175

Histopathologic and Molecular Biomarkers of PD-1/PD-L1 Inhibitor Treatment Response among Patients with Microsatellite Instability‒High Colon Cancer

Jaewon Hyung, Eun Jeong Cho, Jihun Kim, Jwa Hoon Kim, Jeong Eun Kim, Yong Sang Hong, Tae Won Kim, Chang Ohk Sung, Sun Young Kim

Cancer Res Treat. 2022;54(4):1175-1190. Published online January 12, 2022 DOI: https://doi.org/10.4143/crt.2021.1133

Cited By 1

Genitourinary cancer

1191

Optimal Definition of Biochemical Recurrence in Patients Who Receive Salvage Radiotherapy Following Radical Prostatectomy for Prostate Cancer

Sung Uk Lee, Jae-Sung Kim, Young Seok Kim, Jaeho Cho, Seo Hee Choi, Taek-Keun Nam, Song Mi Jeong, Youngkyong Kim, Youngmin Choi, Dong Eun Lee, Won Park, Kwan Ho Cho

Cancer Res Treat. 2022;54(4):1191-1199. Published online December 7, 2021 DOI: https://doi.org/10.4143/crt.2021.985

Gynecologic cancer

1200

Frequency of Mismatch Repair Deficiency/High Microsatellite Instability and Its Role as a Predictive Biomarker of Response to Immune Checkpoint Inhibitors in Gynecologic Cancers

Joseph J. Noh, Min Kyu Kim, Min Chul Choi, Jeong-Won Lee, Hyun Park, Sang Geun Jung, Won Duk Joo, Seung Hun Song, Chan Lee

Cancer Res Treat. 2022;54(4):1200-1208. Published online December 13, 2021 DOI: https://doi.org/10.4143/crt.2021.828

Cited By 1

1209

Genomic Correlates of Unfavorable Outcome in Locally Advanced Cervical Cancer Treated with Neoadjuvant Chemoradiation

Yuchun Wei, Chuqing Wei, Liang Chen, Ning Liu, Qiuxiang Ou, Jiani C. Yin, Jiaohui Pang, Zhenhao Fang, Xue Wu, Xiaonan Wang, Dianbin Mu, Yang Shao, Jinming Yu, Shuanghu Yuan

Cancer Res Treat. 2022;54(4):1209-1218. Published online January 17, 2022 DOI: https://doi.org/10.4143/crt.2021.963

1219

Identification of Patients with Recurrent Epithelial Ovarian Cancer Who Will Benefit from More Than Three Lines of Chemotherapy

Aeran Seol, Ga Won Yim, Joo Yeon Chung, Se Ik Kim, Maria Lee, Hee Seung Kim, Hyun Hoon Chung, Jae-Weon Kim, Noh Hyun Park, Yong Sang Song

Cancer Res Treat. 2022;54(4):1219-1229. Published online November 17, 2021 DOI: https://doi.org/10.4143/crt.2021.1010

Pediatric cancer

1230

Outcome of Intensive Therapy for Children with Relapsed Acute Myeloid Leukemia: A Single Institution Korean Study

Jae Wook Lee, Jae Won Yoo, Seongkoo Kim, Pil-Sang Jang, Nack-Gyun Chung, Bin Cho

Cancer Res Treat. 2022;54(4):1230-1239. Published online December 17, 2021 DOI: https://doi.org/10.4143/crt.2021.1011

Sarcoma

1240

Whole-Genome and Transcriptome Sequencing Identified NOTCH2 and HES1 as Potential Markers of Response to Imatinib in Desmoid Tumor (Aggressive Fibromatosis): A Phase II Trial Study

Joonha Kwon, Jun Hyeong Lee, Young Han Lee, Jeeyun Lee, Jin-Hee Ahn, Se Hyun Kim, Seung Hyun Kim, Tae Il Kim, Kum-Hee Yun, Young Suk Park, Jeong Eun Kim, Kyu Sang Lee, Jung Kyoon Choi, Hyo Song Kim

Cancer Res Treat. 2022;54(4):1240-1255. Published online January 17, 2022 DOI: https://doi.org/10.4143/crt.2021.1194

Cited By 2

Hematologic malignancy

1256

Predictive Parameters of Febrile Neutropenia and Clinical Significance of G-CSF Receptor Signaling Pathway in the Development of Neutropenia during R-CHOP Chemotherapy with Prophylactic Pegfilgrastim in Patients with Diffuse Large B-Cell Lymphoma

Do Young Kim, Jehyun Nam, Joo-Seop Chung, Byeol Eun Jeon, Ji Hyun Lee, Jae-Cheol Jo, Sang-Woo Kim, Ho-Jin Shin

Cancer Res Treat. 2022;54(4):1256-1267. Published online December 31, 2021 DOI: https://doi.org/10.4143/crt.2021.944

1268

Pegfilgrastim Prophylaxis Is Effective in the Prevention of Febrile Neutropenia and Reduces Mortality in Patients Aged ≥ 75 Years with Diffuse Large B-Cell Lymphoma Treated with R-CHOP: A Prospective Cohort Study

Seong Hyun Jeong, Seok Jin Kim, Dok Hyun Yoon, Yong Park, Hye Jin Kang, Youngil Koh, Gyeong-Won Lee, Won-Sik Lee, Deok-Hwan Yang, Young Rok Do, Min Kyoung Kim, Kwai Han Yoo, Yoon Seok Choi, Hwan Jung Yun, Jun Ho Yi, Jae-Cheol Jo, Hyeon-Seok Eom, Jae-Yong Kwak, Ho-Jin Shin, Byeong Bae Park, Shin Young Hyun, Seong Yoon Yi, Ji-Hyun Kwon, Sung Yong Oh, Hyo Jung Kim, Byeong Seok Sohn, Jong Ho Won, Se-Hyung Kim, Ho-Sup Lee, Cheolwon Suh, Won Seog Kim

Cancer Res Treat. 2022;54(4):1268-1277. Published online December 30, 2021 DOI: https://doi.org/10.4143/crt.2021.1168

1278

Tables of Contents (Vol. 54, No. 1~4, 2022)

Cancer Res Treat. 2022;54(4):1278-1288.

1289

Acknowledgment of Reviewers (2022)

Cancer Res Treat. 2022;54(4):1289-1292.