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REVIEW ARTICLE 2022 February 18
Challenges in the Use of Targeted Therapies in Non–Small Cell Lung Cancer
Precision oncology has fundamentally changed how we diagnose and treat cancer. In recent years, there has been a significant change in the management of patients with oncogene-addicted advanced-stage NSCLC. Increasing amounts of identifiable oncogene drivers have led to the deve...
SPECIAL ARTICLE 2022 March 16
Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2019
Purpose The current study provides national cancer statistics and their secular trends in Korea, including incidence, mortality, survival, and prevalence in 2019. Materials and Methods Incidence, survival, and prevalence rates of cancer were calculated using the Korea Nationa...
SPECIAL ARTICLE 2022 March 21
Prediction of Cancer Incidence and Mortality in Korea, 2022
Purpose This study aimed to report the projected cancer incidence and mortality for the year 2022 to estimate Korea’s current cancer burden. Materials and Methods Cancer incidence data from 1999 to 2019 were obtained from the Korea National Cancer Incidence Database, and ca...
ORIGINAL ARTICLE 2021 August 2
Validation of Cancer Diagnosis Based on the National Health Insurance Service Database versus the National Cancer Registry Database in Korea
Purpose This study aimed to assess the feasibility of operational definitions of cancer patients in conducting cancer-related studies using the claims data from the National Health Insurance Service (NHIS). Materials and Methods Cancer incidence data were obtained from the K...
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Review Article
315 Challenges in the Use of Targeted Therapies in Non–Small Cell Lung Cancer
Joel Rivera-Concepcion, Dipesh Uprety, Alex A. Adjei
Cancer Res Treat. 2022;54(2):315-329.   Published online February 18, 2022    DOI: https://doi.org/10.4143/crt.2022.078
                              
Special Articles
330 Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2019
Mee Joo Kang, Young-Joo Won, Jae Jun Lee, Kyu-Won Jung, Hye-Jin Kim, Hyun-Joo Kong, Jeong-Soo Im, Hong Gwan Seo, The Community of Population-Based Regional Cancer Registries
Cancer Res Treat. 2022;54(2):330-344.   Published online March 16, 2022    DOI: https://doi.org/10.4143/crt.2022.128
                              Supplementary         Cited By 3
345 Prediction of Cancer Incidence and Mortality in Korea, 2022
Kyu-Won Jung, Young-Joo Won, Mee Joo Kang, Hyun-Joo Kong, Jeong-Soo Im, Hong Gwan Seo
Cancer Res Treat. 2022;54(2):345-351.   Published online March 21, 2022    DOI: https://doi.org/10.4143/crt.2022.179
                              
Original Articles
General
352 Validation of Cancer Diagnosis Based on the National Health Insurance Service Database versus the National Cancer Registry Database in Korea
Min Soo Yang, Minae Park, Joung Hwan Back, Gyeong Hyeon Lee, Ji Hye Shin, Kyuwoong Kim, Hwa Jeong Seo, Young Ae Kim
Cancer Res Treat. 2022;54(2):352-361.   Published online August 2, 2021    DOI: https://doi.org/10.4143/crt.2021.044
                                 Cited By 2
362 Engineering a High-Affinity PD-1 Peptide for Optimized Immune Cell-Mediated Tumor Therapy
Yilei Chen, Hongxing Huang, Yin Liu, Zhanghao Wang, Lili Wang, Quanxiao Wang, Yan Zhang, Hua Wang
Cancer Res Treat. 2022;54(2):362-374.   Published online August 3, 2021    DOI: https://doi.org/10.4143/crt.2021.424
                              Supplementary      
375 Attitudes toward Risk-Reducing Mastectomy and Risk-Reducing Salpingo-oophorectomy among Young, Unmarried, Healthy Women in Korea
Boyoung Park, Dongwon Kim, Jiyoung Kim, Bom Yi Lee, Junghyun Yoon, Sung-Won Kim
Cancer Res Treat. 2022;54(2):375-382.   Published online August 9, 2021    DOI: https://doi.org/10.4143/crt.2021.449
                              
383 Radiation Response Prediction Model Based on Integrated Clinical and Genomic Data Analysis
Bum-Sup Jang, Ji-Hyun Chang, Seung Hyuck Jeon, Myung Geun Song, Kyung-Hun Lee, Seock-Ah Im, Jong-Il Kim, Tae-You Kim, Eui Kyu Chie
Cancer Res Treat. 2022;54(2):383-395.   Published online August 24, 2021    DOI: https://doi.org/10.4143/crt.2021.759
                              Supplementary      
CNS cancer
396 Influence of Concurrent and Adjuvant Temozolomide on Health-Related Quality of Life of Patients with Grade III Gliomas: A Secondary Analysis of a Randomized Clinical Trial (KNOG-1101 Study)
Grace S. Ahn, Kihwan Hwang, Tae Min Kim, Chul Kee Park, Jong Hee Chang, Tae-Young Jung, Jin Hee Kim, Do-Hyun Nam, Se-Hyuk Kim, Heon Yoo, Yong-Kil Hong, Eun-Young Kim, Dong-Eun Lee, Jungnam Joo, Yu Jung Kim, Gheeyoung Choe, Byung Se Choi, Seok-Gu Kang, Jeong Hoon Kim, Chae-Yong Kim
Cancer Res Treat. 2022;54(2):396-405.   Published online July 6, 2021    DOI: https://doi.org/10.4143/crt.2021.393
                              Supplementary      
Head and Neck cancer
406 Radiotherapy versus Surgery in Early-Stage HPV-Positive Oropharyngeal Cancer
Dong-Yun Kim, Hong-Gyun Wu, Jin Ho Kim, Joo Ho Lee, Soon-Hyun Ahn, Eun-Jae Chung, Keun-Yong Eom, Young Ho Jung, Woo-Jin Jeong, Tack-Kyun Kwon, Suzy Kim, Chan Woo Wee
Cancer Res Treat. 2022;54(2):406-416.   Published online June 23, 2021    DOI: https://doi.org/10.4143/crt.2021.441
                              Supplementary      
417 Radiation-Induced Ocular Surface Disorders and Retinopathy: Ocular Structures and Radiation Dose-Volume Effect
Ozlem Ozkaya Akagunduz, Suzan Guven Yilmaz, Emin Tavlayan, Mine Esen Baris, Filiz Afrashi, Mustafa Esassolak
Cancer Res Treat. 2022;54(2):417-423.   Published online June 24, 2021    DOI: https://doi.org/10.4143/crt.2021.575
                                 Cited By 2
Lung and Thoracic cancer
424 Comparison of the Predictive Power of a Combination versus Individual Biomarker Testing in Non–Small Cell Lung Cancer Patients Treated with Immune Checkpoint Inhibitors
Hyojin Kim, Hyun Jung Kwon, Eun Sun Kim, Soohyeon Kwon, Kyoung Jin Suh, Se Hyun Kim, Yu Jung Kim, Jong Seok Lee, Jin-Haeng Chung
Cancer Res Treat. 2022;54(2):424-433.   Published online July 7, 2021    DOI: https://doi.org/10.4143/crt.2021.583
                              Supplementary      
434 The Clinical Outcomes of Different First-Line EGFR-TKIs Plus Bevacizumab in Advanced EGFR-Mutant Lung Adenocarcinoma
Yen-Hsiang Huang, Kuo-Hsuan Hsu, Chun-Shih Chin, Jeng-Sen Tseng, Tsung-Ying Yang, Kun-Chieh Chen, Kang-Yi Su, Sung-Liang Yu, Jeremy J.W. Chen, Gee-Chen Chang
Cancer Res Treat. 2022;54(2):434-444.   Published online August 2, 2021    DOI: https://doi.org/10.4143/crt.2021.671
                                 Cited By 1
445 miR-4487 Enhances Gefitinib-Mediated Ubiquitination and Autophagic Degradation of EGFR in Non-Small Cell Lung Cancer Cells by Targeting USP37
Mi Seong Kim, So Hui Kim, Sei Hoon Yang, Min Seuk Kim
Cancer Res Treat. 2022;54(2):445-457.   Published online August 3, 2021    DOI: https://doi.org/10.4143/crt.2021.622
                              
458 Histone Deacetylase as a Valuable Predictive Biomarker and Therapeutic Target in Immunotherapy for Non-Small Cell Lung Cancer
Hyun-Seock Shin, Juwhan Choi, Jinhwan Lee, Sung Yong Lee
Cancer Res Treat. 2022;54(2):458-468.   Published online September 10, 2021    DOI: https://doi.org/10.4143/crt.2021.425
                              Supplementary         Cited By 2
Breast cancer
469 Comparison of the Effectiveness and Clinical Outcome of Everolimus Followed by CDK4/6 Inhibitors with the Opposite Treatment Sequence in Hormone Receptor-Positive, HER2-Negative Metastatic Breast Cancer
Hyehyun Jeong, Jae Ho Jeong, Jeong Eun Kim, Jin-Hee Ahn, Kyung Hae Jung, Sung-Bae Kim
Cancer Res Treat. 2022;54(2):469-477.   Published online June 23, 2021    DOI: https://doi.org/10.4143/crt.2021.205
                              Supplementary         Cited By 1
478 Effect of Postoperative Radiotherapy after Primary Tumor Resection in De Novo Stage IV Breast Cancer: A Multicenter Retrospective Study (KROG 19-02)
Yeon Joo Kim, Yeon-Joo Kim, Yong Bae Kim, Ik Jae Lee, Jeanny Kwon, Kyubo Kim, Jihye Cha, Myungsoo Kim, In Young Jo, Jung Hoon Kim, Jaehyeon Park, Jin Hee Kim, Juree Kim, Kyung Hwan Shin, Su Ssan Kim
Cancer Res Treat. 2022;54(2):478-487.   Published online July 12, 2021    DOI: https://doi.org/10.4143/crt.2021.632
                              Supplementary      
488 A Real-world Efficacy of Nab-paclitaxel Monotherapy in Metastatic Breast Cancer
Jung Sun Kim, Koung Jin Suh, Dae-Won Lee, Go-un Woo, Miso Kim, Se Hyun Kim, Han Suk Ryu, Kyung-Hun Lee, Tae-Yong Kim, Sae-Won Han, So Yeon Park, In Ae Park, Jee Hyun Kim, Seock-Ah Im
Cancer Res Treat. 2022;54(2):488-496.   Published online August 13, 2021    DOI: https://doi.org/10.4143/crt.2021.394
                                 Cited By 2
497 Postmastectomy Radiation Therapy for Node-Negative Breast Cancer of 5 cm or Larger Tumors: A Multicenter Retrospective Analysis (KROG 20-03)
Kyubo Kim, Jinhong Jung, Haeyoung Kim, Wonguen Jung, Kyung Hwan Shin, Ji Hyun Chang, Su Ssan Kim, Won Park, Jee Suk Chang, Yong Bae Kim, Sung Ja Ahn, Ik Jae Lee, Jong Hoon Lee, Hae Jin Park, Jihye Cha, Juree Kim, Jin Hwa Choi, Taeryool Koo, Jeanny Kwon, Jin Hee Kim, Mi Young Kim, Shin-Hyung Park, Yeon-Joo Kim
Cancer Res Treat. 2022;54(2):497-504.   Published online August 25, 2021    DOI: https://doi.org/10.4143/crt.2021.933
                                 Cited By 1
Gastrointestinal cancer
505 Real-World Efficacy Data and Predictive Clinical Parameters for Treatment Outcomes in Advanced Esophageal Squamous Cell Carcinoma Treated with Immune Checkpoint Inhibitors
Jwa Hoon Kim, Bokyung Ahn, Seung-Mo Hong, Hwoon-Yong Jung, Do Hoon Kim, Kee Don Choi, Ji Yong Ahn, Jeong Hoon Lee, Hee Kyoung Na, Jong Hoon Kim, Yong-Hee Kim, Hyeong Ryul Kim, Hyun Joo Lee, Sung-Bae Kim, Sook Ryun Park
Cancer Res Treat. 2022;54(2):505-516.   Published online June 23, 2021    DOI: https://doi.org/10.4143/crt.2020.1198
                              Supplementary         Cited By 1
517 Machine Learning Model for Predicting Postoperative Survival of Patients with Colorectal Cancer
Mohamed Hosny Osman, Reham Hosny Mohamed, Hossam Mohamed Sarhan, Eun Jung Park, Seung Hyuk Baik, Kang Young Lee, Jeonghyun Kang
Cancer Res Treat. 2022;54(2):517-524.   Published online June 15, 2021    DOI: https://doi.org/10.4143/crt.2021.206
                              Supplementary      
525 A Hypoxia-Induced SCFFBXL1 E3 Ligase Ubiquitinates and Degrades the MEN1 Tumor Suppressor to Promote Colorectal Cancer Tumorigenesis
Jun Zeng, Xiao-qing Xiao, Zhi-yong Zhou
Cancer Res Treat. 2022;54(2):525-540.   Published online June 29, 2021    DOI: https://doi.org/10.4143/crt.2021.373
                              Supplementary      
541 Inhibition of WEE1 Potentiates Sensitivity to PARP Inhibitor in Biliary Tract Cancer
Hye-Rim Seo, Ah-Rong Nam, Ju-Hee Bang, Kyoung-Seok Oh, Jae-Min Kim, Jeesun Yoon, Tae-Yong Kim, Do-Youn Oh
Cancer Res Treat. 2022;54(2):541-553.   Published online August 6, 2021    DOI: https://doi.org/10.4143/crt.2021.473
                                 Cited By 1
Gynecologic cancer
554 Effectiveness of Concomitant Chemoradiotherapy with Gemcitabine in Locally Advanced Cervical Cancer Patients with Comorbidities
Hasan Brau-Figueroa, Eder Arango-Bravo, Denisse Castro-Eguiluz, Tatiana Galicia-Carmona, Leopoldo Abraham Lugo-Alferez, Ivette Cruz-Bautista, Roberto Jiménez-Lima, Lucely Cetina-Pérez
Cancer Res Treat. 2022;54(2):554-562.   Published online August 10, 2021    DOI: https://doi.org/10.4143/crt.2021.375
                              Supplementary      
Pediatric cancer
563 Vincristine, Irinotecan, and Temozolomide as a Salvage Regimen for Relapsed or Refractory Sarcoma in Children and Young Adults
Hee Young Ju, Meerim Park, Jun Ah Lee, Hyeon Jin Park, Seog Yun Park, June Hyuk Kim, Hyun Guy Kang, Hee Chul Yang, Byung-Kiu Park
Cancer Res Treat. 2022;54(2):563-571.   Published online June 14, 2021    DOI: https://doi.org/10.4143/crt.2021.178
                                 Cited By 2
572 Epidemiology of Acute Leukemia among Children with Down Syndrome in Korea
Young Bae Choi, Keon Hee Yoo
Cancer Res Treat. 2022;54(2):572-578.   Published online August 10, 2021    DOI: https://doi.org/10.4143/crt.2021.368
                              
Sarcoma
579 Clinicopathologic Characteristics and Clinical Outcome of Localized Liposarcoma: A Single-Center Experience over 25 Years and Evaluation of PD-L1 Expression
Heejung Chae, Jeong Eun Kim, Wanlim Kim, Jong-Seok Lee, Si Yeol Song, Min Hee Lee, Hye Won Chung, Kyung-Ja Cho, Joon Seon Song, Jin-Hee Ahn
Cancer Res Treat. 2022;54(2):579-589.   Published online July 6, 2021    DOI: https://doi.org/10.4143/crt.2021.496
                              Supplementary      
590 Incidence Patterns and Outcomes of Ewing Sarcoma in South Korea (1999-2017): A Retrospective Analysis Using Korea Central Cancer Registry Data
Jun Ah Lee, Jiwon Lim, Dayeon Park, Hye Young Jin, Meerim Park, Hyeon Jin Park, Jong Woong Park, June Hyuk Kim, Hyun Guy Kang, Young-Joo Won
Cancer Res Treat. 2022;54(2):590-596.   Published online July 20, 2021    DOI: https://doi.org/10.4143/crt.2021.311
                                 Cited By 1
Hematologic malignancy
597 Plasma Circulating Tumor DNA in Patients with Primary Central Nervous System Lymphoma
Sang Eun Yoon, Yeon Jeong Kim, Joon Ho Shim, Donghyun Park, Junhun Cho, Young Hyeh Ko, Woong-Yang Park, Yeung-Chul Mun, Kyoung Eun Lee, Duck Cho, Won Seog Kim, Seok Jin Kim
Cancer Res Treat. 2022;54(2):597-612.   Published online July 23, 2021    DOI: https://doi.org/10.4143/crt.2021.752
                              Supplementary         Cited By 1
613 Predictive Factors of Event-Free Survival at 24 Months in Patients with Peripheral T-Cell Lymphoma: A Retrospective Study
Yu Ri Kim, Soo-Jeong Kim, Hye Sun Lee, Soyoung Jeon, Hyunsoo Cho, Haerim Chung, Ji Eun Jang, June-Won Cheong, Yoo Hong Min, Jin Seok Kim
Cancer Res Treat. 2022;54(2):613-620.   Published online August 5, 2021    DOI: https://doi.org/10.4143/crt.2021.270
                                 Cited By 1
Palliative medicine
621 A Prognostic Model to Facilitate Palliative Care Referral in Oncology Outpatients
Yu Jung Kim, Yusuke Hiratsuka, Sang-Yeon Suh, Beodeul Kang, Si Won Lee, Hong-Yup Ahn, Koung Jin Suh, Ji-Won Kim, Se Hyun Kim, Jin Won Kim, Keun-Wook Lee, Jee Hyun Kim, Jong Seok Lee
Cancer Res Treat. 2022;54(2):621-629.   Published online July 12, 2021    DOI: https://doi.org/10.4143/crt.2021.483
                              
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