Cancer Research and Treatment

REVIEW ARTICLE 2023 October 5 Recent Developments in the Therapeutic Landscape of Advanced or Metastatic Hormone Receptor–Positive Breast Cancer
Hormone receptor–positive (HR+) disease is the most frequently diagnosed subtype of breast cancer. Among tumor subtypes, natural course of HR+ breast cancer is indolent with favorable prognosis compared to other subtypes such as human epidermal growth factor protein 2–positiv...

ORIGINAL ARTICLE 2023 June 12 Establishment of Patient-Derived Organoids Using Ascitic or Pleural Fluid from Cancer Patients
Purpose Patient-derived tumor cells can be a powerful resource for studying pathophysiological mechanisms and developing robust strategies for precision medicine. However, establishing organoids from patient-derived cells is challenging because of limited access to tissue specim...

ORIGINAL ARTICLE 2023 June 15 Clinicopathological Characteristics of NRG1 Fusion–Positive Solid Tumors in Korean Patients
Purpose Neuregulin 1 (NRG1) gene fusion is a potentially actionable oncogenic driver. The oncoprotein binds to ERBB3-ERBB2 heterodimers and activates downstream signaling, supporting a therapeutic approach for inhibiting ERBB3/ERBB2. However, the frequency and clinicopathologica...

ORIGINAL ARTICLE 2023 April 7 A Multicenter, Prospective, Observational Study to Evaluate Ethanol-Induced Symptoms in Patients Receiving Docetaxel Chemotherapy
Purpose Several previous studies and case reports have reported ethanol-induced symptoms in patients receiving anticancer drugs containing ethanol. Most docetaxel formulations contain ethanol as a solvent. However, there are insufficient data on ethanol-induced symptoms when doc...

Current Issue

Volume 55(4); Oct 2023

Volume 55(3); July 2023

Volume 55(2); April 2023

Editorial

1063

Barriers in Oligometastasis Care in Korea: Radiation Oncologists’ Perspectives

Eui Kyu Chie, Chai Hong Rim, Won Kyung Cho, Yong Chan Ahn

Cancer Res Treat. 2023;55(4):1063-1064. Published online June 27, 2023 DOI: https://doi.org/10.4143/crt.2023.780

Cited By 1

Review Article

1065

Recent Developments in the Therapeutic Landscape of Advanced or Metastatic Hormone Receptor–Positive Breast Cancer

Eunice Yoojin Lee, Dae-Won Lee, Kyung-Hun Lee, Seock-Ah Im

Cancer Res Treat. 2023;55(4):1065-1076. Published online October 5, 2023 DOI: https://doi.org/10.4143/crt.2023.846

Original Articles

General

1077

Establishment of Patient-Derived Organoids Using Ascitic or Pleural Fluid from Cancer Patients

Wonyoung Choi, Yun-Hee Kim, Sang Myung Woo, Yebeen Yu, Mi Rim Lee, Woo Jin Lee, Jung Won Chun, Sung Hoon Sim, Heejung Chae, Hyoeun Shim, Keun Seok Lee, Sun-Young Kong

Cancer Res Treat. 2023;55(4):1077-1086. Published online June 12, 2023 DOI: https://doi.org/10.4143/crt.2022.1630

Cited By 1

1087

Clinicopathological Characteristics of NRG1 Fusion–Positive Solid Tumors in Korean Patients

Yoon Jin Cha, Chung Lee, Bio Joo, Kyung A Kim, Choong-kun Lee, Hyo Sup Shim

Cancer Res Treat. 2023;55(4):1087-1095. Published online June 15, 2023 DOI: https://doi.org/10.4143/crt.2023.682

Cited By 1

1096

A Multicenter, Prospective, Observational Study to Evaluate Ethanol-Induced Symptoms in Patients Receiving Docetaxel Chemotherapy

Young-Woong Won, Jin-Hyoung Kang, Jung Hye Kwon, Dong-Hoe Koo, Jung Hun Kang, Chi Hoon Maeng, Hee Kyung Ahn, Sung Yong Oh, Dae-Won Lee, Joohyuk Sohn, So Yeon Oh, Kyung Hee Lee, Su-Jin Koh, Keun Seok Lee, Chan-Kyu Kim, Ji-Yeon Kim, Jun Ho Ji, Sung-Bae Kim, Joo Young Ha, Ho Young Kim

Cancer Res Treat. 2023;55(4):1096-1103. Published online April 7, 2023 DOI: https://doi.org/10.4143/crt.2022.1565

Head and Neck cancer

1104

Phase II Trial of Combined Durvalumab Plus Tremelimumab with Proton Therapy for Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

Hana Kim, Sehhoon Park, Hyun Ae Jung, Se-Hoon Lee, Keunchil Park, Yong Chan Ahn, Dongryul Oh, Myung-Ju Ahn

Cancer Res Treat. 2023;55(4):1104-1112. Published online May 17, 2023 DOI: https://doi.org/10.4143/crt.2023.502

1113

Individualized Concurrent Chemotherapy for Patients with Stage III-IVa Nasopharyngeal Carcinoma Receiving Neoadjuvant Chemotherapy Combined with Definitive Intensity-Modulated Radiotherapy

Pengjie Ji, Qiongjiao Lu, Xiaoqiang Chen, Yuebing Chen, Xiane Peng, Zhiwei Chen, Cheng Lin, Shaojun Lin, Jingfeng Zong

Cancer Res Treat. 2023;55(4):1113-1122. Published online May 11, 2023 DOI: https://doi.org/10.4143/crt.2022.1651

1123

Outcomes of Salvage Therapy for Oropharyngeal Cancer Recurrence Following Upfront Radiation Therapy and Prognostic Factors

Nayeon Choi, Hack Jung Kim, Heejun Yi, Heejung Kim, Tae Hwan Kim, Han-Sin Jeong, Young-Ik Son, Chung-Hwan Baek, Dongryul Oh, Yong Chan Ahn, Man Ki Chung

Cancer Res Treat. 2023;55(4):1123-1133. Published online May 8, 2023 DOI: https://doi.org/10.4143/crt.2022.1046

Lung and Thoracic cancer

1134

Targeting CD73 to Overcomes Resistance to First-Generation EGFR Tyrosine Kinase Inhibitors in Non–Small Cell Lung Cancer

Miso Kim, Soyeon Kim, Jeemin Yim, Bhumsuk Keam, Tae Min Kim, Yoon Kyung Jeon, Dong-Wan Kim, Dae Seog Heo

Cancer Res Treat. 2023;55(4):1134-1143. Published online May 23, 2023 DOI: https://doi.org/10.4143/crt.2023.311

1144

Expanded Access Program Pralsetinib in Advanced Non–Small Cell Lung Cancer with Rearranged during Transfection (RET) Gene Rearrangement

Youngkyung Jeon, Hyun Ae Jung, Sehhoon Park, Jong-Mu Sun, Jin Seok Ahn, Myung-Ju Ahn, Keunchil Park, Se-Hoon Lee

Cancer Res Treat. 2023;55(4):1144-1151. Published online May 22, 2023 DOI: https://doi.org/10.4143/crt.2023.403

1152

Final Report on Real-World Effectiveness of Sequential Afatinib and Osimertinib in EGFR-Positive Advanced Non–Small Cell Lung Cancer: Updated Analysis of the RESET Study

Taeyun Kim, Tae Won Jang, Chang Min Choi, Mi-Hyun Kim, Sung Yong Lee, Yoon Soo Chang, Kye Young Lee, Seung Joon Kim, Sei Hoon Yang, Jeong Seon Ryu, Jeong Eun Lee, Shin Yup Lee, Chan Kwon Park, Sang Hoon Lee, Seung Hun Jang, Seong Hoon Yoon, Hyung-Joo Oh

Cancer Res Treat. 2023;55(4):1152-1170. Published online May 19, 2023 DOI: https://doi.org/10.4143/crt.2023.493

Cited By 1

1171

Sublobar Resection versus Stereotactic Body Radiation Therapy for Clinical Stage I Non–Small Cell Lung Cancer: A Study Using Data from the Korean Nationwide Lung Cancer Registry

Jeonghee Yun, Jong Ho Cho, Tae Hee Hong, Kyungmi Yang, Yong Chan Ahn, Hong Kwan Kim, Korean Association for Lung Cancer, Korea Central Cancer Registry

Cancer Res Treat. 2023;55(4):1171-1180. Published online April 17, 2023 DOI: https://doi.org/10.4143/crt.2022.1581

1181

Clinical Outcome of Stereotactic Body Radiotherapy in Patients with Early-Stage Lung Cancer with Ground-Glass Opacity Predominant Lesions: A Single Institution Experience

Jeong Yun Jang, Su Ssan Kim, Si Yeol Song, Young Seob Shin, Sei Won Lee, Wonjun Ji, Chang-Min Choi, Eun Kyung Choi

Cancer Res Treat. 2023;55(4):1181-1189. Published online March 21, 2023 DOI: https://doi.org/10.4143/crt.2022.1656

1190

Should We Perform Repeated Re-biopsy for the Detection of T790M Mutation?

Saerom Kim, Soo Han Kim, Jinmi Kim, Mi-Hyun Kim, Min Ki Lee, Jung Seop Eom

Cancer Res Treat. 2023;55(4):1190-1197. Published online April 17, 2023 DOI: https://doi.org/10.4143/crt.2023.320

Cited By 1

Breast cancer

1198

Efficacy of Limited Dose Modifications for Palbociclib-Related Grade 3 Neutropenia in Hormone Receptor–Positive Metastatic Breast Cancer

Seul-Gi Kim, Min Hwan Kim, Sejung Park, Gun Min Kim, Jee Hung Kim, Jee Ye Kim, Hyung Seok Park, Seho Park, Byeong Woo Park, Seung Il Kim, Jung Hwan Ji, Joon Jeong, Kabsoo Shin, Jieun Lee, Hyung-Don Kim, Kyung Hae Jung, Joohyuk Sohn

Cancer Res Treat. 2023;55(4):1198-1209. Published online April 11, 2023 DOI: https://doi.org/10.4143/crt.2022.1543

1210

Prognostic Value of the Evolution of HER2-Low Expression after Neoadjuvant Chemotherapy

Youzhao Ma, Mingda Zhu, Jingyang Zhang, Minhao Lv, Xiuchun Chen, Zhenzhen Liu

Cancer Res Treat. 2023;55(4):1210-1221. Published online April 4, 2023 DOI: https://doi.org/10.4143/crt.2022.1633

Cited By 1

1222

Health-Seeking Behavior Returning to Normalcy Overcoming COVID-19 Threat in Breast Cancer

Eun-Gyeong Lee, Yireh Han, Dong-Eun Lee, Hyeong-Gon Moon, Hyoung Won Koh, Eun-Kyu Kim, So-Youn Jung

Cancer Res Treat. 2023;55(4):1222-1230. Published online April 3, 2023 DOI: https://doi.org/10.4143/crt.2023.364

Gastrointestinal cancer

1231

The Role of Adjuvant Chemotherapy after Neoadjuvant Chemoradiotherapy Followed by Surgery in Patients with Esophageal Squamous Cell Carcinoma

Seong Yong Park, Hong Kwan Kim, Yeong Jeong Jeon, Junghee Lee, Jong Ho Cho, Yong Soo Choi, Young Mog Shim, Jae Il Zo

Cancer Res Treat. 2023;55(4):1231-1239. Published online April 24, 2023 DOI: https://doi.org/10.4143/crt.2022.1417

1240

Development and Validation of Models to Predict Lymph Node Metastasis in Early Gastric Cancer Using Logistic Regression and Gradient Boosting Machine Methods

Hae Dong Lee, Kyung Han Nam, Cheol Min Shin, Hye Seung Lee, Young Hoon Chang, Hyuk Yoon, Young Soo Park, Nayoung Kim, Dong Ho Lee, Sang-Hoon Ahn, Hyung-Ho Kim

Cancer Res Treat. 2023;55(4):1240-1249. Published online March 21, 2023 DOI: https://doi.org/10.4143/crt.2022.1330

1250

A Phase 3 Randomized Clinical Trial to Compare Efficacy and Safety between Combination Therapy and Monotherapy in Elderly Patients with Advanced Gastric Cancer (KCSG ST13-10)

Keun-Wook Lee, Dae Young Zang, Min-Hee Ryu, Hye Sook Han, Ki Hyang Kim, Mi-Jung Kim, Sung Ae Koh, Sung Sook Lee, Dong-Hoe Koo, Yoon Ho Ko, Byeong Seok Sohn, Jin Won Kim, Jin Hyun Park, Byung-Ho Nam, In Sil Choi

Cancer Res Treat. 2023;55(4):1250-1260. Published online May 25, 2023 DOI: https://doi.org/10.4143/crt.2023.333

1261

Clinical Significance of Combining Preoperative and Postoperative Albumin-Bilirubin Score in Colorectal Cancer

Doyoun Kim, Jae-Hoon Lee, Eun-Suk Cho, Su-Jin Shin, Hye Sun Lee, Hwa-Hee Koh, Kang Young Lee, Jeonghyun Kang

Cancer Res Treat. 2023;55(4):1261-1269. Published online April 17, 2023 DOI: https://doi.org/10.4143/crt.2022.1444

Cited By 1

1270

Specific Mutations in APC, with Prognostic Implications in Metastatic Colorectal Cancer

Huan Peng, Jun Ying, Jia Zang, Hao Lu, Xiaokai Zhao, Pengmin Yang, Xintao Wang, Jieyi Li, Ziying Gong, Daoyun Zhang, Zhiguo Wang

Cancer Res Treat. 2023;55(4):1270-1280. Published online April 24, 2023 DOI: https://doi.org/10.4143/crt.2023.415

1281

Differential Perspectives by Specialty on Oligometastatic Colorectal Cancer: A Korean Oligometastasis Working Group’s Comparative Survey Study

Won Kyung Cho, Gyu Sang Yoo, Chai Hong Rim, Jae-Uk Jeong, Eui Kyu Chie, Yong Chan Ahn, Hyeon-Min Cho, Jun Won Um, Yang-Gun Suh, Ah Ram Chang, Jong Hoon Lee, On behalf of the Oligometastasis Working Group, Korean Cancer Association

Cancer Res Treat. 2023;55(4):1281-1290. Published online June 7, 2023 DOI: https://doi.org/10.4143/crt.2023.479

Cited By 1

1291

ARID1A Mutation from Targeted Next-Generation Sequencing Predicts Primary Resistance to Gemcitabine and Cisplatin Chemotherapy in Advanced Biliary Tract Cancer

Sung Hwan Lee, Jaekyung Cheon, Seoyoung Lee, Beodeul Kang, Chan Kim, Hyo Sup Shim, Young Nyun Park, Sanghoon Jung, Sung Hoon Choi, Hye Jin Choi, Choong-kun Lee, Hong Jae Chon

Cancer Res Treat. 2023;55(4):1291-1302. Published online May 3, 2023 DOI: https://doi.org/10.4143/crt.2022.1450

1303

Prevalence and Risk Factors of Germline Pathogenic Variants in Pancreatic Ductal Adenocarcinoma

Kum Hei Ryu, Sunhwa Park, Jung Won Chun, Eunhae Cho, Jongmun Choi, Dong-Eun Lee, Hyoeun Shim, Yun-Hee Kim, Sung-Sik Han, Sang-Jae Park, Sang Myung Woo, Sun-Young Kong

Cancer Res Treat. 2023;55(4):1303-1312. Published online April 3, 2023 DOI: https://doi.org/10.4143/crt.2023.291

1313

Analysis of Plasma Circulating Tumor DNA in Borderline Resectable Pancreatic Cancer Treated with Neoadjuvant Modified FOLFIRINOX: Clinical Relevance of DNA Damage Repair Gene Alteration Detection

Dong-Hoon Lim, Hyunseok Yoon, Kyu-pyo Kim, Baek-Yeol Ryoo, Sang Soo Lee, Do Hyun Park, Tae Jun Song, Dae Wook Hwang, Jae Hoon Lee, Ki Byung Song, Song Cheol Kim, Seung-Mo Hong, Jaewon Hyung, Changhoon Yoo

Cancer Res Treat. 2023;55(4):1313-1320. Published online May 4, 2023 DOI: https://doi.org/10.4143/crt.2023.452

Cited By 1

Genitourinary cancer

1321

Favorable Immunotherapy Plus Tyrosine Kinase Inhibition Outcome of Renal Cell Carcinoma Patients with Low CDK5 Expression

Xianglai Xu, Ying Wang, Zhaoyi Chen, Yanjun Zhu, Jiajun Wang, Jianming Guo

Cancer Res Treat. 2023;55(4):1321-1336. Published online April 3, 2023 DOI: https://doi.org/10.4143/crt.2022.1532

1337

TNM-Based Head-to-Head Comparison of Urachal Carcinoma and Urothelial Bladder Cancer: Stage-Matched Analysis of a Large Multicenter National Cohort

Sang Hun Song, Jaewon Lee, Young Hwii Ko, Jong Wook Kim, Seung Il Jung, Seok Ho Kang, Jinsung Park, Ho Kyung Seo, Hyung Joon Kim, Byong Chang Jeong, Tae-Hwan Kim, Se Young Choi, Jong Kil Nam, Ja Yoon Ku, Kwan Joong Joo, Won Sik Jang, Young Eun Yoon, Seok Joong Yun, Sung-Hoo Hong, Jong Jin Oh

Cancer Res Treat. 2023;55(4):1337-1345. Published online April 17, 2023 DOI: https://doi.org/10.4143/crt.2023.417

Cited By 1

Gynecologic cancer

1346

Safety and Tolerability of Weekly Genexol-PM, a Cremophor-Free Polymeric Micelle Formulation of Paclitaxel, with Carboplatin in Gynecologic Cancer: A Phase I Study

So Hyun Nam, Shin-Wha Lee, Young-Jae Lee, Yong Man Kim

Cancer Res Treat. 2023;55(4):1346-1354. Published online May 15, 2023 DOI: https://doi.org/10.4143/crt.2022.1436

Hematologic malignancy

1355

Intensified First Cycle of Rituximab Plus Eight Cycles of Cyclophosphamide, Doxorubicin, Vincristine, and Prednisolone with Rituximab Chemotherapy for Advanced-Stage or Bulky Diffuse Large B-Cell Lymphoma: A Multicenter Phase II Consortium for Improving Survival of Lymphoma (CISL) Study

Yu Ri Kim, Jin Seok Kim, Won Seog Kim, Hyeon Seok Eom, Deok-Hwan Yang, Sung Hwa Bae, Hyo Jung Kim, Jae Hoon Lee, Suk-Joong Oh, Sung-Soo Yoon, Jae-Yong Kwak, Chul Won Choi, Min Kyoung Kim, Sung Young Oh, Hye Jin Kang, Seung Hyun Nam, Hyeok Shim, Joon Seong Park, Yeung-Chul Mun, Cheolwon Suh, the Korean Society of Hematology Lymphoma Working Party

Cancer Res Treat. 2023;55(4):1355-1362. Published online March 30, 2023 DOI: https://doi.org/10.4143/crt.2023.271