Cancer Research and Treatment

SPECIAL ARTICLE 2021 June 2 The Situation of Life-Sustaining Treatment One Year after Enforcement of the Act on Decisions on Life-Sustaining Treatment for Patients at the End-of-Life in Korea: Data of National Agency for Management of Life-Sustaining Treatment
Purpose The “Act on Hospice and Palliative Care and Decisions on Life-Sustaining Treatment for Patients at the End-of-Life” was enacted on February 3, 2016 and went into effect on February 4, 2018 in Korea. This study reviewed the first year of determination to life-sustainin...

ORIGINAL ARTICLE 2020 January 4 Correlation of NUF2 Overexpression with Poorer Patient Survival in Multiple Cancers
Purpose NUF2 has been implicated in multiple cancers recently, suggesting NUF2 may play a role in the common tumorigenesis process. In this study, we aim to perform comprehensive meta-analysis of NUF2 expression in the cancer types included in the Cancer Genome Atlas (TCGA). Ma...

ORIGINAL ARTICLE 2021 February 18 Pan-cancer Analysis of Tumor Mutational Burden and Homologous Recombination DNA Damage Repair Using Targeted Next-Generation Sequencing
Purpose Current variability in methods for tumor mutational burden (TMB) estimation and reporting demonstrates the urgent need for a homogeneous TMB assessment approach. Here, we compared TMB distributions in different cancer types using two customized targeted panels commonly...

ORIGINAL ARTICLE 2021 January 13 Prognostic Value of Serum Epstein-Barr Virus Antibodies and Their Correlation with TNM Classification in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma
Purpose This study assessed the correlation between Epstein-Barr virus (EBV) biomarkers and the eighth American Joint Committee on Cancer staging system and the prognostic values of IgG antibodies against replication and transcription activator (Rta-IgG), IgA antibodies against ...

Current Issue

Volume 53(4); Oct 2021

Volume 53(3); July 2021

Volume 53(2); April 2021

Editorial

895

The Law Changes Behaviors: Is It Just Enough?

Dae Ho Lee

Cancer Res Treat. 2021;53(4):895-896. Published online September 23, 2021 DOI: https://doi.org/10.4143/crt.2021.1025

Special Articles

897

The Situation of Life-Sustaining Treatment One Year after Enforcement of the Act on Decisions on Life-Sustaining Treatment for Patients at the End-of-Life in Korea: Data of National Agency for Management of Life-Sustaining Treatment

Ha Yeon Lee, Hwa Jung Kim, Jung Hye Kwon, Sun Kyung Baek, Young-Woong Won, Yu Jung Kim, Su Jin Baik, Hyewon Ryu

Cancer Res Treat. 2021;53(4):897-907. Published online June 2, 2021 DOI: https://doi.org/10.4143/crt.2021.327

Cited By 1

908

Life-Sustaining Treatment States in Korean Cancer Patients after Enforcement of Act on Decisions on Life-Sustaining Treatment for Patients at the End of Life

Young-Woong Won, Hwa Jung Kim, Jung Hye Kwon, Ha Yeon Lee, Sun Kyung Baek, Yu Jung Kim, Do Yeun Kim, Hyewon Ryu

Cancer Res Treat. 2021;53(4):908-916. Published online June 2, 2021 DOI: https://doi.org/10.4143/crt.2021.325

Cited By 1

917

Current Status and Cardinal Features of Patient Autonomy after Enactment of the Life-Sustaining Treatment Decisions Act in Korea

Hwa Jung Kim, Yu Jung Kim, Jung Hye Kwon, Young-Woong Won, Ha Yeon Lee, Sun Kyung Baek, Hyewon Ryu, Do Yeun Kim

Cancer Res Treat. 2021;53(4):917-925. Published online June 2, 2021 DOI: https://doi.org/10.4143/crt.2021.324

Cited By 1

926

Preparation and Practice of the Necessary Documents in Hospital for the “Act on Decision of Life-Sustaining Treatment for Patients at the End-of-Life”

Sun Kyung Baek, Hwa Jung Kim, Jung Hye Kwon, Ha Yeon Lee, Young-Woong Won, Yu Jung Kim, Sujin Baik, Hyewon Ryu

Cancer Res Treat. 2021;53(4):926-934. Published online June 2, 2021 DOI: https://doi.org/10.4143/crt.2021.326

Cited By 1

Original Articles

General

935

Patterns of Proton Beam Therapy Use in Clinical Practice between 2007 and 2019 in Korea

Sung Uk Lee, Kyungmi Yang, Sung Ho Moon, Yang-Gun Suh, Gyu Sang Yoo

Cancer Res Treat. 2021;53(4):935-943. Published online May 17, 2021 DOI: https://doi.org/10.4143/crt.2021.409

944

Correlation of NUF2 Overexpression with Poorer Patient Survival in Multiple Cancers

Xiaodan Jiang, Yan Jiang, Senbiao Luo, Karthik Sekar, Clara Kai Ting Koh, Amudha Deivasigamani, Qingzhe Dong, Niankai Zhang, Shenling Li, Fengyun Hao, Brian Kim Poh Goh, London Lucien Ooi, Yu Wang, Kam Man Hui

Cancer Res Treat. 2021;53(4):944-961. Published online January 4, 2020 DOI: https://doi.org/10.4143/crt.2020.466

Cited By 1

962

Role of Interleukin-7 in the Development of and Recovery from Radiation-Induced Lymphopenia: A Post-hoc Analysis of a Prospective Cohort

Hwa Kyung Byun, Seung Yeun Chung, Kyoung-Jin Kim, Jinsil Seong

Cancer Res Treat. 2021;53(4):962-972. Published online January 26, 2021 DOI: https://doi.org/10.4143/crt.2020.1053

973

Pan-cancer Analysis of Tumor Mutational Burden and Homologous Recombination DNA Damage Repair Using Targeted Next-Generation Sequencing

Hai-Yun Wang, Ling Deng, Ying-Qing Li, Xiao Zhang, Ya-Kang Long, Xu Zhang, Yan-Fen Feng, Yuan He, Tao Tang, Xin-Hua Yang, Fang Wang

Cancer Res Treat. 2021;53(4):973-982. Published online February 18, 2021 DOI: https://doi.org/10.4143/crt.2020.798

CNS cancer

983

Long-Term Outcomes and Sequelae Analysis of Intracranial Germinoma: Need to Reduce the Extended-Field Radiotherapy Volume and Dose to Minimize Late Sequelae

Joo Ho Lee, Keun-Yong Eom, Ji Hoon Phi, Chul-Kee Park, Seung Ki Kim, Byung-Kyu Cho, Tae Min Kim, Dae Seog Heo, Kyung Taek Hong, Jung Yoon Choi, Hyoung Jin Kang, Hee Young Shin, Seung Hong Choi, Soon Tae Lee, Sung Hye Park, Kyu-Chang Wang, Il Han Kim

Cancer Res Treat. 2021;53(4):983-990. Published online January 13, 2021 DOI: https://doi.org/10.4143/crt.2020.1052

Cited By 1

Head and Neck Cancer

991

Prognostic Value of Serum Epstein-Barr Virus Antibodies and Their Correlation with TNM Classification in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma

Wan-Ru Zhang, Yu-Yun Du, Chun-Yan Guo, Han-Xing Zhou, Jie-Yi Lin, Xiao-Han Meng, Hao-Yuan Mo, Dong-Hua Luo

Cancer Res Treat. 2021;53(4):991-1003. Published online January 13, 2021 DOI: https://doi.org/10.4143/crt.2020.1298

1004

Recent Treatment Patterns of Oropharyngeal Cancer in Korea Based on the Expert Questionnaire Survey of the Korean Society for Head and Neck Oncology (KSHNO)

Kyu Hye Choi, Jin Ho Song, Yeon-Sil Kim, Ji-hoon Kim, Woo-Jin Jeong, Inn-Chul Nam, Jin Ho Kim, Hee Kyung Ahn, Sang Hoon Chun, Hyun Jun Hong, Young-Hoon Joo, Young-Gyu Eun, Sung Ho Moon, Jeongshim Lee

Cancer Res Treat. 2021;53(4):1004-1014. Published online January 29, 2021 DOI: https://doi.org/10.4143/crt.2020.973

Cited By 1

Lung Cancer

1015

Clinical Significance of Acute Kidney Injury in Lung Cancer Patients

Semin Cho, Eunjeong Kang, Ji Eun Kim, U Kang, Hee Gyung Kang, Minsu Park, Kwangsoo Kim, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Hyung-Jin Yoon, Hajeong Lee

Cancer Res Treat. 2021;53(4):1015-1023. Published online January 18, 2021 DOI: https://doi.org/10.4143/crt.2020.1010

1024

The Clinical Impact of Capmatinib in the Treatment of Advanced Non–Small Cell Lung Cancer with MET Exon 14 Skipping Mutation or Gene Amplification

Wonyoung Choi, Seog-Yun Park, Youngjoo Lee, Kun Young Lim, Minjoung Park, Geon Kook Lee, Ji-Youn Han

Cancer Res Treat. 2021;53(4):1024-1032. Published online January 29, 2021 DOI: https://doi.org/10.4143/crt.2020.1331

1033

Prognostic Factor and Clinical Outcome in Stage III Non-Small Cell Lung Cancer: A Study Based on Real-World Clinical Data in the Korean Population

Ho Cheol Kim, Wonjun Ji, Jae Cheol Lee, Hyeong Ryul Kim, Si Yeol Song, Chang-Min Choi, Korean Association for Lung Cancer, Korea Central Cancer Registry

Cancer Res Treat. 2021;53(4):1033-1041. Published online February 16, 2021 DOI: https://doi.org/10.4143/crt.2020.1350

Cited By 1

1042

Inhibition of lncRNA KCNQ1OT1 Improves Apoptosis and Chemotherapy Drug Response in Small Cell Lung Cancer by TGF-β1 Mediated Epithelial-to-Mesenchymal Transition

Deyu Li, Qin Tong, Yuane Lian, Zhizhong Chen, Yaru Zhu, Weimei Huang, Yang Wen, Qiongyao Wang, Shumei Liang, Man Li, Jianjing Zheng, Zhenhua Liu, Huanxin Liu, Linlang Guo

Cancer Res Treat. 2021;53(4):1042-1056. Published online March 9, 2021 DOI: https://doi.org/10.4143/crt.2020.1208

1057

Conditional Survival of Surgically Treated Patients with Lung Cancer: A Comprehensive Analyses of Overall, Recurrence-free, and Relative Survival

Dong Wook Shin, Jong Ho Cho, Jung Eun Yoo, Juhee Cho, Dong Woog Yoon, Genehee Lee, Sumin Shin, Hong Kwan Kim, Yong Soo Choi, Jhingook Kim, Jae Ill Zo, Young Mog Shim

Cancer Res Treat. 2021;53(4):1057-1071. Published online March 9, 2021 DOI: https://doi.org/10.4143/crt.2020.1308

Breast Cancer

1072

Combination of Simvastatin and FAC Improves Response to Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer

Erwin Danil Yulian, Nurjati Chairani Siregar, Bajuadji

Cancer Res Treat. 2021;53(4):1072-1083. Published online March 9, 2021 DOI: https://doi.org/10.4143/crt.2020.1024

Cited By 1

1084

Talazoparib Versus Chemotherapy in Patients with HER2-negative Advanced Breast Cancer and a Germline BRCA1/2 Mutation Enrolled in Asian Countries: Exploratory Subgroup Analysis of the Phase III EMBRACA Trial

Kyung-Hun Lee, Joohyuk Sohn, Annabel Goodwin, Tiziana Usari, Silvana Lanzalone, Seock-Ah Im, Sung-Bae Kim

Cancer Res Treat. 2021;53(4):1084-1095. Published online March 24, 2021 DOI: https://doi.org/10.4143/crt.2020.1381

Cited By 1

Gastrointestinal Cancer

1096

Phase II Trial of Postoperative Adjuvant Gemcitabine and Cisplatin Chemotherapy Followed by Chemoradiotherapy with Gemcitabine in Patients with Resected Pancreatic Cancer

Kyung-Hun Lee, Eui Kyu Chie, Seock-Ah Im, Jee Hyun Kim, Jihyun Kwon, Sae-Won Han, Do-Youn Oh, Jin-Young Jang, Jae-Sung Kim, Tae-You Kim, Yung-Jue Bang, Sun Whe Kim, Sung W. Ha

Cancer Res Treat. 2021;53(4):1096-1103. Published online December 30, 2020 DOI: https://doi.org/10.4143/crt.2020.928

Cited By 1

1104

Pulmonary Metastasectomy in Colorectal Cancer: A Population-Based Retrospective Cohort Study Using the Korean National Health Insurance Database

Woo Sik Yu, Mi Kyung Bae, Jung Kyu Choi, Young Ki Hong, In Kyu Park

Cancer Res Treat. 2021;53(4):1104-1112. Published online January 15, 2021 DOI: https://doi.org/10.4143/crt.2020.1213

Cited By 2

1113

Fasting Blood Glucose, Cholesterol, and Risk of Primary Liver Cancer: The Kailuan Study

Xiangming Ma, Haozhe Cui, Miaomiao Sun, Qian Liu, Xining Liu, Guangjian Li, Yaochen Wei, Qingjiang Fu, Siqing Liu, Liying Cao

Cancer Res Treat. 2021;53(4):1113-1122. Published online January 19, 2021 DOI: https://doi.org/10.4143/crt.2020.817

Cited By 1

1123

Effect of Preoperative Tumor Under-Staging on the Long-term Survival of Patients Undergoing Radical Gastrectomy for Gastric Cancer

Mi Lin, Qi-Yue Chen, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Chang-Ming Huang

Cancer Res Treat. 2021;53(4):1123-1133. Published online March 5, 2021 DOI: https://doi.org/10.4143/crt.2020.651

1134

Neurocognitive Effects of Chemotherapy for Colorectal Cancer: A Systematic Review and a Meta-Analysis of 11 Studies

Soo Young Hwang, Kwanghyun Kim, Byeonggwan Ha, Dongkyu Lee, Seonung Kim, Seongjun Ryu, Jisu Yang, Sun Jae Jung

Cancer Res Treat. 2021;53(4):1134-1147. Published online March 17, 2021 DOI: https://doi.org/10.4143/crt.2020.1191

Genitourinary Cancer

1148

A Predictive Model Based on Bi-parametric Magnetic Resonance Imaging and Clinical Parameters for Clinically Significant Prostate Cancer in the Korean Population

Tae Il Noh, Chang Wan Hyun, Ha Eun Kang, Hyun Jung Jin, Jong Hyun Tae, Ji Sung Shim, Sung Gu Kang, Deuk Jae Sung, Jun Cheon, Jeong Gu Lee, Seok Ho Kang

Cancer Res Treat. 2021;53(4):1148-1155. Published online December 31, 2020 DOI: https://doi.org/10.4143/crt.2020.1068

1156

Neoadjuvant Chemotherapy–Guided Bladder-Sparing Treatment for Muscle-Invasive Bladder Cancer: Results of a Pilot Phase II Study

Hongzhe Shi, Wen Zhang, Xingang Bi, Dong Wang, Zejun Xiao, Youyan Guan, Kaopeng Guan, Jun Tian, Hongsong Bai, Linjun Hu, Chuanzhen Cao, Weixing Jiang, Zhilong Hu, Jin Zhang, Yan Chen, Shan Zheng, Xiaoli Feng, Changling Li, Yexiong Li, Jianhui Ma, Yueping Liu, Aiping Zhou, Jianzhong Shou

Cancer Res Treat. 2021;53(4):1156-1165. Published online February 10, 2021 DOI: https://doi.org/10.4143/crt.2020.1356

1166

Use of Gemcitabine plus Carboplatin is Associated with Poor Outcomes in Urothelial Carcinoma Patients with Chronic Kidney Disease Stage 4-5

Hyung-Don Kim, Hyeon-Su Im, Jwa Hoon Kim, Hyehyun Jeong, Shin Kyo Yoon, Inkeun Park, Jae Lyun Lee

Cancer Res Treat. 2021;53(4):1166-1173. Published online March 4, 2021 DOI: https://doi.org/10.4143/crt.2021.091

1174

Ferroportin and FBXL5 as Prognostic Markers in Advanced Stage Clear Cell Renal Cell Carcinoma

Cheol Keun Park, Jayoon Heo, Won Sik Ham, Young-Deuk Choi, Sang Joon Shin, Nam Hoon Cho

Cancer Res Treat. 2021;53(4):1174-1183. Published online March 17, 2021 DOI: https://doi.org/10.4143/crt.2021.031

Cited By 1

Pediatric cancer

1184

Effectiveness and Safety of Clofarabine Monotherapy or Combination Treatment in Relapsed/Refractory Childhood Acute Lymphoblastic Leukemia: A Pragmatic, Non-interventional Study in Korea

Jung Yoon Choi, Che Ry Hong, Kyung Taek Hong, Hyoung Jin Kang, Seongkoo Kim, Jae Wook Lee, Pil Sang Jang, Nack-Gyun Chung, Bin Cho, Hyery Kim, Kyung-Nam Koh, Ho Joon Im, Jong Jin Seo, Seung Min Hahn, Jung Woo Han, Chuhl Joo Lyu, Eu Jeen Yang, Young Tak Lim, Keon Hee Yoo, Hong Hoe Koo, Hoon Kook, In Sang Jeon, Hana Cho, Hee Young Shin

Cancer Res Treat. 2021;53(4):1184-1194. Published online January 4, 2021 DOI: https://doi.org/10.4143/crt.2020.289