Expression Pattern of p27 Protein in Primary Gastric Lymphomas

Go, Jai Hyang

doi:2001.33.4.318

Cancer Research and Treatment > Volume 33(4); 2001 > Article

Original Article

Cancer Research and Treatment 2001;33(4): 318-323. doi: https://doi.org/10.4143/crt.2001.33.4.318

Expression Pattern of p27 Protein in Primary Gastric Lymphomas

Jai Hyang Go

Department of Pathology, Dankook University College ofMedicine, Cheonan, Korea. jaihyang@yahoo.co.kr

Published online: August 31, 2001.

ABSTRACT

PURPOSE:
To investigate the expression pattern of p27 protein in primary gastric lymphomas.
MATERIALS AND METHODS:
Immunostaining for the p27 protein was performed in 16 cases of low grade mucosa-associated lymphoid tissue (MALT) lymphomas and 16 cases of high grade B-cell lymphomas of the stomach.
RESULTS:
All low grade MALT lymphomas were positive, however all high grade lymphomas were negative forp27 protein. Most of the monocytoid cells in the low grade lymphoma were unstained.
CONCLUSION:
Loss of p27 protein expression is well correlated with histologic grade and appears to be associated with the high grade transformation seen in primary gastric lymphomas.

Key words: Lymphoma;Stomach;p27 protein