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J Korean Cancer Assoc > Volume 28(5); 1996 > Article
Journal of the Korean Cancer Association 1996;28(5): 835-842.
진행성 식도암에 대한 5-FU 및 Cisplatin ( FP ) 복합화학요법
우인숙, 정경해, 박영이, 이정애, 허대석, 방영주, 김노경
5-Fluorouracil and Cisplatin ( FP ) Combination Chemotherapy in Advanced Esophageal Cancer
In Sook Woo, Kyung Hae Jung, Young Iee Park, Jung Ae Rhee, Dae Seog Heo, Yung Jue Bang, Noe Kyeong Kim
Esophageal Carcinoma is widely disseminated in many patients at the time of diagnosis. Therefore systemic chemotherapy has assumed an important role in the treatment of this disease. We conducted a phase II trial of 5-fluorouracil and cisplatin in 39 patients with advanced esophageal cancer. The regimen consisted of 5-fluorouracil, 1,000 mg/§³/day in 12 hour continuous infusion on day 1 to 5 and cisplatin, 60 mg/§³/day iv on day 1 every three weeks. Response rates were calculated only from 37 patients with measurable disease. The response rate was 39%(complete response 2%, partial response 37%) with a median duration of 4 months (range 2~10 months). Median time of survival for all patients was 9 months(range 1~4 months). The toxicities were moderate. This study demonstrates that combination of 5-fluoriuracil and cisplatin is an efficient and tolerable chemotherapy regimen in patients with advanced esophageal cancer.
Key words: Esophagus, Squamous cell carcinoma, 5-fluorouracil, Cisplatin
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