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J Korean Cancer Assoc > Volume 28(3); 1996 > Article
Journal of the Korean Cancer Association 1996;28(3): 432-443.
대장 및 직장암종에서의 Proliferation Cell Nuclear Antigen 과 Epidermal Growth Factor Receptor 의 발현도와 다른 예후인자와의 관계에 대한 연구
주영채, 김준미, 김영식, 김영배, 황태숙
Expression of Proliferating Cell Nuclear Antigen and Epidermal Growth Factor Receptor in Colorectal carcinomas : Relation of Clinical and Patho
Young Chae Chu, Joon Mee Kim, Young Sik Kim, Young Bae Kim, Tae Sook Hwang
To evaluate the prognostic significance of PCNA and EGFR in colorectal carcinoma, the author analysed 66 colorectal carcinomas in paraffin sections immunohistochemically, using the monoclonal antibody PCNA and EGFR and compared with clinicopathological data. The mean PCNA index of colorectal carcinomas was 49.0¡¾10.8%. PCNA index had positive correlation with lymph node metastasis(p<0.001), distant metastasis(p<0.001), modified Dukes' stage(p<0.001), Jass new prognostic classification grouping(p<0.00l), TNM classification(p<0.001) and tumor size over 10.0cm(p<0.05), degree of histologic differentiation(p< 0.01), fibrosis(p<0.05), perineural invasion(p<0.05), lymphatic and vascular invasion(p<0.05). PCNA expression was more pronounced at the infiltrative margins of the tumor and tumor cells within the lymphatic or vascular channels. But there was no relationship between PCNA index and patients age, sex and tumor location, growth pattern, degree of peritumoral lymphocytic infiltration. The positivity of EGFR in colorectal carcinomas was 93.9% and there was an association between staining intensity and the extent of EGFR expression(rs=0.684, p<0.001) and PCNA index(rs=0.451 & 0.432, p<0.001). There was an association between staining intensity and the extent of EGFR expression and modified Duke's stage(p<0.001), Jass grouping(p<0.001), TNM classification(p<0.001), lymph node metastasis(p<0.001), fibrosis(<0.05), lymphocytic infiltration(p<0.05), lymphatics and vascular invasion(p< 0.01). These results suggest PCNA index and EGFR expression may be a useful prognostic factors in colorectal carcinomas. Knowledge af the percentage of PCNA-positive cells could be especially helpful in deciding to treat patients with adjuvant chemotherapy.
Key words: PCNA, EGFR, Colorectal carcinoma, Prognostic factor
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