Skip Navigation
Skip to contents

Cancer Res Treat : Cancer Research and Treatment

OPEN ACCESS

Articles

Page Path
HOME > J Korean Cancer Assoc > Volume 22(1); 1990 > Article
Original Article
Effects of α-difluormethylornithine ( DFMO ) on Growth Inhibition of Human Gastric and Colorectal Carcinoma Cell Lines
Ho Kyung Chun, Jae Gahb Park, Ee Sook Hwang, Sung Kuk Hong
Journal of the Korean Cancer Association 1990;22(1): 171-183.
  • 2,537 Views
  • 17 Download
  • 0 Crossref
  • 0 Scopus
prev next

DFMO, an irreversible inhibitor of ornithine decarboxylase, blocks polyamine biosynthesis, is reported to have antitumor effects in vitro at the peak achievable plasma concentration (about 0.5 mM). We determined the effects of DFMO on the growth of gastric and colorectal carcinoma cell lines using the semiautomated tetrazollum MTT assay. At a concentration of 0.5 mM and a 4 day incubation periad, DFMO inhibited the growth of 4 gastric cell lines by a median value of 5% and the growth of 7 colorectal cell lines by a median value of 22%. These effects were reversible by the addition of 0.1 mM of putrescine. Conciusians: 1) at the peak achievable plasma concentration, DFMO has very modest inhibitory effects on the growth of gastrointestinal carcinoma cell lines: and 2) DFMO may have a greater growth inhibitory effect on colorectal than on gastric carcinoma cell lines.

  • Cite
    CITE
    export Copy Download
    Close
    Download Citation
    Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

    Format:
    • RIS — For EndNote, ProCite, RefWorks, and most other reference management software
    • BibTeX — For JabRef, BibDesk, and other BibTeX-specific software
    Include:
    • Citation for the content below
    Effects of α-difluormethylornithine ( DFMO ) on Growth Inhibition of Human Gastric and Colorectal Carcinoma Cell Lines
    J Korean Cancer Assoc. 1990;22(1):171-183.
    Close

Cancer Res Treat : Journal of the Korean Cancer Association
Close layer
TOP