HLA-DR typing was performed on 53 Korean patients with biopsy proved invasive carcinoma of the cervix. The patients were compared to 200 healthy controls. The results were as follows: 1) Of 53 patients with invasive carcinoma of the cervix, the frequency of antigens in decreasing order of frequency were DR2(18 cases), DR4(16 cases0, DRw6 and DR7(14 cases), DR5(8cases), DR1(6cases), and DRw8(4 cases). Although the frequency of DR3 in the normal subjects was 15%, it was not decected in the patients with invasive carcinoma of the cervix. 2) A significant increase in the frequency in DRw6, and a significant decrease in the frequencies of DR3 and DRw8 were demonstrated among the patients compared with those in healthy controls(p<0.05).
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