Cancer Research and Treatment

Original Articles

Setting a Health Policy Research Agenda for Controlling Cancer Burden in Korea: Sung-In Jang, Kyoung-Hee Cho, Sun Jung Kim, Kwang-Sig Lee, Eun-Cheol Park; Cancer Res Treat. 2015;47(2):149-157. Published online September 11, 2014; DOI: https://doi.org/10.4143/crt.2013.167

Purpose
The aim of study was to provide suggestions for prioritizing research in effort to reduce cancer burden in Korea based on a comprehensive analysis of cancer burden and Delphi consensus among cancer experts. Materials and Methods Twenty research plans covering 10 topics were selected based on an assessment of the literature, and e-mail surveys were analyzed using a two-round modified Delphi method. Thirty-four out of 79 experts were selected from four organizations to participate in round one, and 21 experts among them had completed round two. Each item had two questions; one regarding the agreement of the topic as a priority item to reduce cancer burden, and the other about the importance of the item on a nine-point scale. A consensus was defined to be an average lower coefficient of variation with less than 30% in importance. Results Seven plans that satisfied the three criteria were selected as priority research plans for reducing cancer burden. These plans are “research into advanced clinical guidelines for thyroid cancer given the current issue with over-diagnosis,” “research into smoking management plans through price and non-price cigarette policy initiatives,” “research into ways to measure the quality of cancer care,” “research on policy development to expand hospice care,” “research into the spread and management of Helicobacter pylori,” “research on palliative care in a clinical setting,” and “research into alternative mammography methods to increase the accuracy of breast cancer screenings.” Conclusion The seven plans identified in this study should be prioritized to reduce the burden of cancer in Korea. We suggest that policy makers and administrators study and invest significant effort in these plans.

Citations

Citations to this article as recorded by

An assessment for health education and health promotion in chronic disease demonstration districts: a comparative study from Hunan Province, China
Qiaohua Xu, Biyun Chen, Donghui Jin, Li Yin, Yuelong Huang
PeerJ.2019; 7: e6579. CrossRef
Cancer, Stress, and Ironies of Cancer Understanding in South Korea
Laura C. Nelson
Medical Anthropology.2017; 36(1): 19. CrossRef
Factors associated with quality of life among family caregivers of terminally ill cancer patients
Youn Seon Choi, Sun Wook Hwang, In Cheol Hwang, Yong Ju Lee, Young Sung Kim, Hyo Min Kim, Chang Ho Youn, Hong Yup Ahn, Su-Jin Koh
Psycho-Oncology.2016; 25(2): 217. CrossRef
Is a Price Increase Policy Enough for Adolescent Smokers?: Factors Affecting the Effectiveness of Increasing Cigarette Prices Among Korean Adolescent Smokers
Yong Suk Lee, Hong-Suk Kim, Hyung-Do Kim, Ki-Bong Yoo, Sung-In Jang, Eun-Cheol Park
Nicotine & Tobacco Research.2016; 18(10): 2013. CrossRef

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Dietary Habit and Helicobacter pylori Infection in Early Gastric Cancer Patient: Sang Ah Lee, Daehee Kang, Weon Seon Hong, Ki Nam Shim, Jae Won Choe, Haymie Choi; Cancer Res Treat. 2002;34(2):104-110. Published online April 30, 2002; DOI: https://doi.org/10.4143/crt.2002.34.2.104

Abstract PDF

PURPOSE
Helicobacter pylori (H. pylori) is now generally accepted to be strongly associated with the development of gastric cancer, as well as intakes of some salted foods, charred foods, etc. To evaluate the association among dietary habits, H. pylori infection, and early gastric cancer in Koreans, a hospital based case-control study was conducted. Material and Method: A total of 268 persons participated in this case-control study. Sixty nine patients were newly diagnosed as an early gastric cancer (EGC) at the Division of Gastroenterology, Department of Internal Medicine, Asan Medical Center, Seoul, Korea. One hundred ninety-nine subjects with no symptoms who visited the Health Promotion Center for their general checkups were selected as the controls. All subjects were examined for H. pylori infection, biochemical blood test the life style, and dietary habit were interviewed by a trained dietition with semi-quantitative food frequency question naire (FFQ) and adaptive salt concentration were taste evaluated.
RESULTS
H. pylori seropositivity was observed in 88.4% in cases, as compared with 74.9% in controls (OR=2.5, 95% CI: 1.1-5.7). The adaptive salt concentration was associated with early gastric cancer risk (chi-squir=50.8, p<0.001). The analysis of food intake frequency demonstrated that early gastric cancer risk was reduced by the intake of clear soups, raw vegetables, fruits and juices, beef with vegetables and soybean curds. On the other hand, high intake of salt-fermented fish and kimchi elevated the risk of early gastric cancer.
CONCLUSION
These results suggest that some dietary factors and H. pylori infection have a significant association with the development of early gastric cancer.

Citations

Citations to this article as recorded by

Dietary intake and cancer incidence in Korean adults: a systematic review and meta-analysis of observational studies
Ji Hyun Kim, Shinyoung Jun, Jeongseon Kim
Epidemiology and Health.2023; 45: e2023102. CrossRef
Effect of dietary vitamin C on gastric cancer risk in the Korean population
Bach Viet Hoang, Jeonghee Lee, Il Ju Choi, Young-Woo Kim, Keun Won Ryu, Jeongseon Kim
World Journal of Gastroenterology.2016; 22(27): 6257. CrossRef
Epidemiology and screening of gastric cancer in Korea
Minkyo Song, Hwi-Won Lee, Daehee Kang
Journal of the Korean Medical Association.2015; 58(3): 183. CrossRef
Gastric Cancer Epidemiology in Korea
Aesun Shin, Jeongseon Kim, Sohee Park
Journal of Gastric Cancer.2011; 11(3): 135. CrossRef
Fresh and pickled vegetable consumption and gastric cancer in Japanese and Korean populations: A meta‐analysis of observational studies
Hyun Ja Kim, Sun Young Lim, Jung‐Sug Lee, Sohee Park, Aesun Shin, Bo Youl Choi, Taichi Shimazu, Manami Inoue, Shoichiro Tsugane, Jeongseon Kim
Cancer Science.2010; 101(2): 508. CrossRef
Identifying the Risk Factors Through the Development of a Predictive Model for Gastric Cancer in South Korea
Dong-Suk Lee, Han-Kwang Yang, Jong-Won Kim, Jeong-Whan Yook, Seong-Hoon Jeon, Sung-Hak Kang, Young-Ju Kim
Cancer Nursing.2009; 32(2): 135. CrossRef

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Polymorphism Analysis of Helicobacter pylori Urease A Gene in Gastric Cancer Samples: Seong Soo Lee, Nam Suck Song, Young Suk Park; J Korean Cancer Assoc. 1997;29(3):375-382.

Abstract PDF: PURPOSE
Several investigators reported the polymerase chain reaction (PCR) method was more sensitive than culture or other routine laboratory tests for the detection of H. pylori. In this study, we established the nested PCR method for the sensitive and specific determination of H. pylori from paraffin-embedded gastric cancer samples, and the polymorphisms of H. pylori urease A gene were analyzed using by restriction fragment length polymorphism (RFLP).
MATERIALS AND METHODS
It was subjected to the nested PCR using two primer pairs from the urease A gene of H. pylori. The sensitivity of the nested PCR assay was investigated with serial dilutions of positive DNA of H. pylori. Polymorphisms of H. pylori were determined by digestion of thirty six PCR positive products with five different restriction endonuclease-MspI, AluI, DdeI, BstNI, and HinfI. RESULTS: Amplified H. pylori PCR products were detected to 106 dilutions (10-3 fg) by nested PCR technique. The polymorphic patterns of five types of H. pylori were found by MspI, DdeI and AluI. Sequence of type V was confirmed by direct sequencing and the sequences recognized by BstNI and HinfI were conserved regions.
CONCLUSIONS
Nested PCR technique is a accurate, sensitive and reliable method for the laboratory diagnosis of H. pylori infection. Moreover nested PCR-RFLP analysis has a potential to differentiate H. pylori strains.

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