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Original Article
- Effectiveness of Radiotherapy for Hepatocellular Carcinoma with Lymph Node Metastasis: A Meta-Analysis
- Sooyoung Hwang, Seoon Hur, Won Sup Yoon, Sunmin Park, Chai Hong Rim
- Received May 2, 2025 Accepted August 11, 2025 Published online August 12, 2025
- DOI: https://doi.org/10.4143/crt.2025.475 [Accepted]
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Abstract
PDF - Purpose
Lymph node metastasis (LNM) of hepatocellular carcinoma (HCC) carries a poor prognosis; however, no standard treatment has been established. Radiotherapy (RT) has demonstrated favorable tumor response, with the advantage of being less affected by anatomical hindrances.
Materials and Methods
Databases were searched up to April 2024. The inclusion criteria were: (1) ≥5 patients with HCC LNM, (2) studies that performed external RT, and (3) reporting survival or response rate (RR). The main effect measures are pooled 1- and 2-year overall survival (OS) rates, response rate (RR) and grade ≥3 complications.
Results
Twelve studies involving 825 patients were included. The pooled 1-year OS rate and 2-year OS rate were 49.3% (95% confidence interval [CI]: 39.2%-59.4%) and 24.5% (95% CI: 17.0%-34.0%), respectively. The median OS ranged from 5.8 to 29.7 months, with a median value of 9.7 months. In one study, 14.7% of patients were prescribed an immunoagent. In other studies, some patients received sorafenib, but no specific systemic therapy was performed for the majority. The pooled RR was 75.1% (95% CI: 66.9%-81.8%). The pooled RR of high dose and low dose groups was 83.8% (95% CI: 76.3-89.3) vs. 55.6% (95% CI: 44.4-66.3), respectively (p<0.001). The pooled rate of grade ≥3 gastrointestinal toxicity was 3.7% (95% CI: 2.1%-6.6%).
Conclusion
RT is an effective and feasible palliative option for HCC LNM. Further researches of combined treatment with novel systemic agents are necessary.
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Review Article
- Intensity-Modulated Radiation Therapy for Uterine Cervical Cancer to Reduce Toxicity and Enhance Efficacy – an Option or a Must?: A Narrative Review
- Sea-Won Lee, Aeran Kim, Sung Jong Lee, Sung Hwan Kim, Jong Hoon Lee
- Cancer Res Treat. 2024;56(1):1-17. Published online August 30, 2023
- DOI: https://doi.org/10.4143/crt.2023.562
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Abstract
PDF
PubReader
ePub - Radiotherapy (RT) is a fundamental modality in treatment of cervical cancer. With advancement of technology, conventional RT used for external beam radiotherapy (EBRT) for over half a century has been rapidly replaced with intensity-modulated radiation therapy (IMRT) especially during the last decade. This newer technique is able to differentiate the intensity of radiation within the same field, thus reduces the inevitable exposure of radiation to normal organs and enables better dose delivery to tumors. Recently, the American Society for Radiation Oncology has released a guideline for RT in cervical cancer. Although a section of the guideline recommends IMRT for the purpose of toxicity reduction, a thorough review of the literature is necessary to understand the current status of IMRT in cervical cancer. This narrative review updates the recent high-level evidences regarding the efficacy and toxicity of IMRT and provides a better understanding of the most innovative techniques currently available for EBRT enabled by IMRT.
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Citations
Citations to this article as recorded by
- Can knowledge-based planning models validated on ethnically diverse patients lead to global standardisation of external beam radiation therapy for locally advanced cervix cancer?
Jeevanshu Jain, Monica Serban, Marianne Sanggaard Assenholt, Varsha Hande, Jamema Swamidas, Yvette Seppenwoolde, Joanne Alfieri, Kari Tanderup, Supriya Chopra
Radiotherapy and Oncology.2025; 204: 110694. CrossRef - Prediction of recurrence risk of cervical cancer after radiotherapy using multi-sequence MRI radiomics
Jie Chen, Lou Liu, Yi Fu, Lu Zhang, Shuyue Li, Juying Zhou, Chenying Ma
Radiation Medicine and Protection.2025; 6(3): 169. CrossRef - Analysis of risk factors for acute radiation toxicity in cervical cancer patients in FIGO IIIC1 and IIIC2 stages treated with definitive chemoradiation
Marija Živković Radojević, Jasmina Jovanović Mirković, Slađana Pirić, Christos Aleksopoulos, Neda Milosavljević
The European Physical Journal Special Topics.2025;[Epub] CrossRef - Comparative impact of supine vs prone positioning on dose distribution, acute toxicity, and setup error in postoperative radiotherapy for cervical cancer: a multidimensional propensity-matched cohort study
Nanjie Xiao, Cuiyun Yuan, Tianshu Zhao, Tie Xu, Jiaomei Zhou, Junfang Liao, Miao Peng, Chenbin Liu, Zhijian Chen, Jing Jin
Frontiers in Oncology.2025;[Epub] CrossRef - Long term clinical outcomes of cervical cancer patients who were recommended surgery but did not undergo it: A SEER database study
Zhaoming Zhang, Hongfu Zhao, Guanghui Cheng
European Journal of Surgical Oncology.2024; 50(10): 108572. CrossRef - Treatment of secondary uterine malignancy following radiotherapy for cervical cancer: a study based on the SEER database
Xiaojing Tong, Yunyun Xiao, Haozhen Li, Hang Zhang, Jiawen Li
BMC Women's Health.2024;[Epub] CrossRef
- Can knowledge-based planning models validated on ethnically diverse patients lead to global standardisation of external beam radiation therapy for locally advanced cervix cancer?
- 7,914 View
- 396 Download
- 5 Web of Science
- 6 Crossref
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