Cancer Research and Treatment

Reply to Commentary on “Clinical Characteristics and Adequate Treatment of Familial Adenomatous Polyposis Combined with Desmoid Tumors”: Jin Cheon Kim; Cancer Res Treat. 2015;47(2):341-341. Published online February 26, 2015; DOI: https://doi.org/10.4143/crt.2015.050

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Commentary on “Clinical Characteristics and Adequate Treatment of Familial Adenomatous Polyposis Combined with Desmoid Tumors”: Edoardo Virgilio, Francesca Di Gregorio, Genoveffa Balducci; Cancer Res Treat. 2015;47(2):339-340. Published online February 26, 2015; DOI: https://doi.org/10.4143/crt.2015.038

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Benzodiazepines for agitation in patients with delirium
David Hui
Current Opinion in Supportive and Palliative Care.2018; 12(4): 489. CrossRef
Reply to Commentary on “Clinical Characteristics and Adequate Treatment of Familial Adenomatous Polyposis Combined with Desmoid Tumors”
Jin Cheon Kim
Cancer Research and Treatment.2015; 47(2): 341. CrossRef

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A Unique Case of Erdheim-Chester Disease with Axial Skeleton, Lymph Node, and Bone Marrow Involvement: Jin Lim, Ki Hwan Kim, Koung Jin Suh, Kyung Ah Yoh, Jin Young Moon, Ji Eun Kim, Eun Youn Roh, In Sil Choi, Jin-Soo Kim, Jin Hyun Park; Cancer Res Treat. 2016;48(1):415-421. Published online February 26, 2015; DOI: https://doi.org/10.4143/crt.2014.160

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Erdheim-Chester disease is a rare non-Langerhans–cell histiocytosis with bone and organ involvement. A 76-year-old man presented with low back pain and a history of visits for exertional dyspnea. We diagnosed him with anemia of chronic disease, cytopenia related to chronic illness, chronic renal failure due to hypertension, and hypothyroidism. However, we could not determine a definite cause or explanation for the cytopenia. Multiple osteosclerotic axial skeleton lesions and axillary lymph node enlargement were detected by computed tomography. Bone marrow biopsy revealed histiocytic infiltration, which was CD68-positive and CD1a-negative. This report describes an unusual presentation of Erdheim-Chester disease involving the bone marrow, axial skeleton, and lymph nodes.

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Erdheim Chester Disease Mimicking Lymphoma: A Case Report
Philipp Moritz Wunschel, Wolfgang Voss, Marc Keberle
RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren.2022; 194(03): 310. CrossRef
Myelopathy Secondary to Isolated Thoracic Spine Involvement Mimicking Metastasis in Erdheim–Chester Disease
Rajesh Rajavelu, Ajoy P. Shetty, Rishi M. Kanna, S Rajasekaran
Indian Spine Journal.2021; 4(1): 133. CrossRef
Diagnosing a Patient with Erdheim-Chester Disease during the COVID-19 Pandemic
Georgia Kaiafa, Dimitrios Pilalas, Triantafyllia Koletsa, Stylianos Daios, Georgios Arsos, Adam Hatzidakis, Adonis Protopapas, Kostas Stamatopoulos, Christos Savopoulos
Medicina.2021; 57(10): 1001. CrossRef
Case of Erdheim–Chester presenting with xanthelasma-like eruption and osteolytic bone lesions: A case report
Evelyn Alarcon Chinchilla, Marie-Pascale Gourde, Karine Turcotte, Steve Mathieu, Mohamed Amin-Hashem
SAGE Open Medical Case Reports.2019;[Epub] CrossRef
Erdheim-Chester Disease Involving Lymph Nodes and Liver Clinically Mimicking Lymphoma: A Case Report
Yeoun Eun Sung, Yoon Seo Lee, Jieun Lee, Kyo Young Lee
Journal of Pathology and Translational Medicine.2018; 52(3): 183. CrossRef
Resolved heart tamponade and controlled exophthalmos, facial pain and diabetes insipidus due to Erdheim-Chester disease
Jaume Monmany, Esther Granell, Laura López, Pere Domingo
BMJ Case Reports.2018; 2018: bcr-2018-225224. CrossRef
18F-FDG PET/CT in Erdheim–Chester Disease: Imaging Findings and Potential BRAF Mutation Biomarker
Jason R. Young, Geoffrey B. Johnson, Robert C. Murphy, Ronald S. Go, Stephen M. Broski
Journal of Nuclear Medicine.2018; 59(5): 774. CrossRef
Erdheim-Chester Disease with Emperipolesis: A Unique Case Involving the Heart
Pengcheng Zhu, Naping Li, Lu Yu, Mariajose Navia Miranda, Guoping Wang, Yaqi Duan
Cancer Research and Treatment.2017; 49(2): 553. CrossRef

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Oxaliplatin-Induced Immune-Mediated Thrombocytopenia: A Case Report: Hyun Sun Woo, Kyoung Hwa Lee, Phill Hoon Yoon, Su Ji Kim, Inkeun Park, Young Saing Kim, Hee Kyung Ahn, Junshik Hong, Dong Bok Shin, Sun Jin Sym; Cancer Res Treat. 2015;47(4):949-953. Published online October 28, 2014; DOI: https://doi.org/10.4143/crt.2014.052

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Oxaliplatin is a third-generation platinum derivative used for metastatic or advanced colorectal cancer treatment. Although myelosuppression is the most common cause of oxaliplatin-induced thrombocytopenia, rare cases of oxaliplatin-induced immunemediated thrombocytopenia are reported. We report a case of a 57-year-old woman with colon cancer who developed gum bleeding and petechiae after oxaliplatin infusion. Laboratory tests revealed grade 4 thrombocytopenia and grade 4 neutropenia. She recovered from the thrombocytopenia and accompanying neutropenia within 4 days with no recurrence following discontinuation of oxaliplatin. Physicians need to be aware of the risk of severe acute thrombocytopenia following oxaliplatin administration.

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Risk Factors of Chemotherapy-Induced Thrombocytopenia After Oxaliplatin-Containing Chemotherapy for Gastrointestinal Malignancies
Ju Li, Wanqing Wang, Kaipeng Jiang, Jiuwei Cui, Chang Wang, Tingting Liang, Yizhuo Wang, Shuhan Liu, Wenshuo Zhou
Journal of Gastrointestinal Cancer.2024; 55(3): 1144. CrossRef
Oxaliplatin Antibody-Related Thrombocytopenia: A Case Report
Khin Pyai, David I LeRoy, Joseph Attallah, Hosam Hakim, Zyad Kafri
Cureus.2024;[Epub] CrossRef
The Many Faces of Immune Thrombocytopenia: Mechanisms, Therapies, and Clinical Challenges in Oncological Patients
Marek Kos, Piotr Tomaka, Paulina Mertowska, Sebastian Mertowski, Julia Wojnicka, Anna Błażewicz, Ewelina Grywalska, Krzysztof Bojarski
Journal of Clinical Medicine.2024; 13(22): 6738. CrossRef
Severe ileum bleeding following adjuvant capecitabine chemotherapy for locally advanced colon cancer: a case report and review of the literature
You Zou, Shuang Liu, Jianhong Wu, Zhen Sun
World Journal of Surgical Oncology.2021;[Epub] CrossRef
A case of idiosyncratic liver injury after oxaliplatin‐induced thrombocytopenia
Shinji Honda, Masayuki Tsujimoto, Tetsuya Minegaki, Tomohiko Mori, Junji Muraoka, Kohshi Nishiguchi
Journal of Clinical Pharmacy and Therapeutics.2020; 45(2): 373. CrossRef
Ototoxicity and Platinum Uptake Following Cyclic Administration of Platinum-Based Chemotherapeutic Agents
Benjamin K. Gersten, Tracy S. Fitzgerald, Katharine A. Fernandez, Lisa L. Cunningham
Journal of the Association for Research in Otolaryngology.2020; 21(4): 303. CrossRef
Oxaliplatin-Induced Thrombocytopenia: A Case Report and Review of Pathophysiology of Various Speculative Mechanisms
Haider Ghazanfar, Iqra Nawaz, Nisha Ali
Cureus.2020;[Epub] CrossRef
Oxaliplatin Treatment Alters Systemic Immune Responses
Vanesa Stojanovska, Monica Prakash, Rachel McQuade, Sarah Fraser, Vasso Apostolopoulos, Samy Sakkal, Kulmira Nurgali
BioMed Research International.2019; 2019: 1. CrossRef
Oxaliplatin Immune-Induced Syndrome Occurs With Cumulative Administration and Rechallenge: Single Institution Series and Systematic Review Study
Katia Bencardino, Gianluca Mauri, Alessio Amatu, Federica Tosi, Erica Bonazzina, Laura Palmeri, Marialuisa Querques, Federica Ravera, Alberto Menegotto, Elisa Boiani, Andrea Sartore-Bianchi, Salvatore Siena
Clinical Colorectal Cancer.2016; 15(3): 213. CrossRef

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Risk Factors in Anticancer Chemotherapy Induced Thrombocytopenia Requiring Platelet Transfusion: Jong Hwa Lee, Jee Sook Hahn, Queh Park, Yun Woong Ko; J Korean Cancer Assoc. 2000;32(6):1093-1099.

Abstract PDF: PURPOSE
Severe thrombocytopenia is a rare but life threatening side effect of anticancer chemotherapy. This study is for delineating risk factors for anticancer chemotherapy induced thrombocytopenia requiring platelet transfusion in cancer patients.
MATERIALS AND METHODS
Ninety seven cases of cancers (stomach cancer 37, lung cancer 31 and breast cancer 29) were included in this study design. Complete blood cell counts were done at day 1 and then twice a week to find lowerest thrombocyte count in each cycle. Discriminant analysis of risk factors for chemotherapy induced thrombocytopenia requiring platelet transfusion were performed.
RESULTS
Anticancer chemotherapy induced thrombocytopenia less than 150,000/ microliter developed in 18 cases (20.0%) at day 20.6 8.0 and mean platelet count was 111,060 35,360/ microliter. Thrombocytopenia less than 100,000/ microliter developed in 10 cases (10.3%) at day 20.2 6.9 and mean platelet count was 56,200 30,460/ microliter. Among them platelet transfusions were needed in 6 cases (6.2%). Using discrininant analysis, day 1 platelet count less than 150,000/ microliter with total lymphocyte count less than 900/ microliter were identified as risk factors for anticancer chemotherapy induced thrombocytopenia requiring platelet transfusion.
CONCLUSION
Thrombocytopenia less than 150,000 microliter with total lymphocyte count less than 900/ microliter before administrating anticancer drugs are high risk factors for platelet transfusion, and needed proper managements.

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Potentials of Fractionated Infusions of Low-dose Peripheral Blood Stem Cells (PBSCs) to Overcome the Hematologic Toxocities after Combination Chemotherapy: Seok Goo Cho, Jun Mo Lee, Jin No Park, Hoon Kyo Kim, Sung Eun Namkoong, Kyung Shick Lee, Chun Choo Kim; J Korean Cancer Assoc. 2000;32(5):943-953.

Abstract PDF: PURPOSE
We tried to evaluate the clinical usefullness of fractionated low-dose infusions of peripheral blood stem cells (PBSCs) as a supportive care.
MATERIALS AND METHODS
Four patients were entered onto this study who were diagnosed to have gastric lymphoma (n=1) and advanced ovarian carcinomas (n=3). To overcome the hematologic toxicities, G-CSF-mobilized PBSCs were collected early in disease course. Harvested products were cryopreserved in aliquotes and then infused after each cycle. Planned therapeutic schedules should be performed without changes of dose and interval regardless of hematologic toxicities.
RESULTS
20 cycles of chemotherapies were performed and data of infused cell doses were as follows: median number of PBSCs infusions, 4.5 (3~5); median MNCs, CFU-GM colony counts per infusion of low-dose PBSCs, 1.7 108/kg (1.0~2.4), 3.2 104/kg (2.1~11.8). Among 20 cycles, delayed recovery of thrombocytopenia was shown on 10 cycles. Leukopenia (III/IV) and thrombocytopenia (III/IV) were shown on 8/6 cycles and 8/2 cycles. In spite of myelosuppression, they were successfully treated with planned dose-intensity. Especially incomplete platelet recovery was successfully rescuced by using fractionated infusions of low-dose PBSCs.
CONCLUSION
These data warrant further clinical trials to evaluate the potentials of fractionated low-dose infusions of PBSCs collected early in disease course for overcoming accumulated hematologic toxicities, especially thrombocytopenia complicated by repeated chemotherapies.

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