Cancer Research and Treatment

Original Article

Rare Cancer

Clinical Experience of Male Primary Choriocarcinoma at the Samsung Medical Center: Young Sok Ji, Se Hoon Park; Cancer Res Treat. 2021;53(3):874-880. Published online December 7, 2020; DOI: https://doi.org/10.4143/crt.2020.1066

Purpose
The objective of this study was to describe and analyze the clinicopathological features of primary choriocarcinoma (PCC) observed in male patients treated at the Samsung Medical Center between 1996 and 2020.
Materials and Methods
We reviewed the clinical records of 14 male patients with PCC retrospectively to assess their demographic, histological, and clinical characteristics at the time of diagnosis as well as identify the treatment outcomes.
Results
The median age of the patients was 33 years. The primary tumor site was the testicles in seven cases (50%), the mediastinum in six cases (43%), and the brain in one case (7%). The most common metastatic site was the lungs (79%), followed by the brain (43%). All patients with PCC received cytotoxic chemotherapy. Twelve patients had records of their response to cytotoxic chemotherapy; of these 12 patients, eight (8/12, 67%) achieved an objective response, and four (4/12, 33%) achieved stable disease response as the best response during chemotherapy.
Conclusion
It is known that most male PCC patients eventually develop resistance to cytotoxic chemotherapy and die. Factors such as poor response to chemotherapy, high disease burden, brain metastasis, and hemoptysis at the time of diagnosis are associated with shorter survival time in male PCC patients. Programmed death-1/programmed death-ligand 1 blockade therapy can be a salvage treatment for chemotherapy-resistant male PCC patients.

Citations

Citations to this article as recorded by

Primary retroperitoneal choriocarcinoma with lung and liver metastasis in a male patient: case report
Guimei Wang, Ronghui Li
Oncologie.2024; 26(1): 167. CrossRef
A poor prognostic male choriocarcinoma with multiple systemic metastases: a case report and the literature review
Wenpeng Huang, Zuohuan Zheng, Zheng Bao, Xiaoyan Xiao, Liming Li, Zhaonan Sun, Lei Kang
Frontiers in Medicine.2024;[Epub] CrossRef
Pediatric primary extragonadal choriocarcinoma - A study on male patients at a single tertiary medical institution
Jui-Ju Tseng, Chi-Yen Chen, Chiung-Wen Liang, Fang-Liang Huang
Pediatrics & Neonatology.2024;[Epub] CrossRef
Comparative analysis of testicular and nontesticular choriocarcinoma: a population-based study
Sakhr Alshwayyat, Maen S. Soudi, Marwa T. Qaddoura, Tala A. Alshwayyat, Obada Ababneh, Hamdah Hanifa, Ramez M. Odat, Rami S. AlAzab
Annals of Medicine & Surgery.2024; 86(12): 6951. CrossRef
The tumor or inflammation? a case report on primary pulmonary choriocarcinoma
Na Wang, Nan Zhang, Xinyue Zhang, Yuanyuan Wang, Yajie Fu, Lingfei Guo, Changhu Liang, Mengru Yu
Frontiers in Oncology.2023;[Epub] CrossRef
Pure testicular choriocarcinoma, a rare and highly malignant subtype with challenging treatment: A case report and review of the literature
Na Lei, Li-Li Lei, Chao-Hong Wang, Chao-Rong Mei
Molecular and Clinical Oncology.2023;[Epub] CrossRef
Antineoplastics

Reactions Weekly.2022; 1890(1): 41. CrossRef
Case Report: Treatment of primary pulmonary choriocarcinoma with lung lobectomy and adjuvant chemotherapy
Andrea M. Johnson, Christiana M. Johnson, Zena Khalil, Maria Stitzel, Deanna Teoh
Gynecologic Oncology Reports.2022; 43: 101064. CrossRef
Extragonadal Germ Cell Tumors of the Mediastinum and Retroperitoneum
David Aguiar Bujanda, Daniel Pérez Cabrera, Laura Croissier Sánchez
American Journal of Clinical Oncology.2022; 45(12): 493. CrossRef

7,068 View
155 Download
10 Web of Science
9 Crossref

Case Reports

Treatment of Pulmonary Tumor Embolism from Choriocarcinoma: Extracorporeal Membrane Oxygenation as a Bridge through Chemotherapy: Jae Heun Chung, Hye Ju Yeo, Hyun Myung Cho, Jin Ook Jang, Byung Min Ye, Gun Yoon, Dong Hoon Shin, Dohyung Kim, Woo Hyun Cho; Cancer Res Treat. 2017;49(1):279-282. Published online June 24, 2016; DOI: https://doi.org/10.4143/crt.2016.125

Abstract PDF PubReader ePub

A 22-year-old woman with a 1-month history of shortness of breath that was treated as a case of tuberculosis and pulmonary embolism was referred to the authors’ hospital. Because of the hemodynamic instability in this patient, venoarterial extracorporeal membrane oxygenation (ECMO) was administered in the intensive care unit. She underwent a pulmonary embolectomy for the treatment of progressive circulatory collapse secondary to a pulmonary embolism. The histopathologic result was consistent with a metastatic choriocarcinoma. Despite the surgical management, persistent refractory cardiogenic shock occurred. Subsequently, the patient was treated with chemotherapy in the presence of ECMO and responded well to chemotherapy. She was discharged after 3 months. This case suggests that metastatic choriocarcinoma should be considered as a differential diagnosis in women of childbearing age presenting with a pulmonary embolism, and ECMO may be beneficial in patients with pulmonary embolism for bridging to surgical embolectomy and chemotherapy.

Citations

Citations to this article as recorded by

Isolated pulmonary artery choriocarcinoma masquerading as pulmonary embolism diagnosed by endovascular biopsy
Simon Doran, Ronan Kernan, Niall McEniff
Radiology Case Reports.2024; 19(8): 3525. CrossRef
Extracorporeal membrane oxygenation in critically ill patients with active hematologic and non-hematologic malignancy: a literature review
Roberto Rabello Filho, Daniel Joelsons, Bruno de Arruda Bravim
Frontiers in Medicine.2024;[Epub] CrossRef
Acute pulmonary tumour embolism and right systolic dysfunction in a hidden intrahepatic cholangiocarcinoma: case report
Alejandra Portillo-Romero, Eric Cuevas-Medina, Maria Jose Santa Ana-Bayona, Santiago Saenz-Ancira, Costantino Mancusi, Megha Agarwal, A Shaheer Ahmed, Federico B Blasi, Polyvios Demetriades, Jonathan Senior
European Heart Journal - Case Reports.2023;[Epub] CrossRef
Advances in the use of ECMO in oncology patient
Xiangnan Teng, Jiali Wu, Jing Liao, Shanling Xu
Cancer Medicine.2023; 12(15): 16243. CrossRef
A rare case of pulmonary artery embolism with choriocarcinoma: A case report and literature review
Pengcheng Wang, Dunqiang Ren, Caihong Guo, Xiaoqian Ding, Yiwei Cao, Peige Zhao, Qiang Wang, Wenjuan Xu
Oncology Letters.2023;[Epub] CrossRef
Extracorporeal Membrane Oxygenator Failure in a Patient With Gestational Trophoblastic Neoplasm: Possible Mechanisms and Considerations in Critical Care
Nathan J. Smith, Beth A. Nance, Lucian A. Durham, Lindsey A. McAlarnen, Erin A. Bishop, M. Tracy Zundel
Journal of Cardiothoracic and Vascular Anesthesia.2022; 36(8): 2583. CrossRef
Extracorporeal membrane oxygenation for lung cancer-related life-threatening hypoxia: A case report
Seung Soo Yoo, Shin Yup Lee, Sun Ha Choi
World Journal of Clinical Cases.2022; 10(25): 8974. CrossRef
Extracorporeal Membrane Oxygenation to Facilitate Chemotherapy—Moving the Goalposts!
Emad A Chishti, Thomas Marsden, Aaron Harris, Zhonglin Hao, Suresh Keshavamurthy
Cureus.2022;[Epub] CrossRef
Dyspnoea unmasked with point of care ultrasound. A Case Report
Priya Ramachandran, Varghese Louis, Uma Devaraj, Kavitha Venkatanarayana, Uma Maheshwari Krishnaswamy
SN Comprehensive Clinical Medicine.2021; 3(5): 1203. CrossRef
Outcomes of extracorporeal membrane oxygenation in adults with active hematologic and nonhematologic malignancy
Chul Park, Ui Won Ko, Ryoung‐Eun Ko, Soo Jin Na, Jeong Hoon Yang, Kyeongman Jeon, Gee Young Suh, Kiick Sung, Yang Hyun Cho
Artificial Organs.2021;[Epub] CrossRef
Acute cardiopulmonary failure in a young woman with high-risk gestational trophoblastic neoplasia: A case of induction chemotherapy during extracorporeal membrane oxygenation
Lindsey A. McAlarnen, Nathan J. Smith, Beth A. Nance, M. Tracy Zundel, Erin A. Bishop
Gynecologic Oncology Reports.2021; 37: 100849. CrossRef
Pulmonary tumor embolism from breast cancer diagnosed by selective aspiration cytology using a Swan-Ganz catheter
Ryohei Aoki, Toyoshi Yanagihara, Hiroshi Mannoji, Syunya Sunami, Nobuhiro Tsuruta, Reiko Yoneda, Makoto Usui
Respiratory Medicine Case Reports.2021; 34: 101527. CrossRef
The Utility of Extracorporeal Membrane Oxygenation in Patients With Hematologic Malignancies: A Literature Review
Praveena Tathineni, Mauna Pandya, Bassem Chaar
Cureus.2020;[Epub] CrossRef
Lessons from a patient with cardiac arrest due to massive pulmonary embolism as the initial presentation of Wilms tumor: a case report and literature review
Atsuna Fukuda, Takeshi Isoda, Naoya Sakamoto, Keisuke Nakajima, Tetsuya Ohta
BMC Pediatrics.2019;[Epub] CrossRef
Diagnosis, Treatment and Follow Up of Acute Pulmonary Embolism: Consensus Practice from the PERT Consortium
Belinda Rivera-Lebron, Michael McDaniel, Kamran Ahrar, Abdulah Alrifai, David M. Dudzinski, Christina Fanola, Danielle Blais, David Janicke, Roman Melamed, Kerry Mohrien, Elizabeth Rozycki, Charles B. Ross, Andrew J. Klein, Parth Rali, Nicholas R. Teman,
Clinical and Applied Thrombosis/Hemostasis.2019;[Epub] CrossRef
Anti-tumor Drug Targets Analysis: Current Insight and Future Prospect
Sheng Wang, Dexi Zhou, Zhenyu Xu, Jing Song, Xueyi Qian, Xiongwen Lv, Jiajie Luan
Current Drug Targets.2019; 20(11): 1180. CrossRef
Pulmonary micro‐tumor emboli resulting in paradoxical emboli: a case report
Louis‐Vincent Morin‐Thibault, Daniel Wiseman, Michelle Fortin, Christian Couture, Steeve Provencher
Pulmonary Circulation.2018; 8(2): 1. CrossRef
Possibility of venoarterial extracorporeal membranous oxygenator being a bridging therapy for hemodynamic deterioration of pulmonary tumor thrombotic microangiopathy prior to initiating chemotherapy
Yoshiaki Iwashita, Takuya Hiramoto, Kei Suzuki, Ryotaro Hashizume, Kazuo Maruyama, Hiroshi Imai
Medicine.2018; 97(37): e12169. CrossRef
Role of chemotherapy and thrombolysis in treatment of choriocarcinoma accompanied with pulmonary embolism
Mei Yang, Li Peng
Medicine.2017; 96(36): e7866. CrossRef
Antineoplastics

Reactions Weekly.2017; 1643(1): 32. CrossRef

9,335 View
191 Download
18 Web of Science
20 Crossref

Mixed Testicular Germ Cell Tumor Presenting as Metastatic Pure Choriocarcinoma Involving Multiple Lung Metastases That Was Effectively Treated with High-dose Chemotherapy: Sang-Cheol Lee, Kyoung Ha Kim, Sung Han Kim, Nam Su Lee, Hee Sook Park, Jong-Ho Won; Cancer Res Treat. 2009;41(4):229-232. Published online December 31, 2009; DOI: https://doi.org/10.4143/crt.2009.41.4.229

Abstract PDF PubReader ePub

Choriocarcinoma in the testis is very rare, and it represents less than 1% (0.3%) of all the testicular germ cell tumors. It is a particularly aggressive variant of non-seminoma tumor, which is characterized by a high serum β-HCG level and multiple lung metastases. The optimal management for this disease remains undefined. We report here on a case of choriocarcinoma with multiple lung metastases, and the patient has achieved continuous remission for 2 years after combination chemotherapy of BEP (bleomycin, etoposide and cisplatin) and sequential high-dose chemotherapy with autologous peripheral stem cell rescue.

Citations

Citations to this article as recorded by

Testicular Mixed Germ Cell Tumor Presenting with Upper Gastrointestinal Bleeding: A Case Report
Emilija Nikolovska Trpchevska, Beti Todorovska, Magdalena Bogdanovska Todorovska, Meri Trajkovska, Dafina Nikolova, Darko Dzambaz, Gjorgji Deriban, Fana Licoska-Josifovikj
PRILOZI.2023; 44(2): 47. CrossRef
Gastrointestinal Bleeding Secondary to Metastatic Duodenal Choriocarcinoma in a Patient with Concomitant Peptic Ulcer Disease
Ahmed Elfiky, Asmaa Mokhtar, Mira Alsheikh, Hassan Almoussawi, Stephen Mulrooney, Haruhiko Sugimura
Case Reports in Gastrointestinal Medicine.2021; 2021: 1. CrossRef
Gastrointestinal Bleeding with Hemodynamic Repercussion due to a Gastric Metastatic Lesion of a Testicular Choriocarcinoma in a Previously Asymptomatic Young Adult
Omar Al Salman, Fahad Malik, Shashank Trivedi, Marwah Alchalabi, Shobhana Chaudhari
GE - Portuguese Journal of Gastroenterology.2020; 27(3): 212. CrossRef
Choriocarcinomas May Be Presented with Abnormal Manifestations
Alpaslan Tanoglu, Tolga Duzenli
International Journal of Cancer Management.2017;[Epub] CrossRef
Metastatic Testicular Choriocarcinoma: A Rare Cause of Upper GI Bleeding
Kirsty Lowe, Jacqueline Paterson, Sharon Armstrong, Shaun Walsh, Max Groome, Craig Mowat
ACG Case Reports Journal.2016; 3(1): 36. CrossRef
Metastatic choriocarcinoma induced separate simultaneous intracerebral haemorrhages: a very rare occurrence and its novel association with Klinefelter syndrome
Maximilian Olavi Joret, Robert M Starke, John Scotter, Peter Heppner
BMJ Case Reports.2015; : bcr2015212777. CrossRef
Contrast-Enhanced Ultrasonography of the Testes
Ounali S. Jaffer, Paul S. Sidhu
Ultrasound Clinics.2013; 8(4): 509. CrossRef
Multiparametric ultrasonography of the testicles
Tobias De Zordo, Daniel Stronegger, Leo Pallwein-Prettner, Chris J. Harvey, Germar Pinggera, Werner Jaschke, Friedrich Aigner, Ferdinand Frauscher
Nature Reviews Urology.2013; 10(3): 135. CrossRef
A Case of Gastrointestinal Bleeding due to Duodenal Metastasis from a Testicular Choriocarcinoma
Magdalene Vardaros, Miral Subhani, Kaleem Rizvon, Vladimir Gotlieb, Paul Mustacchia, Lester Freedman, Vikas Garg, Jaspreet Singh, Ghulam Siddiqui
Journal of Gastrointestinal Cancer.2013; 44(2): 234. CrossRef
Unravelling mechanisms of cisplatin sensitivity and resistance in testicular cancer
R. Koster, M.A.T.M. van Vugt, H. Timmer-Bosscha, J.A. Gietema, S. de Jong
Expert Reviews in Molecular Medicine.2013;[Epub] CrossRef

14,802 View
69 Download
10 Crossref

Primary Gastric Choriocarcinoma: Two Case Reports and Review of the Literatures: Jung Ho Yoon, Min Soo Kim, Eun Hee Kook, Se Han Ahn, Se Young Jeong, Min Sung Han, Jung Kwon Huh, Hye Jin Kang, Im Il Na, Soo Youn Cho, Sang Bum Kim, Baek Yeol Ryoo, Sung Hyun Yang; Cancer Res Treat. 2008;40(3):145-150. Published online September 30, 2008; DOI: https://doi.org/10.4143/crt.2008.40.3.145

Abstract PDF PubReader ePub

Primary gastric choriocarcinoma (PGC) is a rare tumor, and its pathogenesis is still uncertain. Most PGCs have been reported to possess an adenocarcinoma component of variable extent, and pure PGC is especially rare. The diagnosis of PGC is confirmed by exhibition of choriocarcinomatous components on biopsy and exhibition of β-hCG positive cell on immunohistochemical stain and elevation of the serum β-hCG. Moreover it must be confirmed that no other site including gonads displays any tumor masses. The PGC tends to be more invasive and to have early metastasis. The median survival is known to be less than several months. We report two cases. The first case was a 62 year-old man who was diagnosed as advanced gastric cancer (AGC) by endoscopic biopsy with hepatic metasasis and received palliative chemotherapy with modified FOLFOX regimen and Genexol plus cisplatin regimen. He underwent subtotal gastrectomy due to perforation of the stomach during chemotherapy. On post-operative biopsy, He was re-diagnosed as PGC and received another palliative chemotherapy modified FOLFIRI, BEP, EMACO, VIP. However, multiple liver metastases were aggravated, and also serum AFP level increased. Ultimately, the paient died 10 months after initial diagnosis. Another case was a 45 year-old man. On endoscopic biopsy, he was diagnosed as AGC of adenocarcinoma. On Chest and Abdomen CT, multiple pulmonary and hepatic metastasis were also confirmed. On liver biopsy, He was diagnosed as PGC. The immunohistochemical stains were performed and the results were cytokeratin positive, EMA negative and β-hCG weak positive. The serum β-hCG level was highly elevated. BEP, VIP and EMA/CO combination therapy were administered, but he died at 12th months after the initial diagnosis.

Citations

Citations to this article as recorded by

Morphological and molecular pathological features of the breast carcinoma with choriocarcinomatous features: A case report and a literature review
Jingchun Xu, Yi Xu, Cheng Xu, Cong Wang
Frontiers in Oncology.2023;[Epub] CrossRef
Case Report: a rare primary gastric choriocarcinoma revealed on 18F-FDG PET/CT
Yi Zhao, Wei Diao, Suping Li, Mengxi Yang, Zhuzhong Cheng
Frontiers in Oncology.2023;[Epub] CrossRef
Severe thyrotoxicosis as initial presentation of gastric choriocarcinoma: a case report
Nicole M. Iñiguez-Ariza, Dalia Cuenca, Juvenal Franco-Granillo, Alberto Villalobos-Prieto, Janet Pineda-Díaz, Javier Baquera-Heredia
Journal of Medical Case Reports.2022;[Epub] CrossRef
Primary gastric choriocarcinoma: A case report
Zhang Xusheng, Yan Yuke, Meng Yun, Guo Huijun, Peng Jiangshan, Du Xueqin, Yang Xiaojun
Frontiers in Surgery.2022;[Epub] CrossRef
Successful treatment of a high-risk nonseminomatous germ cell tumor using etoposide, methotrexate, actinomycin D, cyclophosphamide, and vincristine: A case report
Jina Yun, Sang W Lee, Sung H Lim, Se H Kim, Chan K Kim, Seong K Park
World Journal of Clinical Cases.2020; 8(21): 5334. CrossRef
Primary Gastric Choriocarcinoma Coexisting with Adenocarcinoma
Joo Hyun Lee, Jeong Kyun Lee, Dong Baek Kang
The Korean Journal of Gastroenterology.2019; 73(6): 350. CrossRef
Primary gastric choriocarcinoma with multiple metastases – A case report and literature review of carcinogenesis
Yiqin Xiong, Michelle X. Yang
Human Pathology: Case Reports.2019; 18: 200330. CrossRef
Collision tumor of choriocarcinoma and small cell carcinoma of the stomach: A case report
Shuichi Fukuda, Yoshinori Fujiwara, Tomoko Wakasa, Keisuke Inoue, Kotaro Kitani, Hajime Ishikawa, Masanori Tsujie, Masao Yukawa, Yoshio Ohta, Masatoshi Inoue
International Journal of Surgery Case Reports.2017; 37: 216. CrossRef
Primary Choriocarcinoma of the Stomach. A Case Report and Review of the Literature
Rahul Raghavapuram, Fadl H Veerankutty, M Anandakumar
Indian Journal of Surgical Oncology.2016; 7(1): 119. CrossRef
A Case of a Duodenal Papilla Adenosquamous Carcinoma with Trophoblastic Differentiation
Daichi KITAGUCHI, Shingo SAKASHITA, Shinji HASHIMOTO, Tatsuya ODA, Nobuhiro OHKOHCHI, Masayuki NOGUCHI
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2016; 77(6): 1440. CrossRef
Biochemical remission by chemoradiotherapy in male mediastinal choriocarcinoma with diffuse lung metastasis: A case report
JING ZHANG, ZHI-JUN WANG, BIN YANG, YOU-YING WEI, LING YANG, YANG HU, YAN-PING HU
Oncology Letters.2016; 11(4): 2615. CrossRef
Primary gastric choriocarcinoma: A rare case
Vilma Florença Martins, Filipa Moreno, J. Ramón Vizcaíno, Jorge Santos
International Journal of Surgery Case Reports.2015; 14: 44. CrossRef
Resectable Primary Gastric Choriocarcinoma with Solitary Synchronous Liver Metastasis
Masafumi Tomita, Eisei Nishino, Tomoya Takami, Yu Oshima, Kotaro Hatano, Satoshi Wakama, Hayato Furue, Yasuhiro Matsuda, Naoki Kataoka, Tomoyuki Yamaguchi
The Japanese Journal of Gastroenterological Surgery.2015; 48(6): 488. CrossRef
Endometrioid adenocarcinoma with choriocarcinomatous differentiation: A case report and review of the literature
MITSUAKI ISHIDA, HIDETOSHI OKABE
Oncology Letters.2013; 6(3): 655. CrossRef
Gastric adenocarcinoma with choriocarcinomatous and hepatoid differentiation
Seong Wook Hwang, Sun Jae Lee, Po Eun Park, Mee Seon Kim, Han‐Ik Bae
Basic and Applied Pathology.2012; 5(1): 22. CrossRef
Pathological Complete Response and Two-year Disease-free Survival in a Primary Gastric Choriocarcinoma Patient with Advanced Liver Metastases Treated with Germ Cell Tumor-based Chemotherapy: A Case Report
Y. Waseda, Y. Komai, A. Yano, Y. Fujii, N. Noguchi, K. Kihara
Japanese Journal of Clinical Oncology.2012; 42(12): 1197. CrossRef
Gastric cancer with choriocarcinoma and yolk sac tumor components: Case report
Nobuo Satake, Motoya Chikakiyo, Toshiyuki Yagi, Yasuhiro Suzuki, Takanori Hirose
Pathology International.2011; 61(3): 156. CrossRef
A Coexistent Case of Primary Gastric Choriocarcinoma and Alpha Fetoprotein-producing Gastric Cancer which Caused Rapid Postoperative Progression
Naoya Sasaki, Yoshiharu Shirakata, Hisashi Shinohara, Kazumi Itoi, Atsuhiko Maki, Yoshifumi Mizuno, Rokuro Mimura, Koushou Takasu
The Japanese Journal of Gastroenterological Surgery.2011; 44(12): 1535. CrossRef

11,936 View
62 Download
18 Crossref

A Case of Primary Gastric Choriocarcinoma Presenting with Amenorrhea: Seung Hyun Nam, Seock Ah Im, Ki Sun Bae, In Sook Kang, Jung Mi Kwon, Kyung Eun Lee, Hye Sung Moon, Sun Hee Sung, Woon Sup Han, Chu Myong Seong, Soon Nam Lee; Cancer Res Treat. 2002;34(6):457-460. Published online December 31, 2002; DOI: https://doi.org/10.4143/crt.2002.34.6.457

Abstract PDF

Primary gastric choriocarcinomas are very rare, and their prognosis is extremely poor. A 37-year-old woman presented with amenorrhea, vaginal spotting and severe nausea, which mimicked a pregnancy and gestational trophoblastic disease. The serum level of the beta-subunit of human chorionic gonadotrophin (beta-hCG) was significantly increased. An endoscopic biopsy of the stomach mass showed the features of a choriocarcinoma, with marked anaplasia and necrosis. Immunohistochemical staining for beta-hCG showed positive results in the choriocarcinoma. Chemotherapy for the choriocarcinoma was administered, but she died 8 months following diagnosis.

Citations

Citations to this article as recorded by

Primary Gastric Choriocarcinoma: Two Case Reports and Review of the Literatures
Jung Ho Yoon, Min Soo Kim, Eun Hee Kook, Se Han Ahn, Se Young Jeong, Min Sung Han, Jung Kwon Huh, Hye Jin Kang, Im Il Na, Soo Youn Cho, Sang Bum Kim, Baek Yeol Ryoo, Sung Hyun Yang
Cancer Research and Treatment.2008; 40(3): 145. CrossRef

4,247 View
34 Download
1 Crossref

Original Articles

Inhibitory Effect of Transforming Growth Fasctor-β1 on Cellular Proliferation and c-myc Expression in Choriocarcinoma Cell Line: Sa Jin Kim, Jin Woo Kim, Jong Gu Rha, Guisera Lee, Seung Kyu Song, Sung Eun Namkoong; J Korean Cancer Assoc. 1995;27(6):961-968.

Abstract PDF: Modulation of cellular proliferation and c-myc oncogene expression after treatment of human choriocarcinoma cell line(BeWo) with trsnsorming growth factor-￥a1(TGF-￥a1) have been investigated by MTT [3-(4,5-dimethylthiaxol-2-yl)-2, 5-diphenyltetrazolium bromide] assay and Northern blotting analysis, respectively. TGF-￥a1 inhibited BeWo cell growth in a dose dependent manner at concentrations of 0.00110 ng/mL. When BeWo cells were exposed to 10 ng/ml of TGF-￥a1,c-myc was repressed after 4hr and completely aboiished at 24hr of stimulation. These results show that TGF-￥a1 may play an antiproliferative effect on BeWo cell growth via c-myc gene product. In vitro analysis of cellular and molecular alterations in BeWo cells in this study may aid in elucidating the mechanism of action of TGF-￥a1 on human choriocarcinoma tissues in vivo.

2,655 View
15 Download

Clinical Trial of Concomitant Thermo - Chemotherapy in Cervix Cancer Patients: Hong Seok Jang, Sei Chul Yoon, Su Mi Chung, Mi Ryeong Ryu, Yeon Shil Kim, Jong Sup Park, Sung Eun NamKoong, Seung Jo Kim, Kyung Sub Shinn; J Korean Cancer Assoc. 1995;27(6):968-978.

PDF

2,532 View
21 Download

First
Prev
Page of 1
Next
Last

Search