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Prognostic Value of TP53 Mutation for Transcatheter Arterial Chemoembolization Failure/Refractoriness in HBV-Related Advanced Hepatocellular Carcinoma
Miao Xue, Yanqin Wu, Wenzhe Fan, Jian Guo, Jialiang Wei, Hongyu Wang, Jizhou Tan, Yu Wang, Wang Yao, Yue Zhao, Jiaping Li
Cancer Res Treat. 2020;52(3):925-937.   Published online March 30, 2020
DOI: https://doi.org/10.4143/crt.2019.533
AbstractAbstract PDFPubReaderePub
Purpose
This study aimed to investigate the clinicopathologic features and mutational landscape of patients with hepatitis B virus (HBV)–related advanced hepatocellular carcinomas (HCC) undergoing transcatheter arterial chemoembolization (TACE).
Materials and Methods
From January 2017 to December 2018, 38 patients newly diagnosed with HBV-related advanced HCC were enrolled in the final analysis. Their pathological tissues and corresponding blood samples before TACE treatment were collected for whole-exome sequencing. Response to TACE was evaluated at 1-3 months after two consecutive use of TACE. Predictive factors were analyzed by univariate and multivariate analyses in a bivariate Logistic regression model. Enrichment of related pathways of all driver genes were acquired using the gene set enrichment analysis (GSEA).
Results
Among 38 patients, 23 (60.5%) exhibited TACE failure/refractoriness. Patients with TACE failure/refractoriness showed higher frequency of TP53 mutation than their counterparts (p=0.020). Univariate and multivariate analyses showed that only vascular invasion and TP53 mutation were significantly correlated with TACE failure/refractoriness in HBV-related advanced HCC. Of the 16 patients without vascular invasion, eight (50.0%) had TP53 mutations, and TP53 mutation was associated with TACE failure/refractoriness (p=0.041). Moreover, GSEA showed that mitogen-activated protein kinase and apoptosis pathways induced by TP53 mutation were possibly associated with TACE failure/refractoriness.
Conclusion
Our study suggested that TP53 mutation was independently related with TACE efficacy, which may work via mitogen-activated protein kinase and apoptosis pathways. These findings may provide evidence to help distinguish patients who will particularly benefit from TACE from those who require more personalized therapeutic regimens and rigorous surveillance in HBV-related advanced HCC.

Citations

Citations to this article as recorded by  
  • Therapeutic efficacy and prognostic indicators in re-resection for recurrent hepatocellular carcinoma: Insights from a retrospective study
    Qi Fan, Pengcheng Wei, Delin Ma, Qian Cheng, Jie Gao, Jiye Zhu, Zhao Li
    Surgery Open Science.2025; 23: 16.     CrossRef
  • TP53 Mutation Predicts Worse Survival and Earlier Local Progression in Patients with Hepatocellular Carcinoma Treated with Transarterial Embolization
    Ken Zhao, Anita Karimi, Luke Kelly, Elena Petre, Brett Marinelli, Erica S. Alexander, Vlasios S. Sotirchos, Joseph P. Erinjeri, Anne Covey, Constantinos T. Sofocleous, James J. Harding, William Jarnagin, Carlie Sigel, Efsevia Vakiani, Etay Ziv, Hooman Yar
    Current Oncology.2025; 32(1): 51.     CrossRef
  • Clinical Therapy: HAIC Combined with Tyrosine Kinase Inhibitors and Programmed Cell Death Protein-1 Inhibitors versus HAIC Alone for Unresectable Hepatocellular Carcinoma
    Baokun Liu, Lujun Shen, Wen Liu, Zhiyong Zhang, Jieqiong Lei, Zhengguo Li, Qinquan Tan, Hengfei Huang, Xingdong Wang, Weijun Fan
    Journal of Hepatocellular Carcinoma.2024; Volume 11: 1557.     CrossRef
  • Enhanced interactions within microenvironment accelerates dismal prognosis in HBV-related HCC after TACE
    Libo Wang, Jiahui Cao, Zaoqu Liu, Shitao Wu, Yin Liu, Ruopeng Liang, Rongtao Zhu, Weijie Wang, Jian Li, Yuling Sun
    Hepatology Communications.2024;[Epub]     CrossRef
  • Development and validation of survival prediction models for patients with hepatocellular carcinoma treated with transcatheter arterial chemoembolization plus tyrosine kinase inhibitors
    Kun Huang, Haikuan Liu, Yanqin Wu, Wenzhe Fan, Yue Zhao, Miao Xue, Yiyang Tang, Shi-Ting Feng, Jiaping Li
    La radiologia medica.2024; 129(11): 1597.     CrossRef
  • Identification of BRD7 by whole-exome sequencing as a predictor for intermediate-stage hepatocellular carcinoma in patients undergoing TACE
    Kun Huang, Yanqin Wu, Wenzhe Fan, Yue Zhao, Miao Xue, Haikuan Liu, Yiyang Tang, Jiaping Li
    Journal of Cancer Research and Clinical Oncology.2023; 149(13): 11247.     CrossRef
  • Prediction model of no-response before the first transarterial chemoembolization for hepatocellular carcinoma: TACF score
    Jia-Wei Zhong, Dan-Dan Nie, Ji-Lan Huang, Rong-Guang Luo, Qing-He Cheng, Qiao-Ting Du, Gui-Hai Guo, Liang-Liang Bai, Xue-Yun Guo, Yan Chen, Si-Hai Chen
    Discover Oncology.2023;[Epub]     CrossRef
  • Mechanisms of Pharmacoresistance in Hepatocellular Carcinoma: New Drugs but Old Problems
    Jose J.G. Marin, Marta R. Romero, Elisa Herraez, Maitane Asensio, Sara Ortiz-Rivero, Anabel Sanchez-Martin, Luca Fabris, Oscar Briz
    Seminars in Liver Disease.2022; 42(01): 087.     CrossRef
  • Non-Apoptotic Programmed Cell Death-Related Gene Signature Correlates With Stemness and Immune Status and Predicts the Responsiveness of Transarterial Chemoembolization in Hepatocellular Carcinoma
    Guixiong Zhang, Wenzhe Fan, Hongyu Wang, Jie Wen, Jizhou Tan, Miao Xue, Jiaping Li
    Frontiers in Cell and Developmental Biology.2022;[Epub]     CrossRef
  • Plasma arginase-1 as a predictive marker for early transarterial chemoembolization refractoriness in unresectable hepatocellular carcinoma
    Wei-Li Xia, Shi-Jun Xu, Yuan Guo, Xiao-Hui Zhao, Hong-Tao Hu, Yan Zhao, Quan-Jun Yao, Lin Zheng, Dong-Yang Zhang, Chen-Yang Guo, Wei-Jun Fan, Hai-Liang Li
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Useful genes for predicting the efficacy of transarterial chemoembolization in hepatocellular carcinoma
    Yuan Guo, Hongtao Hu, Shijun Xu, Weili Xia, Hailiang Li
    Journal of Cancer Research and Therapeutics.2022; 18(7): 1860.     CrossRef
  • Development and Validation of a Predictive Model for Early Refractoriness of Transarterial Chemoembolization in Patients With Hepatocellular Carcinoma
    Tian-Cheng Wang, Tian-Zhi An, Jun-Xiang Li, Zi-Shu Zhang, Yu-Dong Xiao
    Frontiers in Molecular Biosciences.2021;[Epub]     CrossRef
  • Transcatheter arterial chemoembolization followed by surgical resection for hepatocellular carcinoma: a focus on its controversies and screening of patients most likely to benefit
    Zhan-Qi Wei, Yue-Wei Zhang
    Chinese Medical Journal.2021; 134(19): 2275.     CrossRef
  • Recent Updates of Transarterial Chemoembolilzation in Hepatocellular Carcinoma
    Young Chang, Soung Won Jeong, Jae Young Jang, Yong Jae Kim
    International Journal of Molecular Sciences.2020; 21(21): 8165.     CrossRef
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Body Composition Predicts Survival in Patients with Hepatocellular Carcinoma Treated with Transarterial Chemoembolization
Neehar D. Parikh, Peng Zhang, Amit G. Singal, Brian A. Derstine, Venkat Krishnamurthy, Pranab Barman, Akbar K. Waljee, Grace L. Su
Cancer Res Treat. 2018;50(2):530-537.   Published online June 1, 2017
DOI: https://doi.org/10.4143/crt.2017.156
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
The prognosis of patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE) is often uncertain. We aimed to utilize analytic morphomics, a high-throughput imaging analysis, to assess if body composition is predictive of post-TACE survival.
Materials and Methods
We included patients from a single center (Ann Arbor VA)who had TACE as the primary treatment forHCC and had a pre-treatment computed tomography scans. Univariate analysis and multivariate conditional inference tree analysis were utilized to identify the morphomic characteristics predictive of 1-year survival. Resultswere validated in an external cohort(University of MichiganHealth System) ofHCC patientswho underwent TACE as their primary treatment.
Results
In the 75 patients in the derivation cohort, median survival was 439 (interquartile range, 377 to 685) days from receipt of TACE, with 1-year survival of 61%. Visceral fat density (VFD) was the only morphomic factor predictive of overall and 1-year survival (p < 0.001). Patients with VFD above the 56th percentile had a 1-year survival of 39% versus 78% for those below the 56th percentile. VFD also correlated with 1-year survival in the external validation cohort (44% vs. 72%, p < 0.001). In a secondary analysis, patients with higher VFD were significantly more likely to experience hepatic decompensation after TACE (p < 0.001).
Conclusion
VFD served as an objective predictor of mortality in patients undergoing TACE, possibly through its ability to predict hepatic decompensation. VFD may serve as a radiographic biomarker in predicting TACE outcomes.

Citations

Citations to this article as recorded by  
  • Impact of body composition on the prognosis of hepatocellular carcinoma patients treated with transarterial chemoembolization: A systematic review and meta-analysis
    Anrong Wang, Junfeng Li, Changfeng Li, Hui Zhang, Yingfang Fan, Kuansheng Ma, Qiang Wang
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    Valerie Gunchick, Edward Brown, Juan Liu, Jason W. Locasale, Philip A. Philip, Stewart C. Wang, Grace L. Su, Vaibhav Sahai
    JAMA Network Open.2024; 7(10): e2440047.     CrossRef
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    Abdominal Radiology.2024;[Epub]     CrossRef
  • Artificial Intelligence and Machine Learning Predicting Transarterial Chemoembolization Outcomes: A Systematic Review
    Elina En Li Cho, Michelle Law, Zhenning Yu, Jie Ning Yong, Claire Shiying Tan, En Ying Tan, Hirokazu Takahashi, Pojsakorn Danpanichkul, Benjamin Nah, Gwyneth Shook Ting Soon, Cheng Han Ng, Darren Jun Hao Tan, Yuya Seko, Toru Nakamura, Asahiro Morishita, S
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    Berend R. Beumer, Kosei Takagi, Stefan Buettner, Yuzo Umeda, Takahito Yagi, Toshiyoshi Fujiwara, Jeroen L.A. van Vugt, Jan N.M. IJzermans
    International Journal of Surgery.2023; 109(8): 2258.     CrossRef
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    Dan-Dan Wang, Jin-Feng Zhang, Lin-Han Zhang, Meng Niu, Hui-Jie Jiang, Fu-Cang Jia, Shi-Ting Feng
    Hepatobiliary & Pancreatic Diseases International.2023; 22(6): 594.     CrossRef
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    Alexey Surov, Maximilian Thormann, Mattes Hinnerichs, Max Seidensticker, Ricarda Seidensticker, Osman Öcal, Kerstin Schütte, Christoph J. Zech, Christian Loewe, Otto van Delden, Vincent Vandecaveye, Chris Verslype, Bernhard Gebauer, Christian Sengel, Iren
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    European Journal of Radiology.2023; 167: 111025.     CrossRef
  • Preoperative Pectoralis Muscle Index Predicts Distant Metastasis-Free Survival in Breast Cancer Patients
    Wen-juan Huang, Meng-lin Zhang, Wen Wang, Qing-chun Jia, Jia-rui Yuan, Xin Zhang, Shuang Fu, Yu-xi Liu, Shi-di Miao, Rui-tao Wang
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Metabolic abnormalities, liver and body fat in American versus Chinese patients with non‐alcoholic fatty liver disease
    Wei Zhang, Grace L Su, Kaza Sravanthi, Rui Huang, Yi Wang, Huiying Rao, Lai Wei, Anna S Lok
    JGH Open.2022; 6(8): 519.     CrossRef
  • Impact of muscle mass on survival of patients with hepatocellular carcinoma after liver transplantation beyond the Milan criteria
    Berend R. Beumer, Jeroen L.A. van Vugt, Gonzalo Sapisochin, Peter Yoon, Marco Bongini, Di Lu, Xiao Xu, Paolo De Simone, Lorenzo Pintore, Nicolas Golse, Malgorzata Nowosad, William Bennet, Emmanouil Tsochatzis, Evangelia Koutli, Fariba Abbassi, Marco P.A.W
    Journal of Cachexia, Sarcopenia and Muscle.2022; 13(5): 2373.     CrossRef
  • Bone Densities Assessed by Hounsfield Units at L5 in Computed Tomography Image Independently Predict Hepatocellular Carcinoma Development in Cirrhotic Patients
    Christopher Yeh, Ming-Wei Lai, Chau-Ting Yeh, Yang-Hsiang Lin, Jeng-Hwei Tseng
    Journal of Clinical Medicine.2022; 11(19): 5562.     CrossRef
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    Pompilia Radu, Maryam Ebadi, Aldo J. Montano-Loza, Jean Francois Dufour
    Cancers.2022; 14(21): 5290.     CrossRef
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    Leona von Hessen, Marie Roumet, Martin Helmut Maurer, Naomi Lange, Helen Reeves, Jean‐François Dufour, Pompilia Radu
    Liver International.2021; 41(4): 828.     CrossRef
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    Winnie Y. Zou, Binu E. Enchakalody, Peng Zhang, Nidhi Shah, Sameer D. Saini, Nicholas C. Wang, Stewart C. Wang, Grace L. Su
    Hepatology Communications.2021; 5(11): 1901.     CrossRef
  • The role of muscle depletion and visceral adiposity in HCC patients aged 65 and over undergoing TACE
    Jihye Lim, Kyung Won Kim, Yousun Ko, Il-Young Jang, Yung Sang Lee, Young-Hwa Chung, Han Chu Lee, Young-Suk Lim, Kang Mo Kim, Ju Hyun Shim, Jonggi Choi, Danbi Lee
    BMC Cancer.2021;[Epub]     CrossRef
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    Kung-Hao Liang, Peng Zhang, Chih-Lang Lin, Stewart C. Wang, Tsung-Hui Hu, Chau-Ting Yeh, Grace L. Su
    Digestive Diseases and Sciences.2020; 65(7): 2130.     CrossRef
  • Visceral Adipose Tissue Radiodensity Is Linked to Prognosis in Hepatocellular Carcinoma Patients Treated with Selective Internal Radiation Therapy
    Maryam Ebadi, Carlos Moctezuma-Velazquez, Judith Meza-Junco, Vickie E. Baracos, Abha R. DunichandHoedl, Sunita Ghosh, Philippe Sarlieve, Richard J. Owen, Norman Kneteman, Aldo J. Montano-Loza
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    Maryam Ebadi, Rahima A. Bhanji, Abha R. Dunichand-Hoedl, Vera C. Mazurak, Vickie E. Baracos, Aldo J. Montano-Loza
    Nutrients.2020; 12(11): 3463.     CrossRef
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    Wei Zhang, Rui Huang, Yi Wang, Huiying Rao, Lai Wei, Grace L. Su, Anna S. Lok
    Hepatology Communications.2019; 3(12): 1585.     CrossRef
  • Predicting Survival Using Pretreatment CT for Patients With Hepatocellular Carcinoma Treated With Transarterial Chemoembolization: Comparison of Models Using Radiomics
    Jonghoon Kim, Seung Joon Choi, Seung-Hak Lee, Ho Yun Lee, Hyunjin Park
    American Journal of Roentgenology.2018; 211(5): 1026.     CrossRef
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    Joanne Marie O’Rourke, Vandana Mridhu Sagar, Tahir Shah, Shishir Shetty
    World Journal of Gastroenterology.2018; 24(39): 4436.     CrossRef
  • The Adverse Impact of Sarcopenia and Visceral Fat Deposition on the Course of Hepatocellular Carcinoma and the Role of Nutritional Interventions
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  • 25 Web of Science
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Changes in Arterioportal Shunts in Hepatocellular Carcinoma Patients with Portal Vein Thrombosis Who Were Treated with Chemoembolization Followed by Radiotherapy
Dongryul Oh, Sung Wook Shin, Hee Chul Park, Sung Ki Cho, Do Hoon Lim, Seung Woon Paik
Cancer Res Treat. 2015;47(2):251-258.   Published online October 27, 2014
DOI: https://doi.org/10.4143/crt.2014.011
AbstractAbstract PDFPubReaderePub
Purpose
In this study, we retrospectively investigated the prevalence of arterioportal (AP) shunts in hepatocellular carcinoma (HCC) patients with portal vein tumor thrombosis (PVTT) and evaluated the changes in AP shunts after chemoembolization followed by external beam radiation therapy (EBRT).
Materials and Methods
We analyzed 54 HCC patients with PVTT who were treated with chemoembolization followed by EBRT. EBRT was uniformly delivered at a total dose of 30 to 45 Gy (median, 35 Gy), with a daily dose of 2 to 4.5 Gy. Angiographic images of chemoembolization before and after radiation therapy (RT) were reviewed to investigate the AP shunt.
Results
During the initial session of chemoembolization, 33 of 54 patients (61%) had an AP shunt. After EBRT, 32 out of 33 patients had an additional session of chemoembolization and were evaluated for a change in the AP shunt. The AP shunt decreased in 20 of 32 patients (63%) after chemoembolization followed by EBRT. The 1-year calculated overall survival (OS) rate for all patients was 52.6% and the 2-year OS was 36.4%. The median OS in all patients was 13 months. Patients with AP shunt showed poorer median OS than those without AP shunt, but there was no statistically significant difference (median, 12 months vs. 17 months).
Conclusion
The AP shunt frequently occurs in HCC patients with PVTT. This study suggests that a poor prognosis is associated with an AP shunt. Chemoembolization followed by RT may produce a decrease in AP shunts.

Citations

Citations to this article as recorded by  
  • Sorafenib plus drug-eluting bead transarterial chemoembolization for early intrahepatic stage-progressed advanced hepatocellular carcinoma refractory to conventional transarterial chemoembolization
    Wenzhe Fan, Bowen Zhu, Xinlin Zheng, Shufan Yue, Mingjian Lu, Huishuang Fan, Liangliang Qiao, Fuliang Li, Guosheng Yuan, Yanqin Wu, Xinhua Zou, Hongyu Wang, Miao Xue, Jiaping Li
    Journal of Cancer Research and Clinical Oncology.2023; 149(5): 1873.     CrossRef
  • Drug-eluting beads TACE is safe and non-inferior to conventional TACE in HCC patients with TIPS
    Wenzhe Fan, Jian Guo, Bowen Zhu, Shutong Wang, Lei Yu, Wanchang Huang, Huishuang Fan, Fuliang Li, Yanqin Wu, Yue Zhao, Yu Wang, Miao Xue, Hongyu Wang, Jiaping Li
    European Radiology.2021; 31(11): 8291.     CrossRef
  • Diffusion-weighted and dynamic contrast-enhanced magnetic resonance imaging after radiation therapy for bone metastases in patients with hepatocellular carcinoma
    Ji Hyun Lee, Gyu Sang Yoo, Young Cheol Yoon, Hee Chul Park, Hyun Su Kim
    Scientific Reports.2021;[Epub]     CrossRef
  • Multidisciplinary treatment of advanced hepatocellular carcinoma with severe arterioportal shunt: a case report
    Yao-chang Luo, Hai-lin Lu, Wen-ling Song, Fei-fei Xuan
    Journal of International Medical Research.2021;[Epub]     CrossRef
  • Efficacy and safety of transjugular intrahepatic portosystemic shunt combined with transcatheter embolization/chemoembolization in hepatocellular carcinoma with portal hypertension and arterioportal shunt
    Hai-lin Lu, Fei-fei Xuan, Yao-chang Luo, Xiao Qin
    Abdominal Radiology.2021; 46(11): 5417.     CrossRef
  • Portal stent with endovascular brachytherapy improves the efficacy of TACE for hepatocellular carcinoma with main portal vein tumor thrombus
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Pirarubicin, UFT, Leucovorin Chemotherapy in Non-embolizable and Transcatheter Arterial Chemoembolization-Failed Hepatocellular Carcinoma Patients; A Phase II Clinical Study
Kyong Hwa Park, So Young Yoon, Sang Cheul Oh, Jae Hong Seo, Chul Won Choi, Jong Eun Yeon, Byung Soo Kim, Sang Won Shin, Yeul Hong Kim, Kwan Soo Byun, Jun Suk Kim, Chang Hong Lee
Cancer Res Treat. 2002;34(4):280-283.   Published online August 31, 2002
DOI: https://doi.org/10.4143/crt.2002.34.4.280
AbstractAbstract PDF
Hepatocellular carcinomas are one of the most common malignancies in the world. However, no effective therapeutic modality has been proven to prolong the survival of patients in an inoperable stage. The purpose of this study was to determine the response rate and the toxicities of a combination of pirarubicin, UFT and leucovorin in patients with non-embolizable hepatocellular carcinomas, or who had progressed during their transcatheter arterial chemoembolization treatment.
MATERIALS AND METHODS
Of 23 patients with a hepatocellular carcinoma, 11 had progressed during a transcatheter arterial chemoembolization, with the other 12 being transcatheter arterial chemoembolization-naive. All the patients were treated with pirarubicin (70 mg/m2 i.v., day 1), UFT (350 mg/m2 P.O., day 1~21), and leucovorin (25 mg/m2 P.O., day 1~21).
RESULTS
Twenty patients were able to be evaluated, with a partial response being achieved in four, giving an overall response rate of 20% (95% confidence interval, 7~44%). The median overall survival time was 6 months, and the median survival time of the transcatheter arterial chemoembolization-naive patients was significantly longer than that of those treated by transcatheter arterial chemoembolization (p=0.012). The most significant dose-limiting toxicity was leucopenia and thrombocytopenia.
CONCLUSION
The combination of pirarubicin, UFT and leucovorin therapies showed marginal antitumor activity and significant toxicity in patients with non-embolizable or failed transcatheter arterial chemoembolization hepatocellular carcinomas.
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Transarterial Chemoembolization ( TACE ) for Hepatocellular carcinoma: Comparison of Adriamycin alone vs . Cisplatin alone vs . Adriamycin + Cisplatin
Jung Ae Lee, Keun Chil Park, Bong Seog Kim, Young Soo Do, Duk Lim, Tae Sung Park, Chang Min Kim, Jhin Oh Lee, Taik Koo Yun
J Korean Cancer Assoc. 1998;30(6):1156-1167.
AbstractAbstract PDF
PURPOSE
Although transarterial chemoembolization (TACE) has been widely used for the treatment of unresectable hepatocellular carcinoma, it has not been determined yet which chemotherapeutic agents were best for TACE. To determine the best chemotherapeutic regimen for TACE, we performed a prospective randomized study comparing 3 chemo- therapeutic regimen (adriamycin alone vs. cisplatin alone vs. adriamycin + cisplatin).
MATERIALS AND METHODS
The patients with unresectable hepatocellular carcinoma were eligible for this study and were randomly assigned to three treatment groups (A: adriamycin 30 mg/m(2), B: cisplatin 60 mg/m(2), C: adriamycin 30 mg/m(2) + cisplatin 60 mg/m(2)). The TACE were performed by administering the mixture of lipiodol and the assigned chemotherapeutic drugs through the hepatic artery, followed by embolization with gelfoam powder. The treatment was planned to be repeated every 4 weeks.
RESULTS
After 40 patients (14 in group A, 16 in group B, 10 in group C) entered, the study was stopped prematurely because of serious treatment-related complications including 15% of local complications, 18% of hepatic encephalopathy, and 8% of deaths. Because TACE could result in necrosis without reduction of mass size, the response could not be evaluated by the change of mass size, but by the change of serum alpha-fetoprotein level. Of 25 patients who had elevated serum alpha-fetoprotein and were assessable for response, there were one complete response (CR) and 5 partial responses (PR) out of 10 in group A, 5 PRs out of 10 in group B, and 2 PRs out of 5 in group C. There was no difference in response rates among the 3 treatment groups (p > 0.05). The response rate in patients treated with gelform embolization was higher than patients without embolization (63% (12/19) vs 19% (1/6): p<0.05). The median survival (OS) was 23 weeks for all 40 patients, 15 weeks for group A, 42 weeks for group B and 24 weeks for group C. The difference of OS between group A and B was statistically significant (p=0.02). However, the OS was not associated with any prognostic factors including treatment group in multivariate analysis.
CONCLUSION
Although cisplatin seemed to be more effective in TACE than adriamycin, no firm conclusion could be drawn from this prematurely ended study. However, we could conclude that the TACE with gelform powder is so toxic that it could not be given safely to the patients with unresectable hepatocellular carcinoma
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Intrahepatic Recurrence after Transhepatic Arterial Chemoembolization in Hepatocellular Carcinoma
Tae Yong Moon, Byung Soo Kim, Suck Hong Lee, Hak Jin Kim, Sung Yup Lim, Bong Sig Koo
J Korean Cancer Assoc. 1995;27(6):924-929.
AbstractAbstract PDF
Purpose
We have investigated the annual frequency of recurrent intrahepatic tumors and the doubling time of regrowing tumors after transhepatic arterial chemoembolization (TAE) to know the proper time for subsequent TAE. Materials and Methods: Among cases in which a previous TAE was performed, 28 cases showed definite intrahepatic recurrence and 7 cases showed a regrowing tumor in the follow-up liver CT scan and/or hepatic angiography. Resnlts: The annual frequency of intrahepatic recurrence in the 28 tumors was 71.4% (20/28) within one year and 100% within 6 years. The mean doubling time of 7 regrowing tumors was 68.3 days. Conclusion: We concluded that periodically repeated TAE is needed for further treatment of the recurrent and regrowing tumors.
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Effect of Preoperative Transcatheter Arterial Chemoembolization on Recurrence Rate and Survival After Curative Resection in Patients with Hepatocellular Carcinoma
Dong Sup Yoon, Seung Ho Choi, Ki Whang Kim, Hoon Sang Chi, Byong Ro Kim
J Korean Cancer Assoc. 1996;28(4):726-733.
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In order to evaluate the effect of preoperative transcatheter arterial chemoembolization on recurrence rate and survival after curative resection in patients with hepatocellular carcinoma, a retrospective clinical study of 57 patients underwent curative resection was performed. Fifty seven patients with hepatocellular carcinoma, underwent curative liver resection at Yongdong Severance Hospital from June 1985 to June 1995, were divided into two different treatment groups. Of the 57 patients, 25 patients(Group I) had received preoperative transcatheter arterial chemoembolization and 32(Group II) had not received. In any of the variables considered, age, sex, HBsAg, Child class, tumor number, tumor size, a- FP, operative method, no significant difference of patient characteristics between the two groups was found(p>0.05). Using the Kaplan-Meier Product-limit method and log-rank test, the differences of 1, 3, 5-year overall survival and disease-free survival rates, between these comparable groups were analyzed. The l, 3, 5-year overall survival rates in Group I and Group II were, respectively, 95.2%, 59.5%, 39.7% and 76.6%, 58.7%, 44.0%. Furthermore, the disease-free survival rates were, respectively, 81.5%, 50.3%, 50.3% and 69.4%, 43.9%, 30.8 %. This result indicates that there was no statistical significant difference between two groups in overall and disease-free survival. But, we gained a better results in Group I patients especially with total necrosis of tumor. So, further study, when & how we obtained total necrosis of hepatocellular carcinoma preoperatively, will be needed.
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Cancer Res Treat : Cancer Research and Treatment
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