Cancer Research and Treatment

Original Articles

Gastrointestinal cancer

Detection Ability of Quality of Life Changes and Responsiveness of the KOQUSS-40 and the EORTC QLQ-C30/STO22 in Patients Who Underwent Gastrectomy: A Prospective Comparative Study: Bang Wool Eom, Keun Won Ryu, Ji Yeong An, Yun-Suhk Suh, In Cho, Sung Geun Kim, Ji-Ho Park, Hoon Hur, Hyung-Ho Kim, Sang-Hoon Ahn, Sun-Hwi Hwang, Hong Man Yoon, Ki Bum Park, Hyoung-Il Kim, In-Gyu Kwon, Han-Kwang Yang, Byoung-Jo Suh, Sang-Ho Jeong, Tae-Han Kim, Oh Kyoung Kwon, Hye-Seong Ahn, Ji Yeon Park, Ki Young Yoon, Myoung Won Son, Seong-Ho Kong, Young-Gil Son, Geum Jong Song, Jong Hyuk Yun, Jung-Min Bae, Do Joong Park, Sol Lee, Jun-Young Yang, Kyung Won Seo, You-Jin Jang, So Hyun Kang, Joongyub Lee, Hyuk-Joon Lee, on behalf of KOrean QUality of life in Stomach cancer patients Study group (KOQUSS); Cancer Res Treat. 2026;58(1):221-231. Published online March 5, 2025; DOI: https://doi.org/10.4143/crt.2024.1104

Abstract PDF Supplementary Material PubReader ePub

Purpose
The aim of this study is to compare the detection ability of quality of life (QoL) changes and responsiveness of the KOrean QUality of life in Stomach cancer patients Study group (KOQUSS)-40 and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ).
Materials and Methods
A multicenter prospective observational study was conducted to evaluate QoL changes after various gastrectomies between January 2021 and April 2022. Participants were instructed to complete the KOQUSS-40 and EORTC QLQ-C30/STO22 preoperatively and at 1, 3, 6, and 12 months postoperatively. QoL changes over time and QoL responsiveness were assessed for each questionnaire.
Results
Data from 491 patients who underwent curative gastrectomy for gastric cancer at 22 institutions were analyzed. The summary scores of the KOQUSS-40 and EORTC QLQ-STO22 showed significant differences between the total and proximal gastrectomy groups (p=0.044 and p=0.038, respectively), but no difference was observed for the EORTC QLQ-C30. Dysphagia on the KOQUSS-40 was significantly different between the total and proximal gastrectomy groups (p=0.031); however, dysphagia on the EORTC QLQ-STO22 did not differ. The responsiveness of the KOQUSS-40 was similar to that of the EORTC QLQ in patients who experienced ≥ 10% body weight loss, but approximately 10% less in patients receiving adjuvant chemotherapy than the EORTC QLQ.
Conclusion
KOQUSS-40 has several advantages over EORTC QLQ-C30/STO22 when comparing QoL between the total and proximal gastrectomy groups. The findings provide information for researchers investigating the QoL of patients who have undergone curative gastrectomy for gastric cancer.

Citations

Citations to this article as recorded by

Long-term quality of life, financial toxicity, and decision regret following therapeutic and prophylactic gastrectomy for cancer
Frank G. Lee, Jack W. Sample, Chun Fan, Robert A. Vierkant, Sara K. Daniel, Steven Bowers, Nabil Wasif, Mark J. Truty, Michael L. Kendrick, Cornelius A. Thiels, Travis E. Grotz
Gastric Cancer.2026; 29(3): 635. CrossRef
The efficacy of early progressive resistance exercise in the postoperative management of pancreaticoduodenectomy for pancreatic cancer: a randomized controlled trial
Xuexue Liu, Neng Shi, Rui Li, Yuan Song
Frontiers in Surgery.2025;[Epub] CrossRef
Improvement in Quality of Life After Early Interactive Human Coaching via a Mobile App in Postgastrectomy Patients With Gastric Cancer: Prospective Randomized Controlled Trial
Bang Wool Eom, Mira Han, Hong Man Yoon, Young-Woo Kim, So Young Kim, Jin Myoung Oh, Gyung Ah Wie, Keun Won Ryu
JMIR mHealth and uHealth.2025; 13: e75445. CrossRef

4,574 View
180 Download
2 Web of Science
3 Crossref

Proximal Gastrectomy Is Associated with Lower Incidence of Anemia and Vitamin B12 Deficiency Compared to Total Gastrectomy in Patients with Upper Gastric Cancer: Jeong Ho Song, Sung Hyun Park, Minah Cho, Yoo Min Kim, Woo Jin Hyung, Hyoung-Il Kim; Cancer Res Treat. 2025;57(1):174-185. Published online July 3, 2024; DOI: https://doi.org/10.4143/crt.2024.319

Abstract PDF Supplementary Material PubReader ePub

Purpose
Proximal gastrectomy is an alternative to total gastrectomy (TG) for early gastric cancer (EGC) treatment in the upper stomach. However, its benefits in terms of perioperative and long-term outcomes remain controversial. The aim of this study was to compare the perioperative, body compositional, nutritional, and survival outcomes of patients undergoing proximal gastrectomy with double-tract reconstruction (PG-DTR) and TG for pathological stage I gastric cancer in upper stomach.
Materials and Methods
The study included 506 patients who underwent gastrectomy for pathological stage I gastric cancer in the upper stomach between 2015 and 2019. Clinicopathological, perioperative, body compositional, nutritional, and survival outcomes were compared between the PG-DTR and TG groups.
Results
The PG-DTR and TG groups included 197 (38.9%) and 309 (61.1%) patients, respectively. The PG-DTR group had a lower rate of early complications (p=0.041), lower diagnosis rate of anemia and vitamin B12 deficiency (all p < 0.001), and lower replacement rate of iron and vitamin B12 compared to TG group (all p < 0.001). The PG-DTR group showed reduced incidence of sarcopenia at 6-months postoperatively, preserved higher amount of visceral fat after surgery (p=0.032 and p=0.040, respectively), and showed a higher hemoglobin level (p=0.007). Oncologic outcomes were comparable between the groups.
Conclusion
The PG-DTR for EGC located in the upper stomach offered advantages of fewer complications, lower incidence of anemia and vitamin B12 deficiency, less decrease in visceral fat volume, and similar survival compared to TG. Consequently, PG-DTR may be considered a superior alternative treatment option to TG.

Citations

Citations to this article as recorded by

From mechanisms to management: a comprehensive review of sarcopenia in gastric cancer
Wenhao Liu, Hongliang Cao, Xuanpeng Zhou, Luanbiao Sun, Linchun Li, Xinyuan Song, Yang Gao, Jianpeng Xing, Shuohui Gao
Frontiers in Nutrition.2026;[Epub] CrossRef
Enhancing Quality of Life of Proximal Gastrectomy: A Comprehensive Review of Anastomotic Innovations and Challenges
Linchuan Li, Dexu Zhang, Siyi Song, Shuohui Dong, Qian Xu, Guangyong Zhang, Jiankang Zhu
Cancer Medicine.2026;[Epub] CrossRef
Anatomical Understanding and Evolution of Surgical Treatment for Cancer of the Esophagogastric Junction: From Anatomical Controversies to Precision Surgery
Cien Sun, Hao Liu, Dehua Ma, William C. Cho, Pasan Witharana, Jianfei Shen
Gut Medicine.2026; 2(2): 76. CrossRef
Pancreatic atrophy after gastric cancer surgery: influencing factors and effects on BMI and quality of life
Zhaoping Li, Lianlian Cao, Hao Chen, Feng Wang, Liang Tao, Meng Wang
World Journal of Surgical Oncology.2025;[Epub] CrossRef
Proximal Gastrectomy for Upper-third Early Gastric Cancer
Guanhong Min, Kwangyong Kim, Seonghoon Cho, Jaewoo Shim
Journal of Digestive Cancer Research.2024; 12(2): 68. CrossRef

6,507 View
161 Download
2 Web of Science
5 Crossref

Functional Annotation and Gene Set Analysis of Gastric Cancer Risk Loci in a Korean Population: Hyojin Pyun, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Joohon Sung, Jeongseon Kim; Cancer Res Treat. 2024;56(1):191-198. Published online June 20, 2023; DOI: https://doi.org/10.4143/crt.2022.958

Abstract PDF Supplementary Material PubReader ePub

Purpose
We aimed to identify the associated single nucleotide polymorphisms (SNPs) with gastric cancer (GC) risk by genome-wide association study (GWAS) and to explore the pathway enrichment of implicated genes and gene-sets with expression patterns.
Materials and Methods
The study population was comprised of 1,253 GC cases and 4,827 controls from National Cancer Center and an urban community of the Korean Genome Epidemiology Study and their genotyping was performed. SNPs were annotated, and mapped to genes to prioritize by three mapping approaches by functional mapping and annotation (FUMA). The gene-based analysis and gene-set analysis were conducted with full GWAS summary data using MAGMA. Gene-set pathway enrichment test with those prioritized genes were performed.
Results
In GWAS, rs2303771, a nonsynonymous variant of KLHDC4 gene was top SNP associated significantly with GC (odds ratio, 2.59; p=1.32×10^–83). In post-GWAS, 71 genes were prioritized. In gene-based GWAS, seven genes were under significant p < 3.80×10^–6 (0.05/13,114); DEFB108B had the lowest p=5.94×10^–15, followed by FAM86C1 (p=1.74×10^–14), PSCA (p=1.81×10^–14), and KLHDC4 (p=5.00×10^–10). In gene prioritizing, KLDHC4 was the only gene mapped with all three gene-mapping approaches. In pathway enrichment test with prioritized genes, FOLR2, PSCA, LY6K, LYPD2, and LY6E showed strong enrichment related to cellular component of membrane; a post-translation modification by synthesis of glycosylphosphatidylinositol (GPI)-anchored proteins pathway.
Conclusion
While 37 SNPs were significantly associated with the risk of GC, genes involved in signaling pathways related to purine metabolism and GPI-anchored protein in cell membrane are pinpointed to be playing important role in GC.

Citations

Citations to this article as recorded by

KLHDC4 serves as a novel prognostic biomarker and drives tumor progression via PI3K/AKT signaling in clear cell renal cell carcinoma
Qingjiang Xu, Weili Chen, Senming Cao, Xiubin Li, Xiang Wu, Xin Ma
Scientific Reports.2026;[Epub] CrossRef
Investigating the Shared Genetic Architecture Between Leukocyte Telomere Length and Prostate Cancer
Zhizhou Li, Maoyu Wang, Shuxiong Zeng, Ziwei Wang, Yidie Ying, Qing Chen, Chen Zhang, Wei He, Chaoyang Sheng, Yi Wang, Zhensheng Zhang, Chuanliang Xu, Huiqing Wang
The World Journal of Men's Health.2025; 43(3): 616. CrossRef
A rare KLHDC4 variant Glu510Lys is associated with genetic susceptibility and promotes tumor metastasis in nasopharyngeal carcinoma
Xi-Xi Cheng, Guo-Wang Lin, Ya-Qing Zhou, Yi-Qi Li, Shuai He, Yang Liu, Yan-Ni Zeng, Yun-Miao Guo, Shu-Qiang Liu, Wan Peng, Pan-Pan Wei, Chun-Ling Luo, Jin-Xin Bei
Journal of Genetics and Genomics.2025; 52(4): 559. CrossRef
Interaction between dietary nutrients related to one-carbon metabolism intakes and AHCY rs819173 polymorphism in the risk of gastric cancer: a case–control study in Korea
Ha Thi Mien Nguyen, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Yong-Il Kim, Jeongseon Kim
British Journal of Nutrition.2025; 134(5): 353. CrossRef

8,521 View
242 Download
5 Web of Science
4 Crossref

Gastrointestinal Cancer

Development and Validation of a Symptom-Focused Quality of Life Questionnaire (KOQUSS-40) for Gastric Cancer Patients after Gastrectomy: Bang Wool Eom, Joongyub Lee, In Seob Lee, Young-Gil Son, Keun Won Ryu, Sung Geun Kim, Hyoung-Il Kim, Young-Woo Kim, Seong-Ho Kong, Oh Kyoung Kwon, Ji-Ho Park, Ji Yeong An, Chang Hyun Kim, Byoung-Jo Suh, Hong Man Yoon, Myoung Won Son, Ji Yeon Park, Jong-Min Park, Sang-Ho Jeong, Moon-Won Yoo, Geum Jong Song, Han-Kwang Yang, Yun-Suhk Suh, Ki Bum Park, Sang-Hoon Ahn, Dong Woo Shin, Ye Seob Jee, Hye-Seong Ahn, Sol Lee, Jae Seok Min, Haejin In, Ahyoung Kim, Hoon Hur, Hyuk-Joon Lee, on behalf of KOrean QUality of life in Stomach cancer patients Study group (KOQUSS); Cancer Res Treat. 2021;53(3):763-772. Published online December 29, 2020; DOI: https://doi.org/10.4143/crt.2020.1270

Abstract PDF Supplementary Material PubReader ePub

Purpose
Patients who have undergone gastrectomy have unique symptoms that are not appropriately assessed using currently available tools. This study developed and validated a symptom-focused quality of life (QoL) questionnaire for patients who have received gastrectomy for gastric cancer. Materials and Methods Based on a literature review, patient interviews, and expert consultation by the KOrean QUality of life in Stomach cancer patients Study group (KOQUSS), the initial item pool was developed. Two large-scale developmental studies were then sequentially conducted for exploratory factor analyses for content validity and item reduction. The final item pool was validated in a separate cohort of patients and assessed for internal consistency, test-retest reliability, construct validity, and clinical validity.
Results
The initial questionnaire consisted of 46-items in 12 domains. Data from 465 patients at 11 institutions, followed by 499 patients at 13 institutions, were used to conduct item reduction and exploratory factor analyses. The final questionnaire (KOQUSS-40) comprised 40 items within 11 domains. Validation of KOQUSS-40 was conducted on 413 patients from 12 hospitals. KOQUSS-40 was found to have good model fit. The mean summary score of the KOQUSS-40 was correlated with the EORTC QLQ-C30 and STO22 (correlation coefficients, 0.821 and 0.778, respectively). The KOQUSS-40 score was also correlated with clinical factors, and had acceptable internal consistency (> 0.7). Test-retest reliability was greater than 0.8. Conclusion The KOQUSS-40 can be used to assess QoL of gastric cancer patients after gastrectomy and allows for a robust comparison of surgical techniques in clinical trials.

Citations

Citations to this article as recorded by

Symptoms, nutritional outcomes and quality of life after total gastrectomy with Roux-en-Y reconstruction: results of a cross-sectional study conducted on 80 long-term survivors
Annamaria Agnes, Alberto Biondi, Marina Carannante, Antonia Strippoli, Francesco Belia, Laura Lorenzon, Roberto Pezzuto, Flavio Tirelli, Lorenzo Ferri, Ilaria Neri, Domenico D’Ugo, Roberto Persiani
Updates in Surgery.2026; 78(3): 1047. CrossRef
Detection Ability of Quality of Life Changes and Responsiveness of the KOQUSS-40 and the EORTC QLQ-C30/STO22 in Patients Who Underwent Gastrectomy: A Prospective Comparative Study
Bang Wool Eom, Keun Won Ryu, Ji Yeong An, Yun-Suhk Suh, In Cho, Sung Geun Kim, Ji-Ho Park, Hoon Hur, Hyung-Ho Kim, Sang-Hoon Ahn, Sun-Hwi Hwang, Hong Man Yoon, Ki Bum Park, Hyoung-Il Kim, In-Gyu Kwon, Han-Kwang Yang, Byoung-Jo Suh, Sang-Ho Jeong, Tae-Han
Cancer Research and Treatment.2026; 58(1): 221. CrossRef
Long-term quality of life, financial toxicity, and decision regret following therapeutic and prophylactic gastrectomy for cancer
Frank G. Lee, Jack W. Sample, Chun Fan, Robert A. Vierkant, Sara K. Daniel, Steven Bowers, Nabil Wasif, Mark J. Truty, Michael L. Kendrick, Cornelius A. Thiels, Travis E. Grotz
Gastric Cancer.2026; 29(3): 635. CrossRef
Recent evidence on quality of life following total gastrectomy for gastric cancer: A scoping review
Malvina Eleftheriou, Dimitrios Ampazis, Abraham Pouliakis, Michael Doulberis, Konstantinos Toutouzas, Georgios Zografos, Dimitrios Theodorou, Tania Triantafyllou
Medicine International.2026; 6(3): 1. CrossRef
A Multicenter Pilot Randomized Controlled Trial of a Digital Symptom Management Platform (WECARE) for Gastric Cancer Survivors
Geum Jong Song, Jae-Seok Min, Rock Bum Kim, Ki Bum Park, Bang Wool Eom, Jong Hyuk Yun, Hoon Hur, Jeong Ho Song, Hayemin Lee, Su Mi Kim, Eun Young Kim, Hyungkook Yang, Joongyub Lee, Sang-Ho Jeong
Cancers.2026; 18(9): 1329. CrossRef
Longitudinal changes and deterioration factors of quality of life after gastrectomy for gastric cancer during first postoperative year
Tomohiro Osaki, Shigeru Tatebe, Daigo Makita, Ayumi Tsuda, Chihiro Uejima, Kanenori Endo, Keigo Ashida, Yoshiyuki Fujiwara
Journal of Gastrointestinal Surgery Open.2026; 2: 100018. CrossRef
Longitudinal Quality-of-Life Trajectories Following Laparoscopic Distal Gastrectomy: A Comparison Between Billroth I and II Reconstruction Using the KOQUSS-40 Questionnaire
Jae Yeong Yang, Ji Yeon Park, Oh Kyoung Kwon, Ki Bum Park
Journal of Clinical Medicine.2026; 15(10): 3738. CrossRef
Cancer-related fatigue and functional gastrointestinal disorders after total gastrectomy: A case report
Bing Lu, Kai Wen
World Journal of Gastrointestinal Surgery.2026;[Epub] CrossRef
Function Preserving Gastrectomy and Quality of Life
Jeesun Kim, Hyuk-Joon Lee
Journal of Gastric Cancer.2025; 25(1): 247. CrossRef
Is Braun Jejunojejunostomy Necessary? Comparison Between Billroth-II Alone and Billroth-II With Braun Anastomosis After Distal Gastrectomy
Jane Chungyoon Kim, Min Jung Lee, Hyuk-Joon Lee, Kyoyoung Park, Min Kyu Kang, Sa-Hong Kim, Chun Zhuang, Abdullah Almayouf, Ma. Jeanesse C. Bernardo, Jeesun Kim, Yo-Seok Cho, Seong-Ho Kong, Soo-Jeong Cho, Do Joong Park, Han-Kwang Yang
Journal of Gastric Cancer.2025; 25(2): 318. CrossRef
Laparoscopic Pylorus-preserving Gastrectomy Versus Distal Gastrectomy for Early Gastric Cancer
Hyuk-Joon Lee, Young-Woo Kim, Do Joong Park, Sang Uk Han, Keun Won Ryu, Hyung-Ho Kim, Woo Jin Hyung, Ji-Ho Park, Yun-Suhk Suh, Oh-Kyung Kwon, Wook Kim, Young-Kyu Park, Hong Man Yoon, Sang-Hoon Ahn, Seong-Ho Kong, Han-Kwang Yang
Annals of Surgery.2025; 281(4): 573. CrossRef
Prospective Multicenter Observational Study on Postoperative Quality of Life According to Type of Gastrectomy for Gastric Cancer
Sung Eun Oh, Yun-Suhk Suh, Ji Yeong An, Keun Won Ryu, In Cho, Sung Geun Kim, Ji-Ho Park, Hoon Hur, Hyung-Ho Kim, Sang-Hoon Ahn, Sun-Hwi Hwang, Hong Man Yoon, Ki Bum Park, Hyoung-Il Kim, In Gyu Kwon, Han-Kwang Yang, Byoung-Jo Suh, Sang-Ho Jeong, Tae-Han Ki
Journal of Gastric Cancer.2025; 25(2): 382. CrossRef
The efficacy of a symptom management platform among gastric cancer survivors: a study protocol for a randomized controlled trial
Jeong Ho Song, Joongyub Lee, Jae Seok Min, Hyungkook Yang, Jong Hyuk Yun, Hayemin Lee, Eun Young Kim, Su Mi Kim, Sol Lee, Ki Bum Park, Geum Jong Song, Ji Ho Park, Bang Wool Eom, Hoon Hur, Sang Ho Jeong
International Journal of Surgery Protocols.2025; 29(3): 73. CrossRef
Gastrointestinal Sistem Kanserli Hastalarda Öz Yeterlilik İle Yaşam Kalitesi Arasındaki İlişki
Ezgi Karadağ, Yağmur Yaşa, Özlem Uğur
Etkili Hemşirelik Dergisi.2025; 18(4): 593. CrossRef
Validation of a dietary intake questionnaire through nutritional markers and clinical outcomes in patients with gastric cancer following gastrectomy
Tae-Han Kim, Ji-Ho Park, Eun-Jung Jung, Taejin Park, Jin-Kwon Lee, Young-Hye Kim, Young-Joon Lee, Sang-Ho Jeong
Medicine.2025; 104(50): e46469. CrossRef
Global status of research on gastrointestinal cancer patients’ quality of life: A bibliometric and visual analysis from 2003 to 2023
Xiaoqin Wang, Caihua Wang, Wenjin Han, Jiaru Sun, Zhaozhao Hui, Shuangyan Lei, Huili Wu, Xiaohong Liu
Heliyon.2024; 10(1): e23377. CrossRef
Development and Feasibility Assessment of Mobile Application-Based Digital Therapeutics for Postoperative Supportive Care in Gastric Cancer Patients Following Gastrectomy
Ji-Hyeon Park, Hyuk-Joon Lee, JeeSun Kim, Yo-Seok Cho, Sunjoo Lee, Seongmin Park, Hwinyeong Choe, Eunhwa Song, Youngran Kim, Seong-Ho Kong, Do Joong Park, Byung-Ho Nam, Han-Kwang Yang
Journal of Gastric Cancer.2024; 24(4): 420. CrossRef
REsolution of Symptoms afTer Oesophago-gastric cancer REsection delphi (RESTOREd)—standardizing the definition, investigation and management of gastrointestinal symptoms and conditions after surgery
Ben E Byrne, Kwabena Siaw-Acheampong, Orla Evans, Joanna Taylor, Fiona Huddy, Magnus Nilsson, Ewen A Griffiths, Donald Low, James Gossage, Jason Dunn, Sebastian Zeki, Sheraz Markar, Kerry Avery, Jane M Blazeby, Andrew Cockbain, Charlotte Moss, Mieke van H
British Journal of Surgery.2024;[Epub] CrossRef
Surgical decisions and quality of life after gastrectomy for gastric cancer: update from Asian studies
Jia-yi Xu, Dong-yi Yan, Ren-hao Hu, Shun Zhang, Xiao-hua Jiang
Gastrointestinal Tumors.2024;[Epub] CrossRef
Effect of Four Main Gastrectomy Procedures for Proximal Gastric Cancer on Patient Quality of Life: A Nationwide Multi-Institutional Study
Koji Nakada, Akitoshi Kimura, Kazuhiro Yoshida, Nobue Futawatari, Kazunari Misawa, Kuniaki Aridome, Yoshiyuki Fujiwara, Kazuaki Tanabe, Hirofumi Kawakubo, Atsushi Oshio, Yasuhiro Kodera
Journal of Gastric Cancer.2023; 23(2): 275. CrossRef
Quality of life after gastric cancer surgery
Jae Kyun Park, Hyuk-Joon Lee
Foregut Surgery.2023; 3(2): 27. CrossRef
Long-term Functional and Patient-reported Outcomes Between Intra-corporeal Delta-shaped Gastroduodenostomy and Gastrojejunostomy After Laparoscopic Distal Gastrectomy
Sin Hye Park, Hong Man Yoon, Keun Won Ryu, Young-Woo Kim, Mira Han, Bang Wool Eom
Journal of Gastric Cancer.2023; 23(4): 561. CrossRef
Potential Applicability of Local Resection With Prophylactic Left Gastric Artery Basin Dissection for Early-Stage Gastric Cancer in the Upper Third of the Stomach
Yoshimasa Akashi, Koichi Ogawa, Katsuji Hisakura, Tsuyoshi Enomoto, Yusuke Ohara, Yohei Owada, Shinji Hashimoto, Kazuhiro Takahashi, Osamu Shimomura, Manami Doi, Yoshihiro Miyazaki, Kinji Furuya, Shoko Moue, Tatsuya Oda
Journal of Gastric Cancer.2022; 22(3): 184. CrossRef
Systematic review of health-related quality of life (HRQoL) issues associated with gastric cancer: capturing cross-cultural differences
Alison Rowsell, Samantha C. Sodergren, Vassilios Vassiliou, Anne-Sophie Darlington, Marianne G. Guren, Bilal Alkhaffaf, Chantelle Moorbey, Kristopher Dennis, Mitsumi Terada
Gastric Cancer.2022; 25(4): 665. CrossRef
Patient-reported gastrointestinal symptoms following surgery for gastric cancer and the relative risk factors
Rui Xu, Qiong Gu, Shuomeng Xiao, Ping Zhao, Zhi Ding
Frontiers in Oncology.2022;[Epub] CrossRef
Prospective multicentre randomised clinical trial comparing survival rates, quality of life and nutritional status between advanced gastric cancer patients with different follow-up intensities: study protocol for the STOFOLUP trial
Bang Wool Eom, Dong-Hoe Koo, Ji Yeong An, Han Hong Lee, Hyoung-Il Kim, Hoon Hur, Moon-Won Yoo, Min-Hee Ryu, Hyuk-Joon Lee, Su Mi Kim, Ji-Ho Park, Jae Seok Min, Kyung Won Seo, Sang-Ho Jeong, Oh Jeong, Oh Kyoung Kwon, Seung Wan Ryu, Chang Hak Yoo, Jae Moon
BMJ Open.2021; 11(12): e056187. CrossRef

12,663 View
360 Download
22 Web of Science
26 Crossref

Immunohistochemistry Biomarkers Predict Survival in Stage II/III Gastric Cancer Patients: From a Prospective Clinical Trial: Min Hwan Kim, Xianglan Zhang, Minkyu Jung, Inkyung Jung, Hyung Soon Park, Seung-Hoon Beom, Hyo Song Kim, Sun Young Rha, Hyunki Kim, Yoon Young Choi, Taeil Son, Hyoung-Il Kim, Jae-Ho Cheong, Woo Jin Hyung, Sung Hoon Noh, Hyun Cheol Chung; Cancer Res Treat. 2019;51(2):819-831. Published online September 27, 2018; DOI: https://doi.org/10.4143/crt.2018.331

Abstract PDF Supplementary Material PubReader ePub

Purpose
Identification of biomarkers to predict recurrence risk is essential to improve adjuvant treatment strategies in stage II/III gastric cancer patients. This study evaluated biomarkers for predicting survival after surgical resection.
Materials and Methods
This post-hoc analysis evaluated patients from the CLASSIC trial who underwent D2 gastrectomy with or without adjuvant chemotherapy (capecitabine plus oxaliplatin) at the Yonsei Cancer Center. Tumor expressions of thymidylate synthase (TS), excision repair cross-complementation group 1 (ERCC1), and programmed death-ligand 1 (PD-L1) were evaluated by immunohistochemical (IHC) staining to determine their predictive values.
Results
Among 139 patients, IHC analysis revealed high tumor expression of TS (n=22, 15.8%), ERCC1 (n=23, 16.5%), and PD-L1 (n=42, 30.2%) in the subset of patients. Among all patients, high TS expression tended to predict poor disease-free survival (DFS; hazard ratio [HR], 1.80; p=0.053), whereas PD-L1 positivity was associated with favorable DFS (HR, 0.33; p=0.001) and overall survival (OS; HR, 0.38; p=0.009) in multivariate Cox analysis. In the subgroup analysis, poor DFS was independently predicted by high TS expression (HR, 2.51; p=0.022) in the adjuvant chemotherapy subgroup (n=66). High PD-L1 expression was associated with favorable DFS (HR, 0.25; p=0.011) and OS (HR, 0.22; p=0.015) only in the surgery-alone subgroup (n=73). The prognostic impact of high ERCC1 expression was not significant in the multivariate Cox analysis.
Conclusion
This study shows that high TS expression is a predictive factor for worse outcomes on capecitabine plus oxaliplatin adjuvant chemotherapy, whereas PD-L1 expression is a favorable prognostic factor in locally advanced gastric cancer patients.

Citations

Citations to this article as recorded by

Checkpoint kinase 1 protein as a diagnostic marker for pleural mesothelioma
Azadeh Asghari Birbaneh, Christos Meristoudis, Caspar Bundgaard Nielsen, Weronika Maria Szejniuk, Morten Johansen, Peter Derek Christian Leutscher, Vasiliki Panou, Oluf Dimitri Røe
Journal of the American Society of Cytopathology.2026;[Epub] CrossRef
Expression of Thymidylate Synthase in Cancer: A Tissue Microarray Study Involving 17,371 Cancers from 136 Tumor Entities
Florian Lutz, Lisa Sophie Hannemann, Seyma Büyücek, Katharina Möller, Florian Viehweger, Ria Schlichter, Andreas M. Luebke, Martina Kluth, Claudia Hube-Magg, Andrea Hinsch, Christian Bernreuther, Guido Sauter, David Dum, Andreas H. Marx, Ronald Simon, Til
Biomedicines.2026; 14(7): 1599. CrossRef
TMPRSS4 as a prognostic biomarker after gastric cancer surgery in a multicenter retrospective study
Hirofumi Tazawa, Shinji Hato, Shigefumi Yoshino, Shinya Otsuka, Atsusi Takeno, Kazuhiro Toyota, Hiromitsu Moriya, Isao Nozaki, Koji Tanakaya, Hideaki Uchiyama, Akihisa Saito, Kazuya Kuraoka, Takeshi Kato, Takahisa Suzuki, Hirotaka Tashiro
Scientific Reports.2025;[Epub] CrossRef
Bibliometric analysis of tumor marker application in gastric cancer diagnosis from 2019 to 2024
Zhanat Komekbay, Reza Shirazi, Gulnaz Yessultanova, Alisher Garifollin, Anar Tulyayeva, Nurgul Kereyeva, Saule Akhmetova, Abdiraman Kaliev
Frontiers in Medicine.2025;[Epub] CrossRef
AI-Powered Insights into Drug Resistance in Gastric Cancer: A Path Toward Precision Therapy
Negar Mottaghi-Dastjerdi, Mohammad Soltany-Rezaee-Rad
Iranian Journal of Pharmaceutical Research.2025;[Epub] CrossRef
Predictive Value of the nProfiler 1 Assay for the Efficacy of Adjuvant S-1–Based Doublet Chemotherapy in Stage III Gastric Cancer: A Post-Hoc Analysis of a Randomized Phase III Trial
Dong Ki Lee, Choong-kun Lee, Hyo Song Kim, Sun Jin Sym, Dae Young Zang, Ki Hyang Kim, Joo Han Lim, Hae Su Kim, Kyung Hee Lee, Heon Yung Gee, Sun Young Rha, Hyunki Kim, Minkyu Jung
Cancer Research and Treatment.2025; 57(3): 770. CrossRef
Utility of TMPRSS4 as a Prognostic Biomarker and Potential Therapeutic Target in Patients with Gastric Cancer
Hirofumi Tazawa, Takahisa Suzuki, Akihisa Saito, Akira Ishikawa, Toshiaki Komo, Haruki Sada, Norimitsu Shimada, Naoto Hadano, Takashi Onoe, Takeshi Sudo, Yosuke Shimizu, Kazuya Kuraoka, Hirotaka Tashiro
Journal of Gastrointestinal Surgery.2022; 26(2): 305. CrossRef
Scoring systems for PD-L1 expression and their prognostic impact in patients with resectable gastric cancer
Marina Alessandra Pereira, Marcus Fernando Kodama Pertille Ramos, André Roncon Dias, Renan Ribeiro, Leonardo Cardili, Bruno Zilberstein, Ivan Cecconello, Ulysses Ribeiro, Evandro Sobroza de Mello, Tiago Biachi de Castria
Virchows Archiv.2021; 478(6): 1039. CrossRef
Epstein–Barr Virus Positive Gastric Cancer: A Distinct Subtype Candidate for Immunotherapy
Marina Alessandra Pereira, Daniel Amadeus Molon Batista, Marcus Fernando Kodama Pertille Ramos, Leonardo Cardili, Renan Ribeiro e Ribeiro, Andre Roncon Dias, Bruno Zilberstein, Ulysses Ribeiro Jr, Ivan Cecconello, Venâncio Avancini Ferreira Alves, Evandro
Journal of Surgical Research.2021; 261: 130. CrossRef
Cytotoxic T‐lymphocyte‐associated protein 4 in gastric cancer: Prognosis and association with PD‐L1 expression
Marina Alessandra Pereira, Tiago Biachi de Castria, Marcus Fernando Kodama Pertille Ramos, André Roncon Dias, Leonardo Cardili, Rafael Dyer Rodrigues de Moraes, Bruno Zilberstein, Sergio Carlos Nahas, Ulysses Ribeiro, Evandro Sobroza de Mello
Journal of Surgical Oncology.2021; 124(7): 1040. CrossRef
Remnant gastric cancer: a neglected group with high potential for immunotherapy
Marcus Fernando Kodama Pertille Ramos, Marina Alessandra Pereira, Tiago Biachi de Castria, Renan Ribeiro e Ribeiro, Leonardo Cardili, Evandro Sobroza de Mello, Bruno Zilberstein, Ulysses Ribeiro-Júnior, Ivan Cecconello
Journal of Cancer Research and Clinical Oncology.2020; 146(12): 3373. CrossRef
Molecular Bases of Mechanisms Accounting for Drug Resistance in Gastric Adenocarcinoma
Jose J. G. Marin, Laura Perez-Silva, Rocio I. R. Macias, Maitane Asensio, Ana Peleteiro-Vigil, Anabel Sanchez-Martin, Candela Cives-Losada, Paula Sanchon-Sanchez, Beatriz Sanchez De Blas, Elisa Herraez, Oscar Briz, Elisa Lozano
Cancers.2020; 12(8): 2116. CrossRef
Clinical Significance of CLDN18.2 Expression in Metastatic Diffuse-Type Gastric Cancer
Seo Ree Kim, Kabsoo Shin, Jae Myung Park, Han Hong Lee, Kyo Yong Song, Sung Hak Lee, Bohyun Kim, Sang-Yeob Kim, Junyoung Seo, Jeong-Oh Kim, Sang-Young Roh, In-Ho Kim
Journal of Gastric Cancer.2020; 20(4): 408. CrossRef
Prognostic and Predictive Factors for the Curative Treatment of Esophageal and Gastric Cancer in Randomized Controlled Trials: A Systematic Review and Meta-Analysis
van den Ende, ter Veer, Mali, van Berge Henegouwen, Hulshof, van Oijen, van Laarhoven
Cancers.2019; 11(4): 530. CrossRef

15,132 View
320 Download
14 Web of Science
14 Crossref

Genome-Wide Association of Genetic Variation in the PSCA Gene with Gastric Cancer Susceptibility in a Korean Population: Boyoung Park, Sarah Yang, Jeonghee Lee, Hae Dong Woo, Il Ju Choi, Young Woo Kim, Keun Won Ryu, Young-Il Kim, Jeongseon Kim; Cancer Res Treat. 2019;51(2):748-757. Published online September 5, 2018; DOI: https://doi.org/10.4143/crt.2018.162

Abstract PDF Supplementary Material PubReader ePub

Purpose
Half of the world’s gastric cancer cases and the highest gastric cancer mortality rates are observed in Eastern Asia. Although several genome-wide association studies (GWASs) have revealed susceptibility genes associated with gastric cancer, no GWASs have been conducted in the Korean population, which has the highest incidence of gastric cancer.
Materials and Methods
We performed genome scanning of 450 gastric cancer cases and 1,134 controls via Affymetrix Axiom Exome 319 arrays, followed by replication of 803 gastric cancer cases and 3,693 healthy controls.
Results
We showed that the rs2976394 in the prostate stem cell antigen (PSCA) gene is a gastriccancer-susceptibility gene in a Korean population, with genome-wide significance and an odds ratio (OR) of 0.70 (95% confidence interval [CI], 0.64 to 0.77). A strong linkage disequilibrium with rs2294008 was also found, indicating an association with susceptibility. Individuals with the CC genotype of the PSCA gene showed an approximately 2-fold lower risk of gastric cancer compared to those with the TT genotype (OR, 0.47; 95% CI, 0.39 to 0.57). The effect of the PSCA gene on gastric cancer was more prominent in the female population and for diffuse type gastric cancer.
Conclusion
Our result confirmed that the PSCA gene may be the most important susceptibility gene for gastric cancer risk in a Korean population.

Citations

Citations to this article as recorded by

Characterization of Microplastics in Human Gastric Cancer and Control Tissues and Analysis of Associated Genetic Features
Liqiao Chen, Jialin Li, Yan Wu, Han Bao, Xuesong Yang, Guoqing Lv, Ke Ji, Ji Zhang, Xiaojiang Wu, Kai Zhou, Jieli Xu, Jiatian Tang, Xiyuan Han, Anqiang Wang
Advanced Healthcare Materials.2026;[Epub] CrossRef
Interactions Between ADIPOQ rs1501299 Polymorphism, Dietary Macronutrient Composition, and Gastric Cancer Risk: Evidence from a Korean Case–Control Study
Vu Anh Trong Dam, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
Journal of the American Nutrition Association.2026; : 1. CrossRef
Integrative analysis of gastric tissue transcriptomes and gastric cancer GWAS implicates candidate susceptibility genes
Beiping Hu, Min Zhang, Yuhui Yu, Yongchao Liu, Jiawei Wang, Aiping Zhang, Qian Li, Yun Gao, Zhe Li, Lijun Bian, Yuanliang Gu, Xia Zhu, Qiang She, Xuefeng Gao, Bin Deng, Haisheng Fang, Caihong Hu, Yuheng Chen, Yan Chen, Xinya Wang, Xianyong Yin, Meng Zhu,
The American Journal of Human Genetics.2026; 113(7): 1521. CrossRef
Functional Annotation and Gene Set Analysis of Gastric Cancer Risk Loci in a Korean Population
Hyojin Pyun, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Joohon Sung, Jeongseon Kim
Cancer Research and Treatment.2024; 56(1): 191. CrossRef
HiChIP-Based Epigenomic Footprinting Identifies a Promoter Variant of UXS1 That Confers Genetic Susceptibility to Gastroesophageal Cancer
Ansley Gnanapragasam, Eftyhios Kirbizakis, Anna Li, Kyle H. White, Katelyn L. Mortenson, Juliana Cavalcante de Moura, Wajih Jawhar, Yifei Yan, Reilly Falter, Colleen Russett, Betty Giannias, Sophie Camilleri-Broët, Nicholas Bertos, Jonathan Cools-Lartigue
Cancer Research.2024; 84(14): 2377. CrossRef
High Polygenic Risk Scores Positively Associated with Gastric Cancer Risk Interact with Coffee and Polyphenol Intake and Smoking Status in Korean Adults
Meiling Liu, Sang-Shin Song, Sunmin Park
Nutrients.2024; 16(19): 3263. CrossRef
Dietary mercury intake, the IL23R rs10889677 polymorphism, and the risk of gastric cancer in a Korean population: a hospital-based case-control study
Ji Hyun Kim, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
Epidemiology and Health.2024; 46: e2024051. CrossRef
SNP-SNP Interactions and Gastric Cancer Susceptibility in Ardabil Province
Homa Akhavan Aghghaleh, Najmeh Ranji, Hadi Habibollahi
Journal of Ardabil University of Medical Sciences.2024; 24(3): 364. CrossRef
Interaction between dietary potassium intake and TNF-α rs1800629 genetic polymorphism in gastric cancer risk: a case–control study conducted in Korea
Tao Thi Tran, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
British Journal of Nutrition.2023; 130(5): 887. CrossRef
Rare variants confer shared susceptibility to gastrointestinal tract cancer risk
Ji Zheng, Xin Wang, Jingrao Li, Yuanna Wu, Jiang Chang, Junyi Xin, Meilin Wang, Tianpei Wang, Qingyi Wei, Mengyun Wang, Ruoxin Zhang
Frontiers in Oncology.2023;[Epub] CrossRef
The association of dietary fibre intake and the IL13 rs20541 polymorphism with the risk of gastric cancer: a case-control study in Korea
Tao Thi Tran, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
European Journal of Clinical Nutrition.2022; 76(7): 1031. CrossRef
Systematic review of gastric cancer-associated genetic variants, gene-based meta-analysis, and gene-level functional analysis to identify candidate genes for drug development
Sangjun Lee, Han-Kwang Yang, Hyuk-Joon Lee, Do Joong Park, Seong-Ho Kong, Sue K. Park
Frontiers in Genetics.2022;[Epub] CrossRef
Incidence of Hereditary Gastric Cancer May Be Much Higher than Reported
Paula Baraúna de Assumpção, Paulo Pimentel de Assumpção, Fabiano Cordeiro Moreira, Ândrea Ribeiro-dos-Santos, Amanda F. Vidal, Leandro Magalhães, André Salim Khayat, André Maurício Ribeiro-dos-Santos, Giovanna C. Cavalcante, Adenilson Leão Pereira, Inácio
Cancers.2022; 14(24): 6125. CrossRef
Enhancing the Trajectories of Cancer Health Disparities Research: Improving Clinical Applications of Diversity, Equity, Inclusion, and Accessibility
Rachel Martini, Endale Gebregzabher, Lisa Newman, Melissa B. Davis
Cancer Discovery.2022; 12(6): 1428. CrossRef
Identification of Novel Susceptible Genes of Gastric Cancer Based on Integrated Omics Data
Huang Yaoxing, Yu Danchun, Sun Xiaojuan, Jiang Shuman, Yan Qingqing, Jia Lin
Frontiers in Cell and Developmental Biology.2021;[Epub] CrossRef
The Associations of Dietary Iron Intake and the Transferrin Receptor (TFRC) rs9846149 Polymorphism with the Risk of Gastric Cancer: A Case–Control Study Conducted in Korea
Tao Thi Tran, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
Nutrients.2021; 13(8): 2600. CrossRef
Integration of GWAS and eQTL Analysis to Identify Risk Loci and Susceptibility Genes for Gastric Cancer
Jing Ni, Bin Deng, Meng Zhu, Yuzhuo Wang, Caiwang Yan, Tianpei Wang, Yaqian Liu, Gang Li, Yanbing Ding, Guangfu Jin
Frontiers in Genetics.2020;[Epub] CrossRef
Evolutionary History of the Risk of SNPs for Diffuse-Type Gastric Cancer in the Japanese Population
Risa L. Iwasaki, Koji Ishiya, Hideaki Kanzawa-Kiriyama, Yosuke Kawai, Jun Gojobori, Yoko Satta
Genes.2020; 11(7): 775. CrossRef
TNF genetic polymorphism (rs1799964) may modify the effect of the dietary inflammatory index on gastric cancer in a case–control study
Jeeeun Kim, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Joohon Sung, Jeongseon Kim
Scientific Reports.2020;[Epub] CrossRef
Prediction of gastric cancer risk: association between ZBTB20 genetic variance and gastric cancer risk in Chinese Han population
Fei Bai, Ke Xiao
Bioscience Reports.2020;[Epub] CrossRef
Incidence of Stomach and Esophageal Cancers in Mongolia: Data from 2009 to 2018
Tsegmed Sambuu, Nasanjargal Tumurbat, Bayar Davaa, Bolor-Erdene Tudev
Euroasian Journal of Hepato-Gastroenterology.2020; 10(1): 16. CrossRef

13,521 View
255 Download
19 Web of Science
21 Crossref

Effect of Helicobacter pylori Eradication on Long-Term Survival after Distal Gastrectomy for Gastric Cancer: Young-Il Kim, Soo-Jeong Cho, Jong Yeul Lee, Chan Gyoo Kim, Myeong-Cherl Kook, Keun Won Ryu, Young-Woo Kim, Il Ju Choi; Cancer Res Treat. 2016;48(3):1020-1029. Published online November 17, 2015; DOI: https://doi.org/10.4143/crt.2015.264

Abstract PDF PubReader ePub

Purpose
Negative Helicobacter pylori status has been identified as a poor prognostic factor for survival in gastric cancer (GC) patients who underwent surgery. The aim of this study was to examine the effect of H. pylori eradication on long-term outcomes after distal gastrectomy for GC.
Materials and Methods
We analyzed the survival of 169 distal GC patients enrolled in a prospective randomized trial evaluating histologic changes of gastric mucosa after H. pylori eradication in the remnant stomach. The outcomes measured were overall survival (OS) and GC recurrence rates.
Results
The median follow-up duration was 9.4 years. In the modified intention-to-treat analysis including patients who underwent H. pylori treatment (n=87) or placebo (n=82), 5-year OS rates were 98.9% in the treatment group and 91.5% in the placebo group, and KaplanMeier analysis showed no significant difference in OS (p=0.957) between groups. In multivariate analysis, no difference in overall mortality was observed between groups (adjusted hazard ratio [aHR] for H. pylori treatment, 0.75; p=0.495) or H. pylori-eradicated status (aHR for positive H. pylori status, 1.16; p=0.715), while old age, male sex, and advanced stage ≥ IIIa were independent risk factors. Six patients in the treatment group (6.9%) and seven patients in the placebo group (8.5%) had GC recurrences, and GC recurrence rates were not different according to H. pylori treatment (5-year GC recurrence rates, 4.6% in the treatment group vs. 8.5% in the placebo group; p=0.652).
Conclusion
H. pylori eradication for GC patients who underwent distal gastrectomy did not compromise long-term survival after surgery.

Citations

Citations to this article as recorded by

Relationship between Helicobacter pylori infection and programmed death-ligand 1 in gastric cancer: A meta-analysis
Hong-Chang Yang, Cheng-Feng Fu, Li-Jun Qiao, Gen-He Long, Li-Fen Yang, Biao Yao
World Journal of Clinical Oncology.2025;[Epub] CrossRef
The relationship between the eradication of Helicobacter pylori and the occurrence of stomach cancer: an updated meta-analysis and systemic review
Zhouhan Wu, Yi Tang, Meiwen Tang, Zhoutong Wu, Yonghui Xu
BMC Gastroenterology.2025;[Epub] CrossRef
Changes in Helicobacter pylori Status in Patients Who Underwent Partial Gastrectomy for Gastric Cancer Therapy
Yonghoon Choi
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2025; 25(2): 191. CrossRef
The impact of Helicobacter pylori infection on prognosis in patients with postgastrectomy gastric cancer: A systematic review and meta-analysis
Yu-Wei Cao, Tao Jin, Ze-Hua Chen, Pan-Ping Liang, Yi-Ning Gou, Kun Yang
Surgery.2025; 185: 109512. CrossRef
The influence of H. pylori infection in HER2-positive gastric cancer cell lines: insights from Wnt/β-catenin pathway
Valli De Re, Mariateresa Casarotto, Giulia Brisotto, Stefania Zanussi, Mariangela De Zorzi, Ombretta Repetto, Elena Muraro, Paola Spessotto, Paolo Baldo, Vito Racanelli, Marco Vincenzo Lenti, Marino Venerito, Matteo Fassan, Agostino Steffan, Stefano Reald
Frontiers in Immunology.2025;[Epub] CrossRef
Russian consensus on prevention, diagnostics and treatment of gastric cancer. Issues of prevention, early diagnostics, and precancerous diseases
S. R. Abdulkhakov, S. A. Alekseenko, D. N. Andreev, N. V. Bakulina, D. S. Bordin, R. E. Izrailov, V. A. Isakov, S. A. Kurilovich, Yu. A. Kucheryavyy, M. A. Livzan, I. V. Maev, S. V. Morozov, M. F. Osipenko, V. D. Pasechnikov, N. E. Semenov, S. G. Khomerik
Malignant tumours.2025; 15(3): 68. CrossRef
Prognostic factors in gastric cancer survivors comparing Cox proportional hazards and machine learning using a Korean National cohort
Joonki Lee, Aesun Shin
Discover Oncology.2025;[Epub] CrossRef
Follow-Up and Strategies After Curative Surgical Resection for Gastric Cancer
Seokin Kang
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2025; 25(4): 336. CrossRef
Anti–Helicobacter pylori Treatment in Patients With Gastric Cancer After Radical Gastrectomy
Zhoukai Zhao, Ruopeng Zhang, Guoming Chen, Man Nie, Feiyang Zhang, Xiaojiang Chen, Jun Lin, Zewei Chen, Feizhi Lin, Chengzhi Wei, Ziqi Zheng, Shenghang Ruan, Bowen Huang, Yingbo Chen, Runcong Nie
JAMA Network Open.2024; 7(3): e243812. CrossRef
Helicobacter Pylori and Celiac Disease Antibody Positivity Have a Higher Prevalence in Patients With Distal Gastrectomy: A Cross-Sectional Retrospective Study
Kubilay Issever, Ersin Kuloglu, Demet Sengul, Ali Muhtaroglu, Ahmet Cumhur Dulger
Cureus.2023;[Epub] CrossRef
The influence of partial gastrectomy for gastric cancer on the spontaneous disappearance of Helicobacter pylori: A single‐center prospective study
Senichiro Yanagawa, Nobuaki Fujikuni, Kazuaki Tanabe, Masahiro Nakahara, Toshio Noriyuki
Cancer Reports.2023;[Epub] CrossRef
Positive H. pylori status predicts better prognosis of non-cardiac gastric cancer patients: results from cohort study and meta-analysis
Zhifang Jia, Min Zheng, Jing Jiang, Donghui Cao, Yanhua Wu, Yuzheng Zhang, Yingli Fu, Xueyuan Cao
BMC Cancer.2022;[Epub] CrossRef
Effect of gastric cancer screening on long-term survival of gastric cancer patients: results of Korean national cancer screening program
Xuan Quy Luu, Kyeongmin Lee, Jae Kwan Jun, Mina Suh, Kyu-Won Jung, Kui Son Choi
Journal of Gastroenterology.2022; 57(7): 464. CrossRef
Current Evidence for a Paradigm Shift in Gastric Cancer Prevention From Endoscopic Screening toHelicobacter pyloriEradication in Korea
Young-Il Kim, Il Ju Choi
Journal of Gastric Cancer.2022; 22(3): 169. CrossRef
Helicobacter Pylori and Gastric Cancer Progression
Marina A. Senchukova
Current Microbiology.2022;[Epub] CrossRef
Identifying Factors Affecting Cancer-related Death in Patients with Adenocarcinoma Gastric Cancer; An Analysis in the Presence of Competing Risks
Malihe Safari, Hossein Mahjub, Habib Esmaeili, Mohamad Abasi, Ghodratollah Roshanaei
International Journal of Cancer Management.2021;[Epub] CrossRef
T stage and venous invasion are crucial prognostic factors for long-term survival of patients with remnant gastric cancer: a cohort study
Kentaro Matsuo, Sang-Woong Lee, Ryo Tanaka, Yoshiro Imai, Kotaro Honda, Kohei Taniguchi, Hideki Tomiyama, Kazuhisa Uchiyama
World Journal of Surgical Oncology.2021;[Epub] CrossRef
Tracking the Virulent Helicobacter pylori Strains Instead of Its Pan-Screening to Prevent Gastric Cancer
Farid Rahimi, Amin Talebi Bezmin Abadi
BioNanoScience.2020; 10(1): 315. CrossRef
Proton-pump inhibitor and amoxicillin-based triple therapy containing clarithromycin versus metronidazole for Helicobacter pylori: A meta-analysis
Bo Li, Xiaoqian Lan, Li Wang, Jiani Zhao, Jingli Ding, Hao Ding, Jun Lei, Yiping Wei, Wenxiong Zhang
Microbial Pathogenesis.2020; 142: 104075. CrossRef
Effect of Helicobacter pylori eradication after subtotal gastrectomy on the survival rate of patients with gastric cancer: follow-up for up to 15 years
Yonghoon Choi, Nayoung Kim, Chang Yong Yun, Yoon Jin Choi, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Sang-Hoon Ahn, Do Joong Park, Hye Seung Lee, Ji-Won Kim, Jin Won Kim, Keun-Wook Lee, Won Chang, Ji Hoon Park, Yoon Jin Lee, Kyoung Ho Lee, Young Hoon Kim
Gastric Cancer.2020; 23(6): 1051. CrossRef
Impact of the timing of Helicobacter pylori eradication on the risk of development of metachronous lesions after treatment of early gastric cancer: a population-based cohort study
Hyun Ju Kim, Yun Jin Kim, Seung In Seo, Woon Geon Shin, Chan Hyuk Park
Gastrointestinal Endoscopy.2020; 92(3): 613. CrossRef
Helicobacter pylori Eradication in Patients Undergoing Gastrectomy: Diagnosis and Therapy
Youn I Choi, Jun-Won Chung
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2020; 20(3): 204. CrossRef
Helicobacter pylori Eradication in Adult Patients with Acute Idiopathic Thrombocytopenic Purpura (ITP)
Minoosh Moghimi, Yousef Mortazavi, Saeed Razavi-Dizaji, Shahrbanoo Keyhanian, Zahra Ghadimi, Sahar Baba Ali, Saeideh Mazloomzadeh, Sattar Jafari, Reza Mansouri, Masoud Asadi-Khiavi
Journal of Advances in Medical and Biomedical Research.2019; 27(124): 1. CrossRef
Helicobacter pylori Therapy for the Prevention of Metachronous Gastric Cancer
Il Ju Choi, Myeong-Cherl Kook, Young-Il Kim, Soo-Jeong Cho, Jong Yeul Lee, Chan Gyoo Kim, Boram Park, Byung-Ho Nam
New England Journal of Medicine.2018; 378(12): 1085. CrossRef
Helicobacter pyloriEradication in Idiopathic Thrombocytopenic Purpura: A Meta-Analysis of Randomized Trials
Bum Jun Kim, Hyeong Su Kim, Hyun Joo Jang, Jung Han Kim
Gastroenterology Research and Practice.2018; 2018: 1. CrossRef
Do We Need to Retest of Helicobacter pylori Infection after Gastric Cancer Surgery?
Sang Kil Lee
Gut and Liver.2017; 11(2): 169. CrossRef

15,599 View
214 Download
23 Web of Science
26 Crossref

Long-Term Low-Dose Aspirin Use Reduces Gastric Cancer Incidence: A Nationwide Cohort Study: Young-Il Kim, So Young Kim, Ji Hyun Kim, Jun Ho Lee, Young-Woo Kim, Keun Won Ryu, Jong-Hyock Park, Il Ju Choi; Cancer Res Treat. 2016;48(2):798-805. Published online July 14, 2015; DOI: https://doi.org/10.4143/crt.2015.117

Abstract PDF PubReader ePub

Purpose
The aim of this study was to investigate whether aspirin use can reduce the incidence of gastric cancer in patients with hypertension or type 2 diabetes. Materials and Methods A total of 200,000 patients with hypertension or type 2 diabetes were randomly selected from the Korean National Health Insurance claim database. Of these, 3,907 patients who used 100 mg of aspirin regularly (regular aspirin users) and 7,808 patients who did not use aspirin regularly (aspirin non-users) were selected at a frequency of 1:2, matched by age, sex, comorbid illnesses (type 2 diabetes and hypertension), and observation periods. The incidence of gastric cancer in this cohort was then assessed during the observation period of 2004 to 2010.
Results
In the matched cohort, the incidence rates of gastric cancer were 0.8% (31/3,907) for regular aspirin users and 1.1% (86/7,808) for aspirin non-users, but the cumulative incidence rates were not significantly different between groups (p=0.116, log-rank test). However, in multivariate analysis, regular aspirin users had a reduced risk of gastric cancer (adjusted hazard ratio [aHR], 0.71; 95% confidential interval [CI], 0.47 to 1.08; p=0.107). Duration of aspirin use showed significant association with reduction of gastric cancer risk (aHR for each year of aspirin use, 0.85; 95% CI, 0.73 to 0.99; p=0.044), particularly in patients who used aspirin for more than 3 years (aHR, 0.40; 95% CI, 0.16 to 0.98; p=0.045). Conclusion Long-term low-dose aspirin use was associated with reduced gastric cancer risk in patients with hypertension or type 2 diabetes.

Citations

Citations to this article as recorded by

Dose-response relationship between aspirin and gastric cancer risk: A systematic review and meta-analysis
Shan Zhang, Hongwei Wang, Jingjing Ji, Ruiyu Chai, Shiyi Song, Jikang Shi, Siyu Liu
Cancer Epidemiology.2025; 97: 102873. CrossRef
Exposure to Commonly Used Drugs and the Risk of Gastric Cancer: An Umbrella Review of Meta-Analyses
Xiao Bai, Si-Qi Ding, Xue-Ping Zhang, Ming-Hao Han, Dong-Qiu Dai
Cancers.2023; 15(2): 372. CrossRef
In Vitro Assessment of the Synergistic Effect of Aspirin and 5-Fluorouracil in Colorectal Adenocarcinoma Cells
Monica Susan, Ioana Macasoi, Iulia Pinzaru, Cristina Dehelean, Iosif Ilia, Razvan Susan, Ioana Ionita
Current Oncology.2023; 30(7): 6197. CrossRef
Prediction algorithm for gastric cancer in a general population: A validation study
Martin C. S. Wong, Eman Yee‐man Leung, Sarah T. Y. Yau, Sze Chai Chan, Shaohua Xie, Wanghong Xu, Junjie Huang
Cancer Medicine.2023; 12(21): 20544. CrossRef
Evaluation of clopidogrel use on gastric precancerous lesions: Does it have chemopreventive effect?
Taner AKYOL
Journal of Medicine and Palliative Care.2023; 4(5): 524. CrossRef
Safety and effectiveness of low-dose aspirin for the prevention of gastrointestinal cancer in adults without atherosclerotic cardiovascular disease: a population-based cohort study
Jessica J P Shami, Jiaxi Zhao, Swathi Pathadka, Eric Yuk Fai Wan, Joseph Edgar Blais, Pareen Vora, Montse Soriano-Gabarró, Ka Shing Cheung, W K Leung, Ian C K Wong, Esther W Chan
BMJ Open.2022; 12(2): e050510. CrossRef
Association Between Aspirin Use and Gastric Adenocarcinoma: A Prospective Cohort Study
Sohee Kwon, Wenjie Ma, David A. Drew, Samuel J. Klempner, Brianna M. Leonardo, Jacqueline J. Flynn, Yin Cao, Edward L. Giovannucci, Ying Bao, Charles S. Fuchs, Mingyang Song, Andrew T. Chan
Cancer Prevention Research.2022; 15(4): 265. CrossRef
Association of Aspirin, Metformin, and Statin Use with Gastric Cancer Incidence and Mortality: A Nationwide Cohort Study
Mi Hee Cho, Tae Gon Yoo, Su-Min Jeong, Dong Wook Shin
Cancer Prevention Research.2021; 14(1): 95. CrossRef
Antibreast Cancer Activity of Aspirin-Conjugated Chalcone Polymeric Micelles
Do Young Lee, Kang Pa Lee, Suji Beak, Ji Su Park, Young Jin Kim, Kil-Nam Kim, Song-Rae Kim, Myeong Sik Yoon
Macromolecular Research.2021; 29(1): 105. CrossRef
Effect of frequently prescribed drugs on gastric cancer risk
Theresa Weltermann, Christian Schulz, Lukas Macke
Best Practice & Research Clinical Gastroenterology.2021; : 101741. CrossRef
Aspirin Use and Common Cancer Risk: A Meta-Analysis of Cohort Studies and Randomized Controlled Trials
Lijuan Wang, Rongqi Zhang, Lili Yu, Jiarui Xiao, Xuan Zhou, Xinxuan Li, Peige Song, Xue Li
Frontiers in Oncology.2021;[Epub] CrossRef
The Relationship between Diabetes Mellitus and Gastric Cancer and the Potential Benefits of Metformin: An Extensive Review of the Literature
Chin-Hsiao Tseng
Biomolecules.2021; 11(7): 1022. CrossRef
Effect of aspirin use on gastric cancer incidence and survival: A systematic review and meta‐analysis
Ryota Niikura, Yoshihiro Hirata, Yoku Hayakawa, Takuya Kawahara, Atsuo Yamada, Kazuhiko Koike
JGH Open.2020; 4(2): 117. CrossRef
Positive association between dietary inflammatory index and gastric cancer risk: A systematic review and meta-analysis
Ying Liang, Haoyan Jiao, Lingbo Qu, Hao Liu
Nutrition and Cancer.2020; 72(8): 1290. CrossRef
Efficacy of Aspirin in the Primary Prevention of Cardiovascular Diseases and Cancer in the Elderly: A Population-Based Cohort Study in Korea
Minji Jung, Sukhyang Lee
Drugs & Aging.2020; 37(1): 43. CrossRef
Safety of Proton Pump Inhibitors Questioned Based on a Large Randomized Trial of Patients Receiving Rivaroxaban or Aspirin
Johanna Simin, Qing Liu, Romina Fornes, Nele Brusselaers
Gastroenterology.2020; 158(4): 1172. CrossRef
De novo malignancy risk in patients undergoing the first percutaneous coronary intervention: A nationwide population-based cohort study
Soongu Kwak, You-Jung Choi, Soonil Kwon, Seo-Young Lee, Seokhun Yang, Inki Moon, Hyun-Jung Lee, Heesun Lee, Jun-Bean Park, Kyungdo Han, Yong-Jin Kim, Hyung-Kwan Kim
International Journal of Cardiology.2020; 313: 25. CrossRef
Use of proton pump inhibitors and histamine-2 receptor antagonists and risk of gastric cancer in two population-based studies
Peipei Liu, Úna C. McMenamin, Brian T. Johnston, Peter Murchie, Lisa Iversen, Amanda J. Lee, Pauline A. J. Vissers, Chris R. Cardwell
British Journal of Cancer.2020; 123(2): 307. CrossRef
Low‐dose aspirin and risk of gastric and oesophageal cancer: A population‐based study in the United Kingdom using The Health Improvement Network
Luis A. García Rodríguez, Montse Soriano‐Gabarró, Pareen Vora, Lucía Cea Soriano
International Journal of Cancer.2020; 147(9): 2394. CrossRef
Preventing Metachronous Gastric Cancer after the Endoscopic Resection of Gastric Epithelial Neoplasia: Roles of Helicobacter pylori Eradication and Aspirin
Jiro Watari, Toshihiko Tomita, Katsuyuki Tozawa, Tadayuki Oshima, Hirokazu Fukui, Hiroto Miwa
Gut and Liver.2020; 14(3): 281. CrossRef
Acetylsalicylic Acid Exerts Potent Antitumor and Antiangiogenic Effects in Cutaneous and Uveal Melanoma Cell Lines
Dominique Fausto de Souza, Thupten Tsering, Miguel N. Burnier , Vasco Bravo-Filho, Ana Beatriz Toledo Dias, Mohamed Abdouh, Alicia Goyeneche, Julia Valdemarin Burnier
Ocular Oncology and Pathology.2020; 6(6): 442. CrossRef
Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies
Yan Qiao, Tingting Yang, Yong Gan, Wenzhen Li, Chao Wang, Yanhong Gong, Zuxun Lu
BMC Cancer.2018;[Epub] CrossRef
Cumulative Dose Threshold for the Chemopreventive Effect of Aspirin Against Gastric Cancer
Min-hyung Kim, Jooyoung Chang, Warrick Junsuk Kim, Samprit Banerjee, Sang Min Park
American Journal of Gastroenterology.2018; 113(6): 845. CrossRef
Aspirin associated with risk reduction of secondary primary cancer for patients with head and neck cancer: A population-based analysis
Yu-Shan Lin, Chih-Ching Yeh, Shiang-Fu Huang, Yi-Sheng Chou, Li-Tang Kuo, Fung-Chang Sung, Chih-Hsin Muo, Chien-Tien Su, Fu-Hsiung Su, Mohammad R. Akbari
PLOS ONE.2018; 13(8): e0199014. CrossRef
Cumulative Dose Threshold for the Chemopreventive Effect of Aspirin Against Gastric Cancer
Min-hyung Kim, Jooyoung Chang, Warrick Junsuk Kim, Samprit Banerjee, Sang Min Park
American Journal of Gastroenterology.2018; 113(6): 845. CrossRef
Chemoprevention of Gastric Cancer: Non-steroidal Anti-inflammatory Drugs Including Aspirin
Kee Don Choi
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2017; 17(4): 169. CrossRef
Effects of long-term aspirin use on molecular alterations in precancerous gastric mucosa in patients with and without gastric cancer
Yuki Michigami, Jiro Watari, Chiyomi Ito, Ken Hara, Takahisa Yamasaki, Takashi Kondo, Tomoaki Kono, Katsuyuki Tozawa, Toshihiko Tomita, Tadayuki Oshima, Hirokazu Fukui, Takeshi Morimoto, Kiron M. Das, Hiroto Miwa
Scientific Reports.2017;[Epub] CrossRef
Aspirin enhances the cytotoxic activity of bortezomib against myeloma cells via suppression of Bcl-2, survivin and phosphorylation of AKT
Jiang-Hua Ding, Li-Ya Yuan, Guo-An Chen
Oncology Letters.2017; 13(2): 647. CrossRef
Aspirin and non-steroidal anti-inflammatory drugs use reduce gastric cancer risk: A dose-response meta-analysis
Xuan-zhang Huang, You Chen, Jian Wu, Xi Zhang, Cong-cong Wu, Chao-ying Zhang, Shuang-shuang Sun, Wen-jun Chen
Oncotarget.2017; 8(3): 4781. CrossRef
Prognostic value of a novel FPR biomarker in patients with surgical stage II and III gastric cancer
Jing Zhang, Shu-Qi Li, Zhi-Hua Liao, Yu-Huan Jiang, Qing-Gen Chen, Bo Huang, Jing Liu, Yan-Mei Xu, Jin Lin, Hou-Qun Ying, Xiao-Zhong Wang
Oncotarget.2017; 8(43): 75195. CrossRef
Dietary inflammatory index and the risk of gastric cancer in a Korean population
Sunghee Lee, Jeonghee Lee, Il Ju Choi, Young-Woo Kim, Keun Won Ryu, Young-Il Kim, Jin-Kyoung Oh, Binh Thang Tran, Jeongseon Kim
Oncotarget.2017; 8(49): 85452. CrossRef

15,312 View
185 Download
36 Web of Science
31 Crossref

First
Prev
Page of 1
Next
Last

Search