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2 "Yoon Suk Lee"
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Original Articles
Novel Methods of Lymph Node Evaluation for Predicting the Prognosis of Colorectal Cancer Patients with Inadequate Lymph Node Harvest
Taek Soo Kwon, Sung Bong Choi, Yoon Suk Lee, Jun-Gi Kim, Seong Taek Oh, In Kyu Lee
Cancer Res Treat. 2016;48(1):216-224.   Published online April 15, 2015
DOI: https://doi.org/10.4143/crt.2014.312
AbstractAbstract PDFPubReaderePub
Purpose
Lymph node metastasis is an important factor for predicting the prognosis of colorectal cancer patients. However, approximately 60% of patients do not receive adequate lymph node evaluation (less than 12 lymph nodes). In this study, we identified a more effective tool for predicting the prognosis of patients who received inadequate lymph node evaluation.
Materials and Methods
The number of metastatic lymph nodes, total number of lymph nodes examined, number of negative metastatic lymph nodes (NL), lymph node ratio (LR), and the number of apical lymph nodes (APL) were examined, and the prognostic impact of these parameters was examined in patients with colorectal cancer who underwent surgery from January 2004 to December 2011. In total, 806 people were analyzed retrospectively.
Results
In comparison of different lymph node analysis methods for rectal cancer patients who did not receive adequate lymph node dissection, the LR showed a significant difference in overall survival (OS) and the APL predicted a significant difference in disease-free survival (DFS). In the case of colon cancer patients who did not receive adequate lymph node dissection, LR predicted a significant difference in DFS and OS, and the APL predicted a significant difference in DFS.
Conclusion
If patients did not receive adequate lymph node evaluation, the LR and NL were useful parameters to complement N stage for predicting OS in colon cancer, whereas LR was complementary for rectal cancer. The APL could be used for prediction of DFS in all patients.

Citations

Citations to this article as recorded by  
  • Machine learning based predictive model and genetic mutation landscape for high-grade colorectal neuroendocrine carcinoma: a SEER database analysis with external validation
    Ruixin Wu, Sihao Chen, Yi He, Ya Li, Song Mu, Aishun Jin
    Frontiers in Oncology.2025;[Epub]     CrossRef
  • Exploring the value of multiple preprocessors and classifiers in constructing models for predicting microsatellite instability status in colorectal cancer
    Yi Ma, Zhihao Shi, Ying Wei, Feng Shi, Guochu Qin, Zhengyang Zhou
    Scientific Reports.2024;[Epub]     CrossRef
  • An Intelligent System of Predicting Lymph Node Metastasis in Colorectal Cancer Using 3D CT Scans
    Min Xie, Yi Zhang, Xinyang Li, Jiayue Li, Xingyu Zou, Yiji Mao, Haixian Zhang, Subrata Kumar Sarker
    International Journal of Intelligent Systems.2024;[Epub]     CrossRef
  • Rectal Cancer: Are 12 Lymph Nodes the Limit?
    Paweł Mroczkowski, Łukasz Dziki, Tereza Vosikova, Ronny Otto, Anna Merecz-Sadowska, Radosław Zajdel, Karolina Zajdel, Hans Lippert, Olof Jannasch
    Cancers.2023; 15(13): 3447.     CrossRef
  • Minimally invasive surgery versus laparotomy of non-metastatic pT4a colorectal cancer: a propensity score analysis
    Hui-Long Guo, Jing-Yao Chen, You-Zhen Tang, Qian-Lin Zeng, Qing-Long Jian, Ming-Zhe Li, Yu-Long He, Wen-Hui Wu
    International Journal of Surgery.2023;[Epub]     CrossRef
  • Construction of a Prognostic Nomogram for Colorectal Cancer Patients with Fewer than Twelve Lymph Nodes Examined: a Population-Based Study in the SEER Database and China
    Hao Zhang, Hanqing Hu, Zilong Guan, Rui Chen, Chao Xu, Rui Huang, Guiyu Wang
    Journal of Gastrointestinal Surgery.2022; 26(1): 214.     CrossRef
  • A Preoperative Scoring System to Predict the Risk of Inadequate Lymph Node Count in Rectal Cancer
    Hao Zhang, Chunlin Wang, Yunxiao Liu, Hanqing Hu, Guiyu Wang
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • A Modified Tumor‐Node‐Metastasis Staging System for Colon Cancer Patients with Fewer than Twelve Lymph Nodes Examined
    Hao Zhang, Yunxiao Liu, Chunlin Wang, Zilong Guan, Hang Yu, Chao Xu, Mingyu Zheng, Yuliuming Wang, Hanqing Hu, Rui Huang, Guiyu Wang
    World Journal of Surgery.2021; 45(8): 2601.     CrossRef
  • A clinical-radiomics nomogram for the preoperative prediction of lymph node metastasis in colorectal cancer
    Menglei Li, Jing Zhang, Yibo Dan, Yefeng Yao, Weixing Dai, Guoxiang Cai, Guang Yang, Tong Tong
    Journal of Translational Medicine.2020;[Epub]     CrossRef
  • Predictive Value of the Number of Harvested Lymph Nodes and Cut-Off for Lymph Node Ratio in the Prognosis of Stage II and III Colorectal Cancer Patients
    Giovanni Li Destri, Martina Barchitta, Antonio Pesce, Saverio Latteri, Dorotea Bosco, Antonio Di Cataldo, Antonella Agodi, Stefano Puleo
    Journal of Investigative Surgery.2019; 32(1): 1.     CrossRef
  • Application of highly efficient and lowly toxic bufadienolides screened from toad skin in lymphatic chemotherapy for colorectal cancer through a lymphatic metastatic model
    Changzheng He, Zhenyu Zou, Shaoyou Xia, Xiaowei Xing, Shidong Hu, Zilong Hu, Yuxuan Li, Songyan Li, Hongliang Zhang, Yu Yang, Yichen Liu, Xiaolei Xu, Boyan Liu, Yufeng Wang, Yingxin Xu, Xiaohui Du
    International Immunopharmacology.2019; 70: 241.     CrossRef
  • Diffusion kurtosis imaging in identifying the malignancy of lymph nodes during the primary staging of rectal cancer
    J. Yu, X. Dai, H.‐H. Zou, J.‐C. Song, Y. Li, H.‐B. Shi, Q. Xu, H. Shen
    Colorectal Disease.2018; 20(2): 116.     CrossRef
  • Metastatic lymph node ratio demonstrates better prognostic stratification than pN staging in patients with esophageal squamous cell carcinoma after esophagectomy
    Hongdian Zhang, Huagang Liang, Yongyin Gao, Xiaobin Shang, Lei Gong, Zhao Ma, Ke Sun, Peng Tang, Zhentao Yu
    Scientific Reports.2016;[Epub]     CrossRef
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  • 15 Web of Science
  • 13 Crossref
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Clinical Implications of Systemic Inflammatory Response Markers as Independent Prognostic Factors in Colorectal Cancer Patients
Kwang Yeol Paik, In Kyu Lee, Yoon Suk Lee, Na Young Sung, Taek Soo Kwon
Cancer Res Treat. 2014;46(1):65-73.   Published online January 15, 2014
DOI: https://doi.org/10.4143/crt.2014.46.1.65
AbstractAbstract PDFPubReaderePub
PURPOSE
Cancer-related inflammation affects many aspects of malignancy. We confirm the effects of early postoperative systemic inflammation on cancer prognosis.
MATERIALS AND METHODS
Six hundred consecutive patients underwent surgery for colorectal cancer from 2006 to 2009. Measurements of white blood cells, neutrophils, lymphocytes, monocytes, and platelet counts were performed preoperatively, daily until the fourth postoperative day, and subsequently every two days. Patients were divided into three groups based on the days spent on the leukocyte count to drop below 10,000/mm3 after surgery.
RESULTS
Preoperative white blood cell (WBC) counts correlated with stage of disease. In univariate survival analyses, tumor, node, metastasis (TNM) stage, and monocyte count were associated with cancer-free survival. In addition, cancer-free survival outcomes were worse in patients who required more than four days for the normalization of WBC count. A TNM stage greater than II and the neutrophil lymphocyte ratio were associated with the duration of overall survival. In a multivariate analysis of these significant variables, TNM stage, an interval longer than four days for normalization of WBC counts and monocyte count independently associated with cancer-free survival.
CONCLUSION
Postoperative early inflammatory phase and preoperative monocyte count correlate with poor colon cancer prognosis. We can conclude that preoperative and postoperative inflammatory response and period unfavorably affect the metastatic microenvironment.

Citations

Citations to this article as recorded by  
  • Association between preoperative white blood cell counts and thirty-day surgical mortality after craniotomy in adult intracranial tumor patients
    Zhichao Gao, Cheng Huang, Shengjie Fang, Jiaqing Guan, Weifeng Dong
    Frontiers in Neurology.2024;[Epub]     CrossRef
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    Rahul Kumar, Su Lin, Gautam Mehta, Monica D. Mesquita, Joana A. F. Calvao, M. Faisal Sheikh, Banwari Agarwal, R. P. Mookerjee, Rajiv Jalan
    Alimentary Pharmacology & Therapeutics.2024; 60(7): 907.     CrossRef
  • A nomogram of inflammatory indexes for preoperatively predicting the risk of lymph node metastasis in colorectal cancer
    Xuemei Wen, Haoran Sun, Shijiang Du, Junkai Xia, Wenjun Zhang, Fujie Zhang
    Techniques in Coloproctology.2024;[Epub]     CrossRef
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    Carlos Darcy Alves Bersot, Lucas Ferreira Gomes Pereira, Victor Gabriel Vieira Goncho, José Eduardo Guimarães Pereira, Luiz Fernando dos Reis Falcão
    Frontiers in Surgery.2024;[Epub]     CrossRef
  • Influence of Laparoscopic Surgery on Cellular Immunity in Colorectal Cancer: A Systematic Review and Meta-Analysis
    Annika Bohne, Elena Grundler, Helge Knüttel, Alois Fürst, Vinzenz Völkel
    Cancers.2023; 15(13): 3381.     CrossRef
  • Systemic Inflammatory Biomarkers as Surrogate Markers for Stage in Colon Cancer
    Server Sezgin Uludag, Ahmet Necati Sanli, Abdullah Kagan Zengin, Mehmet Faik Ozcelik
    The American Surgeon™.2022; 88(6): 1256.     CrossRef
  • Thrombocytosis predicts poor prognosis of Asian patients with colorectal cancer: A systematic review and meta-analysis
    Shijun Xia, Wenjiang Wu, Linchong Yu, Lijuan Ma, Shiwei Chen, Hao Wang
    Medicine.2022; 101(35): e30275.     CrossRef
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    Shu Wen, Nan Chen, Ying Hu, Litao Huang, Jin Peng, Meina Yang, Xiaoyang Shen, Yang Song, Liangzhi Xu
    Cancer Medicine.2021; 10(5): 1690.     CrossRef
  • Value of combined detection of IFOBT, tumor markers, and inflammatory markers in predicting occurrence of advanced colorectal adenoma
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    World Chinese Journal of Digestology.2021; 29(7): 347.     CrossRef
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    Meilong Wu, Shizhong Yang, Xiaobin Feng, Chengquan Li, Fei Yu, Jiahong Dong, Matthias Reeh
    PLOS ONE.2021; 16(4): e0250091.     CrossRef
  • Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Obstructing Colorectal Cancer Treated by Endoscopic Stenting as a Bridge to Surgery
    Jiwei Guo, Aik Yong Chok, Hui Jun Lim, Wei Xuan Tay, Weng Kit Lye, Lasitha Bhagya Samarakoon, Emile John Tan, Ronnie Mathew
    Annals of Coloproctology.2021; 37(3): 159.     CrossRef
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    BMC Pediatrics.2021;[Epub]     CrossRef
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    Jin Soo Han, Hyoseon Ryu, In Ja Park, Kyung Won Kim, Yongbin Shin, Sun Ok Kim, Seok-Byung Lim, Chan Wook Kim, Yong Sik Yoon, Jong Lyul Lee, Chang Sik Yu, Jin Cheon Kim
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  • Influence of the Enhanced Recovery After Surgery Protocol on Postoperative Inflammation and Short-term Postoperative Surgical Outcomes After Colorectal Cancer Surgery
    Heba Essam Jaloun, In Kyu Lee, Min Ki Kim, Na Young Sung, Suhail Abdullah Al Turkistania, Sun Min Park, Dae Youn Won, Sang Hyun Hong, Bong-Hyeon Kye, Yoon Suk Lee, Hae Myung Jeon
    Annals of Coloproctology.2020; 36(4): 264.     CrossRef
  • Differences in the prognostic impact of post-operative systemic inflammation and infection in colorectal cancer patients: Using white blood cell counts and procalcitonin levels
    Jung Hoon Bae, Chul Seung Lee, Seung Rim Han, Sun Min Park, Yoon Suk Lee, In Kyu Lee
    Surgical Oncology.2020; 35: 374.     CrossRef
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    Ertugrul Osman BURSALIOĞLU
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  • 13,150 View
  • 122 Download
  • 50 Web of Science
  • 45 Crossref
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