KCA
Search
- Page Path
- HOME > Search
Original Article
- Gastrointestinal Cancer
- Risk of Death in Colorectal Cancer Patients with Multi-morbidities of Metabolic Syndrome: A Retrospective Multicohort Analysis
- Qingting Feng, Lingkai Xu, Lin Li, Junlan Qiu, Ziwei Huang, Yiqing Jiang, Tao Wen, Shun Lu, Fang Meng, Xiaochen Shu
- Cancer Res Treat. 2021;53(3):714-723. Published online December 2, 2020
- DOI: https://doi.org/10.4143/crt.2020.481
-
Abstract
PDF
PubReader
ePub - Purpose
The prevalence of multi-morbidities with colorectal cancer (CRC) is known to be increasing. Particularly prognosis of CRC patients co-diagnosed with metabolic syndrome (MetSyn) was largely unknown. We aimed to examine the death risk of CRC patients according to the multiple MetSyn morbidities.
Materials and Methods
We identified CRC patients with MetSyn from the electronic medical records (EMR) systems in five independent hospitals during 2006-2011. Information on deaths was jointly retrieved from EMR, cause of death registry and chronic disease surveillance as well as study-specific questionnaire. Cox proportional hazards regression was used to calculate the overall and CRC-specific hazards ratios (HR) comparing MetSyn CRC cohort with reference CRC cohort.
Results
A total of 682 CRC patients in MetSyn CRC cohort were identified from 24 months before CRC diagnosis to 1 month after. During a median follow-up of 92 months, we totally observed 584 deaths from CRC, 245 being in MetSyn cohort and 339 in reference cohort. Overall, MetSyn CRC cohort had an elevated risk of CRC-specific mortality (HR, 1.49; 95% confidence interval [CI], 1.07 to 1.90) and overall mortality (HR, 1.43; 95% CI, 1.09 to 1.84) compared to reference cohort after multiple adjustment. Stratified analyses showed higher mortality risk among women (HR, 1.87; 95% CI, 1.04 to 2.27) and specific components of MetSyn. Notably, the number of MetSyn components was observed to be significantly related to CRC prognosis.
Conclusion
Our findings supported that multi-morbidities of MetSyn associated with elevated death risk after CRC. MetSyn should be considered as an integrated medical condition more than its components in CRC prognostic management. -
Citations
Citations to this article as recorded by
- Association of Sleep Disturbance With Survival After Colorectal Cancer Diagnosis: Results From the ColoCare Study
Anita R. Peoples, Victoria Damerell, Jennifer Ose, Erin M. Siegel, Tengda Lin, Sheetal Hardikar, Caroline Himbert, Mmadili N. Ilozumba, Petra Schrotz‐King, Sylvia L. Crowder, Adetunji T. Toriola, David Shibata, Christopher I. Li, Doratha A. Byrd, Elena S.
Cancer Medicine.2026;[Epub] CrossRef - Circulating tryptophan–kynurenine pathway metabolites are associated with all‐cause mortality among patients with stage I–III colorectal cancer
Victoria Damerell, Niels Klaassen‐Dekker, Stefanie Brezina, Jennifer Ose, Arve Ulvik, Eline H. van Roekel, Andreana N. Holowatyj, Andreas Baierl, Jürgen Böhm, Martijn J. L. Bours, Hermann Brenner, Johannes H. W. de Wilt, William M. Grady, Nina Habermann,
International Journal of Cancer.2025; 156(3): 552. CrossRef - The metabolic syndrome and its components as prognostic factors in colorectal cancer: A meta‐analysis and systematic review
Bo Lu, Jia‐Ming Qian, Jing‐Nan Li
Journal of Gastroenterology and Hepatology.2023; 38(2): 187. CrossRef - Dysbiotic microbiome variation in colorectal cancer patients is linked to lifestyles and metabolic diseases
Tung Hoang, Minjung Kim, Ji Won Park, Seung-Yong Jeong, Jeeyoo Lee, Aesun Shin
BMC Microbiology.2023;[Epub] CrossRef - Comparing Long-Term Survival Outcomes for Muscle-Invasive Bladder Cancer Patients Who Underwent with Radical Cystectomy and Bladder-Sparing Trimodality Therapy: A Multicentre Cohort Analysis
Junlan Qiu, Haifeng Zhang, Dongkui Xu, Lin Li, Lingkai Xu, Yiqing Jiang, Tao Wen, Shun Lu, Fang Meng, Lin Feng, Xiaochen Shu, Pierfrancesco Franco
Journal of Oncology.2022; 2022: 1. CrossRef - Supportivmedizin, Multimorbidität und Phytotherapie
Reinhard Saller, Maja Dal Cero
Zeitschrift für Phytotherapie.2022; 43(S 01): S6. CrossRef - Cosmc transfection decreases malignant behavior of Tn+ cells and enhances sensitivity to apoptosis when induced by Apo2L/TRAIL via alteration of O-glycan structure
Ruisong Ding, Xingyou Hu, Wen Hu, Zhenzhen Du, Panpan Huang, Mengyang Wang, Jiaoyue Sheng, Yanchao Ma, Ailing Wang, Xiying Luan, Menghua Dong, Qizhi Cao, Yanfen Zou, Tao Hu
Aging.2021; 13(19): 23393. CrossRef
- Association of Sleep Disturbance With Survival After Colorectal Cancer Diagnosis: Results From the ColoCare Study
- 8,358 View
- 114 Download
- 7 Crossref
First
Prev
