Cancer Research and Treatment

Original Articles

Breast cancer

The Association of Estrogen Receptor Activity, Interferon Signaling, and MHC Class I Expression in Breast Cancer: In Hye Song, Young-Ae Kim, Sun-Hee Heo, Won Seon Bang, Hye Seon Park, Yeon ho Choi, Heejae Lee, Jeong-Han Seo, Youngjin Cho, Sung Wook Jung, Hee Jeong Kim, Sei Hyun Ahn, Hee Jin Lee, Gyungyub Gong; Cancer Res Treat. 2022;54(4):1111-1120. Published online December 21, 2021; DOI: https://doi.org/10.4143/crt.2021.1017

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Purpose
The expression of major histocompatibility complex class I (MHC I) has previously been reported to be negatively associated with estrogen receptor (ER) expression. Furthermore, MHC I expression, level of tumor-infiltrating lymphocytes (TILs), and expression of interferon (IFN) mediator MxA are positively associated with one another in human breast cancers. This study aimed to investigate the mechanisms of association of MHC I with ER and IFN signaling.
Materials and Methods
The human leukocyte antigen (HLA)-ABC protein expression was analyzed in breast cancer cell lines. The expressions of HLA-A and MxA mRNAs were analyzed in MCF-7 cells in Gene Expression Omnibus (GEO) data. ER and HLA-ABC expressions, Ki-67 labeling index and TIL levels in tumor tissue were also analyzed in ER+/ human epidermal growth factor receptor 2 (HER2)- breast cancer patients who randomly received either neoadjuvant chemotherapy or estrogen modulator treatment followed by resection.
Results
HLA-ABC protein expression was decreased after β-estradiol treatment or hESR-GFP transfection and increased after fulvestrant or IFN-γ treatment in cell lines. In GEO data, HLA-A and MxA expression was increased after ESR1 shRNA transfection. In patients, ER Allred score was significantly lower and the HLA-ABC expression, TIL levels, and Ki-67 were significantly higher in the estrogen modulator treated group than the chemotherapy treated group.
Conclusion
MHC I expression and TIL levels might be affected by ER pathway modulation and IFN treatment. Further studies elucidating the mechanism of MHC I regulation could suggest a way to boost TIL influx in cancer in a clinical setting.

Citations

Citations to this article as recorded by

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Progesterone receptor-dependent downregulation of MHC class I promotes tumor immune evasion and growth in breast cancer
Julio C Tinoco, Harmony I Saunders, Lauryn Rose Werner, Xiaopeng Sun, Eilidh I Chowanec, Amanda Heard, Prabhakar Chalise, Jeffery M Vahrenkamp, Andrea E Wilson, Cong-Xiao Liu, Gangjun Lei, Junping Wei, Hugo Cros, Hisham Mohammed, Melissa Troester, Charles
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Expression of Immunoproteasome Subunit LMP7 in Breast Cancer and Its Association with Immune-Related Markers: Miseon Lee, In Hye Song, Sun-Hee Heo, Young-Ae Kim, In Ah Park, Won Seon Bang, Hye Seon Park, Gyungyub Gong, Hee Jin Lee; Cancer Res Treat. 2019;51(1):80-89. Published online February 26, 2018; DOI: https://doi.org/10.4143/crt.2017.500

Abstract PDF PubReader ePub

Purpose
In the presence of interferon, proteasome subunits are replaced by their inducible counterparts to form an immunoproteasome (IP) plays a key role in generation of antigenic peptides presented by MHC class I molecules, leading to elicitation of a T cell‒mediated immune response. Although the roles of IP in other cancers, and inflammatory diseases have been extensively studied, its significance in breast cancer is unclear.
Materials and Methods
We investigated the expression of LMP7, an IP subunit, and its relationship with immune system components in two breast cancer cohorts.
Results
In 668 consecutive breast cancer cohort, 40% of tumors showed high level of LMP7 expression, and tumors with high expression of LMP7 had more tumor-infiltrating lymphocytes (TILs) in each subtype of breast cancer. In another cohort of 681 triple-negative breast cancer patients cohort, the expression of LMP7 in tumor cells was significantly correlated with the amount of TILs and the expression of interferon-associated molecules (MxA [p < 0.001] and PKR [p < 0.001]), endoplasmic reticulum stress-associated molecules (PERK [p=0.012], p-eIF2a [p=0.001], and XBP1 [p < 0.001]), and damage-associated molecular patterns (HMGN1 [p < 0.001] and HMGB1 [p < 0.001]). Patients with higher LMP7 expression had better disease-free survival outcomes than those with no or low expression in the positive lymph node metastasis group (p=0.041).
Conclusion
Close association between the TIL levels and LMP7 expression in breast cancer indicates that better antigen presentation through greater LMP7 expression might be associated with more TILs.

Citations

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Predictive Value of Tertiary Lymphoid Structures Assessed by High Endothelial Venule Counts in the Neoadjuvant Setting of Triple-Negative Breast Cancer: In Hye Song, Sun-Hee Heo, Won Seon Bang, Hye Seon Park, In Ah Park, Young-Ae Kim, Suk Young Park, Jin Roh, Gyungyub Gong, Hee Jin Lee; Cancer Res Treat. 2017;49(2):399-407. Published online July 27, 2016; DOI: https://doi.org/10.4143/crt.2016.215

Abstract PDF Supplementary Material PubReader ePub

Purpose
The tertiary lymphoid structure (TLS) is an important source of tumor-infiltrating lymphocytes (TILs), which have a strong prognostic and predictive value in triple-negative breast cancer (TNBC). A previous study reported that the levels of CXCL13 mRNA expression were associated with TLSs, but measuring the gene expression is challenging in routine practice. Therefore, this study evaluated the MECA79-positive high endothelial venule (HEV) densities and their association with the histopathologically assessed TLSs in biopsy samples. In addition, the relationship of TLSs with the CXCL13 transcript levels and clinical outcomes were examined.
Materials and Methods
A total of 108 TNBC patients treated with neoadjuvant chemotherapy (NAC) were studied. The amounts of TILs and TLSs were measured histopathologically using hematoxylin and eosin–stained slides. The HEV densities and TIL subpopulations were measured by immunohistochemistry for MECA79, CD3, CD8, and CD20. CXCL13 mRNA expression levels using a NanoString assay (NanoString Technologies).
Results
The mean number of HEVs in pre-NAC biopsies was 12 (range, 0 to 72). The amounts of TILs and TLSs, HEV density, and CXCL13 expression showed robust correlations with each other. A lower pre-NAC clinical T stage, higher TIL and TLS levels, a higher HEV density, CD20-positive cell density, and CXCL13 expression were significant predictors of a pathologic complete response (pCR). Higher CD8-positive cell density and levels of CXCL13 expression were significantly associated with a better disease-free survival rate.
Conclusion
MECA79-positive HEV density in pre-NAC biopsies is an objective and quantitative surrogate marker of TLS and might be a valuable tool for predicting pCR of TNBC in routine pathology practice.

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npj Precision Oncology.2024;[Epub] CrossRef
Advances in the study of tertiary lymphoid structures in the immunotherapy of breast cancer
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Frontiers in Oncology.2024;[Epub] CrossRef
Macrophages and tertiary lymphoid structures as indicators of prognosis and therapeutic response in cancer patients
Li Niu, Ting Chen, Aodan Yang, Xiwen Yan, Feng Jin, Ang Zheng, Xinyue Song
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International Journal of Molecular Sciences.2024; 25(12): 6423. CrossRef
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International Immunopharmacology.2024; 136: 112184. CrossRef
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Frontiers in Immunology.2024;[Epub] CrossRef
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Clinical and Translational Medicine.2024;[Epub] CrossRef
Density of tertiary lymphoid structures predicts clinical outcome in breast cancer brain metastasis
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Journal for ImmunoTherapy of Cancer.2024; 12(7): e009232. CrossRef
Tertiary lymphoid structures as potential biomarkers for cancer prediction and prognosis
Xin Zhang, Jie Yao, Mei Xie, Yiran Liang, Xuwen Lin, Jialin Song, Xinyu Bao, Xidong Ma, Yuanyong Wang, Yinguang Zhang, Yiming Liu, Wenya Han, Lei Pan, Xinying Xue
International Immunopharmacology.2024; 140: 112790. CrossRef
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Co-expression network and survival analysis of breast cancer inflammation and immune system hallmark genes
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Computational Biology and Chemistry.2024; 113: 108204. CrossRef
Global trends in tertiary lymphoid structures: a bibliometric analysis from 2014 to 2023
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Frontiers in Immunology.2024;[Epub] CrossRef
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Frontiers in Immunology.2024;[Epub] CrossRef
Prognostic value of tumor-infiltrating lymphocyte subtypes and microorganisms in triple-negative breast cancer
Yating Shi, Zhi Guo, Qiang Wang, Huan Deng
Journal of Cancer Research and Therapeutics.2024; 20(7): 1983. CrossRef
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Hao Liu, Zhuoqun Li, Xuan Han, Zhujun Li, Yan Zhao, Fenghua Liu, Ziyu Zhu, Yi Lv, Zhijun Liu, Nana Zhang
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Tertiary lymphoid structures in breast ductal carcinoma in situ correlate with adverse pathological parameters
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Clinical Significance of Tumour-Infiltrating B Lymphocytes (TIL-Bs) in Breast Cancer: A Systematic Literature Review
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B Cells in Breast Cancer Pathology
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Therapeutic Potential of Tumor Metabolic Reprogramming in Triple-Negative Breast Cancer
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International Journal of Molecular Sciences.2023; 24(8): 6945. CrossRef
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Nature.2023; 616(7957): 563. CrossRef
Predictive power of tertiary lymphoid structure signature for neoadjuvant chemotherapy response and immunotherapy benefit in HER2‐negative breast cancer
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P16 expression and presence of lymphoid stroma are correlated with good prognosis in mucoepidermoid carcinoma of the head and neck
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Detection and quantitative analysis of tumor-associated tertiary lymphoid structures
Man Yang, Yurou Che, Kezhen Li, Zengyi Fang, Simin Li, Mei Wang, Yiyao Zhang, Zhu Xu, Liping Luo, Chuan Wu, Xin Lai, Weidong Wang
Journal of Zhejiang University-SCIENCE B.2023; 24(9): 779. CrossRef
Identification of an exosome-related signature associated with prognosis and immune infiltration in breast cancer
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Scientific Reports.2023;[Epub] CrossRef
Association of systemic inflammatory markers and tertiary lymphoid structure with pathological complete response in gastric cancer patients receiving preoperative treatment: a retrospective cohort study
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International Journal of Surgery.2023; 109(12): 4151. CrossRef
The Characteristics of Tumor Microenvironment in Triple Negative Breast Cancer
Yiqi Fan, Shuai He
Cancer Management and Research.2022; Volume 14: 1. CrossRef
Peripheral node addressin, a ligand for L-selectin is found in tumor cells and in high endothelial venules in endometrial cancer
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The Presence of Tertiary Lymphoid Structures Provides New Insight Into the Clinicopathological Features and Prognosis of Patients With Breast Cancer
Bin Wang, Jie Liu, Yin Han, Yaotiao Deng, Jinze Li, Yu Jiang
Frontiers in Immunology.2022;[Epub] CrossRef
Role of tertiary lymphoid organs in the regulation of immune responses in the periphery
Amit I. Bery, Hailey M. Shepherd, Wenjun Li, Alexander S. Krupnick, Andrew E. Gelman, Daniel Kreisel
Cellular and Molecular Life Sciences.2022;[Epub] CrossRef
Tertiary Lymphoid Structures as Mediators of Immunotherapy Response
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Immunotherapy in triple-negative breast cancer: Insights into tumor immune landscape and therapeutic opportunities
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Frontiers in Molecular Biosciences.2022;[Epub] CrossRef
Predictive and prognostic values of tumor infiltrating lymphocytes in breast cancers treated with neoadjuvant chemotherapy: A meta-analysis
Shiqi Li, Ying Zhang, Peigen Zhang, Shuijing Xue, Yu Chen, Lihua Sun, Rui Yang
The Breast.2022; 66: 97. CrossRef
Multiplexed In Situ Spatial Protein Profiling in the Pursuit of Precision Immuno-Oncology for Patients with Breast Cancer
Davide Massa, Anna Tosi, Antonio Rosato, Valentina Guarneri, Maria Vittoria Dieci
Cancers.2022; 14(19): 4885. CrossRef
The Association of Estrogen Receptor Activity, Interferon Signaling, and MHC Class I Expression in Breast Cancer
In Hye Song, Young-Ae Kim, Sun-Hee Heo, Won Seon Bang, Hye Seon Park, Yeon ho Choi, Heejae Lee, Jeong-Han Seo, Youngjin Cho, Sung Wook Jung, Hee Jeong Kim, Sei Hyun Ahn, Hee Jin Lee, Gyungyub Gong
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High endothelial venules associated with better prognosis in esophageal squamous cell carcinoma
Hongmu Li, Lu Tang, Xue Han, Leqi Zhong, Wuyou Gao, Youfang Chen, Jinhua Huang, Zhesheng Wen
Annals of Diagnostic Pathology.2022; 61: 152051. CrossRef
Tertiary lymphoid structures as unique constructions associated with the organization, education, and function of tumor-infiltrating immunocytes
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Journal of Zhejiang University-SCIENCE B.2022; 23(10): 812. CrossRef
Tertiary Lymphoid Structures: A Potential Biomarker for Anti-Cancer Therapy
Ji’an Zou, Yingzhe Zhang, Yue Zeng, Yurong Peng, Junqi Liu, Chaoyue Xiao, Fang Wu
Cancers.2022; 14(23): 5968. CrossRef
Impact of mature tertiary lymphoid structures on prognosis and therapeutic response of Epstein-Barr virus-associated gastric cancer patients
Yi-Xin Yin, Yi-Hong Ling, Xiao-Li Wei, Cai-Yun He, Bing-Zhi Wang, Chun-Fang Hu, Wen-Ping Lin, Run-Cong Nie, Jie-Wei Chen, Jin-Long Lin, Jie Zhou, Juan-Juan Xie, Jing-Ping Yun, Dan Xie, Li-Yan Xue, Mu-Yan Cai
Frontiers in Immunology.2022;[Epub] CrossRef
The Role of Immune Cells in Breast Tissue and Immunotherapy for the Treatment of Breast Cancer
Stephanie L. Goff, David N. Danforth
Clinical Breast Cancer.2021; 21(1): e63. CrossRef
Immune microenvironment in different molecular subtypes of ductal breast carcinoma
Mona Sadeghalvad, Hamid-Reza Mohammadi-Motlagh, Nima Rezaei
Breast Cancer Research and Treatment.2021; 185(2): 261. CrossRef
Cancer-Associated Fibroblasts and T Cells: From Mechanisms to Outcomes
Alfie T Baker, Mohammed H Abuwarwar, Lylarath Poly, Simon Wilkins, Anne L Fletcher
The Journal of Immunology.2021; 206(2): 310. CrossRef
Repenser la place des lymphocytes B et des structures lymphoïdes tertiaires dans l’immunothérapie des cancers
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High endothelial venules are present in pharyngeal and laryngeal carcinomas and they are associated with better prognosis
Georgia Karpathiou, Jean Marc Dumollard, Marie Gavid, Francois Casteillo, Marine Vieville, Jean Michel Prades, Marios Froudarakis, Michel Peoc’h
Pathology - Research and Practice.2021; 220: 153392. CrossRef
Prognostic value of tumor-infiltrating B lymphocytes and plasma cells in triple-negative breast cancer
Hajime Kuroda, Tsengelmaa Jamiyan, Rin Yamaguchi, Akinari Kakumoto, Akihito Abe, Oi Harada, Bayarmaa Enkhbat, Atsuko Masunaga
Breast Cancer.2021; 28(4): 904. CrossRef
Tumor-infiltrating B cells and T cells correlate with postoperative prognosis in triple-negative carcinoma of the breast
Hajime Kuroda, Tsengelmaa Jamiyan, Rin Yamaguchi, Akinari Kakumoto, Akihito Abe, Oi Harada, Atsuko Masunaga
BMC Cancer.2021;[Epub] CrossRef
Tertiary lymphoid structures and B lymphocytes in cancer prognosis and response to immunotherapies
Jacquelot N, Tellier J, Nutt Sl, Belz Gt
OncoImmunology.2021;[Epub] CrossRef
High endothelial venules (HEVs) in immunity, inflammation and cancer
Lucas Blanchard, Jean-Philippe Girard
Angiogenesis.2021; 24(4): 719. CrossRef
Immunohistochemical analysis of L1 cell adhesion molecule and high endothelial venules in breast cancer brain metastasis
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Pathology - Research and Practice.2021; 223: 153484. CrossRef
The Immunology of Hormone Receptor Positive Breast Cancer
Jonathan Goldberg, Ricardo G. Pastorello, Tuulia Vallius, Janae Davis, Yvonne Xiaoyong Cui, Judith Agudo, Adrienne G. Waks, Tanya Keenan, Sandra S. McAllister, Sara M. Tolaney, Elizabeth A. Mittendorf, Jennifer L. Guerriero
Frontiers in Immunology.2021;[Epub] CrossRef
Immune Crosstalk Between Lymph Nodes and Breast Carcinomas, With a Focus on B Cells
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Frontiers in Molecular Biosciences.2021;[Epub] CrossRef
Tumor-Associated Tertiary Lymphoid Structures: From Basic and Clinical Knowledge to Therapeutic Manipulation
Charlotte Domblides, Juliette Rochefort, Clémence Riffard, Marylou Panouillot, Géraldine Lescaille, Jean-Luc Teillaud, Véronique Mateo, Marie-Caroline Dieu-Nosjean
Frontiers in Immunology.2021;[Epub] CrossRef
The 12-CK Score: Global Measurement of Tertiary Lymphoid Structures
Roger Li, Anders Berglund, Logan Zemp, Jasreman Dhillon, Ryan Putney, Youngchul Kim, Rohit K. Jain, G. Daniel Grass, José Conejo-Garcia, James J. Mulé
Frontiers in Immunology.2021;[Epub] CrossRef
Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells
Alyssa Vito, Omar Salem, Nader El-Sayes, Ian P. MacFawn, Ana L. Portillo, Katy Milne, Danielle Harrington, Ali A. Ashkar, Yonghong Wan, Samuel T. Workenhe, Brad H. Nelson, Tullia C. Bruno, Karen L. Mossman
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Frontiers in Immunology.2021;[Epub] CrossRef
High Endothelial Venules: A Vascular Perspective on Tertiary Lymphoid Structures in Cancer
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Frontiers in Immunology.2021;[Epub] CrossRef
Tumor-Infiltrating B Lymphocyte Profiling Identifies IgG-Biased, Clonally Expanded Prognostic Phenotypes in Triple-Negative Breast Cancer
Robert J. Harris, Anthony Cheung, Joseph C.F. Ng, Roman Laddach, Alicia M. Chenoweth, Silvia Crescioli, Matthew Fittall, Diana Dominguez-Rodriguez, James Roberts, Dina Levi, Fangfang Liu, Elena Alberts, Jelmar Quist, Aida Santaolalla, Sarah E. Pinder, Che
Cancer Research.2021; 81(16): 4290. CrossRef
Tertiary lymphoid structure and B‑cell‑related pathways: A potential target in tumor immunotherapy (Review)
Meng Qin, Ying Jin, Ling-Ya Pan
Oncology Letters.2021;[Epub] CrossRef
Heterogeneity of Circulating Tumor Cell–Associated Genomic Gains in Breast Cancer and Its Association with the Host Immune Response
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Cancer Research.2021; 81(24): 6196. CrossRef
Oral cancer-associated tertiary lymphoid structures: gene expression profile and prognostic value
K Li, Q Guo, X Zhang, X Dong, W Liu, A Zhang, Y Li, J Yan, G Jia, Z Zheng, W Tang, L Pan, M An, B Zhang, S Liu, B Fu
Clinical and Experimental Immunology.2020; 199(2): 172. CrossRef
B cells and tertiary lymphoid structures promote immunotherapy response
Beth A. Helmink, Sangeetha M. Reddy, Jianjun Gao, Shaojun Zhang, Rafet Basar, Rohit Thakur, Keren Yizhak, Moshe Sade-Feldman, Jorge Blando, Guangchun Han, Vancheswaran Gopalakrishnan, Yuanxin Xi, Hao Zhao, Rodabe N. Amaria, Hussein A. Tawbi, Alex P. Cogdi
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Neolymphogenesis and Immunogistogochemical Study of Lymph Nodes in Breast Cancer
Sh. Kh. Gantsev, R. A. Rustamkhanov, Sh. R. Kzyrgalin, D. S. Tursumetov
Creative surgery and oncology.2020; 9(4): 266. CrossRef
Duality of B Cell-CXCL13 Axis in Tumor Immunology
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Frontiers in Immunology.2020;[Epub] CrossRef
Predictive and prognostic role of tumour-infiltrating lymphocytes in breast cancer patients with different molecular subtypes: a meta-analysis
Zhao-hua Gao, Cun-xin Li, Ming Liu, Jia-yuan Jiang
BMC Cancer.2020;[Epub] CrossRef
Insights into Tumor-Associated Tertiary Lymphoid Structures: Novel Targets for Antitumor Immunity and Cancer Immunotherapy
Anthony B. Rodriguez, Victor H. Engelhard
Cancer Immunology Research.2020; 8(11): 1338. CrossRef
Pan-cancer analysis of genomic properties and clinical outcome associated with tumor tertiary lymphoid structure
Ziying Lin, Lixia Huang, ShaoLi Li, Jincui Gu, Xiaoxian Cui, Yanbin Zhou
Scientific Reports.2020;[Epub] CrossRef
Presence of tertiary lymphoid structures determines the level of tumor-infiltrating lymphocytes in primary breast cancer and metastasis
Miseon Lee, Sun-Hee Heo, In Hye Song, Hajar Rajayi, Hye Seon Park, In Ah Park, Young-Ae Kim, Heejae Lee, Gyungyub Gong, Hee Jin Lee
Modern Pathology.2019; 32(1): 70. CrossRef
Strong CD8+ lymphocyte infiltration in combination with expression of HLA class I is associated with better tumor control in breast cancer patients treated with neoadjuvant chemotherapy
A. F. de Groot, E. J. Blok, A. Charehbili, C. C. Engels, V. T. H. B. M. Smit, N. G. Dekker-Ensink, H. Putter, E. Meershoek-Klein Kranenbarg, C. J. H. van de Velde, G. J. Liefers, J. W. R. Nortier, P. J. K. Kuppen, S. H. van der Burg, J. R. Kroep
Breast Cancer Research and Treatment.2019; 175(3): 605. CrossRef
The effect of C-X-C motif chemokine ligand 13 in cutaneous squamous cell carcinoma treated with aminolevulinic acid-photodynamic therapy
Lude Zhu, Guolong Zhang, Peiru Wang, Linglin Zhang, Jie Ji, Xiaojing Liu, Zhongxia Zhou, Jingjun Zhao, Xiuli Wang
Photodiagnosis and Photodynamic Therapy.2019; 26: 389. CrossRef
Tertiary lymphoid structures in the era of cancer immunotherapy
Catherine Sautès-Fridman, Florent Petitprez, Julien Calderaro, Wolf Herman Fridman
Nature Reviews Cancer.2019; 19(6): 307. CrossRef
B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma
Johannes Griss, Wolfgang Bauer, Christine Wagner, Martin Simon, Minyi Chen, Katharina Grabmeier-Pfistershammer, Margarita Maurer-Granofszky, Florian Roka, Thomas Penz, Christoph Bock, Gao Zhang, Meenhard Herlyn, Katharina Glatz, Heinz Läubli, Kirsten D. M
Nature Communications.2019;[Epub] CrossRef
Poor Response to Neoadjuvant Chemotherapy Correlates with Mast Cell Infiltration in Inflammatory Breast Cancer
Sangeetha M. Reddy, Alexandre Reuben, Souptik Barua, Hong Jiang, Shaojun Zhang, Linghua Wang, Vancheswaran Gopalakrishnan, Courtney W. Hudgens, Michael T. Tetzlaff, James M. Reuben, Takahiro Tsujikawa, Lisa M. Coussens, Khalida Wani, Yan He, Lily Villarea
Cancer Immunology Research.2019; 7(6): 1025. CrossRef
New Insights into Tumor-Infiltrating B Lymphocytes in Breast Cancer: Clinical Impacts and Regulatory Mechanisms
Meng Shen, Jian Wang, Xiubao Ren
Frontiers in Immunology.2018;[Epub] CrossRef
Hot Spot and Whole-Tumor Enumeration of CD8+ Tumor-Infiltrating Lymphocytes Utilizing Digital Image Analysis Is Prognostic in Triple-Negative Breast Cancer
Patrick J. McIntire, Lina Irshaid, Yifang Liu, Zhengming Chen, Faith Menken, Eugene Nowak, Sandra J. Shin, Paula S. Ginter
Clinical Breast Cancer.2018; 18(6): 451. CrossRef
Correlation with lymphocyte infiltration, but lack of prognostic significance of MECA-79-positive high endothelial venules in primary malignant melanoma
Tímea Sebestyén, Anita Mohos, Gabriella Liszkay, Beáta Somlai, István Gaudi, Andrea Ladányi
Melanoma Research.2018; 28(4): 304. CrossRef
Lymphocyte-Activation Gene-3 Expression and Prognostic Value in Neoadjuvant-Treated Triple-Negative Breast Cancer
Yunxuan Wang, Tieying Dong, Qijia Xuan, Hong Zhao, Ling Qin, Qingyuan Zhang
Journal of Breast Cancer.2018; 21(2): 124. CrossRef
Functions of the CXC ligand family in the pancreatic tumor microenvironment
Nien-Hung Lee, Mehrdad Nikfarjam, Hong He
Pancreatology.2018; 18(7): 705. CrossRef
Antigen Specificity and Clinical Significance of IgG and IgA Autoantibodies Produced in situ by Tumor-Infiltrating B Cells in Breast Cancer
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Frontiers in Immunology.2018;[Epub] CrossRef
Prognostic Significance of Tumor-Infiltrating B Cells and Plasma Cells in Human Cancer
Maartje C.A. Wouters, Brad H. Nelson
Clinical Cancer Research.2018; 24(24): 6125. CrossRef
The Multifaceted Roles of B Cells in Solid Tumors: Emerging Treatment Opportunities
Nicole J. Flynn, Rajasekharan Somasundaram, Kimberly M. Arnold, Jennifer Sims-Mourtada
Targeted Oncology.2017; 12(2): 139. CrossRef
CXCL13-producing TFH cells link immune suppression and adaptive memory in human breast cancer
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JCI Insight.2017;[Epub] CrossRef
Tertiary Lymphoid Structures in Cancer: Drivers of Antitumor Immunity, Immunosuppression, or Bystander Sentinels in Disease?
Emily Jayne Colbeck, Ann Ager, Awen Gallimore, Gareth Wyn Jones
Frontiers in Immunology.2017;[Epub] CrossRef
Distinct Tertiary Lymphoid Structure Associations and Their Prognostic Relevance in HER2 Positive and Negative Breast Cancers
Xia Liu, Julia Y.S. Tsang, Thazin Hlaing, Jintao Hu, Yun-Bi Ni, Siu Ki Chan, Sai Yin Cheung, Gary M. Tse
The Oncologist.2017; 22(11): 1316. CrossRef

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