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2 "Sung Il Choi"
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Original Article
Cytoplasmic Expression of HuR is Related to Cyclooxygenase-2 Expression in Colon Cancer
Sung-Jig Lim, Suk-Hwan Lee, Sun Hyung Joo, Jeong Yoon Song, Sung Il Choi
Cancer Res Treat. 2009;41(2):87-92.   Published online June 30, 2009
DOI: https://doi.org/10.4143/crt.2009.41.2.87
AbstractAbstract PDFPubReaderePub
Purpose

HuR, human family embryonic-lethal abnormal vision-like protein, can bind to mRNA and stabilizes the nucleic acid in the cytoplasm, resulting in more efficient translation. HuR is predominantly present in the nucleus and shuttles between the nucleus and cytoplasm. HuR stabilizes cyclooxygenase-2 (Cox-2) mRNA in several cancers, including breast, stomach, lung and brain cancer.

Materials and Methods

We investigated the expression and cellular location of HuR, as well as evaluated Cox-2 expression in 79 colorectal cancer patients with the use of immunohistochemical methods. The biological implications of HuR localization and Cox-2 expression in colorectal carcinoma were evaluated.

Results

Nuclear HuR expression was observed in 59 (74.7%) tumors and cytoplasmic HuR expression was seen in 25 (31.6%) tumors. Cox-2 immunoreactivity was noted in 42 (53%) tumors. The expression of cytoplasmic HuR was significantly associated with Cox-2 expression (p=0.004). Cytoplasmic expression of HuR showed a correlation with lymphatic invasion (p=0.025) and the presence of a lymph node metastasis (p=0.027). The presence of nuclear HuR showed no correlation with Cox-2 expression or any other of the clinicopathological parameters that were examined.

Conclusion

These results suggest that cytoplasmic translocation of HuR is associated with Cox-2 expression for some colorectal carcinomas.

Citations

Citations to this article as recorded by  
  • Human antigen R: Exploring its inflammatory response impact and significance in cardiometabolic disorders
    Shahenda Salah Abdelsam, Sarah Khalaf Ghanem, Muhammad Ammar Zahid, Hanan H. Abunada, Loulia Bader, Hicham Raïq, Abbas Khan, Aijaz Parray, Laiche Djouhri, Abdelali Agouni
    Journal of Cellular Physiology.2024;[Epub]     CrossRef
  • HuR/miR-124-3p/VDR complex bridges lipid metabolism and tumor development in colorectal cancer
    Fengxing Huang, Luping Bu, Mengting Li, Youwei Wang, Runan Zhang, Yu Shao, Kun Lin, Hong Yang, Qiu Zhao, Lan Liu
    Carcinogenesis.2024;[Epub]     CrossRef
  • Targeting the RNA-Binding Protein HuR in Cancer
    Jennifer M. Finan, Thomas L. Sutton, Dan A. Dixon, Jonathan R. Brody
    Cancer Research.2023; 83(21): 3507.     CrossRef
  • CCAAT/enhancer binding protein (C/EBP) delta promotes the expression of PTX3 and macrophage phagocytosis during A. fumigatus infection
    Lulu Liu, Jinjin Zhong, Bilin Chen, Weiping Wang, Haiyan Xi, Xin Su
    Journal of Leukocyte Biology.2022; 111(6): 1225.     CrossRef
  • CRC-derived exosomes containing the RNA binding protein HuR promote lung cell proliferation by stabilizing c-Myc mRNA
    Hui Xiao, Xiong Ye, Vikalp Vishwakarma, Ranjan Preet, Dan A. Dixon
    Cancer Biology & Therapy.2022; 23(1): 139.     CrossRef
  • The RNA-binding protein HuR in human cancer: A friend or foe?
    Xiaoqing Wu, Liang Xu
    Advanced Drug Delivery Reviews.2022; 184: 114179.     CrossRef
  • The Role of RNA-Binding Protein HuR in Lung Cancer by RNA Sequencing Analysis
    Xiong Ye, Qiang Fu, Hui Xiao
    Frontiers in Genetics.2022;[Epub]     CrossRef
  • miR-29b-3p suppresses the malignant biological behaviors of AML cells via inhibiting NF-κB and JAK/STAT signaling pathways by targeting HuR
    Yong-Jing Tang, Wei Wu, Qiao-Qian Chen, Shu-Han Liu, Zhi-Yuan Zheng, Zhao-Lei Cui, Jian-Ping Xu, Yan Xue, Dong-Hong Lin
    BMC Cancer.2022;[Epub]     CrossRef
  • Mechanistic insights into HuR inhibitor MS-444 arresting embryonic development revealed by low-input RNA-seq and STORM
    Yongqiang Nie, Wei Xu, Geng G. Tian, Xiaowei Li, Yan Guo, Xuefeng Liu, Lin He, Zhifeng Shao, Xiaoyong Li, Ji Wu
    Cell Biology and Toxicology.2022; 38(6): 1175.     CrossRef
  • Circular RNA circE2F2 promotes malignant progression of ovarian cancer cells by upregulating the expression of E2F2 protein via binding to HuR protein
    Meiyin Zhang, Ye Xu, Yongjian Zhang, Bing Li, Ge Lou
    Cellular Signalling.2021; 84: 110014.     CrossRef
  • Understanding and targeting the disease‐related RNA binding protein human antigen R (HuR)
    Christopher W. Schultz, Ranjan Preet, Teena Dhir, Dan A. Dixon, Jonathan R. Brody
    WIREs RNA.2020;[Epub]     CrossRef
  • The Role of VEGFA, COX2, HUR and CUGBP2 in Predicting the Response to Neoadjuvant Therapy in Rectal Cancer Patients
    Henrikas Pauzas, Ugne Gyvyte, Tadas Latkauskas, Laura Kairevice, Paulius Lizdenis, Saulius Svagzdys, Erika Birgiolaite, Irma Kuliaviene, Juozas Kupcinskas, Algimantas Tamelis
    Medicina.2020; 56(4): 192.     CrossRef
  • AU-rich element-binding proteins in colorectal cancer
    Noémie Legrand, Dan A Dixon, Cyril Sobolewski
    World Journal of Gastrointestinal Oncology.2019; 11(2): 71.     CrossRef
  • Inhibition of Caspase-2 Translation by the mRNA Binding Protein HuR: A Novel Path of Therapy Resistance in Colon Carcinoma Cells?
    Wolfgang Eberhardt, Usman Nasrullah, Kristina Haeussler
    Cells.2019; 8(8): 797.     CrossRef
  • Lessons from studying the AU-rich elements in chronic inflammation and autoimmunity
    Niki Lourou, Maxim Gavriilidis, Dimitris L. Kontoyiannis
    Journal of Autoimmunity.2019; 104: 102334.     CrossRef
  • High cytoplasmic HuR expression is associated with advanced pT stage, high grade and increased microvessel density in urothelial bladder carcinoma
    Łukasz Piotr Fus, Paweł Pihowicz, Łukasz Koperski, Janina Maja Marczewska, Barbara Górnicka
    Annals of Diagnostic Pathology.2018; 33: 40.     CrossRef
  • Divergent Innate and Epithelial Functions of the RNA-Binding Protein HuR in Intestinal Inflammation
    Eleni Christodoulou-Vafeiadou, Fotis Ioakeimidis, Margarita Andreadou, Giorgos Giagkas, George Stamatakis, Martin Reczko, Martina Samiotaki, Anastasios D. Papanastasiou, Ioannis Karakasiliotis, Dimitris L. Kontoyiannis
    Frontiers in Immunology.2018;[Epub]     CrossRef
  • Green Tea Polyphenol Induces Changes in Cancer-Related Factors in an Animal Model of Bladder Cancer
    Tomohiro Matsuo, Yasuyoshi Miyata, Akihiro Asai, Yuji Sagara, Bungo Furusato, Junya Fukuoka, Hideki Sakai, Chih-Pin Chuu
    PLOS ONE.2017; 12(1): e0171091.     CrossRef
  • Human antigen R as a predictive marker for response to gemcitabine-based chemotherapy in advanced cisplatin-resistant urothelial cancer
    Yasuyoshi Miyata, Kensuke Mitsunari, Asai Akihiro, Shin-Ichi Watanabe, Tomohiro Matsuo, Kojiro Ohba, Hideki Sakai
    Oncology Letters.2017; 13(2): 811.     CrossRef
  • Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis
    Fernando F. Blanco, Ranjan Preet, Andrea Aguado, Vikalp Vishwakarma, Laura E. Stevens, Alok Vyas, Subhash Padhye, Liang Xu, Scott J. Weir, Shrikant Anant, Nicole Meisner-Kober, Jonathan R. Brody, Dan A. Dixon
    Oncotarget.2016; 7(45): 74043.     CrossRef
  • Novel Targets in Pancreatic Cancer Research
    Geoffrey Kozak, Fernando F. Blanco, Jonathan R. Brody
    Seminars in Oncology.2015; 42(1): 177.     CrossRef
  • HuR represses Wnt/β-catenin-mediated transcriptional activity by promoting cytoplasmic localization of β-catenin
    Inae Kim, Jung Hur, Sunjoo Jeong
    Biochemical and Biophysical Research Communications.2015; 457(1): 65.     CrossRef
  • Exome sequencing of a colorectal cancer family reveals shared mutation pattern and predisposition circuitry along tumor pathways
    Suleiman H. Suleiman, Mahmoud E. Koko, Wafaa H. Nasir, Ommnyiah Elfateh, Ubai K. Elgizouli, Mohammed O. E. Abdallah, Khalid O. Alfarouk, Ayman Hussain, Shima Faisal, Fathelrahamn M. A. Ibrahim, Maurizio Romano, Ali Sultan, Lawrence Banks, Melanie Newport,
    Frontiers in Genetics.2015;[Epub]     CrossRef
  • Combinatorial Control of mRNA Fates by RNA-Binding Proteins and Non-Coding RNAs
    Valentina Iadevaia, André Gerber
    Biomolecules.2015; 5(4): 2207.     CrossRef
  • Association ofCELF2polymorphism and the prognosis of nasopharyngeal carcinoma in southern Chinese population
    Yun-Miao Guo, Ming-Xia Sun, Jing Li, Tong-Tong Liu, Hang-Zhen Huang, Jie-Rong Chen, Wen-Sheng Liu, Qi-Sheng Feng, Li-Zhen Chen, Jin-Xin Bei, Yi-Xin Zeng
    Oncotarget.2015; 6(29): 27176.     CrossRef
  • Clinical significance of HuR expression in human malignancy
    Ioly Kotta-Loizou, Constantinos Giaginis, Stamatios Theocharis
    Medical Oncology.2014;[Epub]     CrossRef
  • Expression of the ELAV-like protein HuR in the cytoplasm is associated with endometrial carcinoma progression
    Dandan Wang, Min Wang, Chang’e Hu, Ting Shuang, Yingying Zhou, Xiaoyu Yan
    Tumor Biology.2014; 35(12): 11939.     CrossRef
  • HuR Regulates Alternative Splicing of the TRA2β Gene in Human Colon Cancer Cells under Oxidative Stress
    Yoko Akaike, Kiyoshi Masuda, Yuki Kuwano, Kensei Nishida, Keisuke Kajita, Ken Kurokawa, Yuzuru Satake, Katsutoshi Shoda, Issei Imoto, Kazuhito Rokutan
    Molecular and Cellular Biology.2014; 34(15): 2857.     CrossRef
  • Multiple Functions of the RNA-Binding Protein HuR in Cancer Progression, Treatment Responses and Prognosis
    Jun Wang, Yan Guo, Huili Chu, Yaping Guan, Jingwang Bi, Baocheng Wang
    International Journal of Molecular Sciences.2013; 14(5): 10015.     CrossRef
  • Cytoplasmic HuR expression correlates with P-gp, HER-2 positivity, and poor outcome in breast cancer
    Zhongpeng Zhu, Baocheng Wang, Jingwang Bi, Cong Zhang, Yan Guo, Huili Chu, Xiuju Liang, Chen Zhong, Jun Wang
    Tumor Biology.2013; 34(4): 2299.     CrossRef
  • The flip-flop HuR: part of the problem or the solution in fighting cancer?
    Jacqueline C. Shultz, Charles E. Chalfant
    Journal of Clinical Investigation.2012; 122(1): 16.     CrossRef
  • Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis
    Anthie Yiakouvaki, Marios Dimitriou, Ioannis Karakasiliotis, Christina Eftychi, Stamatis Theocharis, Dimitris L. Kontoyiannis
    Journal of Clinical Investigation.2012; 122(1): 48.     CrossRef
  • RNA-binding protein HuR autoregulates its expression by promoting alternative polyadenylation site usage
    Weijun Dai, Gen Zhang, Eugene V. Makeyev
    Nucleic Acids Research.2012; 40(2): 787.     CrossRef
  • HuR's role in gemcitabine efficacy: an exception or opportunity?
    Jonathan R. Brody, Gregory E. Gonye
    WIREs RNA.2011; 2(3): 435.     CrossRef
  • High-constitutive HuR phosphorylation at Ser 318 by PKCδ propagates tumor relevant functions in colon carcinoma cells
    Anke Doller, Christine Winkler, Irina Azrilian, Sebastian Schulz, Sylvia Hartmann, Josef Pfeilschifter, Wolfgang Eberhardt
    Carcinogenesis.2011; 32(5): 676.     CrossRef
  • Cytoplasmic HuR expression correlates with angiogenesis, lymphangiogenesis, and poor outcome in lung cancer
    Jun Wang, Baocheng Wang, Jingwang Bi, Cong Zhang
    Medical Oncology.2011; 28(S1): 577.     CrossRef
  • Association between expression of embryonic lethal abnormal vision‐like protein HuR and cyclooxygenase‐2 in oral squamous cell carcinoma
    Jeong‐Dan Cha, ShengJin Li, In‐Ho Cha
    Head & Neck.2011; 33(5): 627.     CrossRef
  • Posttranscriptional regulation of cancer traits by HuR
    Kotb Abdelmohsen, Myriam Gorospe
    WIREs RNA.2010; 1(2): 214.     CrossRef
  • BRCA1-IRIS overexpression abrogates UV-induced p38MAPK/p53 and promotes proliferation of damaged cells
    K Chock, J M S Allison, W M ElShamy
    Oncogene.2010; 29(38): 5274.     CrossRef
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  • 65 Download
  • 39 Crossref
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Case Report
A Case of Multiple Intussusceptions in the Small Intestine Caused by Metastatic Renal Cell Carcinoma
Wan Kyu Eo, Gou Young Kim, Sung Il Choi
Cancer Res Treat. 2008;40(2):97-99.   Published online June 30, 2008
DOI: https://doi.org/10.4143/crt.2008.40.2.97
AbstractAbstract PDFPubReaderePub

Renal cell carcinoma (RCC) may metastasize to almost any organ, but metastasis to the small bowel is rare. Small bowel metastasis from RCC can induce obstruction or bleeding, and perforation can also be induced in rare case. Yet RCC metastasis to the small bowel is unlikely to be a direct cause of intussusceptions. A few cases of intussusceptions caused by small intestinal metastasis of RCC have been reported, but multiple small intestinal intussusceptions are extremely rare. We report here on a 47-year-old male patient who presented to the emergency room with acute abdominal pain. He had undergone radical nephrectomy 2 years previously due to left RCC. The abdominal CT scan revealed enhanced masses with the "target" sign that suggested enteric intussusceptions in the jejunum. Eight pedunculated masses within the small intestinal lumen led to intussusceptions at 30 and 150 cm distal to Treitz ligament. Three segmental resections of the small intestine and functional end to end anastomosis were done. The patient recovered uneventfully from this operation. To the best of our knowledge, this is the 1st report of metastases from RCC that presented as synchronous intraluminal polypoid tumors, and these tumors served as the lead points for two intussusceptions in the jejunum.

Citations

Citations to this article as recorded by  
  • Case Report: Pancreatic metastasis of renal cell carcinoma 16 years after nephrectomy
    Yidan Lou, Kaibo Guo, Song Zheng
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • Solitary metastasis of clear cell renal cell carcinoma in the small intestine 10 years after right nephrectomy
    M.D. Budurova, N.V. Vorobyov, S.I. Poluektov, V.S. Surkova, N.A. Grishin, K.A. Turupaev, M.A. Chernichenko, A.B. Ryabov
    Onkologiya. Zhurnal imeni P.A.Gertsena.2023; 12(6): 57.     CrossRef
  • Metastatic disease masquerading as small intestinal tumoural masses: two case reports and literature review
    Jovell Xing Yi Sim, Ilyana Huda Binte Mohamed Hussain, Wei Qiang Leow
    Proceedings of Singapore Healthcare.2017; 26(4): 263.     CrossRef
  • Severe blood loss anaemia and recurrent intussusceptions as first presentation of bowel metastatic renal cell carcinoma: A case report and review of the literature
    Claudia Trojaniello, Maria Giuseppa Vitale, Biagio Trojaniello, Maria Luisa Lentini Graziano, Mariarosa Coccaro, Giacomo Cartenì, Vincenzo Montesarchio
    Molecular and Clinical Oncology.2017; 7(4): 654.     CrossRef
  • Small bowel intussusception from renal cell carcinoma metastasis: a case report and review of the literature
    Gabriele Bellio, Tommaso Cipolat Mis, Gladiola Kaso, Roberto Dattola, Biagio Casagranda, Marina Bortul
    Journal of Medical Case Reports.2016;[Epub]     CrossRef
  • Small bowel metastasis from pancreatic cancer in a long-term survival patient with synchronous advanced malignant pleural mesothelioma: A case report and literature review
    Morena Fasano, Carminia Maria Della Corte, Giovanni Vicidomini, Valerio Scotti, Pier Francesco Rambaldi, Alfonso Fiorelli, Marina Accardo, Ferdinando De Vita, Mario Santini, Fortunato Ciardiello, Floriana Morgillo
    Oncology Letters.2016; 12(6): 4505.     CrossRef
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    A.-S. Massy Budmiger, V. Nagy, S. Hurlimann, J. Metzger
    Journal of Surgical Case Reports.2015; 2015(4): rjv047.     CrossRef
  • An obscure cause of gastrointestinal bleeding: Renal cell carcinoma metastasis to the small bowel
    Robyn L. Gorski, Salah Abdel Jalil, Manver Razick, Ala' Abdel Jalil
    International Journal of Surgery Case Reports.2015; 15: 130.     CrossRef
  • Recurrent Renal Cell Carcinoma with Synchronous Tumor Growth in Azygoesophageal Recess and Duodenum: A Rare Cause of Anemia and Upper Gastrointestinal Bleeding
    Vamshidhar R. Vootla, Muhammad Kashif, Masooma Niazi, Suresh K. Nayudu
    Case Reports in Oncological Medicine.2015; 2015: 1.     CrossRef
  • Atypical Multiple Ileum Metastases of Renal Cell Carcinoma
    Raffaele Longo, Domenico Gattuso, Roberto Luchetti, Carlo Giannetti, Alessandro Mero, Cinzia Bernardi, Giampietro Gasparini
    Journal of Gastrointestinal Cancer.2013; 44(4): 477.     CrossRef
  • Enduring Response to Everolimus as Third-Line Therapy in a Patient With Advanced Renal Cell Carcinoma, Including Small-Bowel Metastases: Loss of FHIT but Normal VHL Gene Status
    Reuben J. Broom, Imogen Caldwell, Fritha Hanning, Peter Fong, Sanjeev Deva, Paul Oei
    Clinical Genitourinary Cancer.2012; 10(3): 202.     CrossRef
  • A case of wedge resection of duodenum for massive gastrointestinal bleeding due to duodenal metastasis by renal cell carcinoma
    Hongzhi Zhao, Keqiang Han, Jing Li, Ping Liang, Guohua Zuo, Yu Zhang, Hongyan Li
    World Journal of Surgical Oncology.2012;[Epub]     CrossRef
  • Malignant Pleural Mesothelioma Presenting as an Acute Surgical Abdomen due to Metastatic Jejunal Perforation
    Kyoko Gocho, Kazutoshi Isobe, Kyohei Kaburaki, Yoshiko Honda, Aki Mitsuda, Yoshikiyo Akasaka, Nagato Shimada, Keigo Takagi, Sakae Homma
    Internal Medicine.2010; 49(6): 597.     CrossRef
  • 10,216 View
  • 69 Download
  • 13 Crossref
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