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2 "Moran Ki"
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Gastrointestinal Cancer
Population Attributable Fraction of Helicobacter pylori Infection–Related Gastric Cancer in Korea: A Meta-Analysis
Yoon Park, Moran Ki
Cancer Res Treat. 2021;53(3):744-753.   Published online December 15, 2020
DOI: https://doi.org/10.4143/crt.2020.610
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
This study aimed to determine the proportion of gastric cancer attributable to Helicobactor pylori in the Korean population. Infection with H. pylori has been recognized as the most significant risk factor for gastric cancer. In Korea, gastric cancer is the most common cancer that accounted for 13.3% of all cancers in 2016. In particular, men are most commonly diagnosed with gastric cancer; the age-standardized incidence rate in men is 49.6 per 100,000, which is more than twice the incidence in women.
Materials and Methods
The population attributable fraction (PAF) was calculated as a function of the relative risk (RR) of gastric cancer associated with H. pylori infections. To estimate PAF of gastric cancer due to H. pylori, the prevalence of H. pylori infections was extrapolated for the year of 1990 and a pooled RR was obtained by conducting a meta-analysis of studies recently published in Korea.
Results
The estimated prevalence of H. pylori was 76.4% in men and 71.9% in women. The RRs (95% confidence interval) pooled from case-control studies using a random effects model was 1.69 (1.29-2.22) for overall gastric cancer and 2.17 (1.04-4.55) for non-cardia gastric cancer. Using the RR for overall gastric cancer, the estimated PAFs due to H. pylori were 34.5% in men and 33.2% in women.
Conclusion
The occurrence of gastric cancer in Koreans may be affected by other risk factors in addition to H. pylori infection, which may contribute to increasing baseline risk for gastric cancer.

Citations

Citations to this article as recorded by  
  • Trends of gastric cancer burdens attributable to risk factors in China from 2000 to 2050
    Feifan He, Shaoming Wang, Rongshou Zheng, Jianhua Gu, Hongmei Zeng, Kexin Sun, Ru Chen, Li Li, Bingfeng Han, Xinqing Li, Wenqiang Wei, Jie He
    The Lancet Regional Health - Western Pacific.2024; 44: 101003.     CrossRef
  • Estimation of the benefit from pre‐emptive genotyping based on the nationwide cohort data in South Korea
    Ki Young Huh, Sejung Hwang, Joo Young Na, Kyung‐Sang Yu, In‐Jin Jang, Jae‐Yong Chung, Seonghae Yoon
    Clinical and Translational Science.2024;[Epub]     CrossRef
  • Unveiling the Younger Face of Gastric Cancer: A Comprehensive Review of Epidemiology, Risk Factors, and Prevention Strategies
    Kai Kang, Mary Angelica Bagaoisan, YuXin Zhang
    Cureus.2024;[Epub]     CrossRef
  • Gastric cancer—Epidemiology, modifiable and non-modifiable risk factors, challenges and opportunities: An updated review
    Tajul Islam Mamun, Sabrina Younus, Md. Hashibur Rahman
    Cancer Treatment and Research Communications.2024; 41: 100845.     CrossRef
  • Risk factors for gastric cancer: A comprehensive analysis of observational studies
    Yuqing Hui, Chunyi Tu, Danlei Liu, Huijie Zhang, Xiaobing Gong
    Frontiers in Public Health.2023;[Epub]     CrossRef
  • Cardia and non‐cardia gastric cancer risk associated with Helicobacter pylori in East Asia and the West: A systematic review, meta‐analysis, and estimation of population attributable fraction
    Zhongxue Han, Jing Liu, Wenlin Zhang, Qingzhou Kong, Meng Wan, Minjuan Lin, Boshen Lin, Yuming Ding, Miao Duan, Yueyue Li, Xiuli Zuo, Yanqing Li
    Helicobacter.2023;[Epub]     CrossRef
  • Impact of Disability Status on Mortality in Patients with Gastric Cancer: A Nationwide Study Focusing on Regional Disparities
    Woo-Ri Lee, Kyu-Tae Han, Mingee Choi, Seojin Park, Woorim Kim
    Healthcare.2023; 11(5): 641.     CrossRef
  • Characteristics of phenotypic antibiotic resistance of Helicobacter pylori and its correlation with genotypic antibiotic resistance: A retrospective study in Ningxia
    Shengjuan Hu, Yan Zhou, Yanhong Deng, Yang Bo, Xianmei Chen, Wei Yang, Ruichun Shi, Wei Zhao, Zhanbing Hou, Jianping Hu, Jianguo Liu, Xilong Zhang, Heli Yong, Ping Wang, Fei Li, Hailong Qi, Xiaoyun Wang, Lijuan Jin, Ting Cui, Haijiang Yong, Xue Li, Bin Ya
    Helicobacter.2023;[Epub]     CrossRef
  • Comparison of the Concordance of Allergic Diseases between Monozygotic and Dizygotic Twins: A Cross-Sectional Study Using KoGES HTS Data
    Eun Lee, Joo-Hee Kim, Hyo Choi, Ho Kang, Hyun Lim, Ji Kim, Seong-Jin Cho, Eun Nam, Ha Park, Nan Kim, Mi Kwon
    Journal of Personalized Medicine.2023; 13(5): 721.     CrossRef
  • Updated Epidemiology of Gastric Cancer in Asia: Decreased Incidence but Still a Big Challenge
    Wing Sum Shin, Fuda Xie, Bonan Chen, Peiyao Yu, Jun Yu, Ka Fai To, Wei Kang
    Cancers.2023; 15(9): 2639.     CrossRef
  • Associations between Physical Activity and Incidence of Cancer among Overweight Adults in Korea: Results from the Health Examinees-G Study
    Jaesung Choi, JooYong Park, Ji-Eun Kim, Miyoung Lee, Daehee Kang, Aesun Shin, Ji-Yeob Choi
    Cancer Prevention Research.2023; 16(7): 405.     CrossRef
  • Risk Factors to Predict Ocular Metastasis in Older Adult Patients With Gastric Cancer:LDL, ApoA1, and CA724
    Wen-Qing Shi, Shi-Nan Wu, Tie Sun, Hui-Ye Shu, Qi-Chen Yang, Qiu-Yu Li, Ting Su, Yi-Cong Pan, Rong-Bin Liang, Yi Shao
    Technology in Cancer Research & Treatment.2022;[Epub]     CrossRef
  • Effect of gastric cancer screening on long-term survival of gastric cancer patients: results of Korean national cancer screening program
    Xuan Quy Luu, Kyeongmin Lee, Jae Kwan Jun, Mina Suh, Kyu-Won Jung, Kui Son Choi
    Journal of Gastroenterology.2022; 57(7): 464.     CrossRef
  • Comparison of Concordance of Peptic Ulcer Disease, Non-Adenomatous Intestinal Polyp, and Gallstone Disease in Korean Monozygotic and Dizygotic Twins: A Cross-Sectional Study
    Hyo Geun Choi, So Young Kim, Hyun Lim, Joo-Hee Kim, Ji Hee Kim, Seong-Jin Cho, Eun Sook Nam, Kyueng-Whan Min, Ha Young Park, Nan Young Kim, Sangkyoon Hong, Younghee Choi, Ho Suk Kang, Mi Jung Kwon
    International Journal of Environmental Research and Public Health.2022; 19(19): 12708.     CrossRef
  • Cancer Etiology and Prevention Principle: “1 + X”
    Hui Liu, Zigang Dong
    Cancer Research.2021; 81(21): 5377.     CrossRef
  • 8,002 View
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  • 15 Web of Science
  • 15 Crossref
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Trends and Age-Period-Cohort Effects on the Incidence and Mortality Rate of Cervical Cancer in Korea
Eun-Kyeong Moon, Chang-Mo Oh, Young-Joo Won, Jong-Keun Lee, Kyu-Won Jung, Hyunsoon Cho, Jae Kwan Jun, Myong Cheol Lim, Moran Ki
Cancer Res Treat. 2017;49(2):526-533.   Published online September 1, 2016
DOI: https://doi.org/10.4143/crt.2016.316
AbstractAbstract PDFPubReaderePub
Purpose
This study was conducted to describe the trends and age-period-cohort effects on the incidence and mortality rate of cervical cancer in Korea.
Materials and Methods
The incidence and mortality rate of cervical cancer among ≥ 20-year-old women from 1993 to 2012 were obtained from the Korea Central Cancer Registry and the Korean Statistical Information Service. Age-standardized rates were calculated and Joinpoint regression was used to evaluate the trends in the incidence and mortality rate. Age-period-cohort analysis was performed to investigate the independent effects of age, period and cohort.
Results
The incidence of cervical cancer decreased from 32.8 per 100,000 in 1993 to 15.9 per 100,000 in 2012 (annual percent change [APC], –3.9%; 95% confidence interval [CI], –4.2% to –3.6%). The mortality rate decreased from 5.2 per 100,000 in 1993 to 2.1 per 100,000 in 2012 (APC, –4.8%; 95% CI, –5.1% to –4.4%); however, the incidence and mortality rates among young women (< 30 years old) increased. An age-period-cohort model of the incidence and mortality rate showed decreasing period effects between 1993 and 2008 and decreasing cohort effects between 1928 and 1973, while birth cohorts after 1973 exhibited slight increases in the incidence and mortality rate of cervical cancer.
Conclusion
Recent decreases in the incidence and mortality rate of cervical cancer were due to decreases in the period and cohort effects, which reflect the implementation of a cancer screening program and changes in lifestyle. However, our findings also highlighted an increase in cohort effects on the incidence and mortality rate among young women born after 1973.

Citations

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  • Age-period-cohort analysis of self-harm incidence rates by gender in Iran among individuals aged 10–39 years, 1990–2019
    Yousef Ramazani, Alireza Abdi, Shahab Rezaeian, Farid Najafi, Zhyla Aliyavari, Mehdi Moradinazar
    Scientific Reports.2025;[Epub]     CrossRef
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    Subhadra Priyadarshini, Prafulla Kumar Swain, Khushi Agarwal, Diptismita Jena, Sourav Padhee
    AGING MEDICINE.2024; 7(2): 179.     CrossRef
  • Determination of ovarian transposition through prediction of postoperative adjuvant therapy in young patients with early stage cervical cancer undergoing surgery: a Korean multicenter retrospective study (KGOG 1042)
    Woo Yeon Hwang, Chel Hun Choi, Kidong Kim, Moon-Hong Kim, Myong Cheol Lim, Banghyun Lee, Myounghwan Kim, Yun Hwan Kim, Seok Ju Seong, Jong-Min Lee
    Obstetrics & Gynecology Science.2024; 67(3): 296.     CrossRef
  • Global, regional, and national trends in mesothelioma burden from 1990 to 2019 and the predictions for the next two decades
    Wenmin Zhu, Jialin Liu, Yiling Li, Ziwei Shi, Sheng Wei
    SSM - Population Health.2023; 23: 101441.     CrossRef
  • Changes in cervical dysplasia, carcinoma in situ, and cervical cancer after expanding the National Cancer Screening Program to younger women in Korea
    Woorim Kim, Sungyoun Chun, Sang Ah Lee
    International Journal for Quality in Health Care.2023;[Epub]     CrossRef
  • Secular trend in disease burden of leukemia and its subtypes in China from 1990 to 2019 and its projection in 25 years
    Dongdong Niu, Yumei Zhao, Jia Wang, Enlin Ye, Jiasheng Huang, Jie Liu, Xueying Huang, Suru Yue, Xuefei Hou, Jiayuan Wu
    Annals of Hematology.2023; 102(9): 2375.     CrossRef
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    Huanan Kang, Yiming Sun, Xijiao Hu, Li Liu
    Journal of Biochemical and Molecular Toxicology.2022;[Epub]     CrossRef
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    International Journal of Environmental Research and Public Health.2022; 19(9): 5591.     CrossRef
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    Kexin Sun, Rongshou Zheng, Lin Lei, Siwei Zhang, Hongmei Zeng, Shaoming Wang, Li Li, Ru Chen, Bingfeng Han, Ji Peng, Wenqiang Wei, Jie He
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  • 14,706 View
  • 351 Download
  • 35 Web of Science
  • 36 Crossref
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