Cancer Research and Treatment

Original Articles

Predictive Factors for Radiation Pneumonitis in Lung Cancer Treated with Helical Tomotherapy: Youngkyong Kim, Seong Eon Hong, Moonkyoo Kong, Jinhyun Choi; Cancer Res Treat. 2013;45(4):295-302. Published online December 31, 2013; DOI: https://doi.org/10.4143/crt.2013.45.4.295

PURPOSE
Predictive factors for radiation pneumonitis (RP) after helical tomotherapy (HT) may differ from those after linac-based radiotherapy. In this study, we identified predictive factors for RP in patients with lung cancer treated with HT.
MATERIALS AND METHODS
We retrospectively analyzed clinical, treatment-related and dosimetric factors from 31 patients with lung cancer treated with HT. RP was graded according to Common Terminology Criteria for Adverse Events version 4.0 and grade > or =2 RP was defined as a RP event. We used Kaplan-Meier methods to compute the actuarial incidence of RP. For univariate and multivariate analysis, the log-rank test and the Cox proportional regression hazard model were used. We generated receiver-operating characteristics (ROC) curves to define the cutoff values for significant parameters.
RESULTS
The median follow-up duration was 6.6 months (range, 1.6 to 38.5 months). The 2-, 4-, and 6-month actuarial RP event rates were 13.2%, 58.5%, and 67.0%, respectively. There was no grade 4 or more RP. Ipsilateral V5, V10, V15, and contralateral V5 were related with RP event on univariate analysis. By multivariate analysis, ipsilateral V10 was factor most strongly associated with RP event. On the ROC curve, the cutoff values of ipsilateral V5, V10, V15, and contralateral V5 were 67.5%, 58.5%, 50.0%, and 55.5%, respectively.
CONCLUSION
In our study, ipsilateral V5, V10, V15, and contralateral V5 were significant predictive factors for RP after HT.

Citations

Citations to this article as recorded by

A controlled trial comparing dosimetry and radiation pneumonitis between tomotherapy and IMRT in patients with lung or esophageal cancer
Anmei Zhang, Yang Zhang, Jingyun Yang, Lu Chen, Na Wu, Jindong Qian, Hongya Dai, Dingqiang Yang, Lirong Zhao, Liangzhi Zhong, Tianxiang Cui, Fan Yang, Guangpeng Chen, Yixing Gao, Wen Luo, Guanghui Li
Journal of Applied Clinical Medical Physics.2026;[Epub] CrossRef
Predictive factors for severe radiation-induced lung injury in patients with lung cancer and coexisting interstitial lung disease
Shin-Hyung Park, Jae-Kwang Lim, Min Kyu Kang, Jongmoo Park, Chae Moon Hong, Chang Ho Kim, Seung Ick Cha, Jaehee Lee, Seoung-Jun Lee, Jae-Chul Kim
Radiotherapy and Oncology.2024; 192: 110053. CrossRef
Deep-Learning Model Prediction of Radiation Pneumonitis Using Pretreatment Chest Computed Tomography and Clinical Factors
Jang Hyung Lee, Min Kyu Kang, Jongmoo Park, Seoung-Jun Lee, Jae-Chul Kim, Shin-Hyung Park
Technology in Cancer Research & Treatment.2024;[Epub] CrossRef
Pulmonary toxicity of craniospinal irradiation using helical tomotherapy
Joongyo Lee, Euidam Kim, Nalee Kim, Chang-Ok Suh, Yoonsun Chung, Hong In Yoon
Scientific Reports.2022;[Epub] CrossRef
Comparison of Radiation Pneumonitis in Lung Cancer Patients Treated with HT versus IMRT and Circulating Lymphocyte Subsets as Predicting Risk Factors
Xin Zhang, Dingyi Yang, Yong Jiang, Luo Huang, Can Wang, Dan Tao, Xianfeng Liu, Yongyang Lei, Yongzhong Wu, Wei Zhou
Journal of Inflammation Research.2021; Volume 14: 4205. CrossRef
The Efficacy and Safety of Acupuncture for Preventing Radiation Pneumonitis in Patients With Lung Cancer: A Prospective, Single-Blinded, Randomized Pilot Proof-of-Principle Study
Moonkyoo Kong, Seung Hyeun Lee, Jaehyo Kim, Beom-Joon Lee, Kwan-Il Kim
Integrative Cancer Therapies.2020;[Epub] CrossRef
Phase II study of compensator-based non-coplanar intensity-modulated radiotherapy for Stage I non–small-cell lung cancer
Tomohiro Itonaga, Ryuji Mikami, Hidetsugu Nakayama, Tatsuhiko Saito, Sachika Shiraishi, Mitsuru Okubo, Shinji Sugahara, Norihiko Ikeda, Koichi Tokuuye
Journal of Radiation Research.2019; 60(3): 387. CrossRef
Dosimetric Comparison Between Jaw Tracking and No Jaw Tracking in Intensity-Modulated Radiation Therapy
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Technology in Cancer Research & Treatment.2019;[Epub] CrossRef
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Physics in Medicine & Biology.2019; 64(19): 195008. CrossRef
Treatment outcomes and patterns of radiologic appearance after hypofractionated image-guided radiotherapy delivered with helical tomotherapy (HHT) for lung tumours
Stefano Arcangeli, Lorenzo Falcinelli, Stefano Bracci, Alessandro Greco, Alessia Monaco, Jessica Dognini, Cinzia Chiostrini, Rita Bellavita, Cynthia Aristei, Vittorio Donato
The British Journal of Radiology.2017;[Epub] CrossRef
Patterns of CT lung injury and toxicity after stereotactic radiotherapy delivered with helical tomotherapy in early stage medically inoperable NSCLC
S Arcangeli, L Agolli, L Portalone, M R Migliorino, M G Lopergolo, A Monaco, J Dognini, M C Pressello, S Bracci, V Donato
The British Journal of Radiology.2015; 88(1048): 20140728. CrossRef
Early Toxicity in Patients Treated With Postoperative Proton Therapy for Locally Advanced Breast Cancer
John J. Cuaron, Brian Chon, Henry Tsai, Anuj Goenka, David DeBlois, Alice Ho, Simon Powell, Eugen Hug, Oren Cahlon
International Journal of Radiation Oncology*Biology*Physics.2015; 92(2): 284. CrossRef
Risk of radiation-induced pneumonitis after helical and static-port tomotherapy in lung cancer patients and experimental rats
Xianglan Zhang, You Keun Shin, Zhenlong Zheng, Lianhua Zhu, Ik Jae Lee
Radiation Oncology.2015;[Epub] CrossRef
Dosimetric Comparisons of Lung SBRT with Multiple Metastases by Two Advanced Planning Systems
Ye Zhang, Yie Chen, Jie Qiu, Jack Yang
International Journal of Medical Physics, Clinical Engineering and Radiation Oncology.2014; 03(04): 252. CrossRef
Frameless stereotactic body radiation therapy for multiple lung metastases
Qilin Li, Jinming Mu, Wendong Gu, Yuan Chen, Zhonghua Ning, Jianxue Jin, Honglei Pei
Journal of Applied Clinical Medical Physics.2014; 15(4): 105. CrossRef

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Which Patients Might Benefit from Postmastectomy Radiotherapy in Breast Cancer Patients with T1-2 Tumor and 1-3 Axillary Lymph Nodes Metastasis?: Moonkyoo Kong, Seong Eon Hong; Cancer Res Treat. 2013;45(2):103-111. Published online June 30, 2013; DOI: https://doi.org/10.4143/crt.2013.45.2.103

Abstract PDF PubReader ePub

PURPOSE
This study compared the clinical outcomes of T1-2N1 breast cancer patients with and without postmastectomy radiotherapy (PMRT). Risk factors for loco-regional recurrence (LRR) were identified in order to define a subgroup of patients who might benefit from PMRT.
MATERIALS AND METHODS
Of 110 T1-2N1 breast cancer patients who underwent mastectomy from January 1994 through December 2009, 32 patients underwent PMRT and 78 patients did not. Treatment outcomes and risk factors for LRR were analyzed.
RESULTS
The 5- and 10-year LRR rates were both 6.2% in the PMRT group, and 10.4% and 14.6% in the no-PMRT group (p=0.336). In addition, no significant differences in distant metastasis-free survival (DMFS) or overall survival (OS) were observed between patients receiving and not receiving PMRT. In multivariate analysis, factors associated with higher LRR rates included grade 3 disease, extracapsular extension (ECE), and triple negative subtype. Patients who had one or more risk factors for LRR were defined as a high-risk patient group. In the high-risk group, both 5- and 10-year LRR rates for patients who underwent PMRT was 18.2%, and LRR rates of 21.4% at five years and 36.6% at 10 years were observed for patients who did not undergo PMRT (p=0.069).
CONCLUSION
PMRT in T1-2N1 breast cancer patients should be considered according to several prognostic factors in addition to T and N stage. Findings of our study indicated that PMRT did not improve LRR, DMFS, or OS in T1-2N1 breast cancer patients. However, in a subgroup of patients with grade 3 disease, ECE, or triple negative subtype, PMRT might be beneficial.

Citations

Citations to this article as recorded by

Postmastectomy radiation therapy for patients with pT1-2N1 breast cancer over 2 decades in Korea: Korean Radiation Oncology Group 14-21
Mi Sun Kim, Seung Do Ahn, Yong Bae Kim, Won Park, Shin-Hyung Park, Ik Jae Lee, Byung-Ock Choi, Juri Kim, Sung Ja Ahn, Won Sup Yoon, Jin-hee Kim, Jong Hoon Lee, Donghyun Kim, Hye Li Park, Yeon-Joo Kim, Sun Young Lee, Kyung Ran Park
Radiation Oncology Journal.2025; 43(4): 172. CrossRef
A Prognostic Risk Stratification Model to Identify Potential Population Benefiting From Postmastectomy Radiotherapy in T1–2 Breast Cancer With 1–3 Positive Axillary Lymph Nodes
Niuniu Hou, Juliang Zhang, Lu Yang, Ying Wu, Zhe Wang, Mingkun Zhang, Li Yang, Guangdong Hou, Jianfeng Wu, Yidi Wang, Bingyao Dong, Lili Guo, Mei Shi, Rui Ling
Frontiers in Oncology.2021;[Epub] CrossRef
SKIN AND SUBCUTANEOUS ADIPOSE TISSUE DAMAGE AFTER RADIATION THERAPY IN BREAST CANCER PATIENTS
D. Bazyka, O. Litvinenko, S. Bugaytsov, G. Shakhrai
Проблеми радіаційної медицини та радіобіології = Problems of Radiation Medicine and Radiobiology.2021; 26: 18. CrossRef
Multidisciplinary Management of the Axilla in Patients with cT1-T2 N0 Breast Cancer Undergoing Primary Mastectomy: Results from a Prospective Single-Institution Series
Samantha Grossmith, Anvy Nguyen, Jiani Hu, Jennifer K. Plichta, Faina Nakhlis, Linda Cutone, Laura Dominici, Mehra Golshan, Margaret Duggan, Katharine Carter, Esther Rhei, Thanh Barbie, Katherina Calvillo, Suniti Nimbkar, Jennifer Bellon, Julia Wong, Rina
Annals of Surgical Oncology.2018; 25(12): 3527. CrossRef
A prognostic score model to determine which breast cancer patients with 1-3 positive lymph nodes after modified radical mastectomy should receive radiotherapy
Dawei Chen, Haiyong Wang, Xinyu Song, Fang Shi, Li Kong, Jinming Yu
Oncotarget.2018; 9(1): 385. CrossRef
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Jiamao Lin, Cheng Li, Chenyue Zhang, Fang Shi, Haiyong Wang
Future Oncology.2017; 13(16): 1395. CrossRef
Predicting loco-regional recurrence risk in T1, T2 breast cancer with 1–3 positive axillary nodes postmastectomy: Development of a predictive nomogram
T Wadasadawala, S Kannan, S Gudi, A Rishi, A Budrukkar, V Parmar, T Shet, S Desai, S Gupta, R Badwe, R Sarin
Indian Journal of Cancer.2017; 54(1): 352. CrossRef
Comparison of Treatment Outcomes between Breast Conserving Surgery Followed by Radiotherapy and Mastectomy Alone in Patients with T1-2 Stage and 1-3 Axillary Lymph Nodes in the Era of Modern Adjuvant Systemic Treatments
Sang-Won Kim, Mison Chun, Sehwan Han, Yong Sik Jung, Jin Hyuk Choi, Seok Yun Kang, Hyunsoo Jang, Sunmi Jo, William B. Coleman
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Improvement of survival with postmastectomy radiotherapy in patients with 1-3 positive axillary lymph nodes: A systematic review and meta-analysis of the current literature
Hannah Headon, Abdul Kasem, Reham Almukbel, Kefah Mokbel
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ABCB1polymorphism as prognostic factor in breast cancer patients treated with docetaxel and doxorubicin neoadjuvant chemotherapy
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Cancer Science.2015; 106(1): 86. CrossRef
Conservative Axillary Surgery in Breast Cancer Patients Undergoing Mastectomy: Long-Term Results
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Journal of the American College of Surgeons.2014; 218(4): 819. CrossRef

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Preoperative Concurrent Chemoradiotherapy for Locally Advanced Rectal Cancer: Treatment Outcomes and Analysis of Prognostic Factors: Moonkyoo Kong, Seong Eon Hong, Woo Suk Choi, Si-Young Kim, Jinhyun Choi; Cancer Res Treat. 2012;44(2):104-112. Published online June 30, 2012; DOI: https://doi.org/10.4143/crt.2012.44.2.104

Abstract PDF PubReader ePub

PURPOSE
This study was designed to investigate the long-term oncologic outcomes for locally advanced rectal cancer patients after treatment with preoperative concurrent chemoradiotherapy followed by total mesorectal excision, and to identify prognostic factors that affect survival and pathologic response.
MATERIALS AND METHODS
From June 1996 to June 2009, 135 patients with locally advanced rectal cancer were treated with preoperative concurrent chemoradiotherapy followed by total mesorectal excision at Kyung Hee University Hospital. Patient data was retrospectively collected and analyzed in order to determine the treatment outcomes and identify prognostic factors for survival.
RESULTS
The median follow-up time was 50 months (range, 4.5 to 157.8 months). After preoperative chemoradiotherapy, sphincter preservation surgery was accomplished in 67.4% of whole patients. A complete pathologic response was achieved in 16% of patients. The estimated 5- and 8-year overall survival, loco-regional recurrence-free survival, and distant metastasis-free survival rate for all patients was 82.7% and 75.7%, 76.8% and 71.9%, 67.9% and 63.3%, respectively. The estimated 5- and 8-year overall survival, loco-regional recurrence-free survival, and distant metastasis-free survival rate for pathologic complete responders was 100% and 100%, 100% and 88.9%, 95.5% and 95.5%, respectively. In the multivariate analysis, pathologic complete response was significantly associated with overall survival. The predictive factor for pathologic complete response was pretreatment clinical stage.
CONCLUSION
Preoperative chemoradiotherapy for locally advanced rectal cancer resulted in a high rate of overall survival, sphincter preservation, down-staging, and pathologic complete response. The patients achieving pathologic complete response had very favorable outcomes. Pathologic complete response was a significant prognostic factor for overall survival and the significant predictive factor for a pathologic complete response was pretreatment clinical stage.

Citations

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