Skip Navigation
Skip to contents

Cancer Res Treat : Cancer Research and Treatment

OPEN ACCESS

Search

Page Path
HOME > Search
2 "Moonjin Kim"
Filter
Filter
Article category
Keywords
Publication year
Authors
Funded articles
Original Articles
The Role of Plasma Chromogranin A as Assessment of Treatment Response in Non-functioning Gastroenteropancreatic Neuroendocrine Tumors
Moonjin Kim, Sujin Lee, Jeeyun Lee, Se Hoon Park, Joon Oh Park, Young Suk Park, Won Ki Kang, Seung Tae Kim
Cancer Res Treat. 2016;48(1):153-161.   Published online March 7, 2015
DOI: https://doi.org/10.4143/crt.2014.183
AbstractAbstract PDFPubReaderePub
Purpose
Chromogranin A (CgA) has been considered to be valuable not only in the diagnosis but also in monitoring the disease response to treatment. However, only a few studies have been published on this issue. We purposed to evaluate whether biochemical response using plasma CgA level is reliable in concordance with the clinical response of grade 1-3 nonfunctiong gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Materials and Methods Between March 2011 and September 2013, a total of 27 cases in 18 patients were analysed, clinically and radiologically while serial CgA tests were also conducted during treatment. Tumor responses were defined by both Response Evaluation Criteria in Solid Tumors (RECIST) criteria ver. 1.1 and biochemical criteria based on the CgA level.
Results
Among the 27 cases analysed, no difference in the basal CgA level was observed with regard to gender, primary tumor site, tumor grade (World Health Organization classification), liver metastasis, number of metastatic site, and line of chemotherapy. The overall response rate (RR) by RECIST criteria ver. 1.1 was six out of the 27 cases (22.2%) and eight out of the 27 cases (29.6%) for biochemical RR. The overall concordance rates of the response based on RECIST and biochemical criteria were 74%. In grades 1 and 2 GEP-NETs (n=17), the concordance rate of the disease control was 94.1%. There was a significant difference for progression- free survival (PFS) between responders and non-responder in accordance to biochemical criteria (35.73 months vs. 5.93 months, p=0.05). Conclusion This study revealed that changes of the plasma CgA levels were associated with tumour response. Additionally, biochemical response based on serial CgA may be a predictive marker for PFS in GEP-NETs.

Citations

Citations to this article as recorded by  
  • Response heterogeneity as a new biomarker of treatment response in patients with neuroendocrine tumors
    Clarisse Dromain, Marianne Pavel, Maxime Ronot, Niklaus Schaefer, Dalvinder Mandair, Delphine Gueguen, Catherine Cheng, Olivier Dehaene, Kathryn Schutte, David Cahané, Simon Jégou, Félix Balazard
    Future Oncology.2023; 19(32): 2171.     CrossRef
  • Predictive Factors for Resistant Disease with Medical/Radiologic/Liver-Directed Anti-Tumor Treatments in Patients with Advanced Pancreatic Neuroendocrine Neoplasms: Recent Advances and Controversies
    Lingaku Lee, Irene Ramos-Alvarez, Robert T. Jensen
    Cancers.2022; 14(5): 1250.     CrossRef
  • Volumetric 68Ga-DOTA-TATE PET/CT for assessment of whole-body tumor burden as a quantitative imaging biomarker in patients with metastatic gastroenteropancreatic neuroendocrine tumors
    Fiona OHLENDORF, Christoph HENKENBERENS, Thomas BRUNKHORST, Tobias L. ROSS, Hans CHRISTIANSEN, Frank M. BENGEL, Thorsten DERLIN
    The Quarterly Journal of Nuclear Medicine and Molecular Imaging.2022;[Epub]     CrossRef
  • Chromogranin A and serotonin for evaluation of treatment efficacy of neuroendocrine tumors
    N. V. Lyubimova, Yu. S. Timofeev, T. K. Churikova, A. A. Markovich, G. S. Emelianova, I. S. Stilidi, N. E. Kushlinskii
    Almanac of Clinical Medicine.2020; 47(8): 685.     CrossRef
  • Early response assessment and prediction of overall survival after peptide receptor radionuclide therapy
    Daphne M. V. Huizing, Else A. Aalbersberg, Michelle W. J. Versleijen, Margot E. T. Tesselaar, Iris Walraven, Max J. Lahaye, Berlinda J. de Wit–van der Veen, Marcel P. M. Stokkel
    Cancer Imaging.2020;[Epub]     CrossRef
  • From Mouth to Brain: Neuroendocrine Markers Play as a Crosstalk Among Oral and Neurodegenerative Diseases
    Marco Tatullo, Bruna Codispoti, Irina Makeeva, Caterina Benincasa, Gianrico Spagnuolo
    Frontiers in Endocrinology.2019;[Epub]     CrossRef
  • Ki-67 Index of 5% is Better Than 2% in Stratifying G1 and G2 of the World Health Organization Grading System in Pancreatic Neuroendocrine Tumors
    Shao-Wei Gao, Chen-Song Huang, Xi-Tai Huang, Liu-Hua Chen, Wei Chen, Jian-Peng Cai, Xiao-Yu Yin
    Pancreas.2019; 48(6): 795.     CrossRef
  • Baseline plasma chromogranin A levels in patients with well-differentiated neuroendocrine tumors of the pancreas: A potential predictor of postoperative recurrence
    Yoshihide Nanno, Hirochika Toyama, Ippei Matsumoto, Kyoko Otani, Sadaki Asari, Tadahiro Goto, Tetsuo Ajiki, Yoh Zen, Takumi Fukumoto, Yonson Ku
    Pancreatology.2017; 17(2): 291.     CrossRef
  • Clinical outcomes of everolimus in patients with advanced, nonfunctioning pancreatic neuroendocrine tumors: a multicenter study in Korea
    Kyong Joo Lee, Jae Hee Cho, Sang Hyub Lee, Si Young Song, Kwang Hyuk Lee, Seok Jeong, Ji Kon Ryu, Sang Myung Woo, Seungmin Bang, Jong Kyun Lee, Tae Hoon Lee, Woo Hyun Paik, Yong Tae Kim, Woo Jin Lee
    Cancer Chemotherapy and Pharmacology.2017; 80(4): 799.     CrossRef
  • 15,972 View
  • 110 Download
  • 11 Web of Science
  • 9 Crossref
Close layer
Impact on Survival of Regular Postoperative Surveillance for Patients with Early Breast Cancer
Ji Yun Lee, Sung Hee Lim, Min-Young Lee, Haesu Kim, Moonjin Kim, Sungmin Kim, Hyun Ae Jung, Insuk Sohn, Won Ho Gil, Jeong Eon Lee, Seok Won Kim, Seok Jin Nam, Jin Seok Ahn, Young-Hyuck Im, Yeon Hee Park
Cancer Res Treat. 2015;47(4):765-773.   Published online January 13, 2015
DOI: https://doi.org/10.4143/crt.2014.168
AbstractAbstract PDFPubReaderePub
Purpose
The purpose of this study is to evaluate the role of regular postoperative surveillance to improve the prognosis of patients with breast cancer after curative surgery. Materials and Methods We retrospectively analyzed the medical records of 4,119 patients who received curative surgery for breast cancer at Samsung Medical Center between January 2000 and September 2008. Patients were divided into two groups (group I, regular postoperative surveillance; group II, control group) according to their post-therapy follow-up status for the first 5 years after surgery. Results Among the 3,770 patients selected for inclusion, groups I and II contained 3,300 (87%) and 470 (13%) patients, respectively. The recurrence rates at 5 years for groups I and II were 10.6% and 16.4%, respectively (hazard ratio, 0.85; 95% confidence interval [CI], 0.67 to 1.09; p=0.197). The 10-year mortality cumulative rates were 8.8% for group I and 25.4% for group II (hazard ratio, 0.28; 95% CI, 0.22 to 0.35; p < 0.001). In multivariate analysis for recurrence-free survival (RFS), age over 40 years (p < 0.001), histologic grade 1 (p < 0.001), and pathologic stage I (p < 0.001) were associated with longer RFS but not with follow- up status. Multivariate analysis for overall survival (OS) revealed that patients in group I showed significantly improved OS (hazard ratio, 0.29; 95% CI, 0.23 to 0.37; p < 0.001). Additionally, age over 40 years, histologic grade I, and pathologic stage I were independent prognostic factors for OS. Conclusion Regular follow-up for patients with breast cancer after primary surgery resulted in clinically significant improvements in patient OS.

Citations

Citations to this article as recorded by  
  • Follow-up strategy and survival for five common cancers: A meta-analysis
    Boris Galjart, Diederik J. Höppener, Joachim G.J.V. Aerts, Christiaan H. Bangma, Cornelis Verhoef, Dirk J. Grünhagen
    European Journal of Cancer.2022; 174: 185.     CrossRef
  • Clinical Features and Outcomes of Invasive Breast Cancer: Age-Specific Analysis of a Modern Hospital-Based Registry
    Ji-Yeon Kim, Danbee Kang, Seok Jin Nam, Seok Won Kim, Jeong Eon Lee, Jong Han Yu, Se Kyung Lee, Young-Hyuck Im, Jin Seok Ahn, Eliseo Guallar, Juhee Cho, Yeon Hee Park
    Journal of Global Oncology.2019; (5): 1.     CrossRef
  • Follow-Up Recommendations after Curative Resection of Well-Differentiated Neuroendocrine Tumours: Review of Current Evidence and Clinical Practice
    Angela Lamarca, Hamish Clouston, Jorge Barriuso, Mairéad G McNamara, Melissa Frizziero, Was Mansoor, Richard A Hubner, Prakash Manoharan, Sarah O’Dwyer, Juan W Valle
    Journal of Clinical Medicine.2019; 8(10): 1630.     CrossRef
  • Analysis of patient-detected breast cancer recurrence
    Trishul Kapoor, Sean Wrenn, Peter Callas, Ted A. James
    Breast Disease.2017; 37(2): 77.     CrossRef
  • 12,111 View
  • 90 Download
  • 3 Web of Science
  • 4 Crossref
Close layer

Cancer Res Treat : Cancer Research and Treatment
Close layer
TOP