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Original Articles
The Impact of Skin Problems on the Quality of Life in Patients Treated with Anticancer Agents: A Cross-Sectional Study
Jaewon Lee, Jin Lim, Jong Seo Park, Miso Kim, Tae-Yong Kim, Tae Min Kim, Kyung-Hun Lee, Bhumsuk Keam, Sae-Won Han, Je-Ho Mun, Kwang Hyun Cho, Seong Jin Jo
Cancer Res Treat. 2018;50(4):1186-1193.   Published online December 14, 2017
DOI: https://doi.org/10.4143/crt.2017.435
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
Patients treated with anticancer agents often experience a variety of treatment-related skin problems, which can impair their quality of life.
Materials and Methods
In this cross-sectional study, Dermatology Life Quality Index (DLQI) and clinical information were evaluated in patients under active anticancer treatment using a questionnaire survey and their medical records review.
Results
Of 375 evaluated subjects with anticancer therapy, 136 (36.27%) and 114 (30.40%) were treated for breast cancer and colorectal cancer, respectively. We found that women, breast cancer, targeted agent use, and longer duration of anticancer therapy were associated with higher dermatology-specific quality of life distraction. In addition, itching, dry skin, easy bruising, pigmentation, papulopustules on face, periungual inflammation, nail changes, and palmoplantar lesions were associated with significantly higher DLQI scores. Periungual inflammation and palmoplantar lesions scored the highest DLQI.
Conclusion
We believe our findings can be helpful to clinicians in counseling and managing the patients undergoing anticancer therapy.

Citations

Citations to this article as recorded by  
  • The Impact of Dermatologic Adverse Events on the Quality of Life of Oncology Patients: A Review of the Literature
    Annika Belzer, Jolanta J. Pach, Kailyn Valido, Jonathan S. Leventhal
    American Journal of Clinical Dermatology.2024; 25(3): 435.     CrossRef
  • Quality of Life Impact in Patients with Cutaneous Toxicities Caused by Epidermal Growth Factor Receptor Inhibitors and Immunotherapy
    Maria Mannino, Pietro Sollena, Alessandro Di Stefani, Ernesto Rossi, Ettore D’Argento, Giovanni Schinzari, Giampaolo Tortora, Ketty Peris
    Dermatology.2024; 240(4): 523.     CrossRef
  • A comprehensive study of adverse effects of chemotherapy on female breast cancer patients in NORI Cancer Hospital, Islamabad in a developing country
    Areesha Abid, Humza Saeed, Uswa Iftikhar, Muhammad Khubaib Arshad, Muhammad Uzair Shahid, Tayyab Rasool, Faizan Fazal, Aman Goyal, Anum Akbar
    Journal of Oncology Pharmacy Practice.2024;[Epub]     CrossRef
  • Chemotherapy induced alopecia in breast cancer patients: A monocentric prospective study
    Wala Ben Kridis, Olfa Boudawara, Afef Khanfir
    Breast Disease.2024; 43(1): 251.     CrossRef
  • Impact of Xerosis in Patients With Cancer Receiving Epidermal Growth Factor Receptor or Mitogen-Activated Protein Kinase Inhibitors: ATIXI, A Non-Interventional, Prospective, Pilot Study
    Pietro Quaglino, Giuseppe Argenziano, Emi Dika, Michela Starace, Simone Amabile, Paolo Fava, Elvira Moscarella, Bianca Maria Piraccini, Alain Delarue, Olivia Dialla, Fabienne Zumaglini, Giampiero Girolomoni
    Dermatology Practical & Conceptual.2024; 14(4): e2024259.     CrossRef
  • Global trends in adolescent and young adult female cancer burden, 1990-2021: insights from the Global Burden of Disease study
    Z. Huang, J. Wang, H. Liu, B. Wang, M. Qi, Z. Lyu, H. Liu
    ESMO Open.2024; 9(11): 103958.     CrossRef
  • Dermatologic toxicities of chemotherapy: an educational intervention for skin of color women with breast cancer
    Maham Ahmad, Sabrina Saeed, Brianna Olamiju, Andrea Silber, Jonathan Leventhal
    International Journal of Women’s Dermatology.2023; 9(1): e073.     CrossRef
  • Aloe vera gel for prevention of chemotherapy-induced hyperpigmentation: Four case reports
    Chia-Chi Chiu, Yi-Wen Hsiao, Yu-Chuan Wen, Tsung-Yen Chang, Shih-Hsiang Chen, Tang-Her Jaing
    Medicine.2023; 102(25): e34037.     CrossRef
  • Skin-related Quality of Life in Patients with Lung Cancer Taking Oral Targeted Agents: A Single-Center, Cross-Sectional Study
    Joo Mi Park, Jeong Hye Kim
    Asian Oncology Nursing.2023; 23(2): 84.     CrossRef
  • Dermatological Side Effects of Cancer Treatment: Psychosocial Implications—A Systematic Review of the Literature
    Vera Almeida, Daniela Pires, Marta Silva, Maribel Teixeira, Ricardo João Teixeira, André Louro, Maria Alzira Pimenta Dinis, Maria Ferreira, Ana Teixeira
    Healthcare.2023; 11(19): 2621.     CrossRef
  • The role of dermocosmetics in the management of cancer-related skin toxicities: international expert consensus
    Brigitte Dreno, Kiarash Khosrotehrani, Giselle De Barros Silva, Julie Ryan Wolf, Delphine Kerob, Mark Trombetta, Etienne Atenguena, Pascale Dielenseger, Meng Pan, Florian Scotte, Ivan Krakowski, Mario Lacouture
    Supportive Care in Cancer.2023;[Epub]     CrossRef
  • Effectiveness and Tolerability of Natural Herbal Formulations in the Prevention of Radiation-Induced Skin Toxicity in Patients Undergoing Radiotherapy
    Georgios Koukourakis, Georgios Pissakas, Christos G. Ganos, Gregory Sivolapenko, Dimitrios Kardamakis
    The International Journal of Lower Extremity Wounds.2022; 21(1): 75.     CrossRef
  • Effects of the epidermal growth factor receptor inhibitor, gefitinib, on lipid and hyaluronic acid synthesis in cultured HaCaT keratinocytes
    Jang‐Hee Oh, Woojune Hur, Na Li, Seong Jin Jo
    Experimental Dermatology.2022; 31(6): 918.     CrossRef
  • An Emollient PLUS Balm Is Useful for the Management of Xerosis in Patients Treated for Cancer: A Real-World, Prospective, Observational, Multicenter Study
    Véronique Vendrely, Ander Mayor-Ibarguren, Aline Stennevin, Ariadna Ortiz-Brugués
    Dermatology and Therapy.2022; 12(3): 683.     CrossRef
  • Nail pigmentation induced by chemotherapy: an observational study of patients with early-stage breast cancer
    Kuikui Jiang, Simei Shi, Qiulian Lin, Peng Sun, Luan Zhang, Zhongyu Yuan, Ruoxi Hong, Yanxia Shi, Xia Liu, Jingmin Zhang, Jiajia Huang, Xiwen Bi, Wen Xia, Qianyi Lu, Qiufan Zheng, Shusen Wang, Fei Xu
    Holistic Integrative Oncology.2022;[Epub]     CrossRef
  • Cutaneous adverse events in patients receiving anticancer therapy in a tertiary hospital setting: the old and the new
    Hae‐Jin Suh, Ángeles Flórez, Víctor Sacristán, Ángeles Rodríguez Martinez, Francisca Fernández, Lucía Vilanova‐Trillo, Manuel Constenla, Manuel Pereiro
    International Journal of Dermatology.2021; 60(2): 208.     CrossRef
  • The Impact of Acne, Atopic Dermatitis, Skin Toxicities and Scars on Quality of Life and the Importance of a Holistic Treatment Approach
    Brigitte Dreno, Jean Michel Amici, Ann Laure Demessant-Flavigny, Charlotte Wright, Charles Taieb, Seemal R Desai, Andrew Alexis
    Clinical, Cosmetic and Investigational Dermatology.2021; Volume 14: 623.     CrossRef
  • Evaluating health related quality of life in outpatients receiving anti-cancer treatment: results from an observational, cross-sectional study
    Hae-Jin Suh Oh, Ángeles Flórez Menéndez, Víctor Sacristán Santos, Ángeles Rodríguez Martínez, Francisca Fernández Ribeiro, Lucía Vilanova-Trillo, Manuel Constenla Figueiras, Manuel Pereiro Ferreiros
    Health and Quality of Life Outcomes.2021;[Epub]     CrossRef
  • Dermatologic conditions in women receiving systemic cancer therapy
    Michelle N. Ferreira, Julie Y. Ramseier, Jonathan S. Leventhal
    International Journal of Women's Dermatology.2019; 5(5): 285.     CrossRef
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The Keratin-14 Expression in Actinic Keratosis and Squamous Cell Carcinoma: Is This a Prognostic Factor for Tumor Progression?
Kwang Hyun Choi, Gyong Moon Kim, Si Yong Kim
Cancer Res Treat. 2010;42(2):107-114.   Published online June 30, 2010
DOI: https://doi.org/10.4143/crt.2010.42.2.107
AbstractAbstract PDFPubReaderePub
Purpose

Actinic keratosis (AK) is an incipient form of cutaneous squamous cell carcinoma (SCC). We determined if the pattern of expression of keratin-14 (K14) is a factor for tumor progression in AK and SCC.

Materials and Methods

Eighteen sections from the tissues of 16 patients were stained with anti-K14 antibody and p16INK4a. Among the 16 patients, 4 were diagnosed with both SCC and AK at the same site, but AK developed first and SCC developed subsequently. Thus, SCC may have evolved from AK. The other 12 patients were only diagnosed with AK.

Results

In all of the AK and SCC tissues, basement membranes showed positive staining for K14. However, strong reactivities were shown in the spinous and granular layers and focuses of dermal invasion in the SCC tissues developed from AK. Two and 3 of the 12 AK cases had moderately positive reactions for K14 in the spinous and granular layers, respectively. Also, all SCC tissues except one had moderate-to-strong reactions in the basal, spinous, and granular layers for p16INK4a. Two of the 12 AK cases had weak-to-moderate positive reactions in the basal, spinous, and horny layers for p16INK4a.

Conclusion

The results of our study advance our understanding of the pathogenesis of SCC developing from AK. The results also indicate a differential role in the control of K14 in normal epithelia, AK, and SCC. K14 expression in the spinous and granular layers may be a prognostic factor for tumor progression of AK.

Citations

Citations to this article as recorded by  
  • Ex Vivo Analysis of Cell Differentiation, Oxidative Stress, Inflammation, and DNA Damage on Cutaneous Field Cancerization
    Lara Camillo, Elisa Zavattaro, Federica Veronese, Laura Cristina Gironi, Ottavio Cremona, Paola Savoia
    International Journal of Molecular Sciences.2024; 25(11): 5775.     CrossRef
  • Enhanced Metastatic Risk Assessment in Cutaneous Squamous Cell Carcinoma with the 40-Gene Expression Profile Test
    Sherrif F Ibrahim, Julia M Kasprzak, Mary A Hall, Alison L Fitzgerald, Jennifer J Siegel, Sarah J Kurley, Kyle R Covington, Matthew S Goldberg, Aaron S Farberg, Shannon C Trotter, Kenneth Reed, David G Brodland, Shlomo A Koyfman, Ally-Khan Somani, Sarah T
    Future Oncology.2022; 18(7): 833.     CrossRef
  • Validation of a 40-gene expression profile test to predict metastatic risk in localized high-risk cutaneous squamous cell carcinoma
    Ashley Wysong, Jason G. Newman, Kyle R. Covington, Sarah J. Kurley, Sherrif F. Ibrahim, Aaron S. Farberg, Anna Bar, Nathan J. Cleaver, Ally-Khan Somani, David Panther, David G. Brodland, John Zitelli, Jennifer Toyohara, Ian A. Maher, Yang Xia, Kristin Bib
    Journal of the American Academy of Dermatology.2021; 84(2): 361.     CrossRef
  • Expression Profile of Fibroblast Growth Factor Receptors, Keratinocyte Differentiation Markers, and Epithelial Mesenchymal Transition-Related Genes in Actinic Keratosis: A Possible Predictive Factor for Malignant Progression?
    Flavia Persechino, Danilo Ranieri, Luisa Guttieri, Monica Nanni, Maria Rosaria Torrisi, Francesca Belleudi
    Biology.2021; 10(4): 331.     CrossRef
  • Increased Expression of Flightless I in Cutaneous Squamous Cell Carcinoma Affects Wnt/β-Catenin Signaling Pathway
    Gink N. Yang, Xanthe L. Strudwick, Claudine S. Bonder, Zlatko Kopecki, Allison J. Cowin
    International Journal of Molecular Sciences.2021; 22(24): 13203.     CrossRef
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    Veronika Apprich, Theresia Licka, Sabrina Freiler, Cordula Gabriel
    Veterinary Pathology.2020; 57(4): 525.     CrossRef
  • Keratin 14-high subpopulation mediates lung cancer metastasis potentially through Gkn1 upregulation
    Shun Yao, Hsin-Yi Huang, Xiangkun Han, Yi Ye, Zhen Qin, Gaoxiang Zhao, Fuming Li, Guohong Hu, Liang Hu, Hongbin Ji
    Oncogene.2019; 38(36): 6354.     CrossRef
  • Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin
    Manuel Rodríguez-Paredes, Felix Bormann, Günter Raddatz, Julian Gutekunst, Carlota Lucena-Porcel, Florian Köhler, Elisabeth Wurzer, Katrin Schmidt, Stefan Gallinat, Horst Wenck, Joachim Röwert-Huber, Evgeniya Denisova, Lars Feuerbach, Jeongbin Park, Bened
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    Journal of Oral Pathology & Medicine.2017; 46(9): 834.     CrossRef
  • A Mouse Model of Hyperproliferative Human Epithelium Validated by Keratin Profiling Shows an Aberrant Cytoskeletal Response to Injury
    Samal Zhussupbekova, Rohit Sinha, Paula Kuo, Paul F. Lambert, Ian H. Frazer, Zewen K. Tuong
    EBioMedicine.2016; 9: 314.     CrossRef
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    Jason F. Solus, George F. Murphy, Stefan Kraft
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  • 9,152 View
  • 61 Download
  • 15 Crossref
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