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Identification of Significant Prognostic Tissue Markers Associated with Survival in Upper Urinary Tract Urothelial Carcinoma Patients Treated with Radical Nephroureterectomy: A Retrospective Immunohistochemical Analysis Using Tissue Microarray
Sung Han Kim, Weon Seo Park, Boram Park, Jinsoo Chung, Jae Young Joung, Kang Hyun Lee, Ho Kyung Seo
Cancer Res Treat. 2020;52(1):128-138.   Published online June 19, 2019
DOI: https://doi.org/10.4143/crt.2019.119
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
The purpose of this study was to identify prognostic tissue markers for several survival outcomes after radical nephroureterectomy among patients with upper urinary tract urothelial carcinoma using tissue microarray and immunohistochemistry.
Materials and Methods
Retrospectively, data of 162 non-metastatic patients with upper urinary tract urothelial carcinoma after radical nephroureterectomy between 2004 and 2016 were reviewed to determine intravesical recurrence-free survival (IVRFS), disease-free survival (DFS), and overall survival (OS). The expression of 27 tissue markers on a tissue microarray of radical nephroureterectomy samples and prognostic values of clinicopathological parameters were evaluated using immunohistochemistry and Cox proportional hazard models after adjusting for significant prognostic clinicopathological variables. The expression of all tissue markers was categorized into a binary group with continuous H-scores (0-300).
Results
Median follow-up was 53.4 months (range, 3.6 to 176.5 months); and, 58 (35.8%), 48 (29.6%), and 19 (11.7%) bladder recurrence, disease progression, and all cause death, respectively, were identified. After adjusting for significant clinicopathological factors including intravesical instillation for bladder recurrence-free survival, pathologic T category and intravesical instillation for disease progression-free survival , and pathologic T category for OS (p < 0.05), IVRFS was associated with epithelial cadherin (hazard ratio [HR], 0.49), epidermal growth factor receptor/erythroblastosis oncogene B (c-erb) (HR, 2.59), and retinoblastoma protein loss (HR, 1.85); DFS was associated with cyclin D1 (HR, 2.16) and high-molecular-weight cytokeratin (HR, 0.42); OS was associated with E-cadherin (HR, 0.34) and programmed cell death 1 ligand (HR, 13.42) (p < 0.05).
Conclusion
Several significant tissue markers were associated with survival outcomes in upper urinary tract urothelial carcinoma patients treated with radical nephroureterectomy.

Citations

Citations to this article as recorded by  
  • A multi‐institutional retrospective study of open versus laparoscopic nephroureterectomy focused on the intravesical recurrence
    Soichiro Shimura, Kazumasa Matsumoto, Masaomi Ikeda, Shigenori Moroo, Dai Koguchi, Yoshinori Taoka, Takahiro Hirayama, Yasukiyo Murakami, Takuji Utsunomiya, Daisuke Matsuda, Norihiko Okuno, Akira Irie, Masatsugu Iwamura
    Asia-Pacific Journal of Clinical Oncology.2023; 19(1): 71.     CrossRef
  • Upper Tract Urinary Carcinoma: A Unique Immuno-Molecular Entity and a Clinical Challenge in the Current Therapeutic Scenario
    Giulia Mazzaschi, Giulia Claire Giudice, Matilde Corianò, Davide Campobasso, Fabiana Perrone, Michele Maffezzoli, Irene Testi, Luca Isella, Umberto Maestroni, Sebastiano Buti
    Technology in Cancer Research & Treatment.2023;[Epub]     CrossRef
  • Prognostic value of programmed death ligand‐1 and programmed death‐1 expression in patients with upper tract urothelial carcinoma
    Luca Campedel, Eva Compérat, Géraldine Cancel‐Tassin, Justine Varinot, Christian Pfister, Clara Delcourt, Françoise Gobet, Mathieu Roumiguié, Pierre‐Marie Patard, Gwendoline Daniel, Pierre Bigot, Julie Carrouget, Caroline Eymerit, Stéphane Larré, Priscill
    BJU International.2023; 132(5): 581.     CrossRef
  • The Prevalence and Prognostic Role of PD-L1 in Upper Tract Urothelial Carcinoma Patients Underwent Radical Nephroureterectomy: A Systematic Review and Meta-Analysis
    Yi Lu, Jiaqi Kang, Zhiwen Luo, Yuxuan Song, Jia Tian, Zhongjia Li, Xiao Wang, Li Liu, Yongjiao Yang, Xiaoqiang Liu
    Frontiers in Oncology.2020;[Epub]     CrossRef
  • 7,072 View
  • 141 Download
  • 4 Web of Science
  • 4 Crossref
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Retrospective Study of the Significant Predictive Role of Inflammatory Degree in Initial and Repeat Prostate Biopsy Specimens for Detecting Prostate Cancer
Sung Han Kim, Boram Park, Jae Young Joung, Jinsoo Chung, Ho Kyung Seo, Kang Hyun Lee, Weon Seo Park
Cancer Res Treat. 2019;51(3):910-918.   Published online October 2, 2018
DOI: https://doi.org/10.4143/crt.2018.314
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
The purpose of this study was to determine whether histologic inflammation (HI) in initial and repeat prostate biopsy specimens was significantly associated with the detection of prostate cancer.
Materials and Methods
Between 2005 and 2017, the clinicopathological records of patients with high prostatespecific antigen (PSA) levels who underwent initial and repeat prostate biopsies were retrospectively reviewed. The presence of HI and its degree in each biopsied specimen were interpreted by one uropathologist with 20 years of experience. The association between HI and cancer diagnosis was statistically assessed, with p < 0.05 considered significant, and the cancer and non-cancer groups were compared.
Results
Among the 522 patients with a median PSA levels of 6.5 ng/dL, including 258 (49.4%) whose cancer was diagnosed following repeat biopsy, the median degrees of HI in the initial and repeat biopsies were 25.0% and 41.7%, respectively. Furthermore, 211 (40.4%) and 247 (47.3%) patients had HI (> 0%) on biopsied specimens, respectively. Comparison of the cancer and noncancer groups revealed that a greater rate of HI specimens in the initial biopsy was associated with fewer prostate cancer diagnoses following repeat biopsy (p < 0.001). Other comparisons between the cancer and non-cancer groups showed that the cancer group had a significantly higher rate of hypertension, whereas those non-cancer group had a significantly higher rate of benign prostatic hyperplasia and prostatitis (p < 0.05).
Conclusion
A finding of a lesser degree of HI in the initial and a greater degree of HI in the repeat biopsied specimens was associated with the higher probability of cancer diagnosis in patients with high PSA levels.

Citations

Citations to this article as recorded by  
  • Growth and differentiation factor 15 and NF‐κB expression in benign prostatic biopsies and risk of subsequent prostate cancer detection
    Benjamin A. Rybicki, Sudha M. Sadasivan, Yalei Chen, Oleksandr Kravtsov, Watchareepohn Palangmonthip, Kanika Arora, Nilesh S. Gupta, Sean Williamson, Kevin Bobbitt, Dhananjay A. Chitale, Deliang Tang, Andrew G. Rundle, Kenneth A. Iczkowski
    Cancer Medicine.2021; 10(9): 3013.     CrossRef
  • 6,156 View
  • 144 Download
  • 1 Web of Science
  • 1 Crossref
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Geographical Variations and Trends in Major Cancer Incidences throughout Korea during 1999-2013
Young-Joo Won, Kyu-Won Jung, Chang-Mo Oh, Eun-Hye Park, Hyun-Joo Kong, Duk Hyoung Lee, Kang Hyun Lee, The Community of Population-based Regional Cancer Registries
Cancer Res Treat. 2018;50(4):1281-1293.   Published online January 4, 2018
DOI: https://doi.org/10.4143/crt.2017.411
AbstractAbstract PDFPubReaderePub
Purpose
We aimed to describe the temporal trends and district-level geographical variations in cancer incidences throughout Korea during 1999-2013.
Materials and Methods
Data were obtained from the Korean National Cancer Incidence Database. We calculated the age-standardized cumulative cancerincidences according to sex and geographicalregion (metropolitan cities, provinces, and districts) for three 5-year periods (1999-2003, 2004- 2008, and 2009-2013). Each quintile interval contained the same number of regions. Disease maps were created to visualize regional differences in the cancer incidences.
Results
Substantial differences in cancer incidences were observed according to district and cancer type. The largest variations between geographical regions were found for thyroid cancer among both men and women. There was little variation in the incidences of stomach, colorectal, and lung cancer according to geographical region. Substantially elevated incidences of specific cancers were observed in Jeollanam-do (thyroid); Daejeon (colorectum); Jeollanam-do, Gyeongsangbuk-do, and Chungcheongbuk-do (lung); Seocho-gu, Gangnam-gu and Seongnam, Bundang-gu (breast and prostate); Chungcheong and Gyeongsang provinces (stomach); Ulleung-gun and the southern districts of Gyeongsangnam-do and Jeollanam-do (liver); and along the Nakdonggang River (gallbladder and biliary tract).
Conclusion
Mapping regional cancer incidences in Korea allowed us to compare the results according to geographical region. Our results may facilitate the development of infrastructure for systematic cancerincidence monitoring,which could promote the planning and implementation of region-specific cancer management programs.

Citations

Citations to this article as recorded by  
  • Exploring age-standardized cancer incidence rates and regional disparities: A retrospective cohort study of 8 major cancers in South Korea
    Dagyeong Lee, Hye-won Yun, Nayeon Kim, Juwon Park, Kyu-won Jung, Mina Suh, Dong Wook Shin
    Cancer Epidemiology.2024; 91: 102594.     CrossRef
  • Descriptive Analysis of Gastric Cancer Mortality in Korea, 2000-2020
    Tung Hoang, Hyeongtaek Woo, Sooyoung Cho, Jeeyoo Lee, Sayada Zartasha Kazmi, Aesun Shin
    Cancer Research and Treatment.2023; 55(2): 603.     CrossRef
  • Changes in spatial clusters of cancer incidence and mortality over 15 years in South Korea: Implication to cancer control
    Cham Thi Nguyen, Insang Song, Inkyung Jung, Yoon‐Jung Choi, Sun‐Young Kim
    Cancer Medicine.2023; 12(16): 17418.     CrossRef
  • Spatio-temporal trends of the age-at-menarche percentiles among Portuguese women since 1920
    Vitor Rodrigues, Rui Martins, Bruno de Sousa
    BMC Women's Health.2023;[Epub]     CrossRef
  • Regional disparities in major cancer incidence in Korea, 1999-2018
    Eun Hye Park, Mee Joo Kang, Kyu-Won Jung, Eun Hye Park, E Hwa Yun, Hye-Jin Kim, Hyun-Joo Kong, Chang Kyun Choi, Jeong-Soo Im, Hong Gwan Seo
    Epidemiology and Health.2023; 45: e2023089.     CrossRef
  • Estimation of Utility Weights for Prostate-related Health States in Korea
    Seon-Ha Kim, Minsu Ock, Min-Woo Jo, Sungchan Park
    Journal of Preventive Medicine and Public Health.2022; 55(3): 243.     CrossRef
  • A comparison of quality of life between patients with small and large gastric remnant volumes after gastrectomy for gastric cancer
    Jae-Seok Min, Sang-Ho Jeong, Ji-Ho Park, Taehan Kim, Eun-Jung Jung, Young-Tae Ju, Chi-Young Jeong, Ju-Yeon Kim, Miyeong Park, Young-Joon Lee
    Medicine.2021; 100(33): e26954.     CrossRef
  • Spatial epidemiologic analysis of the liver cancer and gallbladder cancer incidence and its determinants in South Korea
    Jieun Jang, Dae-Sung Yoo, Byung Chul Chun
    BMC Public Health.2021;[Epub]     CrossRef
  • Spatial distribution and determinants of thyroid cancer incidence from 1999 to 2013 in Korea
    Jieun Jang, Dae-Sung Yoo, Byung Chul Chun
    Scientific Reports.2021;[Epub]     CrossRef
  • Family History of Gastric Cancer and Helicobacter pylori Treatment
    Il Ju Choi, Chan Gyoo Kim, Jong Yeul Lee, Young-Il Kim, Myeong-Cherl Kook, Boram Park, Jungnam Joo
    New England Journal of Medicine.2020; 382(5): 427.     CrossRef
  • Application of Epidemiological Geographic Information System: An Open-Source Spatial Analysis Tool Based on the OMOP Common Data Model
    Jaehyeong Cho, Seng Chan You, Seongwon Lee, DongSu Park, Bumhee Park, George Hripcsak, Rae Woong Park
    International Journal of Environmental Research and Public Health.2020; 17(21): 7824.     CrossRef
  • 9,480 View
  • 188 Download
  • 11 Web of Science
  • 11 Crossref
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Lifestyle Risk Prediction Model for Prostate Cancer in a Korean Population
Sung Han Kim, Sohee Kim, Jae Young Joung, Whi-An Kwon, Ho Kyung Seo, Jinsoo Chung, Byung-Ho Nam, Kang Hyun Lee
Cancer Res Treat. 2018;50(4):1194-1202.   Published online December 21, 2017
DOI: https://doi.org/10.4143/crt.2017.484
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
The use of prostate-specific antigen as a biomarker for prostate cancer (PC) has been controversial and is, therefore, not used by many countries in their national health screening programs. The biological characteristics of PC in East Asians including Koreans and Japanese are different from those in the Western populations. Potential lifestyle risk factors for PC were evaluated with the aim of developing a risk prediction model.
Materials and Methods
A total of 1,179,172 Korean men who were cancer free from 1996 to 1997, had taken a physical examination, and completed a lifestyle questionnaire, were enrolled in our study to predict their risk for PC for the next eight years, using the Cox proportional hazards model. The model’s performance was evaluated using the C-statistic and Hosmer‒Lemeshow type chi-square statistics.
Results
The risk prediction model studied age, height, body mass index, glucose levels, family history of cancer, the frequency of meat consumption, alcohol consumption, smoking status, and physical activity, which were all significant risk factors in a univariate analysis. The model performed very well (C statistic, 0.887; 95% confidence interval, 0.879 to 0.895) and estimated an elevated PC risk in patients who did not consume alcohol or smoke, compared to heavy alcohol consumers (hazard ratio [HR], 0.78) and current smokers (HR, 0.73) (p < 0.001).
Conclusion
This model can be used for identifying Korean and other East Asian men who are at a high risk for developing PC, as well as for cancer screening and developing preventive health strategies.

Citations

Citations to this article as recorded by  
  • To Drink or Not to Drink? Investigating Alcohol’s Impact on Prostate Cancer Risk
    Aris Kaltsas, Michael Chrisofos, Evangelos N. Symeonidis, Athanasios Zachariou, Marios Stavropoulos, Zisis Kratiras, Ilias Giannakodimos, Asterios Symeonidis, Fotios Dimitriadis, Nikolaos Sofikitis
    Cancers.2024; 16(20): 3453.     CrossRef
  • Machine learning algorithms that predict the risk of prostate cancer based on metabolic syndrome and sociodemographic characteristics: a prospective cohort study
    Tao Thi Tran, Jeonghee Lee, Junetae Kim, Sun-Young Kim, Hyunsoon Cho, Jeongseon Kim
    BMC Public Health.2024;[Epub]     CrossRef
  • Combinations of lifestyle behaviors and cancer risk among Korean adults
    Ngoc Minh Luu, Thi Tra Bui, Thi Phuong Thao Tran, Thi Huyen Trang Nguyen, Jin-Kyoung Oh
    Scientific Reports.2023;[Epub]     CrossRef
  • Cigarette smoking and prostate cancer: A systematic review and meta-analysis of prospective cohort studies
    Sarah Al-Fayez, Ashraf El-Metwally
    Tobacco Induced Diseases.2023; 21(February): 1.     CrossRef
  • Prostate cancer risk prediction based on clinical factors and prostate-specific antigen
    Taewon Hwang, Hyungseok Oh, Jung Ah Lee, Eo Jin Kim
    BMC Urology.2023;[Epub]     CrossRef
  • Association Between Red and Processed Meat Consumption and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis
    Saeedeh Nouri-Majd, Asma Salari-Moghaddam, Azadeh Aminianfar, Bagher Larijani, Ahmad Esmaillzadeh
    Frontiers in Nutrition.2022;[Epub]     CrossRef
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    Amanda J. Macke, Armen Petrosyan
    Biomolecules.2022; 12(3): 375.     CrossRef
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    Yan Jin, Jae Hung Jung, Woong Kyu Han, Eu Chang Hwang, Yoonmi Nho, Narae Lee, Ji Eun Yun, Kwang Suk Lee, Sang Hyub Lee, Hakmin Lee, Su-Yeon Yu
    Investigative and Clinical Urology.2022; 63(3): 251.     CrossRef
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    Ga-Eun Yie, An Na Kim, Hyun Jeong Cho, Minji Kang, Sungji Moon, Inah Kim, Kwang-Pil Ko, Jung Eun Lee, Sue K. Park
    Korean Journal of Community Nutrition.2021; 26(3): 211.     CrossRef
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    Antonio Bandala-Jacques, Kevin Daniel Castellanos Esquivel, Fernanda Pérez-Hurtado, Cristobal Hernández-Silva, Nancy Reynoso-Noverón
    JMIR Cancer.2021; 7(3): e30430.     CrossRef
  • Personalized 5-Year Prostate Cancer Risk Prediction Model in Korea Based on Nationwide Representative Data
    Yohwan Yeo, Dong Wook Shin, Jungkwon Lee, Kyungdo Han, Sang Hyun Park, Keun Hye Jeon, Jungeun Shin, Aesun Shin, Jinsung Park
    Journal of Personalized Medicine.2021; 12(1): 2.     CrossRef
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    Tomoyuki Kawada
    Journal of Cancer Research and Clinical Oncology.2020; 146(6): 1623.     CrossRef
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    Okyaz Eminaga, Omran Al-Hamad, Martin Boegemann, Bernhard Breil, Axel Semjonow
    Health Informatics Journal.2020; 26(2): 945.     CrossRef
  • Tailored Biofunctionalized Biosensor for the Label-Free Sensing of Prostate-Specific Antigen
    Sachin Mishra, Eun-Seong Kim, Parshant Kumar Sharma, Zhi-Ji Wang, Sung-Hyun Yang, Ajeet Kumar Kaushik, Cong Wang, Yang Li, Nam-Young Kim
    ACS Applied Bio Materials.2020; 3(11): 7821.     CrossRef
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    Hye Sim Kim, Tae Hwa Go, Dae Ryong Kang, Jae Hung Jung, Sung Won Kwon, Sae Chul Kim, Jae Mann Song, Hyun Chul Chung, Sang Baek Koh
    Journal of Health Informatics and Statistics.2019; 44(4): 410.     CrossRef
  • 10,112 View
  • 258 Download
  • 13 Web of Science
  • 15 Crossref
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Second Primary Cancer Risk among Kidney Cancer Patients in Korea: A Population-Based Cohort Study
Jae Young Joung, Whi-An Kwon, Jiwon Lim, Chang-Mo Oh, Kyu-Won Jung, Sung Han Kim, Ho Kyung Seo, Weon Seo Park, Jinsoo Chung, Kang Hyun Lee, Young-Joo Won
Cancer Res Treat. 2018;50(1):293-301.   Published online April 19, 2017
DOI: https://doi.org/10.4143/crt.2016.543
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
Secondary primary cancers (SPCs) commonly arise in patients with renal cell carcinoma (RCC). We designed the present study to estimate the SPC incidence in Korean patients with RCC.
Materials and Methods
The study cohort was population-based and consisted of 40,347 individuals from the Korean Central Cancer Registry who were diagnosed with primary renal cancer between 1993 and 2013. Standardized incidence ratios (SIRs) for SPCs were estimated for different ages at diagnosis, latencies, diagnostic periods, and treatments.
Results
For patients with primary RCC, the risk of developing a SPC was higher than the risk of developing cancer in the general population (SIR, 1.13; 95% confidence interval, 1.08 to 1.18). Most cancer types showed higher incidences in patients with RCC than in the general population. However, the relative incidence of gastric cancer as an SPC varied by age. Gastric cancer incidence was elevated in young patients (< 30 years) with RCC, but reduced in older (≥ 30) patients with RCC. Patients with advanced RCC died prematurely, regardless of SPC development. In contrast, those with early-stage RCC survived for longer periods, although SPC development affected their post-RCC survival. After SPC development, women had better survival than men.
Conclusion
In Korean patients with primary RCC, the incidence of SPC was 13% higher than the incidence of cancer in the general population. These findings may play important roles in the conduct of follow-up evaluations and education for patients with RCC.

Citations

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  • Next-generation sequencing identifies the mutational signature of double primary and metastatic malignancies: A case report
    Shiying Tang, Yixiao Deng, Yinan Yan, Jie Bai, Huiying He, Shudong Zhang, Jie Yang, Min Qiu, Xiaojun Tian
    Current Urology.2024;[Epub]     CrossRef
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    Maria B. Bengtsen, Dóra K. Farkas, Henrik T. Sørensen, Mette Nørgaard
    Cancer Medicine.2024;[Epub]     CrossRef
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    George Davey Smith, Albert Hofman, Paul Brennan
    European Journal of Epidemiology.2023; 38(12): 1227.     CrossRef
  • Better Prognosis and Survival in Esophageal Cancer Survivors After Comorbid Second Primary Malignancies: A SEER Database-Based Study
    Jiayue Ye, Sheng Hu, Wenxiong Zhang, Deyuan Zhang, Yang Zhang, Dongliang Yu, Jinhua Peng, Jianjun Xu, Yiping Wei
    Frontiers in Surgery.2022;[Epub]     CrossRef
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    Hong Liu, Xin Heng, Yuan Tian, Zhongming Yang
    Scientific Reports.2022;[Epub]     CrossRef
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    Peter Szatmari, Ezra Susser
    JAMA Psychiatry.2022; 79(12): 1149.     CrossRef
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    Lily N. Trinh, Andrew R. Crawford, Mohammad H. Hussein, Mourad Zerfaoui, Eman A. Toraih, Gregory W. Randolph, Emad Kandil
    Cancers.2021; 13(6): 1402.     CrossRef
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    Lucie Pehalova, Denisa Krejci, Jana Halamkova, Lenka Smardova, Lenka Snajdrova, Ladislav Dusek
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    Haeyoung Kim, Won Park, Su SSan Kim, Sung Ja Ahn, Yong Bae Kim, Tae Hyun Kim, Jin Hee Kim, Jin-Hwa Choi, Hae Jin Park, Jee Suk Chang, Doo Ho Choi
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    Pathology and Oncology Research.2021;[Epub]     CrossRef
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  • Risk of second primary Cancer among bladder Cancer patients: a population-based cohort study in Korea
    Whi-An Kwon, Jae Young Joung, Jiwon Lim, Chang-Mo Oh, Kyu-Won Jung, Sung Han Kim, Ho Kyung Seo, Weon Seo Park, Jinsoo Chung, Kang Hyun Lee, Young-Joo Won
    BMC Cancer.2018;[Epub]     CrossRef
  • 11,578 View
  • 267 Download
  • 18 Web of Science
  • 18 Crossref
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Special Articles
Prediction of Cancer Incidence and Mortality in Korea, 2017
Kyu-Won Jung, Young-Joo Won, Chang-Mo Oh, Hyun-Joo Kong, Duk Hyoung Lee, Kang Hyun Lee
Cancer Res Treat. 2017;49(2):306-312.   Published online March 17, 2017
DOI: https://doi.org/10.4143/crt.2017.130
AbstractAbstract PDFPubReaderePub
Purpose
This study aimed to report on cancer incidence and mortality for the year 2017 in Korea in order to estimate the nation’s current cancer burden.
Materials and Methods
Cancer incidence data from 1999 to 2014 were obtained from the Korea National Cancer Incidence Database, and cancer mortality data from 1993 to 2015 were acquired from Statistics Korea. Cancer incidence and mortality were projected by fitting a linear regression model to observe age-specific cancer rates against observed years, and then multiplying the projected age-specific rates by the age-specific population. The Joinpoint regression model was used to determine at which year the linear trend changed significantly; we only used data of the latest trend.
Results
A total of 221,143 new cancer cases and 80,268 cancer deaths are expected to occur in Korea in 2017. The most common cancer sites are the colorectum, stomach, lung, thyroid, and breast. These five cancers represent half of the overall burden of cancer in Korea. For mortality, the most common sites are the lung, liver, colorectal, stomach, and pancreas.
Conclusion
The incidence rate of all cancers in Korea appears to have decreased mainly because of a decrease in thyroid cancer. These up-to-date estimates of the cancer burden in Korea could be an important resource for planning and evaluation of cancer-control programs.

Citations

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  • Risk Factors for 90-Day Readmission Among Patients with Metastatic Spine Tumors in South Korea: A Nationwide Population-Based Study
    Sung Hyun Noh, Hyung Cheol Kim, Sang Hyun Kim, Pyung Goo Cho
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    元虎 朱
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    Joon Ho, Minkyung Han, Inkyung Jung, Young Suk Jo, Jandee Lee
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    Min Yang, Huiqin Zhang, Jieqiu Zhang, Xiaopeng Yao
    Medicine.2023; 102(47): e35740.     CrossRef
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Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2014
Kyu-Won Jung, Young-Joo Won, Chang-Mo Oh, Hyun-Joo Kong, Duk Hyoung Lee, Kang Hyun Lee, The Community of Population-Based Regional Cancer Registries
Cancer Res Treat. 2017;49(2):292-305.   Published online March 9, 2017
DOI: https://doi.org/10.4143/crt.2017.118
AbstractAbstract PDFPubReaderePub
Purpose
This study presents the 2014 nationwide cancer statistics in Korea, including cancer incidence, survival, prevalence, and mortality.
Materials and Methods
Cancer incidence data from 1999 to 2014 was obtained from the Korea National Cancer Incidence Database and followed until December 31, 2015. Mortality data from 1983 to 2014 were obtained from Statistics Korea. The prevalence was defined as the number of cancer patients alive on January 1, 2015, among all cancer patients diagnosed since 1999. Crude and age-standardized rates (ASRs) for incidence, mortality, prevalence, and 5-year relative survivals were also calculated.
Results
In 2014, 217,057 and 76,611 Koreans were newly diagnosed and died from cancer respectively. The ASRs for cancer incidence and mortality in 2014 were 270.7 and 85.1 per 100,000, respectively. The all-cancer incidence rate has increased significantly by 3.4% annually from 1999 to 2012, and started to decrease after 2012 (2012-2014; annual percent change, –6.6%). However, overall cancer mortality has decreased 2.7% annually since 2002. The 5-year relative survival rate for patients diagnosed with cancer between 2010 and 2014 was 70.3%, an improvement from the 41.2% for patients diagnosed between 1993 and 1995.
Conclusion
Age-standardized cancer incidence rates have decreased since 2012 and mortality rates have also declined since 2002, while 5-year survival rates have improved remarkably from 1993-1995 to 2010-2014 in Korea.

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  • Long-Term Experience of Sperm Cryopreservation in Cancer Patients in a Single Fertility Center
    Seung-Hun Song, Dae Keun Kim, Su Ye Sung, Young Sun Her, Ok-Hee Lee, Myoung Hwa Choi, Hae Kyung Kim, Sang Woo Lyu, Dong Suk Kim
    The World Journal of Men's Health.2019; 37(2): 219.     CrossRef
  • Association between awareness of nutrition labeling and high-density lipoprotein cholesterol concentration in cancer survivors and the general population: The Korean National Health and Nutrition Examination Survey (KNHANES) 2010–2016
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  • Unexpected malignant uterine pathology: Incidence, characteristics and outcome in a large single-center series of hysterectomies for presumed benign uterine disease
    P. Wagner, F.K.F. Kommoss, S. Kommoss, A.D. Hartkopf, I. Pasternak, E. Oberlechner, K. Greif, M. Wallwiener, F. Neis, H. Abele, B. Krämer, C. Reisenauer, A. Staebler, D. Wallwiener, S.Y. Brucker, F.A. Taran
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  • Randomized Phase III Trial of Irinotecan Plus Cisplatin versus Etoposide Plus Cisplatin in Chemotherapy-Naïve Korean Patients with Extensive-Disease Small Cell Lung Cancer
    Dong-Wan Kim, Hoon-Gu Kim, Joo-Hang Kim, Keunchil Park, Hoon-Kyo Kim, Joung Soon Jang, Bong-Seog Kim, Jin-Hyoung Kang, Kyung Hee Lee, Sang-We Kim, Hun Mo Ryoo, Jin-Soo Kim, Ki Hyeong Lee, Jung Hye Kwon, Jin-Hyuk Choi, Sang Won Shin, Seokyung Hahn, Dae Seo
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  • Clinical Features and Association with Visceral Malignancy in 80 Patients with Sebaceous Neoplasms
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  • Prognostic significance of pretreatment lymphocyte percentage and age at diagnosis in patients with locally advanced cervical cancer treated with definite radiotherapy
    Myung-Hwa Jeong, Hyungjoo Kim, Tae-Hun Kim, Moon-Hong Kim, Beob-Jong Kim, Sang-Young Ryu
    Obstetrics & Gynecology Science.2019; 62(1): 35.     CrossRef
  • Cross-national analysis about the difference of histopathological management in Tis and T1 colorectal cancer between Japan and Korea
    Naohisa Yoshida, Yuji Naito, Yutaka Inada, Yoshito Itoh, Sang Pyo Lee, Jeong Hwan Kim, In-Kyung Sung, Hyung Seok Park, Hye Seung Han, Masayoshi Nakanishi, Mitsuo Kishimoto, Sun-Young Lee
    Journal of the Anus, Rectum and Colon.2019; 3(1): 18.     CrossRef
  • Development of a risk scoring system for patients with papillary thyroid cancer
    Kyoungjune Pak, Yun Hak Kim, Sunghwan Suh, Tae Sik Goh, Dae Cheon Jeong, Seong Jang Kim, In Joo Kim, Myoung‐Eun Han, Sae‐Ock Oh
    Journal of Cellular and Molecular Medicine.2019; 23(4): 3010.     CrossRef
  • Symptom experiences and health‐related quality of life among non‐small cell lung cancer patients participating in clinical trials
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  • Adult height in relation to risk of cancer in a cohort of 22,809,722 Korean adults
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  • Association of Periodontitis with Oral Cancer: A Case-Control Study
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    Journal of Dental Research.2019; 98(5): 526.     CrossRef
  • Economic burden of lung cancer: A retrospective cohort study in South Korea, 2002-2015
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  • Relationship Between Preferences for Advance Directive Treatments and Decisional Conflicts Among Low-Income, Home-Based Cancer Management Recipients in Korea
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  • Clinical Outcomes of Conversion Surgery after Neoadjuvant Chemotherapy in Patients with Borderline Resectable and Locally Advanced Unresectable Pancreatic Cancer: A Single-Center, Retrospective Analysis
    Changhoon Yoo, Sang Hyun Shin, Kyu-pyo Kim, Jae Ho Jeong, Heung-Moon Chang, Jun Ho Kang, Sang Soo Lee, Do Hyun Park, Tae Jun Song, Dong Wan Seo, Sung Koo Lee, Myung-Hwan Kim, Jin-hong Park, Dae Wook Hwang, Ki Byung Song, Jae Hoon Lee, Baek-Yeol Ryoo, Song
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  • Association of body mass index with bladder cancer risk in men depends on abdominal obesity
    Jin Bong Choi, Jung Ho Kim, Sung-Hoo Hong, Kyung-Do Han, U-Syn Ha
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  • Prevalence of Pressure Injuries Nationwide from 2009 to 2015: Results from the National Inpatient Sample Database in Korea
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  • Changes in Bone Mineral Density in Women With Breast Cancer
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  • Incidence and Mortality Rates of Second Pancreatic Cancer Among Survivors of Digestive Cancers
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  • Prediction of Recurrence With KRAS Mutational Burden Using Ultrasensitive Digital Polymerase Chain Reaction of Radial Resection Margin of Resected Pancreatic Ductal Adenocarcinoma
    Sung Joo Kim, Mi-Ju Kim, Ji-Soo Han, You-Na Sung, Soyeon An, Jae Hoon Lee, Ki Byung Song, Dae Wook Hwang, Sang Soo Lee, HyungJun Cho, Song Cheol Kim, James R. Eshleman, Seung-Mo Hong
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  • Evaluation of satisfaction with three different cervical cancer screening modalities: clinician-collected Pap test vs. HPV test by self-sampling vs. HPV test by urine sampling
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  • Genomic Characterization of Differentiated Thyroid Carcinoma
    Young Shin Song, Young Joo Park
    Endocrinology and Metabolism.2019; 34(1): 1.     CrossRef
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  • Preoperative neutrophil-lymphocyte ratio and CEA is associated with poor prognosis in patients with synchronous colorectal cancer liver metastasis
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  • Specific protein 1(SP1) regulates the epithelial-mesenchymal transition via lysyl oxidase-like 2(LOXL2) in pancreatic ductal adenocarcinoma
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  • Salvage Concurrent Chemo-radiation Therapy for Loco-regional Recurrence Following Curative Surgery of Non-small Cell Lung Cancer
    Kyung Hwa Lee, Yong Chan Ahn, Hongryull Pyo, Jae Myoung Noh, Seung Gyu Park, Tae Gyu Kim, Eonju Lee, Heerim Nam, Hyebin Lee, Jong-Mu Sun, Jin Seok Ahn, Myung-Ju Ahn, Keunchil Park
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  • Phase I Dose-Finding Study of OPB-111077, a Novel STAT3 Inhibitor, in Patients with Advanced Hepatocellular Carcinoma
    Changhoon Yoo, Jihoon Kang, Ho Yeong Lim, Jee Hyun Kim, Myung-Ah Lee, Kyung-Hun Lee, Tae-You Kim, Baek-Yeol Ryoo
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  • Incidence and Overall Survival of Biliary Tract Cancers in South Korea from 2006 to 2015: Using the National Health Information Database
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  • A retrospective feasibility study of biweekly docetaxel in patients with high-risk metastatic castration-naïve prostate cancer
    Sang Eun Yoon, Youjin Kim, Jangho Cho, Minyong Kang, Hyun Hwan Sung, Hwang Gyun Jeon, Byoung Chang Jeong, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee, Han Yong Choi, Su Jin Lee, Se Hoon Park
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  • Risk of cancer in pre-dialysis chronic kidney disease: A nationwide population-based study with a matched control group
    Sehoon Park, Soojin Lee, Yaerim Kim, Yeonhee Lee, Min Woo Kang, Kyungdo Han, Seoung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim
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  • The economic burden of cancer attributable to obesity in Korea: A population‐based cohort study
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  • Safety of Laparoscopic Oncologic Resection in Elderly Patients with Colorectal Cancer: A Multicenter Retrospective Study Based on Perioperative Short-Term Outcomes
    Bong-Hyeon Kye, Thammanij Rookkachart, Ji-Hoon Kim, Hyung-Jin Kim, Yoon-Suk Lee, In-Kyu Lee, Won Kyung Kang, Hyeon-Min Cho, Seong-Taek Oh
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  • Performance Evaluation of SENTiFIT 270 and FOB Gold Reagent for Detecting Fecal Occult Blood
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  • Expression of NF2 Modulates the Progression of BRAF V600E Mutated Thyroid Cancer Cells
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  • Integrative cancer treatment may have a survival benefit in patients with lung cancer
    Kyeore Bae, Eunseok Kim, Ji-Sook Kong, Jeehye Kim, So-jung Park, Hyeong joon Jun, Chong-kwan Cho, Mi Kyung Kim, Hwa-Seung Yoo
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  • Current status of endoscopic submucosal dissection for early gastric cancer in Korea: role and benefits
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  • Clinical Features and Outcomes of Invasive Breast Cancer: Age-Specific Analysis of a Modern Hospital-Based Registry
    Ji-Yeon Kim, Danbee Kang, Seok Jin Nam, Seok Won Kim, Jeong Eon Lee, Jong Han Yu, Se Kyung Lee, Young-Hyuck Im, Jin Seok Ahn, Eliseo Guallar, Juhee Cho, Yeon Hee Park
    Journal of Global Oncology.2019; (5): 1.     CrossRef
  • The Korean–Advance Directive Model and Factors Associated With Its Completion Among Patients With Hematologic Disorders
    Mee Ok Lee, Jinny Park, Eun Young Park, Youngji Kim, Eunjoo Bang, Seongkum Heo, JinShil Kim
    Journal of Hospice & Palliative Nursing.2019; 21(4): E10.     CrossRef
  • Association between Body Mass Index and Gastric Cancer Risk According to Effect Modification by Helicobacter pylori Infection
    Jieun Jang, Eun-Jung Cho, Yunji Hwang, Elisabete Weiderpass, Choonghyun Ahn, Jeoungbin Choi, Soung-Hoon Chang, Hai-Rim Shin, Min Kyung Lim, Keun-Young Yoo, Sue K. Park
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  • Clinical and Genetic Characteristics of BRCA1/2 Mutation in Korean Ovarian Cancer Patients: A Multicenter Study and Literature Review
    Byung Su Kwon, Jung Mi Byun, Hyun Joo Lee, Dae Hoon Jeong, Tae Hwa Lee, Kyung-Hwa Shin, Dong Soo Suh, Ki Hyung Kim
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  • The Health Burden of Cancer Attributable to Obesity in Korea: A Population-Based Cohort Study
    Joo Eun Lee, Chung Mo Nam, Sang Gyu Lee, Sohee Park, Tae Hyun Kim, Eun-Cheol Park
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  • The burdens of tuberculosis on patients with malignancy: incidence, mortality and relapse
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  • Comprehensive Cancer Panel Sequencing Defines Genetic Diversity and Changes in the Mutational Characteristics of Pancreatic Cancer Patients Receiving Neoadjuvant Treatment
    Kyong-Ah Yoon, Sang Myung Woo, Yun-Hee Kim, Sun-Young Kong, Min Kyoung Lee, Sung-Sik Han, Tae Hyun Kim, Woo Jin Lee, Sang-Jae Park
    Gut and Liver.2019; 13(6): 683.     CrossRef
  • Effect of Different Types of Mammography Equipment on Screening Outcomes: A Report by the Alliance for Breast Cancer Screening in Korea
    Bo Hwa Choi, Eun Hye Lee, Jae Kwan Jun, Keum Won Kim, Young Mi Park, Hye-Won Kim, You Me Kim, Dong Rock Shin, Hyo Soon Lim, Jeong Seon Park, Hye Jung Kim
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  • Amenorrhea and Menopause in Patients with Breast Cancer after Chemotherapy
    Jae Jun Shin, Young Min Choi, Jong Kwan Jun, Kyung-Hun Lee, Tae-Yong Kim, Wonshik Han, Seock-Ah Im
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  • Predictors of Quality of Life and Social Support as a Mediator between Defecation Function and Quality of Life among Rectal Cancer Patients
    Jung Rang Kim, Seon Young Hwang
    Korean Journal of Adult Nursing.2019; 31(5): 487.     CrossRef
  • Psychometric Evaluation of a Korean Version of the Cancer Survivors' Self-efficacy Scale
    Soo Hyun Kim, Bo Gyeong Lee, Ji Yeon Lee, Sei Joong Kim, Min Hee Hur, Moon Hee Lee, Mi Sook Han
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  • Do disinfection byproducts in drinking water have an effect on human cancer risk worldwide? A meta‐analysis
    Laleh R. Kalankesh, Susana Rodríguez‐Couto, Mohammad Ali Zazouli, Mahmood Moosazadeh, Seyednouraddin Mousavinasab
    Environmental Quality Management.2019; 29(2): 105.     CrossRef
  • Relationship between occupational sunlight exposure and the incidence of renal cancer
    Hyun-Suk Jang, Jong-Han Leem, Seong Soo Jeon, Shin-Goo Park, Sangyoon Lee, Yangwon Kang, Go Choi, Hyung Doo Kim, Hyeonwoo Ju, Sung Wook Jang, Youna Won, Hwan-Cheol Kim
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  • Correlates of life-support treatment preferences among low-income home-based cancer management recipients
    JinShil Kim, Seongkum Heo, Mi Yeong Kim, Eun Young Park, Eun Ju Seo, Mee Ok Lee, Bo Yoon Jeong, Jung-Ah Lee
    European Journal of Oncology Nursing.2019; 43: 101665.     CrossRef
  • Clinical outcomes of early gastric cancer with non-curative resection after pathological evaluation based on the expanded criteria
    Hyun Ju Kim, Sang Gyun Kim, Jung Kim, Hyoungju Hong, Hee Jong Lee, Min Seong Kim, Hyunsoo Chung, Hyun Chae Jung, Sudeep Gupta
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  • Association between obstructive sleep apnoea and breast cancer: The Korean National Health Insurance Service Data 2007–2014
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  • Risk of Cancers in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: Results from the Korea National Health Insurance Claims Database 2010–2018
    Sung Soo Ahn, Minkyung Han, Juyoung Yoo, Seung Min Jung, Jason Jungsik Song, Yong-Beom Park, Inkyung Jung, Sang-Won Lee
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  • A Text Mining Analysis of HPV Vaccination Research Trends
    Yedong Son, Hee Sun Kang
    Child Health Nursing Research.2019; 25(4): 458.     CrossRef
  • A Survey on Current Trends of Breast Imaging Practices in Korea
    Bo La Yun, Sun Mi Kim, Mijung Jang, Nariya Cho, Boo-Kyung Han
    Journal of the Korean Society of Radiology.2019; 80(5): 919.     CrossRef
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  • Pro‑apoptotic effect of the novel benzylidene derivative MHY695 in human colon cancer cells
    Gwangbeom Heo, Dongwan Kang, Chaeun Park, Su Kim, Jieun Choo, Yunna Lee, Jin‑Wook Yoo, Yunjin Jung, Jaewon Lee, Nam Kim, Hae Chung, Hyung Moon, Eunok Im
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  • Smoking and Urinary Cotinine Levels Are Predictors of Increased Risk for Gastric Intestinal Metaplasia
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  • Cancer Risk from Exposure to Particulate Matter and Ozone According to Obesity and Health-Related Behaviors: A Nationwide Population-Based Cross-Sectional Study
    Kyoung Jin Kim, Jinyoung Shin, Jaekyung Choi
    Cancer Epidemiology, Biomarkers & Prevention.2019; 28(2): 357.     CrossRef
  • Body Mass Index and Risk of Intestinal Metaplasia: A Cohort Study
    Kyungeun Kim, Yoosoo Chang, Jiin Ahn, Hyo-Joon Yang, Ju Young Jung, Seokkyun Kim, Chong Il Sohn, Seungho Ryu
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  • A Nationwide, Population-Based Epidemiologic Study of Childhood Brain Tumors in Korea, 2005–2014: A Comparison with United States Data
    Ji-Man Kang, Johyun Ha, Eun Kyung Hong, Hee Young Ju, Byung Kiu Park, Sang-Hoon Shin, Young-Joo Won, Kyu-Won Jung, Hyeon Jin Park
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  • A psychological intervention programme for patients with breast cancer under chemotherapy and at a high risk of depression: A randomised clinical trial
    Yeon Hee Kim, Kyung Sook Choi, Kihye Han, Hae Won Kim
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  • Necessity of D2 lymph node dissection in older patients ≥ 80 years with gastric cancer
    Ho Seok Seo, Yoon Ju Jung, Ji Hyun Kim, Cho Hyun Park, Han Hong Lee
    Journal of Geriatric Oncology.2018; 9(2): 115.     CrossRef
  • Mapping patterns of locoregional recurrence following contemporary treatment with radiation therapy for breast cancer: A multi-institutional validation study of the ESTRO consensus guideline on clinical target volume
    Jee Suk Chang, Jeongshim Lee, Mison Chun, Kyung Hwan Shin, Won Park, Jong Hoon Lee, Jin Hee Kim, Won Sup Yoon, Ik Jae Lee, Juree Kim, Hye Li Park, Yong Bae Kim
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  • Prevalence of human papillomavirus genotypes and precancerous cervical lesions in a screening population in the Republic of Korea, 2014–2016
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  • Apoptotic and antiproliferative properties of 3β‐hydroxy‐Δ5‐steroidal congeners from a partially purified column fraction of Dendronephthya gigantea against HL‐60 and MCF‐7 cancer cells
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  • Cancer incidence in northern Thailand: Results from six population‐based cancer registries 1993–2012
    Donsuk Pongnikorn, Karnchana Daoprasert, Narate Waisri, Mathieu Laversanne, Freddie Bray
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  • Incidental Anterior Mediastinal Nodular Lesions on Chest CT in Asymptomatic Subjects
    Soon Ho Yoon, Seung Ho Choi, Chang Hyun Kang, Jin Mo Goo
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  • Changes in Clinical Characteristics of Patients with an Initial Diagnosis of Prostate Cancer in Korea: 10-Year Trends Reported by a Tertiary Center
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    Hyeong Su Kim, Min-Hee Ryu, Dae Young Zang, Sook Ryun Park, Boram Han, Won Ki Kang, Sun Young Rha, Minkyu Jung, Jin-Soo Kim, Byung Woog Kang, Kyung-Hee Lee, Sang-Young Rho, Jung Han Kim, Kab Choong Kim, Ji Woong Cho, Dae Ro Choi, Hyun Lim, Ho Suk Kang, Ja
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  • Psychiatric comorbidities among ovarian cancer survivors in South Korea: A nationwide population‐based, longitudinal study
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  • Analysis of Motion-dependent Clinical Outcome of Tumor Tracking Stereotactic Body Radiotherapy for Prostate Cancer
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  • Left-Sided Colectomy: One of the Important Risk Factors of Metachronous Colorectal Adenoma After Colectomy for Colon Cancer
    Gee Young Yun, Hee Seok Moon, In Sun Kwon, Ju Seok Kim, Sun Hyung Kang, Eaum Seok Lee, Seok Hyun Kim, Jae Kyu Sung, Byung Seok Lee, Hyun Yong Jeong
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  • A national survey of lung cancer specialists’ views on low-dose CT screening for lung cancer in Korea
    Dong Wook Shin, Sohyun Chun, Young Il Kim, Seung Joon Kim, Jung Soo Kim, SeMin Chong, Young Sik Park, Sang-Yun Song, Jin Han Lee, Hee Kyung Ahn, Eun Young Kim, Sei Hoon Yang, Myoung Kyu Lee, Deog Gon Cho, Tae Won Jang, Ji Woong Son, Jeong-Seon Ryu, Moon-J
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  • The prevalence and clinical significance of postgastrectomy anemia in patients with early-stage gastric cancer: A retrospective cohort study
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  • Budget Impact of the Accreditation Program for Clinical Laboratories on Colorectal Cancer Screening via Fecal Immunochemical Testing: Results from the National Cancer Screening Program in Korea
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  • Galanin is an epigenetically silenced tumor suppressor gene in gastric cancer cells
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  • The Correlation Between Serum Chemokines and Clinical Outcome in Patients with Advanced Biliary Tract Cancer
    Su Jin Lee, Jung Eun Kim, Seung Tae Kim, Jeeyun Lee, Se Hoon Park, Joon Oh Park, Won Ki Kang, Young Suk Park, Ho Yeong Lim
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  • Use of complementary and alternative medicine by lymphoma survivors in South Korea
    Kisook Kim, Soo Hyun Kim, Oh Nam Ok, Im-Ryung Kim, Suyeon Lee, So Hee Kim, Won Seog Kim, Min-Hee Ryu, Moon Hee Lee
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  • Forty‐nine gastric cancer cell lines with integrative genomic profiling for development of c‐MET inhibitor
    Hyun Jeong Kim, Sun Kyoung Kang, Woo Sun Kwon, Tae Soo Kim, Inhye Jeong, Hei‐Cheul Jeung, Michael Kragh, Ivan D. Horak, Hyun Cheol Chung, Sun Young Rha
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  • Pre-treatment anxiety is associated with persistent chemotherapy-induced peripheral neuropathy in women treated with neoadjuvant chemotherapy for breast cancer
    Kwang-Min Lee, Dooyoung Jung, Heesung Hwang, Kyung-Lak Son, Tae-Yong Kim, Seock-Ah Im, Kyung-Hun Lee, Bong-Jin Hahm
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  • Comparison of the short-term outcomes of reduced-port laparoscopic surgery and conventional multiport surgery in colon cancer: a propensity score matching analysis
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Original Article
Current Trends in the Incidence and Survival Rate of Urological Cancers in Korea
Jae Young Joung, Jiwon Lim, Chang-Mo Oh, Kyu-Won Jung, Hyunsoon Cho, Sung Han Kim, Ho Kyung Seo, Weon Seo Park, Jinsoo Chung, Kang Hyun Lee, Young-Joo Won
Cancer Res Treat. 2017;49(3):607-615.   Published online September 23, 2016
DOI: https://doi.org/10.4143/crt.2016.139
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
This descriptive study assessed the current trends in the incidence of urological cancers and patient survival in Korea.
Materials and Methods
In this nationwide retrospective observational study based on the data from the Korea National Cancer Incidence Database (KNCIDB), this study analyzed the age-standardized incidence rates (ASRs) and annual percentage changes (APCs) of kidney, bladder, prostate, testicular, and penile cancers as well as cancer of the renal pelvis and ureter between 1999 and 2012. The relative survival rates (RSRs) were calculated for urological cancer patients diagnosed between 1993 and 2012 from the KNCIDB data.
Results
Prostate cancer was diagnosed in 66,812 individuals followed by bladder (41,549) and kidney (36,836) cancers. The overall ASR (18.26 per 100,000) increased with age because of the higher ASRs of bladder and prostate cancers in the elderly. The ASR for kidney cancer was highest in the 40-59-year-old group, whereas testicular cancer occurred most frequently before the age of 40. The incidence of most urological cancers increased (overall APC, 6.39%; p < 0.001), except for penile (APC, –2.01%; p=0.05) and bladder (APC, –0.40%; p=0.25) cancers. The overall survival increased steadily (5-year RSR, 66.4% in 1993-1995 vs. 84.2% in 2008-2012; p < 0.001), particularly for prostate (by 34.10%) and kidney (by 16.30%) cancers, but not for renal pelvis and ureter cancers (–7.20%).
Conclusion
The most common urological cancer in Korea was prostate cancer followed by bladder and kidney cancers. The incidence of most urological cancers, except for penile and bladder cancers, increased. Survival also increased, particularly for prostate and kidney cancers.

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Special Articles
Prediction of Cancer Incidence and Mortality in Korea, 2016
Kyu-Won Jung, Young-Joo Won, Chang-Mo Oh, Hyun-Joo Kong, Hyunsoon Cho, Jong-Keun Lee, Duk Hyoung Lee, Kang Hyun Lee
Cancer Res Treat. 2016;48(2):451-457.   Published online March 25, 2016
DOI: https://doi.org/10.4143/crt.2016.092
AbstractAbstract PDFPubReaderePub
Purpose
To estimate of Korea’s current cancer burden, this study aimed to report on projected cancer incidence and mortality rates for the year 2016.
Materials and Methods
Cancer incidence data from 1999 to 2013 were obtained from the Korea National Cancer Incidence Database, and cancer mortality data from 1993 to 2014 were acquired from Statistics Korea. Cancer incidence in 2016 was projected by fitting a linear regression model to observed age-specific cancer incidence rates against observed years, then multiplying the projected age-specific rates by the age-specific population. The Joinpoint regression model was used to determine at which year the linear trend changed significantly.
Results
A total of 254,962 new cancer cases and 75,172 cancer deaths are expected to occur in Korea in 2016. The five leading primary cancer incident sites in 2016 were estimated colorectal, stomach, lung, liver and thyroid cancer in men; thyroid, breast, colorectal, stomach, and lung cancer in women.
Conclusion
Currently cancer is one of the foremost public health concerns in Korea. Although cancer rates are anticipated to decrease the nation’s cancer burden will continue to increase as the population ages.

Citations

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Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2013
Chang-Mo Oh, Young-Joo Won, Kyu-Won Jung, Hyun-Joo Kong, Hyunsoon Cho, Jong-Keun Lee, Duk Hyoung Lee, Kang Hyun Lee, The Community of Population-Based Regional Cancer Registries
Cancer Res Treat. 2016;48(2):436-450.   Published online March 3, 2016
DOI: https://doi.org/10.4143/crt.2016.089
AbstractAbstract PDFPubReaderePub
Purpose
This study described the 2013 nationwide cancer statistics in Korea, including cancer incidence, survival, prevalence, and mortality.
Materials and Methods
Cancer incidence data from 1999-2013 were obtained from Korea National Cancer Incidence Database and followed until December 31, 2014. Mortality data from 1983-2013 were obtained from Statistics Korea. The prevalence was defined as the number of cancer patients alive on January 1, 2014 among all cancer patients diagnosed since 1999. Crude, and age-standardized and 5-year relative survival rates were also calculated.
Results
In 2013, a total of 225,343 and 75,334 Koreans were newly diagnosed and died from cancer, respectively. The age-standardized rates for cancer incidence and mortality in 2013 were 290.5 and 87.9 per 100,000, respectively. The age-standardized cancer incidence rate increased 3.1% annually between 1999 and 2013. However, the overall cancer incidence rates have decreased slightly in recent years (2011 to 2013). The age-standardized rate for all-cancer mortality has decreased 2.7% annually since 2002. Overall, the 5-year relative survival rate for people diagnosed with cancer between 2009 and 2013 was 69.4%, which represents an improved survival rate as compared with 41.2% for people diagnosed between 1993 and 1995.
Conclusion
Age-standardized cancer incidence rates have decreased between 2011 and 2013; mortality rates have also declined since 2002, while 5-year survival rates have improved remarkably from 1993-1995 to 2009-2013 in Korea.

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Original Article
Systemic Treatments for Metastatic Renal Cell Carcinoma: 10-Year Experience of Immunotherapy and Targeted Therapy
Sung Han Kim, Weon Seo Park, Sun Ho Kim, Jae Young Joung, Ho Kyung Seo, Kang Hyun Lee, Jinsoo Chung
Cancer Res Treat. 2016;48(3):1092-1101.   Published online January 28, 2016
DOI: https://doi.org/10.4143/crt.2015.316
AbstractAbstract PDFPubReaderePub
Purpose
The purpose of this study is to compare the outcomes of first-line systemic targeted therapy (TT) and immunotherapy (IT) in patients with metastatic renal cell carcinoma (mRCC).
Materials and Methods
This study was a retrospective review of the data of 262 patients treated with systemic IT or TT with tyrosine kinase inhibitors between 2003 and 2013. The objective response rate (ORR), progression-free survival (PFS), and overall survival (OS) were assessed using Response Evaluation Criteria in Solid Tumor ver. 1.0 criteria and the Kaplan-Meier method with log-rank test.
Results
During the median 4.3-month treatment and the 24-month follow-up period, the ORR/PFS/OS of the overall first-line and second-line therapy were 41.9%/8.1 months/16.8 months and 27.5%/6.5 months/15.3 months, respectively. The first-line TT/IT/sequential IT had a PFS of 9.3/6.4/5.7 months and an OS of 15.8/16.5/40.6 months (all p < 0.05). The second-line of TT/IT had a PFS of 7.1/2.1 months (both p < 0.05) and an OS of 16.6/8.6 months (p=0.636), respectively. Pazopanib provided the best median PFS of 11.0 months (p < 0.001) and a quadruple IT regimen had a superior PFS (p=0.522). For OS, sequential treatment with IT and TT was superior compared to treatment with either IT or TT alone (40.6/16.5/15.8 months, p=0.014). The prognosis according to the Memorial Sloan Kettering Cancer Center model showed that favorable/intermediate/poor risk groups had a PFS of 8.5/10.4/2.3 months, and an OS of 43.1/20.4/5.6 months, respectively. The prognosis calculated using the Heng model showed that the favorable/intermediate/poor risk groups had a PFS of 9.2/3.9/2.7 months, and an OS of 32.4/16.5/6.1months, respectively (all p < 0.001).
Conclusion
In patients with mRCC, TT provided a better PFS and OS compared with IT.

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Prediction of Cancer Incidence and Mortality in Korea, 2015
Kyu-Won Jung, Young-Joo Won, Chang-Mo Oh, Hyun-Joo Kong, Hyunsoon Cho, Duk Hyoung Lee, Kang Hyun Lee
Cancer Res Treat. 2015;47(2):142-148.   Published online March 17, 2015
DOI: https://doi.org/10.4143/crt.2015.066
AbstractAbstract PDFPubReaderePub
Purpose
For estimation of Korea’s current cancer burden, this study aimed to report on the projected cancer incidence and mortality rates for the year 2015. Materials and Methods Cancer incidence data from 1999 to 2012 were obtained from the Korea National Cancer Incidence Database, and cancer mortality data from 1993 to 2013 were acquired from Statistics Korea. The cancer incidence in 2015 was projected by fitting a linear regression model to the observed age-specific cancer incidence rates against the observed years and then multiplying the projected age-specific rates by the age-specific population. A similar procedure was used for cancer mortality, except a Joinpoint regression model was used to determine at which year the linear trend changed significantly.
Results
A total of 280,556 new cancer cases and 76,698 cancer deaths are expected to occur in Korea in 2015. The crude incidence rate per 100,000 of all sites combined will likely reach 551.6 and the age-standardized incidence rate, 347.6. The estimated five leading primary cancer incidence sites are the stomach, colorectum, lung, prostate, and liver in men; and thyroid, breast, colorectum, stomach, and lung in women. The projected crude mortality rate of all sites combined and age-standardized rate is 150.8 and 82.4, respectively. Conclusion Cancer is currently one of the foremost public health concerns in Korea, and as the population ages, the nation’s cancer burden will continue to increase.

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Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2012
Kyu-Won Jung, Young-Joo Won, Hyun-Joo Kong, Chang-Mo Oh, Hyunsoon Cho, Duk Hyoung Lee, Kang Hyun Lee
Cancer Res Treat. 2015;47(2):127-141.   Published online March 3, 2015
DOI: https://doi.org/10.4143/crt.2015.060
AbstractAbstract PDFPubReaderePub
Purpose
The aim of this study was to report nationwide cancer statistics in Korea, including incidence, mortality, survival, and prevalence, and their trends. Materials and Methods Incidence data from 1993 to 2012 were obtained from the Korea National Cancer Incidence Database, and vital status was followed through December 31, 2013. Mortality data from 1983 to 2012 were obtained from Statistics Korea. Crude and age-standardized rates for incidence, mortality, and prevalence, and relative survival were calculated. Results A total of 224,177 cancer cases and 73,759 cancer deaths were reported in 2012, and there were 1,234,879 prevalent cases identified in Korea as of January 1, 2013. Over the past 14 years (1999-2012), overall incidence rates have increased by 3.3% per year. The incidence rates of liver and cervical cancers have decreased, while those of thyroid, breast, prostate, and colorectal cancers have increased. Notably, incidence of thyroid cancer increased by 22.3% per year in both sexes and has been the most common cancer since 2009. The mortality for all cancers combined decreased by 2.7% per year from 2002 to 2012. Five-year relative survival rates of patients diagnosed in the last 5 years (2008-2012) have improved by 26.9% compared with those from 1993 to1995. Conclusion Overall cancer mortality rates have declined since 2002 in Korea, while incidence has increased and survival has improved.

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    Journal of Preventive Medicine and Public Health.2016; 49(3): 143.     CrossRef
  • The Lived Experience of Suffering of Family with Cancer Patients: Parse’s Human Becoming Research Method
    Ye-Sook Choi
    The Korean Journal of Hospice and Palliative Care.2016; 19(2): 127.     CrossRef
  • Develop 3D Prostate Cancer Visualization Tool in Smart Care System
    Byung Uk Ahn, Seung Won Shin, Moon Hyung Choi, Seung Eun Jung, Kwang Gi Kim
    Journal of Korea Multimedia Society.2016; 19(2): 163.     CrossRef
  • Estimation of Recurrence Risk After Normal 18F-FDG PET/CT in Nonsmall-Cell Lung Cancer
    Kyoungjune Pak, Seong-Jang Kim, Phillip J. Koo, Samuel Chang
    Cancer Biotherapy and Radiopharmaceuticals.2016; 31(5): 174.     CrossRef
  • Hypofractionated stereotactic body radiotherapy in low- and intermediate-risk prostate carcinoma
    Hun Jung Kim, Jeong Hoon Phak, Woo Chul Kim
    Radiation Oncology Journal.2016; 34(4): 260.     CrossRef
  • Dietary patterns and colorectal cancer risk in a Korean population
    Yoon Park, Jeonghee Lee, Jae Hwan Oh, Aesun Shin, Jeongseon Kim
    Medicine.2016; 95(25): e3759.     CrossRef
  • Snake Venom synergized Cytotoxic Effect of Natural Killer Cells on NCI H358 Human Lung Cancer Cell Growth through Induction of Apoptosis
    Jae Woo Oh, Ho Sueb Song
    The Acupuncture.2016; 33(2): 1.     CrossRef
  • News Portrayal of Cancer: Content Analysis of Threat and Efficacy by Cancer Type and Comparison with Incidence and Mortality in Korea
    Minsun Shim, Yong-Chan Kim, Su Yeon Kye, Keeho Park
    Journal of Korean Medical Science.2016; 31(8): 1231.     CrossRef
  • Performance of Screening Mammography: A Report of the Alliance for Breast Cancer Screening in Korea
    Eun Hye Lee, Keum Won Kim, Young Joong Kim, Dong-Rock Shin, Young Mi Park, Hyo Soon Lim, Jeong Seon Park, Hye-Won Kim, You Me Kim, Hye Jung Kim, Jae Kwan Jun
    Korean Journal of Radiology.2016; 17(4): 489.     CrossRef
  • Identification of an N staging system that predicts oncologic outcome in resected left-sided pancreatic cancer
    Sung Hyun Kim, Ho Kyoung Hwang, Woo Jung Lee, Chang Moo Kang
    Medicine.2016; 95(26): e4035.     CrossRef
  • Association between obesity and local control of advanced rectal cancer after combined surgery and radiotherapy
    Yunseon Choi, Yun-Han Lee, Sung Kwang Park, Heunglae Cho, Ki Jung Ahn
    Radiation Oncology Journal.2016; 34(2): 113.     CrossRef
  • The clinical utilization of radiation therapy in Korea between 2009 and 2013
    Jin-Kyu Kang, Mi-Sook Kim, Won-Il Jang, Young Seok Seo, Hee Jin Kim, Chul Koo Cho, Hyung Jun Yoo, Eun Kyung Paik, Yu Jin Cha, Hyun Jin Song
    Radiation Oncology Journal.2016; 34(2): 88.     CrossRef
  • Relationship between Salt Preference and Gastric Cancer Screening: An Analysis of a Nationwide Survey in Korea
    Ji-Yeon Shin, Jeongseon Kim, Kui Son Choi, Mina Suh, Boyoung Park, Jae Kwan Jun
    Cancer Research and Treatment.2016; 48(3): 1037.     CrossRef
  • Changing Patterns of Primary Treatment in Korean Men with Prostate Cancer Over 10 Years: A Nationwide Population Based Study
    Jinsung Park, Beomseok Suh, Dong Wook Shin, Jun Hyuk Hong, Hanjong Ahn
    Cancer Research and Treatment.2016; 48(3): 899.     CrossRef
  • Effects of hand grip strength on shoulder muscle activity in breast cancer patients
    Tae-Won Yun, Byoung-Hee Lee
    Physical Therapy Rehabilitation Science.2016; 5(2): 95.     CrossRef
  • The Structural Equation Model on Resilience of Breast Cancer Patients Receiving Chemotherapy
    Jeong Ha Yang, Ok Soo Kim
    Journal of Korean Academy of Nursing.2016; 46(3): 327.     CrossRef
  • Gastric Cancer with Peritoneal Tuberculosis: Challenges in Diagnosis and Treatment
    Amer Saeed Alshahrani, In Seob Lee
    Journal of Gastric Cancer.2016; 16(2): 111.     CrossRef
  • Is there a difference in clinicopathological outcomes of renal tumor between young and old patients? A multicenter matched-pair analysis
    Jeong Ho Kim, Yong Hyun Park, Yong June Kim, Seok Ho Kang, Seok Soo Byun, Sung-Hoo Hong
    Scandinavian Journal of Urology.2016; 50(5): 387.     CrossRef
  • Doctors' Ageism towards the Elderly Cancer Patients: Focusing on Disclosure of Cancer Diagnosis and Explanation on Treatment
    Yeonok Lim, Dae Young Zang, Dae Ro Choi, Seok Yun Kang, Young Suk Park, Hyunsook Yoon, Hyunjoo Lee, Yojin Kim, Ilsung Nam, Kyoungwon Choi
    Korean Journal of Health Promotion.2016; 16(2): 101.     CrossRef
  • The Effect of A Salivation Stimulation Method on Xerostomia in Colon Cancer Patients after Surgery
    Anna Kim, Jeong Sook Park
    Asian Oncology Nursing.2016; 16(2): 75.     CrossRef
  • Quality of life changes during adjuvant chemotherapy in patients with colon cancer
    Seo Hee Lee, Taek-Gu Lee, Moo Jun Baek, Jang Jin Kim, Sung-Su Park, Sang-Jeon Lee
    Korean Journal of Clinical Oncology.2016; 12(1): 60.     CrossRef
  • Preventive effect of fermented red ginseng on cisplatin-induced nephrotoxicity mouse
    Ja-Kyoung Hyun, O Jun Kwon, Joo Young Lee, Seong-Soo Roh, Young-Bae Seo
    Journal of Applied Biological Chemistry.2016; 59(2): 113.     CrossRef
  • Prostate‐specific antigen kinetics following hypofractionated stereotactic body radiotherapy versus conventionally fractionated external beam radiotherapy for low‐ and intermediate‐risk prostate cancer
    Seok Ho Lee, Hun Jung Kim, Woo Chul Kim
    Asia-Pacific Journal of Clinical Oncology.2016; 12(4): 388.     CrossRef
  • Sex Disparity in Gastric Cancer: Female Sex is a Poor Prognostic Factor for Advanced Gastric Cancer
    Hae Won Kim, Jie-Hyun Kim, Beom Jin Lim, HyunKi Kim, Hoguen Kim, Jae Jun Park, Young Hoon Youn, Hyojin Park, Sung Hoon Noh, Jong Won Kim, Seung Ho Choi
    Annals of Surgical Oncology.2016; 23(13): 4344.     CrossRef
  • Resection of Diminutive and Small Colorectal Polyps: What Is the Optimal Technique?
    Jun Lee
    Clinical Endoscopy.2016; 49(4): 355.     CrossRef
  • The Role of Laparoscopic Radical Hysterectomy in Early-Stage Adenocarcinoma of the Uterine Cervix
    Jeong-Yeol Park, Daeyeon Kim, Dae-Shik Suh, Jong-Hyeok Kim, Yong-Man Kim, Young-Tak Kim, Joo-Hyun Nam
    Annals of Surgical Oncology.2016; 23(S5): 825.     CrossRef
  • Clinical characteristics and potential aetiologies of non‐B non‐C hepatocellular carcinoma in hepatitis B virus endemic area
    Seung Bum Lee, Kang Mo Kim, Jihyun An, Danbi Lee, Ju Hyun Shim, Young‐Suk Lim, Han Chu Lee, Young‐Hwa Chung, Yung Sang Lee
    Liver International.2016; 36(9): 1351.     CrossRef
  • Association of human papillomavirus type 16 and its genetic variants with cervical lesion in Korea
    Jeong Su Park, Sue Shin, Eui‐Chong Kim, Ji Eun Kim, Yong Beom Kim, Sohee Oh, Eun Youn Roh, Jong Hyun Yoon
    APMIS.2016; 124(11): 950.     CrossRef
  • Bowel Preparation Formulations and Salvage Options for Inadequate Preparation
    Jun Lee
    The Korean Journal of Gastroenterology.2016; 68(2): 61.     CrossRef
  • Gallstones and the Risk of Gallbladder Cancer Mortality: A Cohort Study
    Seungho Ryu, Yoosoo Chang, Kyung Eun Yun, Hyun-Suk Jung, Jun Ho Shin, Hocheol Shin
    American Journal of Gastroenterology.2016; 111(10): 1476.     CrossRef
  • Symptom Severity according to the Presence of Depressive and Anxiety Symptoms among Patients with Head and Neck Cancer
    Hyun-Joo Kim, Ok-Hee Cho, Yang-Sook Yoo
    Korean Journal of Adult Nursing.2016; 28(2): 148.     CrossRef
  • Quantification of epidermal growth factor receptor (EGFR) mutation may be a predictor of EGFR‐tyrosine kinase inhibitor treatment response
    Ha Young Park, Hyung Joo Oh, Ki‐Hyun Kim, Tae‐Ok Kim, Cheol‐Kyu Park, Hong‐Jun Shin, Jung‐Hwan Lim, Yong‐Soo Kwon, In‐Jae Oh, Yu‐Il Kim, Sung‐Chul Lim, Young‐Chul Kim, Yoo‐Duk Choi
    Thoracic Cancer.2016; 7(6): 639.     CrossRef
  • A pilot study of concurrent chemoradiotherapy with gemcitabine and cisplatin in patients with locally advanced biliary tract cancer
    Kyong Joo Lee, Seung Woo Yi, Jihye Cha, Jinsil Seong, Seungmin Bang, Si Young Song, Hee Man Kim, Seung Woo Park
    Cancer Chemotherapy and Pharmacology.2016; 78(4): 841.     CrossRef
  • Recent advances in multiple myeloma: a Korean perspective
    Junshik Hong, Jae Hoon Lee
    The Korean Journal of Internal Medicine.2016; 31(5): 820.     CrossRef
  • The Fruit Hull of Gleditsia sinensis Enhances the Anti‐Tumor Effect of cis‐Diammine Dichloridoplatinum II (Cisplatin)
    Kyun Ha Kim, Chang-Woo Han, Seong Hoon Yoon, Yun Seong Kim, Jong-In Kim, Myungsoo Joo, Jun-Yong Choi, Siyaram Pandey
    Evidence-Based Complementary and Alternative Medicine.2016;[Epub]     CrossRef
  • Surgical and obstetrical outcomes after laparoscopic radical trachelectomy and pelvic lymphadenectomy for early cervical cancer
    So-Eun Yoo, Kyeong A So, Seon-Ah Kim, Mi Kyung Kim, Yoo Kyung Lee, In-Ho Lee, Tae-Jin Kim, Ki Heon Lee
    Obstetrics & Gynecology Science.2016; 59(5): 373.     CrossRef
  • Detecting Asymptomatic Recurrence in Early-Stage Endometrial Cancer
    Jung-Yun Lee, Ji Hee Kim, Jung Won Seo, Hee Seung Kim, Jae-Weon Kim, Noh Hyun Park, Yong-Sang Song
    International Journal of Gynecological Cancer.2016; 26(8): 1434.     CrossRef
  • Preoperative chemoradiotherapy for elderly patients with locally advanced rectal cancer—a real-world outcome study
    Younak Choi, Jee Hyun Kim, Ji-Won Kim, Jin Won Kim, Keun-Wook Lee, Heung-Kwon Oh, Duck-Woo Kim, Sung-Bum Kang, Changhoon Song, Jae-Sung Kim
    Japanese Journal of Clinical Oncology.2016; 46(12): 1108.     CrossRef
  • The number of retrieved lymph nodes needed for accurate staging differs based on the presence of preoperative chemoradiation for rectal cancer
    Jeonghee Han, Gyoung Tae Noh, Shen Ann Yeo, Chinock Cheong, Min Soo Cho, Hyuk Hur, Byung Soh Min, Kang Young Lee, Nam Kyu Kim
    Medicine.2016; 95(38): e4891.     CrossRef
  • Cancer-specific incidence rates of tuberculosis
    Gi Hyeon Seo, Min Jae Kim, Soyoung Seo, Boram Hwang, Eugene Lee, Yujin Yun, Minsun Choi, Moonsuk Kim, Jin Won Kim, Eu Suk Kim, Hong Bin Kim, Kyoung-Ho Song
    Medicine.2016; 95(38): e4919.     CrossRef
  • Dietary Patterns for Women With Triple-negative Breast Cancer and Dense Breasts
    Yukyung Go, Minsung Chung, Yongsoon Park
    Nutrition and Cancer.2016; 68(8): 1281.     CrossRef
  • Cause of Death in Korean Men with Prostate Cancer: an Analysis of Time Trends in a Nationwide Cohort
    Jinsung Park, Beomseok Suh, Dong Wook Shin, Jun Hyuk Hong, Hanjong Ahn
    Journal of Korean Medical Science.2016; 31(11): 1802.     CrossRef
  • Preoperative Body Mass Index May Determine the Prognosis of Advanced Gastric Cancer
    Dong Hwan Jun, Beom Jin Kim, Ji Hoon Park, Jae G. Kim, Kyong-Choun Chi, Joong-Min Park, Mi Kyung Kim, Hyun Kang
    Nutrition and Cancer.2016; 68(8): 1295.     CrossRef
  • Effect of Previous Gastrectomy on the Performance of Postoperative Colonoscopy
    Sunghwan Kim, Jeongmin Choi, Tae Han Kim, Seong-Ho Kong, Yun-Suhk Suh, Jong Pil Im, Hyuk-Joon Lee, Sang Gyun Kim, Seung-Yong Jeong, Joo Sung Kim, Han-Kwang Yang
    Journal of Gastric Cancer.2016; 16(3): 167.     CrossRef
  • Prognostic Factors for Node-Negative Advanced Gastric Cancer after Curative Gastrectomy
    Eun Woo Lee, Woo Yong Lee, Ho-Seok Koo
    Journal of Gastric Cancer.2016; 16(3): 161.     CrossRef
  • Is There a Role for Adjuvant Therapy in R0 Resected Gallbladder Cancer?: A Propensity Score-Matched Analysis
    Se-Il Go, Young Saing Kim, In Gyu Hwang, Eun Young Kim, Sung Yong Oh, Jun Ho Ji, Haa-Na Song, Se Hoon Park, Joon Oh Park, Jung Hun Kang
    Cancer Research and Treatment.2016; 48(4): 1274.     CrossRef
  • Moderating Effects of Optimism and Family Support on the Depression of Family Caregivers of Cancer Patients
    Kyoungwon Choi, Dae Ro Choi, Dae Young Zang, Young Suk Park, Seok Yun Kang, Hyunsook Yoon, Yeon Ok Lim, Yojin Kim, Ilsung Nam, Hyen Joo Lee
    Korean Journal of Health Promotion.2016; 16(3): 192.     CrossRef
  • Effects of a Navigation Program for Patients with Newly Diagnosed Gastric Cancer: A Randomized Controlled Trial
    Yeon Seo Hong, Jeong Yun Park, So Hee Kim, Sun A Kim, Yeon Hee Kim
    Asian Oncology Nursing.2016; 16(3): 132.     CrossRef
  • Analysis of NF-κ B and Clinical Prognostic Factors in Clear Cell Renal Cell Carcinoma
    Young Lee, Jeonghyouk Choi, Dong-Gi Lee, Koo Han Yoo, Gyeong Eun Min, Hyung-Lae Lee, Kyu Yeoun Won, Sung-Jig Lim
    The Korean Journal of Urological Oncology.2016; 14(2): 63.     CrossRef
  • A geographical study of thyroid cancer incidence in north-west England following the Windscale nuclear reactor fire of 1957
    Richard J Q McNally, Richard Wakeford, Peter W James, Nermine O Basta, Robert D Alston, Mark S Pearce, Alex T Elliott
    Journal of Radiological Protection.2016; 36(4): 934.     CrossRef
  • Targeting the Phosphatidylinositol-3-kinase Pathway in Gastric Cancer: Can Omics Improve Outcomes?
    Phu Tran, Cham Nguyen, Samuel J. Klempner
    International Neurourology Journal.2016; 20(Suppl 2): S131.     CrossRef
  • A Comparison of Open, Laparoscopic, and Robotic Surgery in the Treatment of Right-sided Colon Cancer
    Jeonghyun Kang, Yoon Ah Park, Seung Hyuk Baik, Seung-Kook Sohn, Kang Young Lee
    Surgical Laparoscopy, Endoscopy & Percutaneous Techniques.2016; 26(6): 497.     CrossRef
  • Dietary protein and fat intake in relation to risk of colorectal adenoma in Korean
    Sun Young Yang, Young Sun Kim, Jung Eun Lee, Jueun Seol, Ji Hyun Song, Goh Eun Chung, Jeong Yoon Yim, Sun Hee Lim, Joo Sung Kim
    Medicine.2016; 95(49): e5453.     CrossRef
  • Unkindness Experience of Health Care Provider in Patients with Breast Cancer
    Sue-Kyung Sohn, Ick-Jee Kim, Mi-SunKim Kim, Kyeong-Hee Shin, Min-Suk Lee, Eun-Mee Lee
    Journal of East-West Nursing Research.2016; 22(1): 51.     CrossRef
  • Anal Human Papillomavirus Infection among HIV-Infected Men in Korea
    Chang Hun Lee, Sun Hee Lee, Shinwon Lee, Heerim Cho, Kye-Hyung Kim, Jung Eun Lee, Eun ju Jung, Su jin Lee, Eun Jung Kim, Ki Hyung Kim, Eunsoo Moon, Hong Je Cho, Maria Lina Tornesello
    PLOS ONE.2016; 11(8): e0161460.     CrossRef
  • Timing of Surgical Management of Papillary Thyroid Cancer Diagnosed during Pregnancy
    Yoonseok Kim, Changhoon Lee, Eunae Jae, Youngjin Lee, Jueun Jung, Susun Kim, Mihyang Kim, Eunsuk Lee, Chunsuk Park, Jaemook Park, Hyunwoo Jung, Musil Park, Jaejun Lee, Junmo Ahn, Soo Lee
    International Journal of Thyroidology.2016; 9(2): 168.     CrossRef
  • Postoperative radiotherapy appeared to improve the disease free survival rate of patients with extrahepatic bile duct cancer at high risk of loco-regional recurrence
    Mi Young Kim, Jin Hee Kim, Yonghoon Kim, Sang Jun Byun
    Radiation Oncology Journal.2016; 34(4): 297.     CrossRef
  • Health Behaviors and Associated Sociodemographic Factors in Cervical Cancer Survivors Compared with Matched Non-Cancer Controls
    Boyoung Park, Se Ik Kim, Sang-Soo Seo, Sokbom Kang, Sang-Yoon Park, Myong Cheol Lim, Michael Scheurer
    PLOS ONE.2016; 11(8): e0160682.     CrossRef
  • Weight Change and Associated Factors in Long-Term Breast Cancer Survivors
    Hye-Yeon Koo, Young-Gyun Seo, Mi-Hee Cho, Min-Jung Kim, Ho-Chun Choi, William B. Coleman
    PLOS ONE.2016; 11(7): e0159098.     CrossRef
  • Treatment outcomes after adjuvant radiotherapy following surgery for patients with stage I endometrial cancer
    Jiyoung Kim, Kyung-Ja Lee, Kyung-Ran Park, Boram Ha, Yi-Jun Kim, Wonguen Jung, Rena Lee, Seung Cheol Kim, Hye Sung Moon, Woong Ju, Yun Hwan Kim, Jihae Lee
    Radiation Oncology Journal.2016; 34(4): 265.     CrossRef
  • A Lymph Node Staging System for Gastric Cancer: A Hybrid Type Based on Topographic and Numeric Systems
    Yoon Young Choi, Ji Yeong An, Hitoshi Katai, Yasuyuki Seto, Takeo Fukagawa, Yasuhiro Okumura, Dong Wook Kim, Hyoung-Il Kim, Jae-Ho Cheong, Woo Jin Hyung, Sung Hoon Noh, Anthony W.I. Lo
    PLOS ONE.2016; 11(3): e0149555.     CrossRef
  • Physical, Psychological and Social Symptoms, Activity and Education of Children and Adolescents with Acute Lymphoblastic Leukemia Receiving Maintenance Chemotherapy
    Hee Sung Yoon, Kwang Sung Kim, Sun Hee Choi, So Eun Choi, Kyoung A Kim, Kyoung Eon Kim
    Asian Oncology Nursing.2016; 16(4): 169.     CrossRef
  • Acute High-Dose and Chronic Lifetime Exposure to Alcohol Consumption and Differentiated Thyroid Cancer: T-CALOS Korea
    Yunji Hwang, Kyu Eun Lee, Elisabete Weiderpass, Young Joo Park, Young Jun Chai, Hyungju Kwon, Do Joon Park, BeLong Cho, Ho-Chun Choi, Daehee Kang, Sue K. Park, Li Wang
    PLOS ONE.2016; 11(3): e0151562.     CrossRef
  • Pilot Study of a Next-Generation Sequencing-Based Targeted Anticancer Therapy in Refractory Solid Tumors at a Korean Institution
    Hyung Soon Park, Sun Min Lim, Sora Kim, Sangwoo Kim, Hye Ryun Kim, KyuBum Kwack, Min Goo Lee, Joo-Hang Kim, Yong Wha Moon, Masaru Katoh
    PLOS ONE.2016; 11(4): e0154133.     CrossRef
  • Oral Bisphosphonates and Upper Gastrointestinal Cancer Risks in Asians with Osteoporosis: A Nested Case-Control Study Using National Retrospective Cohort Sample Data from Korea
    Sun-Young Jung, Hyun Soon Sohn, Eun-Ja Park, Hae Sun Suh, Ji-Won Park, Jin-Won Kwon, Chi-Ling Chen
    PLOS ONE.2016; 11(3): e0150531.     CrossRef
  • The Delayed Risk Stratification System in the Risk of Differentiated Thyroid Cancer Recurrence
    Aldona Kowalska, Agnieszka Walczyk, Iwona Pałyga, Danuta Gąsior-Perczak, Klaudia Gadawska-Juszczyk, Monika Szymonek, Tomasz Trybek, Katarzyna Lizis-Kolus, Dorota Szyska-Skrobot, Estera Mikina, Stefan Hurej, Janusz Słuszniak, Ryszard Mężyk, Stanisław Góźdź
    PLOS ONE.2016; 11(4): e0153242.     CrossRef
  • UEG Week 2016 Poster Presentations

    United European Gastroenterology Journal.2016; 4(5_suppl): A157.     CrossRef
  • A Comparison of Spatial Pattern Detection Methods for Major Cancer Mortality in Korea
    Jiyu Kim, Myeonggyun Lee, Inkyung Jung
    Asia Pacific Journal of Public Health.2016; 28(6): 539.     CrossRef
  • Survival Analysis of Advanced Non–Small Cell Lung Cancer Patients Treated by Using Wheel Balance Cancer Therapy
    Jongmin Kim, Chong-Kwan Cho, Hwa-Seung Yoo
    Integrative Cancer Therapies.2016; 15(4): 467.     CrossRef
  • Antitumor and apoptosis-inducing effects of α-mangostin extracted from the pericarp of the mangosteen fruit (Garcinia mangostana L.) in YD-15 tongue mucoepidermoid carcinoma cells
    HAE NIM LEE, HYE YEON JANG, HYEONG JIN KIM, SEONG AH SHIN, GANG SIK CHOO, YOUNG SEOK PARK, SANG KI KIM, JI YOUN JUNG
    International Journal of Molecular Medicine.2016; 37(4): 939.     CrossRef
  • Preoperative chemoradiotherapy followed by transanal local excision for T3 distal rectal cancer: A case report
    SEUNG-GU YEO
    Experimental and Therapeutic Medicine.2016; 11(4): 1465.     CrossRef
  • Long non-coding RNA ATB promotes growth and epithelial-mesenchymal transition and predicts poor prognosis in human prostate carcinoma
    SONG XU, XIAO-MING YI, CHAO-PENG TANG, JING-PING GE, ZHENG-YU ZHANG, WEN-QUAN ZHOU
    Oncology Reports.2016; 36(1): 10.     CrossRef
  • Characteristics of and risk factors for colorectal neoplasms in young adults in a screening population
    Seung Eun Lee, Hee Bum Jo, Won Gun Kwack, Yun Jin Jeong, Yeo-Jin Yoon, Hyoun Woo Kang
    World Journal of Gastroenterology.2016; 22(10): 2981.     CrossRef
  • Differential diagnosis of breast masses in South Korean premenopausal women using diffuse optical spectroscopic imaging
    Anaïs Leproux, You Me Kim, Jun Won Min, Christine E. McLaren, Wen-Pin Chen, Thomas D. O’Sullivan, Seung-ha Lee, Phil-Sang Chung, Bruce J. Tromberg
    Journal of Biomedical Optics.2016; 21(7): 074001.     CrossRef
  • Celecoxib and sulindac inhibit TGF-β1-induced epithelial-mesenchymal transition and suppress lung cancer migration and invasion via downregulation of sirtuin 1
    Byong-Ki Cha, Young-Suk Kim, Ki-Eun Hwang, Kyung-Hwa Cho, Seon-Hee Oh, Byoung-Ryun Kim, Hong-Young Jun, Kwon-Ha Yoon, Eun-Taik Jeong, Hak-Ryul Kim
    Oncotarget.2016; 7(35): 57213.     CrossRef
  • Relationship between insulin-like growth factor axis gene polymorphisms and clinical outcome in advanced gastric cancer patients treated with FOLFOX
    Sung Yong Oh, Aesun Shin, Seong-Geun Kim, Jung-Ah Hwang, Seung Hyun Hong, Yeon-Su Lee, Hyuk-Chan Kwon
    Oncotarget.2016; 7(21): 31204.     CrossRef
  • Strategies to improve treatment outcome in gastric cancer: A retrospective analysis of patients from two high-volume hospitals in Korea and China
    Kun Yang, Yoon Young Choi, Wei-Han Zhang, Xin-Zu Chen, Mi Kyung Song, Jinae Lee, Bo Zhang, Zhi-Xin Chen, Hyoung-Il Kim, Jia-Ping Chen, Jae-Ho Cheong, Zong-Guang Zhou, Woo Jin Hyung, Jian-Kun Hu, Sung Hoon Noh
    Oncotarget.2016; 7(28): 44660.     CrossRef
  • Downregulation of osteoprotegerin expression in metastatic colorectal carcinoma predicts recurrent metastasis and poor prognosis
    Ahrim Moon, Sung-Im Do, Hyun-Soo Kim, Youn-Wha Kim
    Oncotarget.2016; 7(48): 79319.     CrossRef
  • The Korean guideline for colorectal cancer screening
    Dae Kyung Sohn, Min Ju Kim, Younhee Park, Mina Suh, Aesun Shin, Hee Young Lee, Jong Pil Im, Hyoen-Min Cho, Sung Pil Hong, Baek-hui Kim, Yongsoo Kim, Jeong Wook Kim, Hyun-Soo Kim, Chung Mo Nam, Dong Il Park, Jun Won Um, Soon Nam Oh, Hwan Sub Lim, Hee Jin C
    Journal of the Korean Medical Association.2015; 58(5): 420.     CrossRef
  • The different role of intratumoral and peritumoral lymphangiogenesis in gastric cancer progression and prognosis
    Kyung Ho Pak, Ara Jo, Hye Ji Choi, Younghee Choi, Hyunki Kim, Jae-Ho Cheong
    BMC Cancer.2015;[Epub]     CrossRef
  • Total and Dietary Calcium Intake and Colorectal Adenoma in Korean Adults
    Ju Eun Seol, Chang Ho Cho, Sung Hi Kim, Jung Eun Lee
    Journal of Cancer Prevention.2015; 20(2): 153.     CrossRef
  • Association of Dietary Vitamin D and Calcium With Genetic Polymorphisms in Colorectal Neoplasia
    Yoon Park, Jeongseon Kim
    Journal of Cancer Prevention.2015; 20(2): 97.     CrossRef
  • The role of surgery in stage IV gastric cancer
    Dong-Seok Han
    Korean Journal of Clinical Oncology.2015; 11(1): 1.     CrossRef
  • Epidemiology of prostate cancer in South Korea
    Hyun Ho Han, Jae Won Park, Joon Chae Na, Byung Ha Chung, Choung-Soo Kim, Woo Jin Ko
    Prostate International.2015; 3(3): 99.     CrossRef
  • Comparison of Quality of Life and Nutritional Status in Gastric Cancer Patients Undergoing Gastrectomies
    Hee-Sook Lim, Gyu-Seok Cho, Yoon-Hyung Park, Soon-Kyung Kim
    Clinical Nutrition Research.2015; 4(3): 153.     CrossRef
  • Evolution of Gastric Cancer Treatment: From the Golden Age of Surgery to an Era of Precision Medicine
    Yoon Young Choi, Sung Hoon Noh, Jae-Ho Cheong
    Yonsei Medical Journal.2015; 56(5): 1177.     CrossRef
  • Identification of occult tumors by whole-specimen mapping in solitary papillary thyroid carcinoma
    Seog Yun Park, Yuh-S Jung, Chang Hwan Ryu, Chang Yoon Lee, You Jin Lee, Eun Kyung Lee, Seok-Ki Kim, Tae Sung Kim, Tae Hyun Kim, Jeyun Jang, Daeyoon Park, Seung Myung Dong, Jae-Goo Kang, Jin Soo Lee, Junsun Ryu
    Endocrine-Related Cancer.2015; 22(4): 679.     CrossRef
  • <i>Helicobacter Pylori</i> Infection and Related Gastrointestinal Diseases
    Chang Seok Bang, Gwang Ho Baik
    The Korean Journal of Medicine.2015; 89(2): 142.     CrossRef
  • Comparison of two different S-1 plus cisplatin dosing schedules as first-line chemotherapy for metastatic and/or recurrent gastric cancer: a multicenter, randomized phase III trial (SOS)
    M.-H. Ryu, E. Baba, K.H. Lee, Y.I. Park, N. Boku, I. Hyodo, B.-H. Nam, T. Esaki, C. Yoo, B.-Y. Ryoo, E.-K. Song, S.-H. Cho, W.K. Kang, S.H. Yang, D.Y. Zang, D.B. Shin, S.R. Park, K. Shinozaki, T. Takano, Y.-K. Kang
    Annals of Oncology.2015; 26(10): 2097.     CrossRef
  • Has the National Cancer Screening Program reduced income inequalities in screening attendance in South Korea?
    Sujin Kim, Soonman Kwon, S. V. Subramanian
    Cancer Causes & Control.2015; 26(11): 1617.     CrossRef
  • Lung Cancer Screening: Update
    Hyae Young Kim
    Journal of the Korean Society of Radiology.2015; 73(3): 137.     CrossRef
  • Laparoscopic Sentinel Node Navigation Surgery for Gastric Cancer
    Keun Won Ryu
    The Journal of Minimally Invasive Surgery.2015; 18(3): 63.     CrossRef
  • It needs adaptation to the 2015 Korean guideline for breast cancer screening
    Jong-Myon Bae
    Journal of the Korean Medical Association.2015; 58(9): 833.     CrossRef
  • Hormone Replacement Therapy and Risk of Breast Cancer in Korean Women: A Quantitative Systematic Review
    Jong-Myon Bae, Eun Hee Kim
    Journal of Preventive Medicine and Public Health.2015; 48(5): 225.     CrossRef
  • Laparoscopic Total Gastrectomy in Elderly Patients (≥70 Years) with Gastric Carcinoma: A Retrospective Study
    Hong Sung Jung, Young Kyu Park, Seong Yeob Ryu, Oh Jeong
    Journal of Gastric Cancer.2015; 15(3): 176.     CrossRef
  • Anti-Cancer Effects of Oldenlandia diffusa extract on WiDr human colorectal adenocarcinoma cells
    Soojin Lee, Huijin Gim, Ji Hwan Shim, Hyun Soo Park, Byung Joo Kim
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Case Report
A Case Report of Partial Nephrectomy of Mucinous Cystadenocarcinoma in Kidney and Its Literature Review
Sung Han Kim, Heong Dong Yuk, Weon Seo Park, Sun Ho Kim, Jae Young Joung, Ho Kyung Seo, Kang Hyun Lee, Jinsoo Chung
Cancer Res Treat. 2016;48(2):838-842.   Published online February 13, 2015
DOI: https://doi.org/10.4143/crt.2014.219
AbstractAbstract PDFPubReaderePub
Mucinous cystadenocarcinoma (MC) of the kidney is a rare epithelial tumor originating from the renal pelvic urothelium and few study cases have been reported. Because of the rarity of these tumors and their unknown histogenesis, its diagnosis is difficult until surgical exploration. We report here on a 55-year-old man referred to the urology department from the hepatology department because of a cystic renal mass measuring approximately 5 cm in size, which was detected incidentally under ultrasonography during the routine examination of liver. The renal mass was finally diagnosed as MC originating from kidney after partial nephrectomy and the patient still showed no evidence of recurrence until 12 months postoperatively. This is the first report on a case of renal MC in a patient who underwent partial nephrectomy. The aim of this report is to present our unusual case of MC and also review the previous literature on the pathological and radiological aspects of MC of kidney.

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    Kasi Viswanath Gali, Arun Chawla, K. R. Surag, Sunil Pillai Bhaskara, Padmaraj Hegde
    BMC Urology.2024;[Epub]     CrossRef
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    Zikuan Ning, Haoxun Zhang, Bowen Wang, Yingwei Wang, Yiwen Liu, Boju Tao, Guoling Zhang, Hua Liu, Chunyang Wang
    Frontiers in Surgery.2023;[Epub]     CrossRef
  • Mucinous cystadenocarcinoma in the renal pelvis: primary or secondary? Case report and literature review
    An Tamsin, Charlotte Schillebeeckx, Charlotte Van Langenhove, Kathy Vander Eeckt, Dieter Ost, Kevin Wetzels
    Acta Chirurgica Belgica.2020; 120(6): 417.     CrossRef
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Original Article
Bcl-2 as a Predictive Factor for Biochemical Recurrence after Radical Prostatectomy: An Interim Analysis
In-Chang Cho, Han Soo Chung, Kang Su Cho, Jeong Eun Kim, Jae Young Joung, Ho Kyung Seo, Jinsoo Chung, Weon Seo Park, Eun Kyung Hong, Kang Hyun Lee
Cancer Res Treat. 2010;42(3):157-162.   Published online September 30, 2010
DOI: https://doi.org/10.4143/crt.2010.42.3.157
AbstractAbstract PDFPubReaderePub
Purpose

The objective of this study was to determine Bcl-2 expression in localized prostate cancer and its potential role as a predictive factor for biochemical recurrence (BCR).

Materials and Methods

This study included 171 Korean patients with newly diagnosed adenocarcinoma of the prostate who underwent radical prostatectomy (RP) without neoadjuvant therapy at a single center between February 2005 and May 2009. RP specimens obtained from these patients were analyzed for the expression of Bcl-2 using tissue microarray. The values of Bcl-2 and other clinicopathologic factors were evaluated. Statistical analysis was performed with contingency table analysis, chi-square tests, and a Cox proportional hazard model.

Results

Bcl-2 expression was immunohistologically-confirmed in 42 patients (24.6%). Bcl-2 expression was not associated with conventional clinicopathologic factors. Bcl-2 negative patients had a significantly longer mean BCR-free survival than Bcl-2-positive patients (p=0.036). Among several variables, a high Gleason score in the RP specimen (≥8), extraprostatic extension, seminal vesicle invasion (SVI), lymphovascular invasion (LVI), and Bcl-2 expression were significant predictors of BCR based on univariate analysis. Multivariate Cox proportional hazards analysis revealed that BCR was significantly associated with a high prostate specific antigen level (p=0.047), SVI (p<0.001), a positive surgical margin (p=0.004) and Bcl-2 expression (p=0.012).

Conclusion

Bcl-2 expression in RP specimens is associated with a significantly worse outcome, suggesting a potential clinical role for Bcl-2. Post-operative Bcl-2 could be a significant predictor of outcome after RP.

Citations

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