Cancer Research and Treatment

Original Articles

Gonadal and Sexual Dysfunction in Childhood Cancer Survivors: Ju Young Yoon, Hyeon Jin Park, Hee Young Ju, Jong Hyung Yoon, Jin Soo Chung, Sang Hyun Hwang, Dong Ock Lee, Hye Young Shim, Byung-Kiu Park; Cancer Res Treat. 2017;49(4):1057-1064. Published online January 25, 2017; DOI: https://doi.org/10.4143/crt.2016.197

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Purpose
Few studies have addressed gonadal and sexual dysfunctions in childhood cancer survivors. We evaluated the prevalence rates and risk factors for gonadal failure among adolescent/young adult childhood cancer survivors and their sexual function.
Materials and Methods
Subjects were childhood cancer survivors aged 15-29 years who had completed therapy more than 2 years ago. Demographic and medical characteristics were obtained from the patients’ medical records. In addition, hormonal evaluation and semen analysis were performed and sexual function was evaluated via questionnaire.
Results
The study included 105 survivors (57 males, 48 females), of which 61 were adults (age > 19 years) and 44 were adolescents. In both males and females, the proportion of survivors with low sex hormone levels did not differ among age groups or follow-up period. Thirteen female subjects (27.1%) needed sex hormone replacement, while five males subjects (8.8%) were suspected of having hypogonadism, but none were receiving sex hormone replacement. Of 27 semen samples, 14 showed azospermia or oligospermia. The proportion of normospermia was lower in the high cyclophosphamide equivalent dose (CED) group (CED ≥ 8,000 mg/m2) than the low CED group (27.3% vs. 62.5%, p=0.047). Among adults, none were married and only 10 men (35.7%) and eight women (34.3%) were in a romantic relationship. Though a significant proportion (12.0% of males and 5.3% of females) of adolescent survivors had experienced sexual activity, 13.6% had not experienced sex education.
Conclusion
The childhood cancer survivors in this study showed a high prevalence of gonadal/sexual dysfunction; accordingly, proper strategies are needed to manage these complications.

Citations

Citations to this article as recorded by

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Ryuta Urakawa, Amane Noi, Hiroto Kageyama, Mikiko Ueda, Yoshiko Hashii, Kenji Ikeda
Cancer Medicine.2025;[Epub] CrossRef
Sexual and reproductive complications and concerns of survivors of childhood, adolescent and adult cancer
Brigitte Gerstl, Christina Signorelli, Claire E. Wakefield, Rebecca Deans, Tejnei Vaishnav, Karen Johnston, Kristen Neville, Richard J. Cohn, Antoinette Anazodo
Journal of Cancer Survivorship.2024; 18(4): 1201. CrossRef
α‐Ketoglutarate Improves Ovarian Reserve Function in Primary Ovarian Insufficiency by Inhibiting NLRP3‐Mediated Pyroptosis of Granulosa Cells
Ke Liu, Yafei Wu, Wenqin Yang, Tianlong Li, Zhongxu Wang, Shu Xiao, Zhenghua Peng, Meng Li, Wenhao Xiong, Meixiang Li, Xi Chen, Shun Zhang, Xiaocan Lei
Molecular Nutrition & Food Research.2024;[Epub] CrossRef
Huangqi‐Guizhi‐Wuwutang protects against oligospermia in mice by promoting the proliferation of spermatogenic stem cells: A comprehensive study using HPLC‐Q‐TOF/MS and experimental pharmacology
Yuan Zhao, Jinru Wu, Xiangbin Li, Lin Zheng, Qiugu Chen, Shangbin Zhang, Jianping Chen
Biomedical Chromatography.2024;[Epub] CrossRef
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Quinn Carroll Rainer, Justin Michael Dubin, Navin Chakravarthy Balaji, Victoria Troesch, William Terry, Varun Monga, Lindsey Clifford, Jamie Shoag, Aubrey Greer, Sirpi Nackeeran, Alejandro Aaron Rodriguez, Premal Patel, Lisa Paz, Bruce Richard Kava, Warre
Journal of Adolescent and Young Adult Oncology.2023; 12(1): 93. CrossRef
Reproductive Care of Childhood and Adolescent Cancer Survivors: A 12-Year Evaluation
Antoinette Catherine Anazodo, Sumin Choi, Christina Signorelli, Sarah Ellis, Karen Johnston, Claire E. Wakefield, Rebecca Deans, Kristen A. Neville, Richard J. Cohn
Journal of Adolescent and Young Adult Oncology.2021; 10(2): 131. CrossRef
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Incidence and Survival of Childhood Cancer in Korea: Hyeon Jin Park, Eun-Kyeong Moon, Ju Young Yoon, Chang-Mo Oh, Kyu-Won Jung, Byung Kiu Park, Hee Young Shin, Young-Joo Won; Cancer Res Treat. 2016;48(3):869-882. Published online January 21, 2016; DOI: https://doi.org/10.4143/crt.2015.290

Abstract PDF PubReader ePub

Purpose
An epidemiologic study of childhood cancer would provide useful information on cancer etiology and development of management guidelines.
Materials and Methods
Data from the Korea National Cancer Incidence Database were used to examine the incidence and survival of cancer in patients aged 0-14 years. Patients were grouped according to the International Classification of Childhood Cancer, 3rd edition. Age-specific and age-standardized incidences per million and estimated annual percentage change (APC) were calculated by sex and age. Five-year relative survival was calculated for four periods from 1993 to 2011.
Results
The study comprised 15,113 patients with malignant neoplasms. Age-standardized incidence rates for all cancers were 134.9 per million children in 1999-2011 and 144.0 and 124.9 per million for males and females, respectively (M/F ratio, 1.2; p < 0.05). The highest incidences were observed for ‘leukemias, myeloproliferative diseases, and myelodysplastic diseases’ (group I) (46.4), ‘central nervous system neoplasms’ (group III) (18.3), and ‘lymphomas and reticuloendothelial neoplasms’ (group II) (13.4). Age-standardized incidence increased from 117.9 in 1999 to 155.3 in 2011, with an APC of 2.4% (95% confidence interval, 2.1 to 2.7). There was a significant increase of APC in ‘neuroblastoma and other peripheral nervous cell tumors’ (group IV) (5.6%) and ‘other malignant epithelial neoplasms and malignant melanomas’ (group XI) (5.6%). The 5-year relative survival rate for all childhood cancers improved significantly from 56.2% (1993-1995) to 78.2% (2007-2011) (males, 56.7% to 77.7%; females, 55.5% to 78.8%).
Conclusion
This study provides reliable information on incidence and survival trends for childhood cancer in Korea.

Citations

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Case Report

Reversible Proximal Renal Tubular Dysfunction after One-Time Ifosfamide Exposure: Young Il Kim, Ju Young Yoon, Jun Eul Hwang, Hyun Jeong Shim, Woo Kyun Bae, Sang Hee Cho, Ik-Joo Chung; Cancer Res Treat. 2010;42(4):244-246. Published online December 31, 2010; DOI: https://doi.org/10.4143/crt.2010.42.4.244

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The alkylating agent ifosfamide is an anti-neoplastic used to treat various pediatric and adult malignancies. Its potential urologic toxicities include glomerulopathy, tubulopathy and hemorrhagic cystitis. This report describes a case of proximal renal tubular dysfunction and hemorrhagic cystitis in a 67-year-old male given ifosfamide for epitheloid sarcoma. He was also receiving an oral hypoglycemic agent for type 2 diabetes mellitus and had a baseline glomerular filtration rate of 51.5 mL/min/1.73 m². Despite mesna prophylaxis, the patient experienced dysuria and gross hematuria after a single course of ifosfamide plus adriamycin. The abrupt renal impairment and serum/urine electrolyte imbalances that ensued were consistent with Fanconi's syndrome. However, normal renal function and electrolyte status were restored within 14 days, simply through supportive measures. A score of 8 by Naranjo adverse drug reaction probability scale indicated these complications were most likely treatment-related, although they developed without known predisposing factors. The currently undefined role of diabetic nephropathy in adult ifosfamide nephrotoxicity merits future investigation.

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