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Original Article
The Bone Morphogenesis Protein-2 (BMP-2) is Associated with Progression to Metastatic Disease in Gastric Cancer
Yong Park, Jee Won Kim, Dae Sik Kim, Eui Bae Kim, Se Jong Park, Jin Yong Park, Woo Suk Choi, Jong Gyu Song, Hee Yun Seo, Sang Cheul Oh, Byung Soo Kim, Jong Jae Park, Yeul Hong Kim, Jun Suk Kim
Cancer Res Treat. 2008;40(3):127-132.   Published online September 30, 2008
DOI: https://doi.org/10.4143/crt.2008.40.3.127
AbstractAbstract PDFPubReaderePub
Purpose

Bone Morphogenetic Proteins (BMPs) are members of the TGF-β superfamily and it has been demonstrated that BMPs enhance migration, invasion and metastasis. The purpose of this study was to identify the association between the serum BMP-2 level and the progression status of gastric cancer.

Materials and Methods

Fifty-five patients with metastatic gastric cancer (metastatic disease group), six patients with early gastric cancer without lymph node metastasis (the EGC group), and ten healthy control subjects were enrolled in this study. The serum BMP-2 level was quantified by use of a commercially available ELISA kit. In EGC group patients and patients with metastatic disease, whole blood was obtained before endoscopic mucosal resection and before the commencement of a scheduled cycle of systemic chemotherapy, respectively.

Results

No significant difference in the mean serum BMP-2 levels was observed between the control subjects and the EGC group patients (87.95 pg/ml for the control subjects and 84.50 pg/ml for the EGC group, p=1.0). However, the metastatic disease group patients had a significantly higher level of serum BMP (179.61 pg/ml) than the control subjects and EGC group patients (87.95 pg/ml for the control subjects and 84.50 pg/ml for the EGC group, p<0.0001). Moreover, the mean serum BMP-2 level from patients with a bone metastasis was significantly higher than the mean serum BMP-2 level from patients without a bone metastasis (204.73 pg/ml versus 173.33 pg/ml, p=0.021).

Conclusions

BMP-2 seems to have a role in progression to metastatic disease in gastric cancer, especially in the late stage of tumorigenesis, including invasion and metastasis. BMP-2 may facilitate bone metastasis in gastric cancer. To confirm these findings, further studies are required with tissue specimens and the use of a cancer cell line.

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  • Duality of bone morphogenetic proteins in cancer: A comprehensive analysis
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  • BMP2 inhibits cell proliferation by downregulating EZH2 in gastric cancer
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    Computational and Structural Biotechnology Journal.2021; 19: 4110.     CrossRef
  • BMP Signaling in Development, Stem Cells, and Diseases of the Gastrointestinal Tract
    Yongchun Zhang, Jianwen Que
    Annual Review of Physiology.2020; 82(1): 251.     CrossRef
  • Relaxin enhances bone regeneration with BMP‐2‐loaded hydroxyapatite microspheres
    Sahitya Injamuri, Mohamed N. Rahaman, Youqu Shen, Yue‐Wern Huang
    Journal of Biomedical Materials Research Part A.2020; 108(5): 1231.     CrossRef
  • Annatto-Derived Tocotrienol Promotes Mineralization of MC3T3-E1 Cells by Enhancing BMP-2 Protein Expression via Inhibiting RhoA Activation and HMG-CoA Reductase Gene Expression


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    Drug Design, Development and Therapy.2020; Volume 14: 969.     CrossRef
  • Detection of circulating BMP5 as a risk factor for Barrett’s esophagus
    Ana C. P. Correia, Silvia Calpe, Nahid Mostafavi, Sanne Johanna Maria Hoefnagel, Maria del Carmen Sancho-Serra, Patricia S. de Koning, Kausilia K. Krishnadath
    Scientific Reports.2020;[Epub]     CrossRef
  • The Dual Role of Bone Morphogenetic Proteins in Cancer
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    Molecular Therapy - Oncolytics.2018; 8: 1.     CrossRef
  • Embryonic bone morphogenetic protein and nodal induce invasion in melanocytes and melanoma cells
    Tobias Sinnberg, Heike Niessner, Mitch P. Levesque, Christoph Dettweiler, Claus Garbe, Christian Busch
    Biology Open.2018;[Epub]     CrossRef
  • Decreased expression of bone morphogenetic protein-2 is correlated with biochemical recurrence in prostate cancer: Immunohistochemical analysis
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    Scientific Reports.2018;[Epub]     CrossRef
  • Computational model of mesenchymal migration in 3D under chemotaxis
    F. O. Ribeiro, M. J. Gómez-Benito, J. Folgado, P. R. Fernandes, J. M. García-Aznar
    Computer Methods in Biomechanics and Biomedical Engineering.2017; 20(1): 59.     CrossRef
  • Bone morphogenetic protein-2 and tumor growth: Diverse effects and possibilities for therapy
    Haijun Tian, Jie Zhao, Elsa J. Brochmann, Jeffrey C. Wang, Samuel S. Murray
    Cytokine & Growth Factor Reviews.2017; 34: 73.     CrossRef
  • BMP signaling pathways affect differently migration and invasion of esophageal squamous cancer cells
    Min Hu, Facai Cui, Fengzhen Liu, Jinlin Wang, Xiaoxia Wei, Yi Li
    International Journal of Oncology.2017; 50(1): 193.     CrossRef
  • Overexpression of colorectal cancer oncogene CHRDL2 predicts a poor prognosis
    Jian Sun, Xuan Liu, Hong Gao, Long Zhang, Qing Ji, Ziyuan Wang, Lihong Zhou, Yan Wang, Hua Sui, Zhongze Fan, Qi Li
    Oncotarget.2017; 8(7): 11489.     CrossRef
  • BMP10 inhibited the growth and migration of gastric cancer cells
    Haiming Lei, Jian Wang, Peihua Lu, Xinghua Si, Koulan Han, Tingyan Ruan, Junjie Lu
    Tumor Biology.2016; 37(3): 3025.     CrossRef
  • How does the pathophysiological context influence delivery of bone growth factors?
    Xiaohua Yu, Darilis Suárez-González, Andrew S. Khalil, William L. Murphy
    Advanced Drug Delivery Reviews.2015; 84: 68.     CrossRef
  • Inactivation of the Phosphatidylinositol 3‐Kinase/Akt Pathway is Involved in BMP9‐mediated Tumor‐suppressive Effects in Gastric Cancer Cells
    Liang Duan, Liwei Ye, Rui Wu, Haiyan Wang, Xueru Li, Huan Li, Shimei Yuan, He Zha, Hui Sun, Yunyuan Zhang, Xian Chen, Yan Zhang, Lan Zhou
    Journal of Cellular Biochemistry.2015; 116(6): 1080.     CrossRef
  • Identifying an ovarian cancer cell hierarchy regulated by bone morphogenetic protein 2
    Yun-Jung Choi, Patrick N. Ingram, Kun Yang, Lan Coffman, Mangala Iyengar, Shoumei Bai, Dafydd G. Thomas, Euisik Yoon, Ronald J. Buckanovich
    Proceedings of the National Academy of Sciences.2015;[Epub]     CrossRef
  • Association Between BMP-2 and Carcinogenicity
    Branko Skovrlj, Steven M. Koehler, Paul A. Anderson, Sheeraz A. Qureshi, Andrew C. Hecht, James C. Iatridis, Samuel K. Cho
    SPINE.2015; 40(23): 1862.     CrossRef
  • In silico Mechano-Chemical Model of Bone Healing for the Regeneration of Critical Defects: The Effect of BMP-2
    Frederico O. Ribeiro, María José Gómez-Benito, João Folgado, Paulo R. Fernandes, José Manuel García-Aznar, Masaya Yamamoto
    PLOS ONE.2015; 10(6): e0127722.     CrossRef
  • Comparative transcriptome analysis between metastatic and non-metastatic gastric cancer reveals potential biomarkers
    DAN FENG, XIAOFEI YE, ZHENXIN ZHU, ZIRAN WEI, QINGPING CAI, YAJIE WANG
    Molecular Medicine Reports.2015; 11(1): 386.     CrossRef
  • Gastric stem cells and gastric cancer stem cells
    Myoung-Eun Han, Sae-Ock Oh
    Anatomy & Cell Biology.2013; 46(1): 8.     CrossRef
  • Cancer stem cells: the ‘heartbeat’ of gastric cancer
    Guihua Xu, Jie Shen, Xiaohui Ou Yang, Masakiyo Sasahara, Xiulan Su
    Journal of Gastroenterology.2013; 48(7): 781.     CrossRef
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    Asian Pacific Journal of Cancer Prevention.2013; 14(9): 5293.     CrossRef
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    Cell Biochemistry and Function.2012; 30(7): 582.     CrossRef
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    Medical Hypotheses.2012; 79(5): 582.     CrossRef
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    Renal Failure.2012; 34(10): 1355.     CrossRef
  • Bone Morphogenetic Protein-4-induced Epithelial-Mesenchymal Transition and Invasiveness Through Smad1-mediated Signal Pathway in Squamous Cell Carcinoma of the Head and Neck
    Ting Xu, Chang-yun Yu, Jin-jie Sun, Yong Liu, Xing-wei Wang, Lei-ming Pi, Yong-quan Tian, Xin Zhang
    Archives of Medical Research.2011; 42(2): 128.     CrossRef
  • Bone Morphogenetic Protein-2 and -4 Play Tumor Suppressive Roles in Human Diffuse-Type Gastric Carcinoma
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    The American Journal of Pathology.2011; 179(6): 2920.     CrossRef
  • Metastatic function of BMP-2 in gastric cancer cells: The role of PI3K/AKT, MAPK, the NF-κB pathway, and MMP-9 expression
    Myoung Hee Kang, Sang Cheul Oh, Hyun Joo Lee, Han Na Kang, Jung Lim Kim, Jun Suk Kim, Young A. Yoo
    Experimental Cell Research.2011; 317(12): 1746.     CrossRef
  • Downregulation of hemojuvelin prevents inhibitory effects of bone morphogenetic proteins on iron metabolism in hepatocellular carcinoma
    Ulrike Maegdefrau, Stephanie Arndt, Georgi Kivorski, Claus Hellerbrand, Anja-Katrin Bosserhoff
    Laboratory Investigation.2011; 91(11): 1615.     CrossRef
  • Coding polymorphisms of bone morphogenetic protein 2 contribute to the development of childhood IgA nephropathy
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    Experimental and Therapeutic Medicine.2011; 2(2): 337.     CrossRef
  • Bone morphogenetic protein-2 levels are elevated in the patients with gastric cancer and correlate with disease progression
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    Medical Oncology.2010; 27(4): 1192.     CrossRef
  • The Yin and Yang of bone morphogenetic proteins in cancer
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    Experimental Cell Research.2010; 316(1): 24.     CrossRef
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