Cancer Research and Treatment

Original Articles

Breast cancer

Short-term Impact of Hormone Replacement Therapy on Risk of Breast Cancer in BRCA Mutation Carriers: A Nationwide Study in South Korea: Hye Yeon Kim, Jisoo Park, Seok Joo Moon, Sohyeon Jeong, Jin Hwa Hong, Jae Kwan Lee, Geum Joon Cho, Hyun-Woong Cho; Cancer Res Treat. 2024;56(1):143-148. Published online August 16, 2023; DOI: https://doi.org/10.4143/crt.2023.653

Purpose
BRCA1/2 mutations are well-known risk factors for breast and ovarian cancers in women. Risk-reducing salpingo-oophorectomy (RRSO) is the standard treatment for preventing ovarian cancer with BRCA mutations. Postmenopausal syndrome (symptoms after RRSO can be alleviated by hormone replacement therapy (HRT); however, the use of HRT in carriers of BRCA mutations has been controversial because of the concern that HRT increases the risk of breast cancer. This study aimed to evaluate the effects of HRT in BRCA mutation carriers who underwent RRSO.
Materials and Methods
A total of 151 carriers, who underwent RRSO between 2013 and 2020 after the diagnosis of BRCA1 or BRCA2 mutations were selected and followed up for a median of 3.03 years. Patients were divided into two groups: those who received HRT after RRSO (n=33) and those who did not (n=118). We compared the incidence of breast cancer over time between these two groups.
Results
There was no significant difference in the incidence of breast cancer between women who received HRT and those who did not (p=0.229). Multivariate logistic regression analysis, adjusted for age and parity revealed no significant difference in the risk of breast cancer between these two groups (hazard ratio, 0.312; 95% confidence interval, 0.039 to 2.480; p=0.278).
Conclusion
In this study, we found no relationship between post-RRSO HRT and breast cancer in the population with BRCA mutations. Therefore, healthcare providers may consider the alleviation of symptoms of postmenopausal syndrome through HRT in patients who underwent RRSO.

Citations

Citations to this article as recorded by

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Orietta Nicolis, Denisse De Los Angeles, Carla Taramasco
Frontiers in Oncology.2024;[Epub] CrossRef

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Gynecologic Cancer

Performance and Diagnostic Accuracy of Human Papillomavirus Testing on Self-Collected Urine and Vaginal Samples in a Referral Population: Hyun-Woong Cho, Jin Hwa Hong, Kyung Jin Min, Yung-Taek Ouh, Seok Ju Seong, Jun Hye Moon, Seong Hwan Cho, Jae Kwan Lee; Cancer Res Treat. 2021;53(3):829-836. Published online December 24, 2020; DOI: https://doi.org/10.4143/crt.2020.1165

Abstract PDF PubReader ePub

Purpose
The study aimed to evaluate the diagnostic accuracy of polymerase chain reaction ‒based high-risk human papillomavirus (HPV) assays on self-collected vaginal and urine samples for detection of precancerous cervical lesions in referral population.
Materials and Methods
Women referred for colposcopy following abnormal cytology, were included this study. A total of 314 matched urine, vaginal, and cervical samples were collected. All samples were tested for HPV DNA using the RealTime HR-S HPV and Anyplex II HPV 28 assays. Primary endpoints were sensitivity for cervical intraepithelial neoplasia (CIN) 2+/CIN3+ and specificity for Result
The sensitivity of Realtime HR-S and Anyplex HPV assay was 93.13% (95% confidence interval [CI], 87.36 to 96.81) and 90.08% (95% CI, 83.63 to 94.61) for CIN2+ (n=130); specificity for Conclusion
The detection performance for hrHPV and CIN2+ on self-collected vaginal samples was comparable to that of clinician-collected cervical samples. On the other hand, HPV tests using urine were inferior to those using clinician-collected cervical samples in terms of detecting hrHPV and CIN2+.

Citations

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Preventive Medicine Reports.2026; 62: 103393. CrossRef
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Frontiers in Oncology.2026;[Epub] CrossRef
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Gabriel Gonçalves Santiago Lima, Annielson de Souza Costa, Mayara Souza Alves, Jose Antonio Orellana Turri, Lea Tami Suzuki Zuchelo, Noely Paula Cristina Lorenzi, Eduardo Carvalho de Arruda Veiga, Isabel C.E. Sorpreso, Edmund C. Baracat, José Maria Soares
Clinics.2026; 81: 100898. CrossRef
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Altynshash Rakhat, Gulzhanat Aimagambetova
Viruses.2026; 18(6): 681. CrossRef
Diagnostic accuracy of human papillomavirus testing on self-collected samples among women referred for colposcopy
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Scientific Reports.2025;[Epub] CrossRef
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Byeong-Min Park, Soohyun Kim, Jieun Choi, Yoonkyung Song, Seungman Park, Randall Hayden
Journal of Clinical Microbiology.2025;[Epub] CrossRef
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Journal of Medical Virology.2023;[Epub] CrossRef
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