Cancer Research and Treatment

Original Articles

Pretreatment Lymph Node Metastasis as a Prognostic Significance in Cervical Cancer: Comparison between Disease Status: Soo Young Jeong, Hyea Park, Myeong Seon Kim, Jun Hyeok Kang, E Sun Paik, Yoo-Young Lee, Tae Joong Kim, Jeong Won Lee, Byoung-Gie Kim, Duk Soo Bae, Chel Hun Choi; Cancer Res Treat. 2020;52(2):516-523. Published online October 29, 2019; DOI: https://doi.org/10.4143/crt.2019.328

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Purpose
Lymph node metastasis (LNM) is the most significant prognostic factor in cervical cancer that was recently incorporated into the International Federation of Gynecology and Obstetrics (FIGO) staging system. This study was performed to evaluate whether the prognostic significance of LNM differs according to disease status.
Materials and Methods
Patients with FIGO stage IB or higher cervical cancer who had pretreatment computed tomography and/or magnetic resonance imaging studies as well as long-term follow-up were enrolled in this retrospective study. The hazard ratio (HR) of Cox regression was used to determine the prognostic significance of LNM. The HRs were compared between the different tumor groups (based on stage, histology, tumor size, primary treatment, age, parametrium involvement, and lymphovascular space invasion).
Results
A total of 970 patients treated between January 1999 and December 2007 were included. The pretreatment LNM had prognostic significance in patients with stage IB1/IIA (HR for progression-free survival 2.10, p=0.001; HR for overall survival 1.99, p=0.005). However, the significance gradually decreased or disappeared with advancing stages. Similarly, the prognostic significance of the pretreatment LNM decreased with advancing disease status, including old age, parametrial involvement or lymphovascular space involvement. In contrast, the tumor size was associated with the prognostic significance of LNM with advancing status. The significance of the clinical LNM did not reflect the significance of the clinical stage. In contrast, the tumor size, parametrial involvement, and significance of the pathologic LNM reflected the clinical stage.
Conclusion
In patients with cervical cancer, pretreatment LNM on imaging has different clinical significance depending on the tumor status.

Citations

Citations to this article as recorded by

Development of cervical intraepithelial neoplasia and invasive cervical cancer due to oxidative stress
Amir Asotić, Memić Asotić, Muhamed Memić, Kerim Asotić, Amra Asotić
Sanamed.2024; 19(1): 39. CrossRef
Investigating and Analyzing Prognostic Factors and Their Impact on Recurrent Cervical Cancers
Ashish Uke, Shweta B Dahake, Anurag Luharia, Monika Luharia, Gaurav V Mishra, Chanrashekhar Mahakalkar
Cureus.2024;[Epub] CrossRef
Based on 3D-PDU and clinical characteristics nomogram for prediction of lymph node metastasis and lymph-vascular space invasion of early cervical cancer preoperatively
Shuang Dong, Yan-Qing Peng, Ya-Nan Feng, Xiao-Ying Li, Li-Ping Gong, Shuang Zhang, Xiao-Shan Du, Li-Tao Sun
BMC Women's Health.2024;[Epub] CrossRef
Recent Advances in Cervical Cancer Management: A Review on Novel Prognostic Factors in Primary and Recurrent Tumors
Angela Santoro, Frediano Inzani, Giuseppe Angelico, Damiano Arciuolo, Emma Bragantini, Antonio Travaglino, Michele Valente, Nicoletta D’Alessandris, Giulia Scaglione, Stefania Sfregola, Alessia Piermattei, Federica Cianfrini, Paola Roberti, Gian Franco Za
Cancers.2023; 15(4): 1137. CrossRef
Identification of lymph node metastasis in pre‐operation cervical cancer patients by weakly supervised deep learning from histopathological whole‐slide biopsy images
Qingqing Liu, Nan Jiang, Yiping Hao, Chunyan Hao, Wei Wang, Tingting Bian, Xiaohong Wang, Hua Li, Yan zhang, Yanjun Kang, Fengxiang Xie, Yawen Li, XuJi Jiang, Yuan Feng, Zhonghao Mao, Qi Wang, Qun Gao, Wenjing Zhang, Baoxia Cui, Taotao Dong
Cancer Medicine.2023; 12(17): 17952. CrossRef
Roles of DWI and T2-weighted MRI volumetry in the evaluation of lymph node metastasis and lymphovascular invasion of stage IB–IIA cervical cancer
Y. Wang, X. Chen, H. Pu, Y. Yuan, S. Li, G. Chen, Y. Liu, H. Li
Clinical Radiology.2022; 77(3): 224. CrossRef
Risk Factor Assessment of Lymph Node Metastasis in Patients With FIGO Stage IB1 Cervical Cancer
Mu Xu, Xiaoyan Xie, Liangzhi Cai, Yongjin Xie, Qiao Gao, Pengming Sun
Frontiers in Oncology.2022;[Epub] CrossRef
Intravoxel Incoherent Motion (IVIM) MR Quantification in Locally Advanced Cervical Cancer (LACC): Preliminary Study on Assessment of Tumor Aggressiveness and Response to Neoadjuvant Chemotherapy
Miriam Dolciami, Silvia Capuani, Veronica Celli, Alessandra Maiuro, Angelina Pernazza, Innocenza Palaia, Violante Di Donato, Giusi Santangelo, Stefania Maria Rita Rizzo, Paolo Ricci, Carlo Della Rocca, Carlo Catalano, Lucia Manganaro
Journal of Personalized Medicine.2022; 12(4): 638. CrossRef
The prognostic significance of pretreatment squamous cell carcinoma antigen levels in cervical cancer patients treated by concurrent chemoradiation therapy and a comparison of dosimetric outcomes and clinical toxicities between tomotherapy and volumetric
Yuan-Kai Cheng, Shih-Hsun Kuo, Heng-Hsuan Yen, Jing-Hu Wu, Yu-Chieh Chen, Ming-Yii Huang
Radiation Oncology.2022;[Epub] CrossRef
What MRI-based tumor size measurement is best for predicting long-term survival in uterine cervical cancer?
Njål Lura, Kari S. Wagner-Larsen, David Forsse, Jone Trovik, Mari K. Halle, Bjørn I. Bertelsen, Øyvind Salvesen, Kathrine Woie, Camilla Krakstad, Ingfrid S. Haldorsen
Insights into Imaging.2022;[Epub] CrossRef
Clinical value of MRI, serum SCCA, and CA125 levels in the diagnosis of lymph node metastasis and para-uterine infiltration in cervical cancer
Chao Ran, Jian Sun, Yunhui Qu, Na Long
World Journal of Surgical Oncology.2021;[Epub] CrossRef
A Novel Four-Gene Prognostic Signature as a Risk Biomarker in Cervical Cancer
Jun Wang, Hua Zheng, Yatian Han, Geng Wang, Yanbin Li, Cuida Meng
International Journal of Genomics.2020; 2020: 1. CrossRef

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Setup Error and Effectiveness of Weekly Image-Guided Radiation Therapy of TomoDirect for Early Breast Cancer: Mi Joo Chung, Guk Jin Lee, Young Jin Suh, Hyo Chun Lee, Sea-Won Lee, Songmi Jeong, Jeong Won Lee, Sung Hwan Kim, Dae Gyu Kang, Jong Hoon Lee; Cancer Res Treat. 2015;47(4):774-780. Published online February 13, 2015; DOI: https://doi.org/10.4143/crt.2014.189

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Purpose
This study investigated setup error and effectiveness of weekly image-guided radiotherapy (IGRT) of TomoDirect for early breast cancer. Materials and Methods One hundred and fifty-one breasts of 147 consecutive patients who underwent breast conserving surgery followed by whole breast irradiation using TomoDirect in 2012 and 2013 were evaluated. All patients received weekly IGRT. The weekly setup errors from simulation to each treatment in reference to chest wall and surgical clips were measured. Random, systemic, and 3-dimensional setup errors were assessed. Extensive setup error was defined as 5 mm above the margin in any directions.
Results
All mean errors were within 3 mm of all directions. The mean angle of gantry shifts was 0.6°. The mean value of absolute 3-dimensional setup error was 4.67 mm. In multivariate analysis, breast size (odds ratio, 2.82; 95% confidence interval, 1.00 to 7.90) was a significant factor for extensive error. The largest significant deviation of setup error was observed in the first week of radiotherapy (p < 0.001) and the deviations gradually decreased with time. The deviation of setup error was 5.68 mm in the first week and within 5 mm after the second week. Conclusion In this study, there was a significant association between breast size and significant setup error in breast cancer patients who received TomoDirect. The largest deviation occurred in the first week of treatment. Therefore, patients with large breasts should be closely observed on every fraction and fastidious attention is required in the first fraction of IGRT.

Citations

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Does deformation of immobilization devices impact treatment accuracy in thoracic cancer radiotherapy?
Lianzi Zhao, Louzheng Zhang, Yiwen Hu, Yang Zhong
Journal of Applied Clinical Medical Physics.2025;[Epub] CrossRef
AAPM Task Group Report 306: Quality control and assurance for tomotherapy: An update to Task Group Report 148
Quan Chen, Yi Rong, Jay W. Burmeister, Edward H. Chao, Nathan A. Corradini, David S. Followill, X. Allen Li, An Liu, X. Sharon Qi, Hairong Shi, Jennifer B. Smilowitz
Medical Physics.2023;[Epub] CrossRef
Robustness of VMAT to setup errors in postmastectomy radiotherapy of left-sided breast cancer: Impact of bolus thickness
Yipeng He, Sijia Chen, Xiang Gao, Lirong Fu, Zheng Kang, Jun Liu, Liwan Shi, Yimin Li, Akif Enes Arikan
PLOS ONE.2023; 18(1): e0280456. CrossRef
ESTRO-ACROP guideline for positioning, immobilisation and setup verification for local and loco-regional photon breast cancer irradiation
M.E. Mast, A. Leong, S.S. Korreman, G. Lee, H. Probst, P. Scherer, Y. Tsang
Technical Innovations & Patient Support in Radiation Oncology.2023; 28: 100219. CrossRef
Critical Factors of Dose Distribution in Breast Cancer Tomotherapy With Metallic Port Breast Tissue Expander: Image Correction, Delivery Mode, and Volume Impact
Hsing-Yi Lee, Yu-Hsiu Yen, Yu-Lun Tsai, Pei-Chih Tu, Chi-Ming Pu, Chia-Hong Lin, Louis Tak Lui, Suzun Shaw, Ching-Jung Wu, Hsin-Hua Nien
Technology in Cancer Research & Treatment.2022;[Epub] CrossRef
Factors impacting on patient setup analysis and error management during breast cancer radiotherapy
Ioana-Claudia Costin, Loredana G. Marcu
Critical Reviews in Oncology/Hematology.2022; 178: 103798. CrossRef
Postoperative radiotherapy with intensity-modulated radiation therapy versus 3-dimensional conformal radiotherapy in early breast cancer: A randomized clinical trial of KROG 15-03
Kyu Hye Choi, Sung Ja Ahn, Jae Uk Jeong, Mina Yu, Jin Hee Kim, Bae Kwon Jeong, Joo Hwan Lee, Sung Hwan Kim, Jong Hoon Lee
Radiotherapy and Oncology.2021; 154: 179. CrossRef
Analysis of local setup errors of sub-regions in cone-beam CT-guided post-mastectomy radiation therapy
Jidan Zhou, Shuai Li, Chengwei Ye, Konglong Shen, An Li, Gang Chen, Xiaoyu Li, Sen Bai, Weifeng Wang, Renming Zhong
Journal of Radiation Research.2020; 61(3): 457. CrossRef
A Prospective Study to Investigate the Placement of Setup Skin Markings for Larger Breasted Women Undergoing External Beam Radiotherapy (RT) for Breast Cancer
Chris Osam Doudoo, Neill Roberts, Emmanuel Amankwaa Frempong, Clement Edusa, Kwamena Beecham, Kofi Agyiri, Promise Ahiagbenyo, George Felix Acquah, Dominic Gadeka Eric Abakuri, Michael Mordey, Anna Maria Anim, Bismark Djan
International Journal of Scientific Research in Science and Technology.2019; : 99. CrossRef
Dosimetric Comparison of Setup Errors in Intensity Modulated Radiation Therapy with Deep Inspiration Breath Holding in Breast Cancer Radiation Therapy
Ham Il-Sik, Cho Pyong-Kon, Jung Kang-Kyo
Journal of Radiological Science and Technology.2019; 42(2): 137. CrossRef
Setup Error Assessment and Correction in Planar kV Image- Versus Cone Beam CT Image-Guided Radiation Therapy: A Clinical Study of Early Breast Cancer Treated With External Beam Partial Breast Irradiation
Wei Wang, Ting Yu, Min Xu, Qian Shao, Yingjie Zhang, Jianbin Li
Technology in Cancer Research & Treatment.2019;[Epub] CrossRef
A Potential Anti-Tumor Herb Bred in a Tropical Fruit: Insight into the Chemical Components and Pharmacological Effects of Momordicae Semen
Xiao-Rong Xu, Chuan-Hong Luo, Bo Cao, Run-Chun Xu, Fang Wang, Xi-Chuan Wei, Ting Zhang, Li Han, Ding-Kun Zhang
Molecules.2019; 24(21): 3949. CrossRef
Xihuang pill promotes apoptosis of Treg cells in the tumor microenvironment in 4T1 mouse breast cancer by upregulating MEKK1/SEK1/JNK1/AP-1 pathway
Liang Su, Yiming Jiang, Yu Xu, Xinye Li, Wenbin Gao, Chunwei Xu, Changqian Zeng, Jie Song, Wencai Weng, Wenbo Liang
Biomedicine & Pharmacotherapy.2018; 102: 1111. CrossRef
The Antitumor Effect of Xihuang Pill on Treg Cells Decreased in Tumor Microenvironment of 4T1 Breast Tumor‐Bearing Mice by PI3K/AKT~AP‐1 Signaling Pathway
Xin-ye Li, Liang Su, Yi-ming Jiang, Wen-bin Gao, Chun-wei Xu, Chang-qian Zeng, Jie Song, Yu Xu, Wen-cai Weng, Wen-bo Liang, Jian-Li Gao
Evidence-Based Complementary and Alternative Medicine.2018;[Epub] CrossRef
Setup errors and effectiveness of Optical Laser 3D Surface imaging system (Sentinel) in postoperative radiotherapy of breast cancer
Xiaobo Wei, Mengjiao Liu, Yun Ding, Qilin Li, Changhai Cheng, Xian Zong, Wenming Yin, Jie Chen, Wendong Gu
Scientific Reports.2018;[Epub] CrossRef
Applying human factors engineering methods for hazard identification and mitigation in the radiotherapy process
Mariana Bernardes, Clarissa Trzesniak, Patricia Trbovich, Carlos Henrique Pereira Mello
Safety Science.2018; 109: 270. CrossRef
Compared with intensity‐modulated radiotherapy, image‐guided radiotherapy reduces severity of acute radiation‐induced skin toxicity during radiotherapy in patients with breast cancer
Jang‐Chun Lin, Jo‐Ting Tsai, Yu‐Ching Chou, Ming‐Hsien Li, Wei‐Hsiu Liu
Cancer Medicine.2018; 7(8): 3622. CrossRef
A topology-based method to mitigate the dosimetric uncertainty caused by the positional variation of the boost volume in breast conservative radiotherapy
Peng-Yi Lee, Chih-Yuan Lin, Shang-Wen Chen, Chun-Ru Chien, Chun-Nan Chu, Hsiu-Ting Hsu, Ji-An Liang, Ying-Jun Lin, An-Cheng Shiau
Radiation Oncology.2017;[Epub] CrossRef
Setup deviations for whole-breast radiotherapy with TomoDirect: A comparison of weekly and biweekly image-guided protocols
Jae Hong Jung, Joo-Young Jung, Sun Hyun Bae, Seong Kwon Moon, Kwang Hwan Cho
Journal of the Korean Physical Society.2016; 69(7): 1247. CrossRef
Displacement of Surgical Clips during Postoperative Radiotherapy in Breast Cancer Patients Who Received Breast-Conserving Surgery
SooYoon Sung, Joo Hwan Lee, Jong Hoon Lee, Sung Hwan Kim, Yoo-Kang Kwak, Sea-Won Lee, Ye Won Jeon, Young Jin Suh
Journal of Breast Cancer.2016; 19(4): 417. CrossRef
Review on the Applications and Molecular Mechanisms ofXihuangPill in Tumor Treatment
Qiujun Guo, Jinyin Lin, Rui Liu, Yebo Gao, Shulin He, Xinyao Xu, Baojin Hua, Conghuang Li, Wei Hou, Honggang Zheng, Yanju Bao
Evidence-Based Complementary and Alternative Medicine.2015; 2015: 1. CrossRef

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179 Download
21 Web of Science
21 Crossref

The Efficacy of External Beam Radiotherapy for Airway Obstruction in Lung Cancer Patients: Jeong Won Lee, Jong Hoon Lee, Hoon-Kyo Kim, Byoung Yong Shim, Ho Jung An, Sung Hwan Kim; Cancer Res Treat. 2015;47(2):189-196. Published online September 12, 2014; DOI: https://doi.org/10.4143/crt.2013.261

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Purpose
The objective of this study was to evaluate external beam radiotherapy (EBRT) in lung cancer patients who suffer from airway obstruction. Materials and Methods Medical data of 95 patients with a lung mass that obstructed the airway and received EBRT for it were analyzed. Fifty-nine patients (62.1%) had non-small cell lung cancer and 36 patients (37.9%) had small cell lung cancer. Radiotherapy was given at 8 to 45 Gy (median, 30 Gy) in 1 to 15 fractions (median, 10 fractions). The response to EBRT was assessed through changes in radiographic findings and/or subjective symptoms between before and after EBRT. The median follow-up duration was 124 days. The primary end point was the airway-obstruction resolving rate after EBRT. The secondary end points were patient survival and toxic effects of EBRT. Results Improvement of airway obstruction after EBRT on chest X-ray was achieved in 75 of 95 patients (78.9%). The median time for resolving the radiologic findings and/or symptoms of airway obstruction after EBRT was 7 days (range, 1 to 76 days). The 1-year survival rate was significantly higher in responders than non-responders (12.5% vs. 0.0%, p < 0.001). The biologically effective dose of ≥ 39 Gyα/β=10 (p < 0.01) and the longest obstructive lesion of < 6 cm (p=0.04) were significantly associated with a good response to EBRT in resolving the airway obstruction. No one had grade 3 or higher acute and chronic toxicities. Conclusion EBRT is an effective treatment in relieving airway obstruction without severe toxicities in lung cancer patients.

Citations

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Nathaniel M. Ivanick, Emily R. Oakley, Rajesh Kunadharaju, Craig Brackett, David A. Bellnier, Lawrence M. Tworek, Sergei N. Kurenov, Sandra O. Gollnick, Alan D. Hutson, Theresa M. Busch, Gal Shafirstein
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Electrospray Mediated Localized and Targeted Chemotherapy in a Mouse Model of Lung Cancer
Paulius Ruzgys, Stephan Böhringer, Ayse Sila Dokumaci, Yvonne Hari, Christian M. Schürch, Frido Brühl, Stefan Schürch, Sönke Szidat, Carsten Riether, Saulius Šatkauskas, Thomas Geiser, David Hradetzky, Amiq Gazdhar
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Hoon Sik Choi, Bae Kwon Jeong, Hojin Jeong, In Bong Ha, Ki Mun Kang
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Lonny Yarmus, Christopher Mallow, Jason Akulian, Cheng Ting Lin, David Ettinger, Russell Hales, Kinh Ranh Voong, Hans Lee, David Feller-Kopman, Roy Semaan, Kirk Seward, Momen M. Wahidi
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Erin J Song, Chris R Kelsey, Bastiaan Driehuys, Leith Rankine
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