Hyung-Jun Kim, Jun Yeun Cho, Yeon Joo Lee, Jong Sun Park, Young-Jae Cho, Ho Il Yoon, Jin-Haeng Chung, Sukki Cho, Kwhanmien Kim, Kyung Won Lee, Jae Ho Lee, Choon-Taek Lee
Cancer Res Treat. 2019;51(4):1540-1548. Published online March 25, 2019
Purpose
Lung cancers presenting as subsolid nodule commonly have peripheral location, making the cancer-pleura relationship noteworthy. We aimed to evaluate the effect of pleural attachment and/or indentation on visceral pleural invasion (VPI) and recurrence-free survival.
Materials and Methods
Patients who underwent curative resection of lung cancer as subsolid nodules from April 2007 to January 2016 were retrospectively evaluated. They were divided into four groups according to their relationship with the pleura. Clinical, radiographical, and pathological findings were analyzed.
Results
Among 404 patients with malignant subsolid nodule, 120 (29.7%) had neither pleural attachment nor indentation, 26 (6.4%) had attachment only, 117 (29.0%) had indentation only, and 141 (34.9%) had both. VPI was observed in nodules of 36 patients (8.9%), but absent in nonsolid nodules and in those without pleural attachment and/or indentation. Compared to subsolid nodules with concurrent pleural attachment and indentation, those with attachment only (odds ratio, 0.12; 95% confidence interval [CI], 0.02 to 0.98) and indentation only (odds ratio, 0.10; 95% CI, 0.03 to 0.31) revealed lower odds of VPI. On subgroup analysis, the size of the solid portion was associated with VPI among those with pleural attachment and indentation (p=0.021). Such high-risk features for VPI were associated with earlier lung cancer recurrence (adjusted hazard ratio, 3.31; 95% CI, 1.58 to 6.91).
Conclusion
Concurrent pleural attachment and indentation are risk factors for VPI, and the odds increase with larger solid portion in subsolid nodules. Considering the risk of recurrence, early surgical resection could be encouraged in these patients.
Citations
Citations to this article as recorded by
A CT-based deep learning model: visceral pleural invasion and survival prediction in clinical stage IA lung adenocarcinoma Xiaofeng Lin, Kunfeng Liu, Kunwei Li, Xiaojuan Chen, Biyun Chen, Sheng Li, Huai Chen, Li Li iScience.2024; 27(1): 108712. CrossRef
CT-Based Intratumoral and Peritumoral Radiomics Nomograms for the Preoperative Prediction of Spread Through Air Spaces in Clinical Stage IA Non-small Cell Lung Cancer Yun Wang, Deng Lyu, Lei Hu, Junhong Wu, Shaofeng Duan, Taohu Zhou, Wenting Tu, Yi Xiao, Li Fan, Shiyuan Liu Journal of Imaging Informatics in Medicine.2024; 37(2): 520. CrossRef
Prognostic Analysis of Stage I Non-Small Cell Lung Cancer Abutting Adjacent Structures on Preoperative Computed Tomography Soohwan Choi, Sun Kyun Ro, Seok Whan Moon Journal of Chest Surgery.2024; 57(2): 136. CrossRef
Nomogram using intratumoral and peritumoral radiomics for the preoperative prediction of visceral pleural invasion in clinical stage IA lung adenocarcinoma Yun Wang, Deng Lyu, Su Hu, Yanqing Ma, Shaofeng Duan, Yayuan Geng, Taohu Zhou, Wenting Tu, Yi Xiao, Li Fan, Shiyuan Liu Journal of Cardiothoracic Surgery.2024;[Epub] CrossRef
Nomogram for predicting invasive lung adenocarcinoma in small solitary pulmonary nodules Mengchao Xue, Rongyang Li, Junjie Liu, Ming Lu, Zhenyi Li, Huiying Zhang, Hui Tian Frontiers in Oncology.2024;[Epub] CrossRef
Analysis of postoperative recurrence-free survival in non–small cell lung cancer patients based on consensus clustering Q. Tian, S.-Y. Zhou, Y.-H. Qin, Y.-Y. Wu, C. Qin, H. Zhou, J. Shi, S.-F. Duan, F. Feng Clinical Radiology.2024; 79(10): e1214. CrossRef
Predicting bone metastasis-free survival in non-small cell lung cancer from preoperative CT via deep learning Jia Guo, Jianguo Miao, Weikai Sun, Yanlei Li, Pei Nie, Wenjian Xu npj Precision Oncology.2024;[Epub] CrossRef
Tumour–pleura relationship on CT is a risk factor for occult lymph node metastasis in peripheral clinical stage IA solid adenocarcinoma Chengzhou Zhang, Liping Wang, Xiaoting Cai, Mengfei Li, Dandan Sun, Ping Wang European Radiology.2023; 33(5): 3083. CrossRef
Analysis of the relevance between computed tomography characterization and pathology of pulmonary ground-glass nodules with different pathology types Zhang Youguo, Wang Chengye, Cheng Xiaofei, Zhang Xuefei, Liu Changhong Turkish Journal of Thoracic and Cardiovascular Surgery.2023; 31(1): 95. CrossRef
Risk factors for loss of pulmonary function after wedge resection for peripheral ground-glass opacity dominant lung cancer Tomohiro Miyoshi, Hiroyuki Ito, Masashi Wakabayashi, Tadayoshi Hashimoto, Yuta Sekino, Kenji Suzuki, Masahiro Tsuboi, Yasumitsu Moriya, Ichiro Yoshino, Tetsuya Isaka, Aritoshi Hattori, Takahiro Mimae, Mitsuhiro Isaka, Tomohiro Maniwa, Makoto Endo, Hiroshi European Journal of Cardio-Thoracic Surgery.2023;[Epub] CrossRef
Volumetric analysis of intravoxel incoherent motion diffusion-weighted imaging in preoperative assessment of non-small cell lung cancer Jianqin Jiang, Yigang Fu, Lili Zhang, Jia Liu, Xiaowen Gu, Weiwei Shao, Lei Cui, Gaofeng Xu Japanese Journal of Radiology.2022; 40(9): 903. CrossRef
A Nomogram Combined Radiomics and Clinical Features as Imaging Biomarkers for Prediction of Visceral Pleural Invasion in Lung Adenocarcinoma Xinyi Zha, Yuanqing Liu, Xiaoxia Ping, Jiayi Bao, Qian Wu, Su Hu, Chunhong Hu Frontiers in Oncology.2022;[Epub] CrossRef
Radiologists with and without deep learning–based computer-aided diagnosis: comparison of performance and interobserver agreement for characterizing and diagnosing pulmonary nodules/masses Tomohiro Wataya, Masahiro Yanagawa, Mitsuko Tsubamoto, Tomoharu Sato, Daiki Nishigaki, Kosuke Kita, Kazuki Yamagata, Yuki Suzuki, Akinori Hata, Shoji Kido, Noriyuki Tomiyama European Radiology.2022; 33(1): 348. CrossRef
The value of CT radiomics features to predict visceral pleural invasion in ≤3 cm peripheral type early non-small cell lung cancer Shu-Hua Wei, Jin-Mei Zhang, Bin Shi, Fei Gao, Zhao-Xuan Zhang, Li-Ting Qian Journal of X-Ray Science and Technology.2022; 30(6): 1115. CrossRef
Pathological components and CT imaging analysis of the area adjacent pleura within the pure ground-glass nodules with pleural deformation in invasive lung adenocarcinoma Yining Jiang, Ziqi Xiong, Wenjing Zhao, Di Tian, Qiuping Zhang, Zhiyong Li BMC Cancer.2022;[Epub] CrossRef
Development and validation of a deep learning signature for predicting lymph node metastasis in lung adenocarcinoma: comparison with radiomics signature and clinical-semantic model Xiaoling Ma, Liming Xia, Jun Chen, Weijia Wan, Wen Zhou European Radiology.2022; 33(3): 1949. CrossRef
Lung-RADS Version 1.1: Challenges and a Look Ahead, From the AJR Special Series on Radiology Reporting and Data Systems Lydia Chelala, Rydhwana Hossain, Ella A. Kazerooni, Jared D. Christensen, Debra S. Dyer, Charles S. White American Journal of Roentgenology.2021; 216(6): 1411. CrossRef
Predicting pathological lymph node status in clinical stage IA peripheral lung adenocarcinoma Keiju Aokage, Kenji Suzuki, Masashi Wakabayashi, Tomonori Mizutani, Aritoshi Hattori, Haruhiko Fukuda, Shun-Ichi Watanabe European Journal of Cardio-Thoracic Surgery.2021; 60(1): 64. CrossRef
Discriminating Small-Sized (2 cm or Less), Noncalcified, Solitary Pulmonary Tuberculoma and Solid Lung Adenocarcinoma in Tuberculosis-Endemic Areas Jingping Zhang, Tingting Han, Jialiang Ren, Chenwang Jin, Ming Zhang, Youmin Guo Diagnostics.2021; 11(6): 930. CrossRef
Association of postoperative recurrence with radiological and clinicopathological features in patients with stage IA–IIA lung adenocarcinoma Yanyan Zhang, Fengnian Zhao, Minghao Wu, Yunqing Zhao, Ying Liu, Qian Li, Guiming Zhou, Zhaoxiang Ye European Journal of Radiology.2021; 141: 109802. CrossRef
Characterization of Newly Detected Costal Pleura–attached Noncalcified Nodules at Annual Low-Dose CT Screenings Yeqing Zhu, Rowena Yip, Nan You, Qiang Cai, Claudia I. Henschke, David F. Yankelevitz, Claudia I. Henschke, David F. Yankelevitz, Rowena Yip, Dongming Xu, Mary Salvatore, Raja Flores, Andrea Wolf, David S. Mendelson, Dorothy I. McCauley, Mildred Chen, Dan Radiology.2021; 301(3): 724. CrossRef
Clinicopathological and computed tomographic features associated with occult lymph node metastasis in patients with peripheral solid non-small cell lung cancer Xiao-Qun He, Tian-You Luo, Xian Li, Ji-Wen Huo, Jun-Wei Gong, Qi Li European Journal of Radiology.2021; 144: 109981. CrossRef
Surgical Extent for Ground Glass Nodules Suk Ki Cho Journal of Chest Surgery.2021; 54(5): 338. CrossRef
CT-guided microcoil localization for pulmonary nodules before VATS: a retrospective evaluation of risk factors for pleural marking failure Yanyan Xu, Lingchuan Ma, Hongliang Sun, Zhenguo Huang, Zhenrong Zhang, Fei Xiao, Qianli Ma, Chuandong Li, Xiaomeng Zhang, Sheng Xie European Radiology.2020; 30(10): 5674. CrossRef
Management of Nodules Attached to the Costal Pleura at Low-Dose CT Screening for Lung Cancer Yeqing Zhu, Rowena Yip, Nan You, Claudia I. Henschke, David F. Yankelevitz Radiology.2020; 297(3): 710. CrossRef
PURPOSE Previously, we reported that the expression of E-cadherin was significantly decreased according to the increase of the level of hepatocyte growth factor (HGF) in gastric cancer tissue. In this work, the effect of HGF on the cell-cell adhesion and intracellular distribution of E-cadherin in the gastric carcinoma cell lines were studied.
MATERIALS AND METHODS: Western blot analysis was performed to confirm the presence or abscence of c-Met and E-cadherin in SNU-1, 5, and 16 cells.
Tyrosine phosphorylation of c-Met, E-cadherin, alpha-, beta-, gamma-catenins was checked by immunoprecipitation. The morphologic changes induced by HGF were studied with immunocytochemical staining. Functional proportion of E-cadherin was estimated by cell fractionation. The effect of HGF on cell proliferation and invasion was also assessed. RESULTS Among SNU-1, 5, and 16 cell lines, only SNU-16 cells expressed both E-cadherin and c-Met. A morphological change from epithelial shape to fibroblastic one was observed in the SNU-16 cells after treatment with HGF. In addition, E-cadherin expression of the SNU-16 cells was shifted from the membrane and to the cytoplasm, and the functional fraction of E-cadherin was decreased in the SNU-16 cells treated with HGF. On the other hand, HGF increased the proliferation and invasion of the SNU-16 cells. CONCLUSION These results suggest that HGF may regulate cell adhesion in gastric carcinomas via the cellular redistribution and functional change of E-cadherin.
PURPOSE This study was aimed to isolate cDNAs putatively associated with doxorubicin resistance or sensitivity in gastric carcinoma cell line. MATERIALS AND METHODS A doxorubicin-sensitive parental SNU-16 and doxorubicin resistant SNU-16DOX cell line were used. Differential display-PCR(DD-PCR) was employed to screen for differentially expressed cDNA fragment either in parental or resistant cell line and followed by subtractive hybridization to discriminate true positive from false positive clones. The sequences were determined and compared to the sequence data base registered at the GenBank. RESULTS Four clones(16, 19, 21, and 22 clone) were isolated, of which three(16, 19 and 21 clone) was downexpressed, and one(22 clone) was overexpressed in doxorubicin resistant cell line. All four clones were found to be novel sequences. Further analysis for these clones are under characterization. CONCLUSION Four partial cDNA clones that are putatively associated with doxorubicin resistance or sensitivity in gastric carcinoma cell line were isolated.
PURPOSE Hepatocyte growth factor (HGF) is a modulator of epithelial cell proliferation and motility. In this study, we measured the level of HGF in sera and tumor extracts of gastric adenocarcinoma using an enzyme-linked immunoassay and evaluated its association with tumor progression. MATERIALS AND METHODS The level of HGF in the sera of seventy-five patients with gastric adenocarcinoma and in the tumor extracts of forty-two tumors were examined in this study. The level of HGF was determined by an Immunis HGF EIA kit (Institute of Immunology). RESULTS The mean level of HGF in the sera of patients was 0.26+/-0.19 ng/ml, which was significantly higher than in those of healthy controls (0.14+/-0.07 ng/ml, p<0.05); the levels of HGF in the sera of patients increased according to the progression of the stage of cancer (p<0.05). The mean level of HGF in tumor extracts was 8.22+/-9.27 microgram/g protein, which was significantly higher than in those of healthy controls (1.95+/-1.45 microgram/g protein, p<0.05); the levels of HGF in the tumor extracts were correlated significantly with the progression of the tumor stage (p<0.05). The mean level of HGF in the tumors of diffuse type was 11.28+/-11.74 microgram/g protein, which was significantly higher than in those of intestinal type (5.16+/-4.31 microgram/g protein, p<0.05). CONCLUSION HGF may play an important role in the progression and differentiation of gastric adenocarcinoma.