Cancer Research and Treatment

Original Articles

Pediatric cancer

Malignant Hepatocellular Neoplasm, Not Otherwise Specified, Displays Poorer Chemoresponsiveness and Postoperative Prognosis Than Hepatoblastoma: In Hye Song, Sujin Gang, Hee Mang Yoon, Pyeong Hwa Kim, Bokyung Ahn, Jihun Kim, Deok Hoon Kim, Jung-Man Namgoong, Kyung-Nam Koh; Cancer Res Treat. 2026;58(2):642-655. Published online May 12, 2025; DOI: https://doi.org/10.4143/crt.2025.117

Abstract PDF Supplementary Material PubReader ePub

Purpose
Malignant hepatocellular neoplasm, not otherwise specified (HCN-NOS) is a provisional diagnostic entity, characterised by intermediate or a combination of hepatoblastoma and pediatric hepatocellular carcinoma (p-HCC) features. We compared the characteristics of HCN-NOS with hepatoblastoma and p-HCC.
Materials and Methods
The records of 148 pediatric patients diagnosed with hepatocellular malignancy after resection were retrieved from the institutional database. Clinical parameters and histopathology slides were reviewed to re-establish each patient’s diagnosis. Molecular analyses were conducted in 37 patients.
Results
Patients were profiled as 21 (14.2%) with HCN-NOS, 109 (73.6%) with hepatoblastoma, and 18 (12.2%) with p-HCC. The median age was 8.6 years in HCN-NOS, 1.2 years in hepatoblastoma, and 7.9 years in p-HCC. Background liver disease was frequently observed in p-HCC (11/18, 61%) but infrequent in HCN-NOS (4/21, 19%) and hepatoblastoma (4/109, 3.7%). HCN-NOS presented with a more advanced PRETEXT stage (p=0.012), metastasis (p < 0.001), and lymphovascular invasion (p < 0.001) than hepatoblastoma and p-HCC. Patients with HCN-NOS received longer cycles of preoperative chemotherapy; however, they reported a lower decrease in serum alpha-fetoprotein and tumor size than hepatoblastoma (p=0.043, p=0.004, and p=0.044, respectively). HCN-NOS was an independent poor prognostic factor for event-free survival (hazard ratio, 4.968; 95% confidence interval, 2.004 to 12.32; p < 0.001).
Conclusion
The possibility of HCN-NOS should be considered in pediatric patients with liver cancer, especially those ≥ 5 years old with no background liver disease. Because HCN-NOS exhibits poor chemoresponsiveness and unfavourable postoperative prognosis, liver transplantation should be strongly considered.

Citations

Citations to this article as recorded by

Conversion Hepatectomy After New FP Therapy for Malignant Hepatocellular Neoplasm, Not Otherwise Specified: A Case Report
Etsuko Moriyama, Hironori Koga, Takashi Niizeki, Hideki Iwamoto, Shigeo Shimose, Tomotake Shirono, Takahiko Tokushige, Masahito Nakano, Ryoko Kuromatsu, Toru Goto, Masaki Honda, Taizo Hibi, Yoshiki Mikami, Reiichiro Kondo, Jun Akiba, Takumi Kawaguchi
Hepatology Research.2026; 56(6): 1047. CrossRef

3,374 View
171 Download
1 Web of Science
1 Crossref

Gastrointestinal cancer

Presence of RB1 or Absence of LRP1B Mutation Predicts Poor Overall Survival in Patients with Gastric Neuroendocrine Carcinoma and Mixed Adenoneuroendocrine Carcinoma: In Hye Song, Bokyung Ahn, Young Soo Park, Deok Hoon Kim, Seung-Mo Hong; Cancer Res Treat. 2025;57(2):492-506. Published online September 27, 2024; DOI: https://doi.org/10.4143/crt.2024.667

Abstract PDF Supplementary Material PubReader ePub

Purpose
Neuroendocrine carcinomas (NECs) of the stomach are extremely rare, but fatal. However, our understanding of the genetic alterations in gastric NECs is limited. We aimed to evaluate genomic and clinicopathological characteristics of gastric NECs and mixed adenoneuroendocrine carcinomas (MANECs).
Materials and Methods
Fourteen gastric NECs, three gastric MANECs, and 1,381 gastric adenocarcinomas were retrieved from the departmental next-generation sequencing database between 2017 and 2022. Clinicopathological parameters and next-generation sequencing test results were retrospectively collected and reviewed.
Results
Gastric NECs and MANECs frequently harbored alterations of TP53, RB1, SMARCA4, RICTOR, APC, TOP1, SLX4, EGFR, BRCA2, and TERT. In contrast, gastric adenocarcinomas exhibited alterations of TP53, CDH1, LRP1B, ARID1A, ERBB2, GNAS, CCNE1, NOTCH, and MYC. Mutations of AKT3, RB1, and SLX4; amplification of BRCA2 and RICTOR; and deletion of ADAMTS18, DDX11, KLRC3, KRAS, MAX, NFKBIA, NUDT7, and RB1 were significantly more frequent in gastric NECs and MANECs than in gastric adenocarcinomas. The presence of LRP1B mutation was significantly associated with longer overall survival (OS), whereas RB1 mutation and advanced TNM stage were associated with shorter OS.
Conclusion
We identified frequently mutated genes and potential predictors of survival in patients with gastric NECs and MANECs.

Citations

Citations to this article as recorded by

Malignant Hepatocellular Neoplasm, Not Otherwise Specified, Displays Poorer Chemoresponsiveness and Postoperative Prognosis Than Hepatoblastoma
In Hye Song, Sujin Gang, Hee Mang Yoon, Pyeong Hwa Kim, Bokyung Ahn, Jihun Kim, Deok Hoon Kim, Jung-Man Namgoong, Kyung-Nam Koh
Cancer Research and Treatment.2026; 58(2): 642. CrossRef
Intraductal Papillary Squamous Neoplasm (IPSN) of the Pancreas: Histological and Molecular Characterization of a Novel and Distinct Intraductal Cancer Precursor
Michele Bevere, Antonio Pea, Volkan Adsay, Olca Basturk, Lodewijk A. Brosens, Irene Esposito, Ralph H. Hruban, David Klimstra, Seung-Mo Hong, Aatur D. Singhi, Seung Soo Lee, Paola Mattiolo, Davide Pasini, Andrea Mafficini, Paola Piccoli, Serena Pedron, Ca
Modern Pathology.2026; 39(7): 101011. CrossRef
Mixed adenoneuroendocrine carcinoma of the gallbladder: a case report and literature review
Zhenghui Sui, Wei Wang, De Zhang, Yifan Sun, Jiajing Li, Xingwei Gu, Ganggang Miao
Frontiers in Oncology.2026;[Epub] CrossRef
Hepatoid adenocarcinoma of the stomach and non-hepatoid alpha-fetoprotein-producing gastric cancer exhibit a high degree of molecular similarity
Liqiao Chen, Xuesong Yang, Peiyu Zhu, Han Bao, Yan Wu, Ke Ji, Ji Zhang, Xiaojiang Wu, Kai Zhou, Jieli Xu, Jiatian Tang, Anqiang Wang, Zhaode Bu
Cellular Oncology.2025;[Epub] CrossRef

5,164 View
142 Download
2 Web of Science
4 Crossref

Breast cancer

Diagnostic Assessment of Deep Learning Algorithms for Frozen Tissue Section Analysis in Women with Breast Cancer: Young-Gon Kim, In Hye Song, Seung Yeon Cho, Sungchul Kim, Milim Kim, Soomin Ahn, Hyunna Lee, Dong Hyun Yang, Namkug Kim, Sungwan Kim, Taewoo Kim, Daeyoung Kim, Jonghyeon Choi, Ki-Sun Lee, Minuk Ma, Minki Jo, So Yeon Park, Gyungyub Gong; Cancer Res Treat. 2023;55(2):513-522. Published online September 6, 2022; DOI: https://doi.org/10.4143/crt.2022.055

Abstract PDF Supplementary Material PubReader ePub

Purpose
Assessing the metastasis status of the sentinel lymph nodes (SLNs) for hematoxylin and eosin–stained frozen tissue sections by pathologists is an essential but tedious and time-consuming task that contributes to accurate breast cancer staging. This study aimed to review a challenge competition (HeLP 2019) for the development of automated solutions for classifying the metastasis status of breast cancer patients.
Materials and Methods
A total of 524 digital slides were obtained from frozen SLN sections: 297 (56.7%) from Asan Medical Center (AMC) and 227 (43.4%) from Seoul National University Bundang Hospital (SNUBH), South Korea. The slides were divided into training, development, and validation sets, where the development set comprised slides from both institutions and training and validation set included slides from only AMC and SNUBH, respectively. The algorithms were assessed for area under the receiver operating characteristic curve (AUC) and measurement of the longest metastatic tumor diameter. The final total scores were calculated as the mean of the two metrics, and the three teams with AUC values greater than 0.500 were selected for review and analysis in this study.
Results
The top three teams showed AUC values of 0.891, 0.809, and 0.736 and major axis prediction scores of 0.525, 0.459, and 0.387 for the validation set. The major factor that lowered the diagnostic accuracy was micro-metastasis.
Conclusion
In this challenge competition, accurate deep learning algorithms were developed that can be helpful for making a diagnosis on intraoperative SLN biopsy. The clinical utility of this approach was evaluated by including an external validation set from SNUBH.

Citations

Citations to this article as recorded by

Detection of metastatic breast carcinoma in sentinel lymph node frozen sections using an artificial intelligence-assisted system
Chia-Ping Chang, Chih-Yi Hsu, Hsiang Sheng Wang, Peng-Chuna Feng, Wen-Yih Liang
Pathology - Research and Practice.2025; 267: 155836. CrossRef
Value of frozen section to tailor surgical staging in apparent early-stage epithelial ovarian cancer
Stefano Di Berardino, Nicolò Bizzarri, Marianna Ciancia, Francesca Moro, Belen Padial Urtueta, Claudia Marchetti, Gian Franco Zannoni, Giovanni Scambia, Anna Fagotti
International Journal of Gynecological Cancer.2025; : 101746. CrossRef
Comparing the diagnostic efficacy of optical coherence tomography and frozen section for margin assessment in breast-conserving surgery: a meta-analysis
Shishun Fan, Huirui Zhang, Zhenyu Meng, Ang Li, Yuqing Luo, Yueping Liu
Journal of Clinical Pathology.2024; 77(8): 517. CrossRef
Intraoperative Margin Assessment in Breast Conservation Surgery: A Necessity or a Luxury?
Srijan Shukla, Nisha Hariharan
Annals of Surgical Oncology.2023; 30(9): 5314. CrossRef

10,934 View
240 Download
5 Web of Science
4 Crossref

The Association of Estrogen Receptor Activity, Interferon Signaling, and MHC Class I Expression in Breast Cancer: In Hye Song, Young-Ae Kim, Sun-Hee Heo, Won Seon Bang, Hye Seon Park, Yeon ho Choi, Heejae Lee, Jeong-Han Seo, Youngjin Cho, Sung Wook Jung, Hee Jeong Kim, Sei Hyun Ahn, Hee Jin Lee, Gyungyub Gong; Cancer Res Treat. 2022;54(4):1111-1120. Published online December 21, 2021; DOI: https://doi.org/10.4143/crt.2021.1017

Abstract PDF Supplementary Material PubReader ePub

Purpose
The expression of major histocompatibility complex class I (MHC I) has previously been reported to be negatively associated with estrogen receptor (ER) expression. Furthermore, MHC I expression, level of tumor-infiltrating lymphocytes (TILs), and expression of interferon (IFN) mediator MxA are positively associated with one another in human breast cancers. This study aimed to investigate the mechanisms of association of MHC I with ER and IFN signaling.
Materials and Methods
The human leukocyte antigen (HLA)-ABC protein expression was analyzed in breast cancer cell lines. The expressions of HLA-A and MxA mRNAs were analyzed in MCF-7 cells in Gene Expression Omnibus (GEO) data. ER and HLA-ABC expressions, Ki-67 labeling index and TIL levels in tumor tissue were also analyzed in ER+/ human epidermal growth factor receptor 2 (HER2)- breast cancer patients who randomly received either neoadjuvant chemotherapy or estrogen modulator treatment followed by resection.
Results
HLA-ABC protein expression was decreased after β-estradiol treatment or hESR-GFP transfection and increased after fulvestrant or IFN-γ treatment in cell lines. In GEO data, HLA-A and MxA expression was increased after ESR1 shRNA transfection. In patients, ER Allred score was significantly lower and the HLA-ABC expression, TIL levels, and Ki-67 were significantly higher in the estrogen modulator treated group than the chemotherapy treated group.
Conclusion
MHC I expression and TIL levels might be affected by ER pathway modulation and IFN treatment. Further studies elucidating the mechanism of MHC I regulation could suggest a way to boost TIL influx in cancer in a clinical setting.

Citations

Citations to this article as recorded by

The Immunoregulatory Roles of ERα in Breast Cancer: Mechanisms, Crosstalk, and Therapeutic Insights
Afsoon Dehghani
Journal of Cancer Prevention.2026; 31(1): 1. CrossRef
Identifying Safeguards Disabled by Epstein-Barr Virus Infections in Genomes From Patients With Breast Cancer: Chromosomal Bioinformatics Analysis
Bernard Friedenson
JMIRx Med.2025; 6: e50712. CrossRef
Progesterone receptor-dependent downregulation of MHC class I promotes tumor immune evasion and growth in breast cancer
Julio C Tinoco, Harmony I Saunders, Lauryn Rose Werner, Xiaopeng Sun, Eilidh I Chowanec, Amanda Heard, Prabhakar Chalise, Jeffery M Vahrenkamp, Andrea E Wilson, Cong-Xiao Liu, Gangjun Lei, Junping Wei, Hugo Cros, Hisham Mohammed, Melissa Troester, Charles
Journal for ImmunoTherapy of Cancer.2025; 13(3): e010179. CrossRef
Neoadjuvant Chemotherapy Efficacy in Breast Cancer: Insights from Magnetic Resonance Imaging Compilation (MAGIC)
Honghong Wu, Zebo Huang, Jie Wang
Academic Radiology.2025; 32(8): 4369. CrossRef
Prenatal Bisphenol B Exposure Induces Adult Male Offspring Reproductive Dysfunction via ERα Inhibition-Triggered MHC I-Mediated Testicular Immunological Responses
Nannan Chen, Xiaotian Li, Shenrui Zhou, Xin Peng, Senlin Xue, Yuetong Liu, Tingwang Jiang, Wei Yan
Toxics.2025; 13(6): 423. CrossRef
The untapped potential of radiation and immunotherapy for hormone receptor-positive breast cancer
Matthew Fenton, Miki Yoneyama, Erik Wennerberg, Tom Lund, Andrew Tutt, Alan Melcher, Sandra Demaria, Navita Somaiah
npj Breast Cancer.2025;[Epub] CrossRef
Dendrimer-Mediated Delivery Enhances Therapeutic Efficacy in Triple-Negative Breast Cancer
Anunay James Pulukuri, Anubhav Dhull, Aqib Iqbal Dar, Anu Rani, Rishi Sharma, Clifford E. Berkman, Anjali Sharma
Biomacromolecules.2025; 26(9): 5979. CrossRef
Neoadjuvant Immunotherapy in Hormone Receptor-Positive Breast Cancer: From Tumor Microenvironment Reprogramming to Combination Therapy Strategies
Zimei Tang, Tao Huang, Tinglin Yang
International Journal of Molecular Sciences.2025; 26(23): 11596. CrossRef
Toxic Epidermal Necrolysis and Steven–Johnson Syndrome During the Postpartum Period: A Literature Review with a Rare Case Presentation
Natalia Katarzyna Mazur-Ejankowska, Maciej Ejankowski, Magdalena Emilia Grzybowska, Jakub Żółkiewicz, Ewa Gostkowska, Wioletta Barańska-Rybak, Dariusz Grzegorz Wydra
Journal of Clinical Medicine.2025; 15(1): 17. CrossRef
Estrogen receptor regulation of the immune microenvironment in breast cancer
Conor McGuinness, Kara L. Britt
The Journal of Steroid Biochemistry and Molecular Biology.2024; 240: 106517. CrossRef
Bioinformatic-Experimental Screening Uncovers Multiple Targets for Increase of MHC-I Expression through Activating the Interferon Response in Breast Cancer
Xin Li, Zilun Ruan, Shuzhen Yang, Qing Yang, Jinpeng Li, Mingming Hu
International Journal of Molecular Sciences.2024; 25(19): 10546. CrossRef
Hormone Receptor Signaling and Breast Cancer Resistance to Anti-Tumor Immunity
Alexandra Moisand, Mathilde Madéry, Thomas Boyer, Charlotte Domblides, Céline Blaye, Nicolas Larmonier
International Journal of Molecular Sciences.2023; 24(20): 15048. CrossRef

9,789 View
196 Download
11 Web of Science
12 Crossref

Challenge for Diagnostic Assessment of Deep Learning Algorithm for Metastases Classification in Sentinel Lymph Nodes on Frozen Tissue Section Digital Slides in Women with Breast Cancer: Young-Gon Kim, In Hye Song, Hyunna Lee, Sungchul Kim, Dong Hyun Yang, Namkug Kim, Dongho Shin, Yeonsoo Yoo, Kyowoon Lee, Dahye Kim, Hwejin Jung, Hyunbin Cho, Hyungyu Lee, Taeu Kim, Jong Hyun Choi, Changwon Seo, Seong il Han, Young Je Lee, Young Seo Lee, Hyung-Ryun Yoo, Yongju Lee, Jeong Hwan Park, Sohee Oh, Gyungyub Gong; Cancer Res Treat. 2020;52(4):1103-1111. Published online June 30, 2020; DOI: https://doi.org/10.4143/crt.2020.337

Abstract PDF PubReader ePub

Purpose
Assessing the status of metastasis in sentinel lymph nodes (SLNs) by pathologists is an essential task for the accurate staging of breast cancer. However, histopathological evaluation of sentinel lymph nodes by a pathologist is not easy and is a tedious and time-consuming task. The purpose of this study is to review a challenge competition (HeLP 2018) to develop automated solutions for the classification of metastases in hematoxylin and eosin–stained frozen tissue sections of SLNs in breast cancer patients.
Materials and Methods
A total of 297 digital slides were obtained from frozen SLN sections, which include post–neoadjuvant cases (n = 144, 48.5%) in Asan Medical Center, South Korea. The slides were divided into training, development, and validation sets. All of the imaging datasets have been manually segmented by expert pathologists. A total of 10 participants were allowed to use the Kakao challenge platform for six weeks with two P40 GPUs. The algorithms were assessed in terms of the AUC (area under receiver operating characteristic curve).
Results
The top three teams showed 0.986, 0.985, and 0.945 AUCs for the development set and 0.805, 0.776, and 0.765 AUCs for the validation set. Micrometastatic tumors, neoadjuvant systemic therapy, invasive lobular carcinoma, and histologic grade 3 were associated with lower diagnostic accuracy.
Conclusion
In a challenge competition, accurate deep learning algorithms have been developed, which can be helpful in making frozen diagnosis of intraoperative sentinel lymph node biopsy. Whether this approach has clinical utility will require evaluation in a clinical setting

Citations

Citations to this article as recorded by

Detection of metastatic breast carcinoma in sentinel lymph node frozen sections using an artificial intelligence-assisted system
Chia-Ping Chang, Chih-Yi Hsu, Hsiang Sheng Wang, Peng-Chuna Feng, Wen-Yih Liang
Pathology - Research and Practice.2025; 267: 155836. CrossRef
Fusing Domains for Tumor Detection in Frozen Section Histopathology Using Joint Feature Alignment and Self-Knowledge Distillation
Eunsu Kim, Yoo Jin Lee, Jonghyun Lee, Hyeseong Lee, D M Bappy, Sangjeong Ahn, Sung Hak Lee
IEEE Access.2025; 13: 190745. CrossRef
Diagnostic Assessment of Deep Learning Algorithms for Frozen Tissue Section Analysis in Women with Breast Cancer
Young-Gon Kim, In Hye Song, Seung Yeon Cho, Sungchul Kim, Milim Kim, Soomin Ahn, Hyunna Lee, Dong Hyun Yang, Namkug Kim, Sungwan Kim, Taewoo Kim, Daeyoung Kim, Jonghyeon Choi, Ki-Sun Lee, Minuk Ma, Minki Jo, So Yeon Park, Gyungyub Gong
Cancer Research and Treatment.2023; 55(2): 513. CrossRef
Artificial intelligence and frozen section histopathology: A systematic review
Benjamin G. Gorman, Mark A. Lifson, Nahid Y. Vidal
Journal of Cutaneous Pathology.2023; 50(9): 852. CrossRef
Effectiveness of transfer learning for enhancing tumor classification with a convolutional neural network on frozen sections
Young-Gon Kim, Sungchul Kim, Cristina Eunbee Cho, In Hye Song, Hee Jin Lee, Soomin Ahn, So Yeon Park, Gyungyub Gong, Namkug Kim
Scientific Reports.2020;[Epub] CrossRef

11,535 View
218 Download
18 Web of Science
5 Crossref

Expression of Immunoproteasome Subunit LMP7 in Breast Cancer and Its Association with Immune-Related Markers: Miseon Lee, In Hye Song, Sun-Hee Heo, Young-Ae Kim, In Ah Park, Won Seon Bang, Hye Seon Park, Gyungyub Gong, Hee Jin Lee; Cancer Res Treat. 2019;51(1):80-89. Published online February 26, 2018; DOI: https://doi.org/10.4143/crt.2017.500

Abstract PDF PubReader ePub

Purpose
In the presence of interferon, proteasome subunits are replaced by their inducible counterparts to form an immunoproteasome (IP) plays a key role in generation of antigenic peptides presented by MHC class I molecules, leading to elicitation of a T cell‒mediated immune response. Although the roles of IP in other cancers, and inflammatory diseases have been extensively studied, its significance in breast cancer is unclear.
Materials and Methods
We investigated the expression of LMP7, an IP subunit, and its relationship with immune system components in two breast cancer cohorts.
Results
In 668 consecutive breast cancer cohort, 40% of tumors showed high level of LMP7 expression, and tumors with high expression of LMP7 had more tumor-infiltrating lymphocytes (TILs) in each subtype of breast cancer. In another cohort of 681 triple-negative breast cancer patients cohort, the expression of LMP7 in tumor cells was significantly correlated with the amount of TILs and the expression of interferon-associated molecules (MxA [p < 0.001] and PKR [p < 0.001]), endoplasmic reticulum stress-associated molecules (PERK [p=0.012], p-eIF2a [p=0.001], and XBP1 [p < 0.001]), and damage-associated molecular patterns (HMGN1 [p < 0.001] and HMGB1 [p < 0.001]). Patients with higher LMP7 expression had better disease-free survival outcomes than those with no or low expression in the positive lymph node metastasis group (p=0.041).
Conclusion
Close association between the TIL levels and LMP7 expression in breast cancer indicates that better antigen presentation through greater LMP7 expression might be associated with more TILs.

Citations

Citations to this article as recorded by

The role of immunoproteasome in diabetes and diabetes-related complications
Mengwen Wang, Lingyun Luo, Lei Dai, Hesong Zeng, Hongjie Wang
Genes & Diseases.2026; 13(3): 101861. CrossRef
Association of Proteasome Activity and Pool Heterogeneity with Markers Determining the Molecular Subtypes of Breast Cancer
Irina Kondakova, Elena Sereda, Evgeniya Sidenko, Sergey Vtorushin, Valeria Vedernikova, Alexander Burov, Pavel Spirin, Vladimir Prassolov, Timofey Lebedev, Alexey Morozov, Vadim Karpov
Cancers.2025; 17(1): 159. CrossRef
Recent Advances in the Development of Immunoproteasome Inhibitors as Anti-Cancer Agents: The Past 5 Years
Francesca Mancuso, Carla Di Chio, Francesca Di Matteo, Gerardina Smaldone, Nunzio Iraci, Salvatore Vincenzo Giofrè
Molecules.2025; 30(3): 755. CrossRef
Unraveling UPR-mediated intercellular crosstalk: Implications for immunotherapy resistance mechanisms
Si Lu, Qimin Zhou, Rongjie Zhao, Lei Xie, Wen-Ming Cao, Yu-Xiong Feng
Cancer Letters.2025; 617: 217613. CrossRef
LMP7-Specific Inhibitor M3258 Modulates the Tumor Microenvironment of Triple-Negative Breast Cancer and Inflammatory Breast Cancer
Xuemei Xie, Jangsoon Lee, Ganiraju C. Manyam, Troy Pearson, Gina Walter-Bausch, Manja Friese-Hamim, Sheng Zhao, Julia Jabs, Angela A. Manginelli, Nadine Piske, Thomas Mrowiec, Corinna M. Wolf, Bharat S. Kuntal, Debu Tripathy, Jing Wang, Michael P. Sanders
Cancers.2025; 17(11): 1887. CrossRef
From oncogenesis to prognosis: the roles of the immunoproteasome in cancer
Delphine Béland, Mélissa Viens, Emma Mary Kalin, Marie-Claude Bourgeois-Daigneault
Frontiers in Immunology.2025;[Epub] CrossRef
Current landscape of the immunoproteasome: implications for disease and therapy
Zifeng Zou, Yanglin Hao, Zetong Tao, Weicong Ye, Zilong Luo, Xiaohan Li, Ran Li, Kexiao Zheng, Jiahong Xia, Chao Guo, Xi Zhang, Jie Wu
Cell Death Discovery.2025;[Epub] CrossRef
Protein post-translational modifications and tumor immunity: A pan-cancer perspective
Haoling Zhang, Qilu Yan, Shuya Jiang, Dan Hu, Ping Lu, Shaowei Li, Doblin Sandai, Haolong Zhang, Wangzheqi Zhang, Chenglong Zhu
Physics of Life Reviews.2025; 55: 142. CrossRef
Multikinase inhibitors modulate non-constitutive proteasome expression in colorectal cancer cells
Alexander Burov, Ekaterina Grigorieva, Timofey Lebedev, Valeria Vedernikova, Vladimir Popenko, Tatiana Astakhova, Olga Leonova, Pavel Spirin, Vladimir Prassolov, Vadim Karpov, Alexey Morozov
Frontiers in Molecular Biosciences.2024;[Epub] CrossRef
Upregulation of MHC I antigen processing machinery gene expression in breast cancer cells by Trichostatin A
A. H. Murtadha, N. A. Sharudin, I. I.M. Azahar, A. T. Che Has, N. F. Mokhtar
Молекулярная биология.2024; 58(1): 121. CrossRef
Immunoproteasome acted as immunotherapy ‘coffee companion’ in advanced carcinoma therapy
Shaoyan Shi, Xuehai Ou, Chao Liu, Hao Wen, Ke Jiang
Frontiers in Immunology.2024;[Epub] CrossRef
Immunoediting in acute myeloid leukemia: Reappraising T cell exhaustion and the aberrant antigen processing machinery in leukemogenesis
Ching-Yun Wang, Shiuan-Chen Lin, Kao-Jung Chang, Han-Ping Cheong, Sin-Rong Wu, Cheng-Hao Lee, Ming-Wei Chuang, Shih-Hwa Chiou, Chih-Hung Hsu, Po-Shen Ko
Heliyon.2024; 10(21): e39731. CrossRef
ONX0914 inhibition of immunoproteasome subunit LMP7 ameliorates diabetic cardiomyopathy via restraining endothelial–mesenchymal transition
Mengwen Wang, Yujian Liu, Lei Dai, Xiaodan Zhong, Wenjun Zhang, Yang Xie, Hesong Zeng, Hongjie Wang
Clinical Science.2023; 137(16): 1297. CrossRef
The dichotomous role of immunoproteasome in cancer: Friend or foe?
Boya Chen, Haiying Zhu, Bo Yang, Ji Cao
Acta Pharmaceutica Sinica B.2023; 13(5): 1976. CrossRef
Cancer Immunology: Immune Escape of Tumors—Expression and Regulation of HLA Class I Molecules and Its Role in Immunotherapies
Yuan Wang, Simon Jasinski-Bergner, Claudia Wickenhauser, Barbara Seliger
Advances in Anatomic Pathology.2023; 30(3): 148. CrossRef
Increased expression of the immunoproteasome subunits PSMB8 and PSMB9 by cancer cells correlate with better outcomes for triple-negative breast cancers
Karen Geoffroy, Bruna Araripe Saraiva, Melissa Viens, Delphine Béland, Marie-Claude Bourgeois-Daigneault
Scientific Reports.2023;[Epub] CrossRef
Adaptation of the Tumor Antigen Presentation Machinery to Ionizing Radiation
Mi-Heon Lee, Duang Ratanachan, Zitian Wang, Jacob Hack, Lobna Adbulrahman, Nicholas P Shamlin, Mirna Kalayjian, Jean Philippe Nesseler, Ekambaram Ganapathy, Christine Nguyen, Josephine A Ratikan, Nicolas A Cacalano, David Austin, Robert Damoiseaux, Benjam
The Journal of Immunology.2023; 211(4): 693. CrossRef
Upregulation of MHC I Antigen Processing Machinery Gene Expression in Breast Cancer Cells by Trichostatin A
A. H. Murtadha, N. A. Sharudin, I. I. M. Azahar, A. T. Che Has, N. F. Mokhtar
Molecular Biology.2023; 57(6): 1212. CrossRef
Emodin alleviates high glucose-induced oxidative stress, inflammation and extracellular matrix accumulation of mesangial cells by the circ_0000064/miR-30c-5p/Lmp7 axis
Li Sun, Yanquan Han, Chuqiao Shen, Huan Luo, Zhuo Wang
Journal of Receptors and Signal Transduction.2022; 42(3): 302. CrossRef
Methylation of Immune-Related Genes in Peripheral Blood Leukocytes and Breast Cancer
Tian Tian, JinMing Fu, DaPeng Li, YuPeng Liu, HongRu Sun, Xuan Wang, XianYu Zhang, Ding Zhang, Ting Zheng, Yashuang Zhao, Da Pang
Frontiers in Oncology.2022;[Epub] CrossRef
Analysis on methylation and expression of PSMB8 and its correlation with immunity and immunotherapy in lung adenocarcinoma
Tongji Xie, Guangyu Fan, Liling Huang, Ning Lou, Xiaohong Han, Puyuan Xing, Yuankai Shi
Epigenomics.2022; 14(22): 1427. CrossRef
A few good peptides: MHC class I-based cancer immunosurveillance and immunoevasion
Devin Dersh, Jaroslav Hollý, Jonathan W. Yewdell
Nature Reviews Immunology.2021; 21(2): 116. CrossRef
Expression of the immunoproteasome subunit β5i in non-small cell lung carcinomas
Takayuki Kiuchi, Utano Tomaru, Akihiro Ishizu, Makoto Imagawa, Sari Iwasaki, Akira Suzuki, Noriyuki Otsuka, Yoshihito Ohhara, Ichiro Kinoshita, Yoshihiro Matsuno, Hirotoshi Dosaka-Akita, Masanori Kasahara
Journal of Clinical Pathology.2021; 74(5): 300. CrossRef
High immunoproteasome concentration in the plasma of patients with newly diagnosed multiple myeloma treated with bortezomib is predictive of longer OS
Wioletta Breczko, Dorota Lemancewicz, Janusz Dzięcioł, Janusz Kłoczko, Łukasz Bołkun
Advances in Medical Sciences.2021; 66(1): 21. CrossRef
Methods for the Discovery of Small Molecules to Monitor and Perturb the Activity of the Human Proteasome
Marianne E Maresh, Andres F Salazar-Chaparro, Darci J Trader
Future Medicinal Chemistry.2021; 13(2): 99. CrossRef
Immunoproteasome Function in Normal and Malignant Hematopoiesis
Nuria Tubío-Santamaría, Frédéric Ebstein, Florian H. Heidel, Elke Krüger
Cells.2021; 10(7): 1577. CrossRef
Integrated genomic analysis of proteasome alterations across 11,057 patients with 33 cancer types: clinically relevant outcomes in framework of 3P medicine
Na Li, Xianquan Zhan
EPMA Journal.2021; 12(4): 605. CrossRef
The Functional and Mechanistic Roles of Immunoproteasome Subunits in Cancer
Satyendra Chandra Tripathi, Disha Vedpathak, Edwin Justin Ostrin
Cells.2021; 10(12): 3587. CrossRef
The Immunoproteasome: An Emerging Target in Cancer and Autoimmune and Neurological Disorders
Breanna L. Zerfas, Marianne E. Maresh, Darci J. Trader
Journal of Medicinal Chemistry.2020; 63(5): 1841. CrossRef
Differential prognostic impact of CD8+ T cells based on human leucocyte antigen I and PD-L1 expression in microsatellite-unstable gastric cancer
Yoonjin Kwak, Jiwon Koh, Yujun Park, Yun Ji Hong, Kyoung Un Park, Hyung-Ho Kim, Do Joong Park, Sang-Hoon Ahn, Woo Ho Kim, Hye Seung Lee
British Journal of Cancer.2020; 122(9): 1399. CrossRef
Tradeoff between metabolic i-proteasome addiction and immune evasion in triple-negative breast cancer
Alaknanda Adwal, Priyakshi Kalita-de Croft, Reshma Shakya, Malcolm Lim, Emarene Kalaw, Lucinda D Taege, Amy E McCart Reed, Sunil R Lakhani, David F Callen, Jodi M Saunus
Life Science Alliance.2020; 3(7): e201900562. CrossRef
Targeting purine synthesis in ASS1-expressing tumors enhances the response to immune checkpoint inhibitors
Rom Keshet, Joo Sang Lee, Lital Adler, Muhammed Iraqi, Yarden Ariav, Lisha Qiu Jin Lim, Shaul Lerner, Shiran Rabinovich, Roni Oren, Rotem Katzir, Hila Weiss Tishler, Noa Stettner, Omer Goldman, Hadas Landesman, Sivan Galai, Yael Kuperman, Yuri Kuznetsov,
Nature Cancer.2020; 1(9): 894. CrossRef
Proteasomes and Several Aspects of Their Heterogeneity Relevant to Cancer
Alexey V. Morozov, Vadim L. Karpov
Frontiers in Oncology.2019;[Epub] CrossRef
Protein Barcodes Enable High-Dimensional Single-Cell CRISPR Screens
Aleksandra Wroblewska, Maxime Dhainaut, Benjamin Ben-Zvi, Samuel A. Rose, Eun Sook Park, El-Ad David Amir, Anela Bektesevic, Alessia Baccarini, Miriam Merad, Adeeb H. Rahman, Brian D. Brown
Cell.2018; 175(4): 1141. CrossRef

12,464 View
322 Download
34 Web of Science
34 Crossref

Predictive Value of Tertiary Lymphoid Structures Assessed by High Endothelial Venule Counts in the Neoadjuvant Setting of Triple-Negative Breast Cancer: In Hye Song, Sun-Hee Heo, Won Seon Bang, Hye Seon Park, In Ah Park, Young-Ae Kim, Suk Young Park, Jin Roh, Gyungyub Gong, Hee Jin Lee; Cancer Res Treat. 2017;49(2):399-407. Published online July 27, 2016; DOI: https://doi.org/10.4143/crt.2016.215

Abstract PDF Supplementary Material PubReader ePub

Purpose
The tertiary lymphoid structure (TLS) is an important source of tumor-infiltrating lymphocytes (TILs), which have a strong prognostic and predictive value in triple-negative breast cancer (TNBC). A previous study reported that the levels of CXCL13 mRNA expression were associated with TLSs, but measuring the gene expression is challenging in routine practice. Therefore, this study evaluated the MECA79-positive high endothelial venule (HEV) densities and their association with the histopathologically assessed TLSs in biopsy samples. In addition, the relationship of TLSs with the CXCL13 transcript levels and clinical outcomes were examined.
Materials and Methods
A total of 108 TNBC patients treated with neoadjuvant chemotherapy (NAC) were studied. The amounts of TILs and TLSs were measured histopathologically using hematoxylin and eosin–stained slides. The HEV densities and TIL subpopulations were measured by immunohistochemistry for MECA79, CD3, CD8, and CD20. CXCL13 mRNA expression levels using a NanoString assay (NanoString Technologies).
Results
The mean number of HEVs in pre-NAC biopsies was 12 (range, 0 to 72). The amounts of TILs and TLSs, HEV density, and CXCL13 expression showed robust correlations with each other. A lower pre-NAC clinical T stage, higher TIL and TLS levels, a higher HEV density, CD20-positive cell density, and CXCL13 expression were significant predictors of a pathologic complete response (pCR). Higher CD8-positive cell density and levels of CXCL13 expression were significantly associated with a better disease-free survival rate.
Conclusion
MECA79-positive HEV density in pre-NAC biopsies is an objective and quantitative surrogate marker of TLS and might be a valuable tool for predicting pCR of TNBC in routine pathology practice.

Citations

Citations to this article as recorded by

Role of tumor‑infiltrating lymphocytes and miR‑155 in breast cancer: Insights into carcinogenesis and their potential as prognostic biomarkers (Review)
Miriam Alvares‑Vilela, Franciele Schlemmer, Sabrina Ferrari, Mary-Ann Xavier, Ricardo Titze‑De‑Almeida
Oncology Reports.2026;[Epub] CrossRef
The Correlation Between CD8+ Tumor-Infiltrating Lymphocytes and the Efficacy of Neoadjuvant Therapy in Breast Cancer
Guosheng Feng, Mingqiang Zhong, Danmin Xie, Xianbin Yuan, Shui Lu, Jianfang Zhu, Shan Gao, Zhongqiu Yi, Haiyong Lin, Jinlin Zheng, Hongyu Zhou, Yanjing Wang
Breast Cancer: Targets and Therapy.2026; Volume 18: 1. CrossRef
The Role of B Cells in Tumorigenesis and Immunotherapy
Guoping Yin, Lingna Qi, Na Kang, Tong Li, Cuifeng Li, Yile E. Liu, Jingying Ye, Wanli Liu
Immune Network.2026;[Epub] CrossRef
Spatial and phenotypic plasticity of B cells in remodeling the tumor microenvironment
Yan Gao, Yinghui Peng, Yihong Chen, Shan Zeng, Hong Shen, Alberto Martin, Changjing Cai, Ying Han
Journal for ImmunoTherapy of Cancer.2026; 14(3): e014745. CrossRef
Predictive impact of systemic inflammation and tertiary lymphoid structures on pathological complete response in neoadjuvant-treated advanced esophageal squamous carcinoma patients
Hanlin Xu, Dapeng Wu, Xin Xia, Changgang Feng, Pengyang Su, Yichen Zhou, Xiaojuan Yang, Yuanyong Wang, Renquan Zhang
Pathology - Research and Practice.2026; 282: 156462. CrossRef
Mature Tertiary Lymphoid Structures in Breast Cancers Are Associated With Antitumor Immunity and Better Prognosis
Shibo Yu, Mirte Dekker, Mieke C. Zwager, Lorian Slagter-Menkema, Tineke van der Sluis, Carolina P. Schröder, Marcel A.T.M. van Vugt, Bert van der Vegt
Modern Pathology.2026; 39(6): 101004. CrossRef
Heterogeneity, immunological mechanisms and translational prospects of tertiary lymphoid structures in cancer therapy
Junjie Zheng, Hui Huang, Wanqiao Li, Shijia Li, Jialin Liu, Zhihao Lu, Cihui Yan, Wencheng Zhang
The Innovation Oncology.2026; 1(1): 100011. CrossRef
TCF1+CD4+ T cells and microglia co-orchestrate tertiary lymphoid structures to enhance prognosis and immunotherapy in non-small cell lung cancer with brain metastases
Qian Yu, Rongxin Liao, Haoyu Zheng, Lin Li, Yusheng Huang, Yihao Tao, Rui Deng, Hengqiu He, Li Yu, Jingyao Lin, Shunping Huang, Xiaoyue Zhang, Zaicheng Xu, Zhenzhou Yang, Yuan Peng
eBioMedicine.2026; 127: 106280. CrossRef
Defining the rules of engagement: B cells, antibodies and cancer control
Stephen L. Nutt, Julie Tellier, Jessica Da Gama Duarte
Cellular & Molecular Immunology.2026; 23(6): 607. CrossRef
Therapeutic potential of tertiary lymphoid structures in breast cancer (Review)
Liangxiao Zhu, Meigui Li, Feng Liu, Fenghou Gao
Molecular Medicine Reports.2026; 33(6): 1. CrossRef
Tertiary lymphoid structures in breast cancer: formation, immune functions and clinical implications
Wenting Dong, Shichao Ai, Xiaofei Shen, Yongzhong Yao
Frontiers in Immunology.2026;[Epub] CrossRef
The discovery of high endothelial venules. A historical note
Domenico Ribatti
Translational Research in Anatomy.2025; 38: 100379. CrossRef
Immune microenvironment spatial landscapes of tertiary lymphoid structures in gastric cancer
Yi Xie, Haoxin Peng, Yajie Hu, Keren Jia, Jiajia Yuan, Dan Liu, Yanyan Li, Xujiao Feng, Jian Li, Xiaotian Zhang, Yu Sun, Lin Shen, Yang Chen
BMC Medicine.2025;[Epub] CrossRef
Bi-level graph learning unveils prognosis-relevant tumor microenvironment patterns in breast multiplexed digital pathology
Zhenzhen Wang, Cesar A. Santa-Maria, Aleksander S. Popel, Jeremias Sulam
Patterns.2025; 6(3): 101178. CrossRef
Multifaceted function of B cells in tumorigenesis
Na Kang, Qinghui Duan, Xin Min, Tong Li, Yuxin Li, Ji Gao, Wanli Liu
Frontiers of Medicine.2025; 19(2): 297. CrossRef
Prognostic significance of CD8 + tumor-infiltrating lymphocytes in operable breast cancer: a meta-analysis
Ruijie Niu, Cheng Wang, Yiqun Xie, Shuangshuang Li, Qian Zhao, Yuqing Chang, Zubing Mei
BMC Cancer.2025;[Epub] CrossRef
Machine learning model for predicting tertiary lymphoid structures and treatment response in triple-negative breast cancer
Yidan Lin, Yushuai Yu, Qing Wang, Kaiyan Huang, Shukai Guo, Jie Zhang, Yihui He, Xin Yu, Jiwen Zhang, Fan Meng, Shicong Tang, Junhui Yuan, Chuangui Song
npj Precision Oncology.2025;[Epub] CrossRef
An ultrasound-based model for predicting the response to neoadjuvant chemotherapy in early stage triple negative breast cancer patients
Yuyang Tong, Yi Wei, Peixuan Sun, Cai Chang
BMC Medical Imaging.2025;[Epub] CrossRef
The tertiary lymphoid structure-related signature identified PTGDS in regulating PD-L1 and promoting the proliferation and migration of glioblastoma
Wantao Wu, He Li, Zeyu Wang, Ziyu Dai, Xisong Liang, Peng Luo, Kun Liu, Hao Zhang, Nan Zhang, Shuyu Li, Chi Zhang
Heliyon.2024; 10(1): e23915. CrossRef
Tertiary lymphoid structures, a historical reappraisal
Domenico Ribatti
Tissue and Cell.2024; 86: 102288. CrossRef
Immune cells within tertiary lymphoid structures are associated with progression‐free survival in patients with locoregional recurrent breast cancer
Jinyuan Gu, Jiaming Wang, Yue Sun, Xinrui Mao, Chao Qian, Xinyu Tang, Ji Wang, Hui Xie, Lijun Ling, Yi Zhao, Xiaoan Liu, Kai Zhang, Hong Pan, Shui Wang, Cong Wang, Wenbin Zhou
Cancer Medicine.2024;[Epub] CrossRef
Spatial Distribution of Immune Cells Drives Resistance to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer
Benedetta Donati, Francesca Reggiani, Federica Torricelli, Giacomo Santandrea, Teresa Rossi, Alessandra Bisagni, Elisa Gasparini, Antonino Neri, Laura Cortesi, Guglielmo Ferrari, Giancarlo Bisagni, Moira Ragazzi, Alessia Ciarrocchi
Cancer Immunology Research.2024; 12(1): 120. CrossRef
The Emerging Role of Tertiary Lymphoid Structures in Breast Cancer: A Narrative Review
Dana Narvaez, Jorge Nadal, Adrian Nervo, María Victoria Costanzo, Claudio Paletta, Fernando E. Petracci, Sergio Rivero, Alexis Ostinelli, Berenice Freile, Diego Enrico, Maria Teresa Pombo, Mora Amat, Edgar Danilo Aguirre, Matias Chacon, Federico Waisberg
Cancers.2024; 16(2): 396. CrossRef
Digital image analysis and machine learning-assisted prediction of neoadjuvant chemotherapy response in triple-negative breast cancer
Timothy B. Fisher, Geetanjali Saini, T. S. Rekha, Jayashree Krishnamurthy, Shristi Bhattarai, Grace Callagy, Mark Webber, Emiel A. M. Janssen, Jun Kong, Ritu Aneja
Breast Cancer Research.2024;[Epub] CrossRef
Translational and oncologic significance of tertiary lymphoid structures in pancreatic adenocarcinoma
Zachary Gao, Joseph Azar, Huili Zhu, Sophia Williams-Perez, Sung Wook Kang, Celia Marginean, Mark P. Rubinstein, Shalini Makawita, Hyun-Sung Lee, E. Ramsay Camp
Frontiers in Immunology.2024;[Epub] CrossRef
Tertiary lymphoid structures predict survival and response to neoadjuvant therapy in locally advanced rectal cancer
Qianyu Wang, Wentao Zhong, Xiaofei Shen, Zechen Hao, Meng Wan, Xiaopeng Yang, Ran An, Hongyan Zhu, Huiyun Cai, Tao Li, Yuan Lv, Xing Dong, Gang Chen, Aijun Liu, Junfeng Du
npj Precision Oncology.2024;[Epub] CrossRef
Advances in the study of tertiary lymphoid structures in the immunotherapy of breast cancer
Xin Li, Han Xu, Ziwei Du, Qiang Cao, Xiaofei Liu
Frontiers in Oncology.2024;[Epub] CrossRef
Macrophages and tertiary lymphoid structures as indicators of prognosis and therapeutic response in cancer patients
Li Niu, Ting Chen, Aodan Yang, Xiwen Yan, Feng Jin, Ang Zheng, Xinyue Song
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2024; 1879(5): 189125. CrossRef
Peripheral Blood CD8+ T-Lymphocyte Immune Response in Benign and Subpopulations of Breast Cancer Patients
Marek Lenárt, Peter Bober, Miroslav Marcin, Soňa Tkáčiková, Mária Kacírová, Michal Alexovič, Dávid Tóth, Natália Madárová, Jozef Radoňak, Peter Urdzík, Ján Fedačko, Ján Sabo
International Journal of Molecular Sciences.2024; 25(12): 6423. CrossRef
Integrated analysis of multiple transcriptomic approaches and machine learning integration algorithms reveals high endothelial venules as a prognostic immune-related biomarker in bladder cancer
Jinge Zhang, Yuan Huang, Xing Tan, Zihuan Wang, Ranyang Cheng, Shenlan Zhang, Yuwen Chen, Feifan Jiang, Wanlong Tan, Xiaolin Deng, Fei Li
International Immunopharmacology.2024; 136: 112184. CrossRef
Intratumoral high endothelial venules in solid tumors: a pooled study
Bin Wang, Yin Han, Jie Liu, Xinyao Zhang, Yaotiao Deng, Yu Jiang
Frontiers in Immunology.2024;[Epub] CrossRef
B‐cell performance in chemotherapy: Unravelling the mystery of B‐cell therapeutic potential
Zizhuo Li, Anqi Lin, Zhifei Gao, Aimin Jiang, Minying Xiong, Jiapeng Song, Zaoqu Liu, Quan Cheng, Jian Zhang, Peng Luo
Clinical and Translational Medicine.2024;[Epub] CrossRef
Density of tertiary lymphoid structures predicts clinical outcome in breast cancer brain metastasis
Yuan-Yuan Zhao, Zhen Fan, Bao-Rui Tao, Zun-Guo Du, Zhi-Feng Shi
Journal for ImmunoTherapy of Cancer.2024; 12(7): e009232. CrossRef
Tertiary lymphoid structures as potential biomarkers for cancer prediction and prognosis
Xin Zhang, Jie Yao, Mei Xie, Yiran Liang, Xuwen Lin, Jialin Song, Xinyu Bao, Xidong Ma, Yuanyong Wang, Yinguang Zhang, Yiming Liu, Wenya Han, Lei Pan, Xinying Xue
International Immunopharmacology.2024; 140: 112790. CrossRef
Tumor-Infiltrating Lymphocyte Scoring in Neoadjuvant-Treated Breast Cancer
Noémie Thomas, Soizic Garaud, Mireille Langouo, Doïna Sofronii, Anaïs Boisson, Alexandre De Wind, Valérie Duwel, Ligia Craciun, Dennis Larsimont, Ahmad Awada, Karen Willard-Gallo
Cancers.2024; 16(16): 2895. CrossRef
Co-expression network and survival analysis of breast cancer inflammation and immune system hallmark genes
Ayaka Yakushi, Masahiro Sugimoto, Takanori Sasaki
Computational Biology and Chemistry.2024; 113: 108204. CrossRef
Global trends in tertiary lymphoid structures: a bibliometric analysis from 2014 to 2023
Yiwen Bao, Zeming Mo, Shuang Wang, Jinhua Long, Honghong Zhang, Yujun Xu, Honglian Jiang, Tianbao Qian, Zhu Zeng
Frontiers in Immunology.2024;[Epub] CrossRef
Prognostic value of tertiary lymphoid structures in triple-negative breast cancer: integrated analysis with the tumor microenvironment and clinicopathological features
Florence Boissière-Michot, Marie-Christine Chateau, Simon Thézenas, Virginie Lafont, Evelyne Crapez, Priyanka Sharma, Angélique Bobrie, Pascal Roger, Séverine Guiu, William Jacot
Frontiers in Immunology.2024;[Epub] CrossRef
Prognostic value of tumor-infiltrating lymphocyte subtypes and microorganisms in triple-negative breast cancer
Yating Shi, Zhi Guo, Qiang Wang, Huan Deng
Journal of Cancer Research and Therapeutics.2024; 20(7): 1983. CrossRef
The prognostic impact of tumor-infiltrating B lymphocytes in patients with solid malignancies: A systematic review and meta-analysis
Hao Liu, Zhuoqun Li, Xuan Han, Zhujun Li, Yan Zhao, Fenghua Liu, Ziyu Zhu, Yi Lv, Zhijun Liu, Nana Zhang
Critical Reviews in Oncology/Hematology.2023; 181: 103893. CrossRef
Tertiary lymphoid structures in breast ductal carcinoma in situ correlate with adverse pathological parameters
Lixia Zeng, Valerie Cui Yun Koh, Xiao‐Yang Chen, Puay Hoon Tan
Histopathology.2023; 82(5): 779. CrossRef
Can CXCL13 be a prognostic marker in clear cell renal cell carcinoma?
Esma Sayar, Ayşegül Yabacı, Ganime Coban
Indian Journal of Pathology and Microbiology.2023; 66(1): 54. CrossRef
Clinical Significance of Tumour-Infiltrating B Lymphocytes (TIL-Bs) in Breast Cancer: A Systematic Literature Review
Brian M. Lam, Clare Verrill
Cancers.2023; 15(4): 1164. CrossRef
B cell‐dependent subtypes and treatment‐based immune correlates to survival in stage 3 and 4 lung adenocarcinomas
Susan Raju Paul, Ivan Valiev, Skylar E. Korek, Vladimir Zyrin, Diana Shamsutdinova, Olga Gancharova, Alexander Zaitsev, Ekaterina Nuzhdina, Diane L. Davies, Ibiayi Dagogo‐Jack, Felix Frenkel, Jessica H. Brown, Joshua M. Hess, Sarah Viet, Jason L. Petersen
FASEB BioAdvances.2023; 5(4): 156. CrossRef
High endothelial venules in cancer: Regulation, function, and therapeutic implication
Gerlanda Vella, Yichao Hua, Gabriele Bergers
Cancer Cell.2023; 41(3): 527. CrossRef
B Cells in Breast Cancer Pathology
Mengyuan Li, Angela Quintana, Elena Alberts, Miu Shing Hung, Victoire Boulat, Mercè Martí Ripoll, Anita Grigoriadis
Cancers.2023; 15(5): 1517. CrossRef
Therapeutic Potential of Tumor Metabolic Reprogramming in Triple-Negative Breast Cancer
Gyöngyi Munkácsy, Libero Santarpia, Balázs Győrffy
International Journal of Molecular Sciences.2023; 24(8): 6945. CrossRef
RETRACTED ARTICLE: Antibodies against endogenous retroviruses promote lung cancer immunotherapy
Kevin W. Ng, Jesse Boumelha, Katey S. S. Enfield, Jorge Almagro, Hongui Cha, Oriol Pich, Takahiro Karasaki, David A. Moore, Roberto Salgado, Monica Sivakumar, George Young, Miriam Molina-Arcas, Sophie de Carné Trécesson, Panayiotis Anastasiou, Annika Fend
Nature.2023; 616(7957): 563. CrossRef
Predictive power of tertiary lymphoid structure signature for neoadjuvant chemotherapy response and immunotherapy benefit in HER2‐negative breast cancer
François Bertucci, Alexandre De Nonneville, Pascal Finetti, Emilie Mamessier
Cancer Communications.2023; 43(8): 943. CrossRef
P16 expression and presence of lymphoid stroma are correlated with good prognosis in mucoepidermoid carcinoma of the head and neck
Yeseul Kim, Joon Seon Song, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim, Kyung-Ja Cho
Pathology - Research and Practice.2023; 251: 154874. CrossRef
The Possible Role of Anti- and Protumor-Infiltrating Lymphocytes in Pathologic Complete Response in Early Breast Cancer Patients Treated with Neoadjuvant Systemic Therapy
Klara Geršak, Blaž Matija Geršak, Barbara Gazić, Andreja Klevišar Ivančič, Primož Drev, Nina Ružić Gorenjec, Cvetka Grašič Kuhar
Cancers.2023; 15(19): 4794. CrossRef
Detection and quantitative analysis of tumor-associated tertiary lymphoid structures
Man Yang, Yurou Che, Kezhen Li, Zengyi Fang, Simin Li, Mei Wang, Yiyao Zhang, Zhu Xu, Liping Luo, Chuan Wu, Xin Lai, Weidong Wang
Journal of Zhejiang University-SCIENCE B.2023; 24(9): 779. CrossRef
Identification of an exosome-related signature associated with prognosis and immune infiltration in breast cancer
Qiaonan Guo, Kelun Pan, Pengjun Qiu, Zundong Liu, Jianpeng Chen, Jianqing Lin
Scientific Reports.2023;[Epub] CrossRef
Association of systemic inflammatory markers and tertiary lymphoid structure with pathological complete response in gastric cancer patients receiving preoperative treatment: a retrospective cohort study
Yingying Wu, Junjie Zhao, Zhaoming Wang, Dan Liu, Chenyu Tian, Botian Ye, Yihong Sun, Haojie Li, Xuefei Wang
International Journal of Surgery.2023; 109(12): 4151. CrossRef
The Characteristics of Tumor Microenvironment in Triple Negative Breast Cancer
Yiqi Fan, Shuai He
Cancer Management and Research.2022; Volume 14: 1. CrossRef
Peripheral node addressin, a ligand for L-selectin is found in tumor cells and in high endothelial venules in endometrial cancer
Georgia Karpathiou, Viviana Sramek, Sami Dagher, Mousa Mobarki, Maroa Dridi, Tiphanie Picot, Celine Chauleur, Michel Peoc’h
Pathology - Research and Practice.2022; 233: 153888. CrossRef
The Presence of Tertiary Lymphoid Structures Provides New Insight Into the Clinicopathological Features and Prognosis of Patients With Breast Cancer
Bin Wang, Jie Liu, Yin Han, Yaotiao Deng, Jinze Li, Yu Jiang
Frontiers in Immunology.2022;[Epub] CrossRef
Role of tertiary lymphoid organs in the regulation of immune responses in the periphery
Amit I. Bery, Hailey M. Shepherd, Wenjun Li, Alexander S. Krupnick, Andrew E. Gelman, Daniel Kreisel
Cellular and Molecular Life Sciences.2022;[Epub] CrossRef
Tertiary Lymphoid Structures as Mediators of Immunotherapy Response
Raj G. Vaghjiani, Joseph J. Skitzki
Cancers.2022; 14(15): 3748. CrossRef
Immunotherapy in triple-negative breast cancer: Insights into tumor immune landscape and therapeutic opportunities
Rita Ribeiro, Maria João Carvalho, João Goncalves, João Nuno Moreira
Frontiers in Molecular Biosciences.2022;[Epub] CrossRef
Predictive and prognostic values of tumor infiltrating lymphocytes in breast cancers treated with neoadjuvant chemotherapy: A meta-analysis
Shiqi Li, Ying Zhang, Peigen Zhang, Shuijing Xue, Yu Chen, Lihua Sun, Rui Yang
The Breast.2022; 66: 97. CrossRef
Multiplexed In Situ Spatial Protein Profiling in the Pursuit of Precision Immuno-Oncology for Patients with Breast Cancer
Davide Massa, Anna Tosi, Antonio Rosato, Valentina Guarneri, Maria Vittoria Dieci
Cancers.2022; 14(19): 4885. CrossRef
The Association of Estrogen Receptor Activity, Interferon Signaling, and MHC Class I Expression in Breast Cancer
In Hye Song, Young-Ae Kim, Sun-Hee Heo, Won Seon Bang, Hye Seon Park, Yeon ho Choi, Heejae Lee, Jeong-Han Seo, Youngjin Cho, Sung Wook Jung, Hee Jeong Kim, Sei Hyun Ahn, Hee Jin Lee, Gyungyub Gong
Cancer Research and Treatment.2022; 54(4): 1111. CrossRef
High endothelial venules associated with better prognosis in esophageal squamous cell carcinoma
Hongmu Li, Lu Tang, Xue Han, Leqi Zhong, Wuyou Gao, Youfang Chen, Jinhua Huang, Zhesheng Wen
Annals of Diagnostic Pathology.2022; 61: 152051. CrossRef
Tertiary lymphoid structures as unique constructions associated with the organization, education, and function of tumor-infiltrating immunocytes
Jing Chen, Jian Chen, Lie Wang
Journal of Zhejiang University-SCIENCE B.2022; 23(10): 812. CrossRef
Tertiary Lymphoid Structures: A Potential Biomarker for Anti-Cancer Therapy
Ji’an Zou, Yingzhe Zhang, Yue Zeng, Yurong Peng, Junqi Liu, Chaoyue Xiao, Fang Wu
Cancers.2022; 14(23): 5968. CrossRef
Impact of mature tertiary lymphoid structures on prognosis and therapeutic response of Epstein-Barr virus-associated gastric cancer patients
Yi-Xin Yin, Yi-Hong Ling, Xiao-Li Wei, Cai-Yun He, Bing-Zhi Wang, Chun-Fang Hu, Wen-Ping Lin, Run-Cong Nie, Jie-Wei Chen, Jin-Long Lin, Jie Zhou, Juan-Juan Xie, Jing-Ping Yun, Dan Xie, Li-Yan Xue, Mu-Yan Cai
Frontiers in Immunology.2022;[Epub] CrossRef
The Role of Immune Cells in Breast Tissue and Immunotherapy for the Treatment of Breast Cancer
Stephanie L. Goff, David N. Danforth
Clinical Breast Cancer.2021; 21(1): e63. CrossRef
Immune microenvironment in different molecular subtypes of ductal breast carcinoma
Mona Sadeghalvad, Hamid-Reza Mohammadi-Motlagh, Nima Rezaei
Breast Cancer Research and Treatment.2021; 185(2): 261. CrossRef
Cancer-Associated Fibroblasts and T Cells: From Mechanisms to Outcomes
Alfie T Baker, Mohammed H Abuwarwar, Lylarath Poly, Simon Wilkins, Anne L Fletcher
The Journal of Immunology.2021; 206(2): 310. CrossRef
Repenser la place des lymphocytes B et des structures lymphoïdes tertiaires dans l’immunothérapie des cancers
Claire Germain, Hélène Kaplon, Marie-Caroline Dieu-Nosjean
médecine/sciences.2021; 37(2): 130. CrossRef
High endothelial venules are present in pharyngeal and laryngeal carcinomas and they are associated with better prognosis
Georgia Karpathiou, Jean Marc Dumollard, Marie Gavid, Francois Casteillo, Marine Vieville, Jean Michel Prades, Marios Froudarakis, Michel Peoc’h
Pathology - Research and Practice.2021; 220: 153392. CrossRef
Prognostic value of tumor-infiltrating B lymphocytes and plasma cells in triple-negative breast cancer
Hajime Kuroda, Tsengelmaa Jamiyan, Rin Yamaguchi, Akinari Kakumoto, Akihito Abe, Oi Harada, Bayarmaa Enkhbat, Atsuko Masunaga
Breast Cancer.2021; 28(4): 904. CrossRef
Tumor-infiltrating B cells and T cells correlate with postoperative prognosis in triple-negative carcinoma of the breast
Hajime Kuroda, Tsengelmaa Jamiyan, Rin Yamaguchi, Akinari Kakumoto, Akihito Abe, Oi Harada, Atsuko Masunaga
BMC Cancer.2021;[Epub] CrossRef
Tertiary lymphoid structures and B lymphocytes in cancer prognosis and response to immunotherapies
Jacquelot N, Tellier J, Nutt Sl, Belz Gt
OncoImmunology.2021;[Epub] CrossRef
High endothelial venules (HEVs) in immunity, inflammation and cancer
Lucas Blanchard, Jean-Philippe Girard
Angiogenesis.2021; 24(4): 719. CrossRef
Immunohistochemical analysis of L1 cell adhesion molecule and high endothelial venules in breast cancer brain metastasis
Georgia Karpathiou, Florian Camy, Jean Marc Dumollard, Michel Peoc’h
Pathology - Research and Practice.2021; 223: 153484. CrossRef
The Immunology of Hormone Receptor Positive Breast Cancer
Jonathan Goldberg, Ricardo G. Pastorello, Tuulia Vallius, Janae Davis, Yvonne Xiaoyong Cui, Judith Agudo, Adrienne G. Waks, Tanya Keenan, Sandra S. McAllister, Sara M. Tolaney, Elizabeth A. Mittendorf, Jennifer L. Guerriero
Frontiers in Immunology.2021;[Epub] CrossRef
Immune Crosstalk Between Lymph Nodes and Breast Carcinomas, With a Focus on B Cells
Elena Alberts, Isobelle Wall, Dinis Pedro Calado, Anita Grigoriadis
Frontiers in Molecular Biosciences.2021;[Epub] CrossRef
Tumor-Associated Tertiary Lymphoid Structures: From Basic and Clinical Knowledge to Therapeutic Manipulation
Charlotte Domblides, Juliette Rochefort, Clémence Riffard, Marylou Panouillot, Géraldine Lescaille, Jean-Luc Teillaud, Véronique Mateo, Marie-Caroline Dieu-Nosjean
Frontiers in Immunology.2021;[Epub] CrossRef
The 12-CK Score: Global Measurement of Tertiary Lymphoid Structures
Roger Li, Anders Berglund, Logan Zemp, Jasreman Dhillon, Ryan Putney, Youngchul Kim, Rohit K. Jain, G. Daniel Grass, José Conejo-Garcia, James J. Mulé
Frontiers in Immunology.2021;[Epub] CrossRef
Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells
Alyssa Vito, Omar Salem, Nader El-Sayes, Ian P. MacFawn, Ana L. Portillo, Katy Milne, Danielle Harrington, Ali A. Ashkar, Yonghong Wan, Samuel T. Workenhe, Brad H. Nelson, Tullia C. Bruno, Karen L. Mossman
Communications Biology.2021;[Epub] CrossRef
Cancer Immunotherapies: From Efficacy to Resistance Mechanisms – Not Only Checkpoint Matters
Shuyue Wang, Kun Xie, Tengfei Liu
Frontiers in Immunology.2021;[Epub] CrossRef
High Endothelial Venules: A Vascular Perspective on Tertiary Lymphoid Structures in Cancer
Gerlanda Vella, Sophie Guelfi, Gabriele Bergers
Frontiers in Immunology.2021;[Epub] CrossRef
Tumor-Infiltrating B Lymphocyte Profiling Identifies IgG-Biased, Clonally Expanded Prognostic Phenotypes in Triple-Negative Breast Cancer
Robert J. Harris, Anthony Cheung, Joseph C.F. Ng, Roman Laddach, Alicia M. Chenoweth, Silvia Crescioli, Matthew Fittall, Diana Dominguez-Rodriguez, James Roberts, Dina Levi, Fangfang Liu, Elena Alberts, Jelmar Quist, Aida Santaolalla, Sarah E. Pinder, Che
Cancer Research.2021; 81(16): 4290. CrossRef
Tertiary lymphoid structure and B‑cell‑related pathways: A potential target in tumor immunotherapy (Review)
Meng Qin, Ying Jin, Ling-Ya Pan
Oncology Letters.2021;[Epub] CrossRef
Heterogeneity of Circulating Tumor Cell–Associated Genomic Gains in Breast Cancer and Its Association with the Host Immune Response
Nisha Kanwar, Zaldy Balde, Ranju Nair, Melanie Dawe, Shiyi Chen, Manjula Maganti, Eshetu G. Atenafu, Sabrina Manolescu, Carrie Wei, Amanda Mao, Fred Fu, Dan Wang, Alison Cheung, Yulia Yerofeyeva, Rachel Peters, Kela Liu, Christine Desmedt, Christos Sotiri
Cancer Research.2021; 81(24): 6196. CrossRef
Oral cancer-associated tertiary lymphoid structures: gene expression profile and prognostic value
K Li, Q Guo, X Zhang, X Dong, W Liu, A Zhang, Y Li, J Yan, G Jia, Z Zheng, W Tang, L Pan, M An, B Zhang, S Liu, B Fu
Clinical and Experimental Immunology.2020; 199(2): 172. CrossRef
B cells and tertiary lymphoid structures promote immunotherapy response
Beth A. Helmink, Sangeetha M. Reddy, Jianjun Gao, Shaojun Zhang, Rafet Basar, Rohit Thakur, Keren Yizhak, Moshe Sade-Feldman, Jorge Blando, Guangchun Han, Vancheswaran Gopalakrishnan, Yuanxin Xi, Hao Zhao, Rodabe N. Amaria, Hussein A. Tawbi, Alex P. Cogdi
Nature.2020; 577(7791): 549. CrossRef
Neolymphogenesis and Immunogistogochemical Study of Lymph Nodes in Breast Cancer
Sh. Kh. Gantsev, R. A. Rustamkhanov, Sh. R. Kzyrgalin, D. S. Tursumetov
Creative surgery and oncology.2020; 9(4): 266. CrossRef
Duality of B Cell-CXCL13 Axis in Tumor Immunology
Angel J. Rubio, Tyrone Porter, Xuemei Zhong
Frontiers in Immunology.2020;[Epub] CrossRef
Predictive and prognostic role of tumour-infiltrating lymphocytes in breast cancer patients with different molecular subtypes: a meta-analysis
Zhao-hua Gao, Cun-xin Li, Ming Liu, Jia-yuan Jiang
BMC Cancer.2020;[Epub] CrossRef
Insights into Tumor-Associated Tertiary Lymphoid Structures: Novel Targets for Antitumor Immunity and Cancer Immunotherapy
Anthony B. Rodriguez, Victor H. Engelhard
Cancer Immunology Research.2020; 8(11): 1338. CrossRef
Pan-cancer analysis of genomic properties and clinical outcome associated with tumor tertiary lymphoid structure
Ziying Lin, Lixia Huang, ShaoLi Li, Jincui Gu, Xiaoxian Cui, Yanbin Zhou
Scientific Reports.2020;[Epub] CrossRef
Presence of tertiary lymphoid structures determines the level of tumor-infiltrating lymphocytes in primary breast cancer and metastasis
Miseon Lee, Sun-Hee Heo, In Hye Song, Hajar Rajayi, Hye Seon Park, In Ah Park, Young-Ae Kim, Heejae Lee, Gyungyub Gong, Hee Jin Lee
Modern Pathology.2019; 32(1): 70. CrossRef
Strong CD8+ lymphocyte infiltration in combination with expression of HLA class I is associated with better tumor control in breast cancer patients treated with neoadjuvant chemotherapy
A. F. de Groot, E. J. Blok, A. Charehbili, C. C. Engels, V. T. H. B. M. Smit, N. G. Dekker-Ensink, H. Putter, E. Meershoek-Klein Kranenbarg, C. J. H. van de Velde, G. J. Liefers, J. W. R. Nortier, P. J. K. Kuppen, S. H. van der Burg, J. R. Kroep
Breast Cancer Research and Treatment.2019; 175(3): 605. CrossRef
The effect of C-X-C motif chemokine ligand 13 in cutaneous squamous cell carcinoma treated with aminolevulinic acid-photodynamic therapy
Lude Zhu, Guolong Zhang, Peiru Wang, Linglin Zhang, Jie Ji, Xiaojing Liu, Zhongxia Zhou, Jingjun Zhao, Xiuli Wang
Photodiagnosis and Photodynamic Therapy.2019; 26: 389. CrossRef
Tertiary lymphoid structures in the era of cancer immunotherapy
Catherine Sautès-Fridman, Florent Petitprez, Julien Calderaro, Wolf Herman Fridman
Nature Reviews Cancer.2019; 19(6): 307. CrossRef
B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma
Johannes Griss, Wolfgang Bauer, Christine Wagner, Martin Simon, Minyi Chen, Katharina Grabmeier-Pfistershammer, Margarita Maurer-Granofszky, Florian Roka, Thomas Penz, Christoph Bock, Gao Zhang, Meenhard Herlyn, Katharina Glatz, Heinz Läubli, Kirsten D. M
Nature Communications.2019;[Epub] CrossRef
Poor Response to Neoadjuvant Chemotherapy Correlates with Mast Cell Infiltration in Inflammatory Breast Cancer
Sangeetha M. Reddy, Alexandre Reuben, Souptik Barua, Hong Jiang, Shaojun Zhang, Linghua Wang, Vancheswaran Gopalakrishnan, Courtney W. Hudgens, Michael T. Tetzlaff, James M. Reuben, Takahiro Tsujikawa, Lisa M. Coussens, Khalida Wani, Yan He, Lily Villarea
Cancer Immunology Research.2019; 7(6): 1025. CrossRef
New Insights into Tumor-Infiltrating B Lymphocytes in Breast Cancer: Clinical Impacts and Regulatory Mechanisms
Meng Shen, Jian Wang, Xiubao Ren
Frontiers in Immunology.2018;[Epub] CrossRef
Hot Spot and Whole-Tumor Enumeration of CD8+ Tumor-Infiltrating Lymphocytes Utilizing Digital Image Analysis Is Prognostic in Triple-Negative Breast Cancer
Patrick J. McIntire, Lina Irshaid, Yifang Liu, Zhengming Chen, Faith Menken, Eugene Nowak, Sandra J. Shin, Paula S. Ginter
Clinical Breast Cancer.2018; 18(6): 451. CrossRef
Correlation with lymphocyte infiltration, but lack of prognostic significance of MECA-79-positive high endothelial venules in primary malignant melanoma
Tímea Sebestyén, Anita Mohos, Gabriella Liszkay, Beáta Somlai, István Gaudi, Andrea Ladányi
Melanoma Research.2018; 28(4): 304. CrossRef
Lymphocyte-Activation Gene-3 Expression and Prognostic Value in Neoadjuvant-Treated Triple-Negative Breast Cancer
Yunxuan Wang, Tieying Dong, Qijia Xuan, Hong Zhao, Ling Qin, Qingyuan Zhang
Journal of Breast Cancer.2018; 21(2): 124. CrossRef
Functions of the CXC ligand family in the pancreatic tumor microenvironment
Nien-Hung Lee, Mehrdad Nikfarjam, Hong He
Pancreatology.2018; 18(7): 705. CrossRef
Antigen Specificity and Clinical Significance of IgG and IgA Autoantibodies Produced in situ by Tumor-Infiltrating B Cells in Breast Cancer
Soizic Garaud, Pawel Zayakin, Laurence Buisseret, Undine Rulle, Karina Silina, Alexandre de Wind, Gert Van den Eyden, Denis Larsimont, Karen Willard-Gallo, Aija Linē
Frontiers in Immunology.2018;[Epub] CrossRef
Prognostic Significance of Tumor-Infiltrating B Cells and Plasma Cells in Human Cancer
Maartje C.A. Wouters, Brad H. Nelson
Clinical Cancer Research.2018; 24(24): 6125. CrossRef
The Multifaceted Roles of B Cells in Solid Tumors: Emerging Treatment Opportunities
Nicole J. Flynn, Rajasekharan Somasundaram, Kimberly M. Arnold, Jennifer Sims-Mourtada
Targeted Oncology.2017; 12(2): 139. CrossRef
CXCL13-producing TFH cells link immune suppression and adaptive memory in human breast cancer
Chunyan Gu-Trantien, Edoardo Migliori, Laurence Buisseret, Alexandre de Wind, Sylvain Brohée, Soizic Garaud, Grégory Noël, Vu Luan Dang Chi, Jean-Nicolas Lodewyckx, Céline Naveaux, Hugues Duvillier, Stanislas Goriely, Denis Larsimont, Karen Willard-Gallo
JCI Insight.2017;[Epub] CrossRef
Tertiary Lymphoid Structures in Cancer: Drivers of Antitumor Immunity, Immunosuppression, or Bystander Sentinels in Disease?
Emily Jayne Colbeck, Ann Ager, Awen Gallimore, Gareth Wyn Jones
Frontiers in Immunology.2017;[Epub] CrossRef
Distinct Tertiary Lymphoid Structure Associations and Their Prognostic Relevance in HER2 Positive and Negative Breast Cancers
Xia Liu, Julia Y.S. Tsang, Thazin Hlaing, Jintao Hu, Yun-Bi Ni, Siu Ki Chan, Sai Yin Cheung, Gary M. Tse
The Oncologist.2017; 22(11): 1316. CrossRef

19,383 View
591 Download
121 Web of Science
111 Crossref

First
Prev
Page of 1
Next
Last

Search