Cancer Research and Treatment

Original Articles

Impact of Hyperglycemia on Survival and Infection-Related Adverse Events in Patients with Metastatic Colorectal Cancer Who Were Receiving Palliative Chemotherapy: Yong Joo Hong, Hye-Suk Han, Yusook Jeong, Jiwon Jeong, Sung-Nam Lim, Hyung Jin Choi, Hyun-Jung Jeon, Tae-Keun Oh, Sang-Jeon Lee, Ki Hyeong Lee; Cancer Res Treat. 2014;46(3):288-296. Published online July 15, 2014; DOI: https://doi.org/10.4143/crt.2014.46.3.288

Purpose
Non-metastatic colorectal cancer patients with diabetes have poor overall survival than those without diabetes. However, the effect of hyperglycemia on survival after diagnosis of metastatic colorectal cancer (CRC) has not been assessed. Therefore, we assessed the impact of hyperglycemia on the survival and infection-related adverse events (AEs) in patients with metastatic CRC. Materials and Methods We reviewed the records of 206 patients with newly diagnosed metastatic CRC who were treated with palliative chemotherapy from March 2000 to December 2012 at Chungbuk National University Hospital. The mean glucose level of each patient was calculated using all available glucose results. Results The mean glucose levels ranged between 76.8 and 303.5 mg/dL, and patients were categorized into quartiles in accordance to their mean glucose level: group 1 (< 106.7 mg/dL), group 2 (106.7-117.2 mg/dL), group 3 (117.3-142.6 mg/dL), and group 4 (> 142.6 mg/dL). The median overall survival for patients in groups 1, 2, 3, and 4 were 22.6, 20.1, 18.9, and 17.9 months, respectively; however, this difference was not statistically significant (p=0.643). Compared with patients in group 1, those in groups 2, 3, and 4 were at a higher risk of infection-related AEs, according to a multivariate analysis (p=0.002). Conclusion Hyperglycemia was not associated with shorter survival; however, it was associated with infection-related AEs in patients with newly diagnosed metastatic CRC receiving palliative chemotherapy.

Citations

Citations to this article as recorded by

Glucocorticoid-Induced Hyperglycemia in Oncologic Outpatients: A Narrative Review Using the Quadruple Aim Framework
Ihab Kandil, Erin Keely
Canadian Journal of Diabetes.2022; 46(7): 730. CrossRef
Association of Comorbid Diabetes With Clinical Outcomes and Healthcare Utilization in Colorectal Cancer Survivors
Susan Storey, Zuoyi Zhang, Xiao Luo, Diane Von Ah, Megan Metzger, Jie Zhang, Amrutha Jakka, Kun Huang
Oncology Nursing Forum.2021; 48(2): 195. CrossRef
The influence on survival of glucocorticoid induced diabetes in cancer patients with metastatic spinal cord compression
Helga Schultz, Ulrik Pedersen-Bjergaard, Andreas Kryger Jensen, Svend Aage Engelholm, Peter Lommer Kristensen
Clinical and Translational Radiation Oncology.2018; 11: 19. CrossRef
Measurement of Hyperglycemia and Impact on Health Outcomes in People With Cancer: Challenges and Opportunities
Susan Storey, Diane Ah, Marilyn Hammer
Oncology Nursing Forum.2017; 44(4): E141. CrossRef
Glycemic modulation in neuro-oncology: experience and future directions using a modified Atkins diet for high-grade brain tumors
Roy E. Strowd, Mackenzie C. Cervenka, Bobbie J. Henry, Eric H. Kossoff, Adam L. Hartman, Jaishri O. Blakeley
Neuro-Oncology Practice.2015; 2(3): 127. CrossRef
The Role of Glucose Modulation and Dietary Supplementation in Patients With Central Nervous System Tumors
Roy E. Strowd, Stuart A. Grossman
Current Treatment Options in Oncology.2015;[Epub] CrossRef

12,277 View
72 Download
7 Web of Science
6 Crossref

Diagnostic Value of Circulating Extracellular miR-134, miR-185, and miR-22 Levels in Lung Adenocarcinoma-Associated Malignant Pleural Effusion: Yoon Mi Shin, Jieun Yun, Ok-Jun Lee, Hye-Suk Han, Sung-Nam Lim, Jin Young An, Ki Hyeong Lee, Ki Man Lee, Kang Hyeon Choe; Cancer Res Treat. 2014;46(2):178-185. Published online April 15, 2014; DOI: https://doi.org/10.4143/crt.2014.46.2.178

Abstract PDF PubReader ePub

Purpose

The accurate and timely diagnosis of malignant pleural effusion (MPE) in lung cancer patients is important because MPE has a poor prognosis and is classified as stage IV disease. Molecular biomarkers for pleural effusion, such as circulating extracellular microRNAs (miRNAs) isolated from pleural fluid, may help in the diagnosis of MPE. The present study examined whether miRNAs that are deregulated in lung cancer (miR-134, miR-185, and miR-22) can serve as diagnostic markers for lung adenocarcinoma-associated MPE (LA-MPE).

Materials and Methods

Real-time reverse transcription quantitative polymerase chain reaction was used to measure the expression of the three miRNAs in samples from 87 patients with pleural effusion comprising 45 LA-MPEs and 42 benign pleural effusions (BPEs). The area under the receiver operating characteristic curve (AUC) was then used to evaluate the diagnostic performance of each of the three miRNAs and compare it with that of the common tumor marker, carcinoembryonic antigen (CEA).

Results

The expression of all three miRNAs was significantly lower in LA-MPE than in BPE (p <0.001). The AUCs for miR-134, miR-185, miR-22, and CEA were 0.721, 0.882, 0.832, and 0.898, respectively. Combining CEA with the three miRNAs increased the diagnostic performance, yielding an AUC of 0.942 (95% confidence interval, 0.864 to 0.982), with a sensitivity of 91.9% and a specificity of 92.5%.

Conclusion

The present study suggests that the expression levels of circulating extracellular miR-134, miR-185, and miR-22 in patients with pleural effusion may have diagnostic value when differentiating between LA-MPE and BPE.

Citations

Citations to this article as recorded by

Key methodological challenges in detecting circulating miRNAs in different biofluids
Chitra Mestry, Tester F Ashavaid, Swarup AV Shah
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine.2023; 60(1): 14. CrossRef
MiRNAs in Lung Adenocarcinoma: Role, Diagnosis, Prognosis, and Therapy
Yongan Song, Leonardo Kelava, István Kiss
International Journal of Molecular Sciences.2023; 24(17): 13302. CrossRef
High Diagnostic and Prognostic Value of miRNAs Compared with the Carcinoembryonic Antigen As A Traditional Tumor Marker
Neda Yaghoubi , Farnaz Zahedi Avval , Majid Khazaei, Amirhossein Sahebkar , Seyed Hamid Aghaee-Bakhtiari
Anti-Cancer Agents in Medicinal Chemistry.2022; 22(2): 206. CrossRef
Diagnostic utility of pleural cell-free nucleic acids in undiagnosed pleural effusions
Wen Zhao, Xi-Shan Cao, Yu-Ling Han, Xu-Hui Wen, Wen-Qi Zheng, Zhi-De Hu
Clinical Chemistry and Laboratory Medicine (CCLM).2022; 60(10): 1518. CrossRef
Construction and analysis of expression profile of exosomal lncRNAs in pleural effusion in lung adenocarcinoma
Xiaolu Huang, Huixin Zhou, Xiang Yang, Wenjing Shi, Lijuan Hu, Junjun Wang, Fan Zhang, Fanggui Shao, Meijuan Zhang, Feng Jiang, Yumin Wang
Journal of Clinical Laboratory Analysis.2022;[Epub] CrossRef
Molecular testing on serous effusions
Ben Davidson
Diagnostic Cytopathology.2021; 49(5): 640. CrossRef
Diving into the Pleural Fluid: Liquid Biopsy for Metastatic Malignant Pleural Effusions
Maria Alba Sorolla, Anabel Sorolla, Eva Parisi, Antonieta Salud, José M. Porcel
Cancers.2021; 13(11): 2798. CrossRef
Four plasma miRNAs act as biomarkers for diagnosis and prognosis of non‑small cell lung cancer
He-Guo Jiang, Chun-Hua Dai, Ya-Ping Xu, Qian Jiang, Xian-Bin Xia, Yang Shu, Jian Li
Oncology Letters.2021;[Epub] CrossRef
Molecular testing on serous effusion: An update
Saumya Sahu, Parikshaa Gupta, Pranab Dey
Cytojournal.2021; 18: 35. CrossRef
Non-coding RNA and lung cancer progression
Afeez Adekunle Ishola, Anita Silas La’ah, Hung Dinh Le, Viet Quoc Nguyen, Yi-Ping Yang, Shih-Jie Chou, Hsiao-Yun Tai, Chian-Shiu Chien, Mong-Lien Wang
Journal of the Chinese Medical Association.2020; 83(1): 8. CrossRef
Role of microRNAs as Clinical Cancer Biomarkers for Ovarian Cancer: A Short Overview
Cristina Elena Staicu, Dragoș-Valentin Predescu, Călin Mircea Rusu, Beatrice Mihaela Radu, Dragos Cretoiu, Nicolae Suciu, Sanda Maria Crețoiu, Silviu-Cristian Voinea
Cells.2020; 9(1): 169. CrossRef
microRNA exchange via extracellular vesicles in cancer
Luyen Tien Vu, Jinhua Gong, Thach Tuan Pham, Yeokyeong Kim, Minh T. N. Le
Cell Proliferation.2020;[Epub] CrossRef
MicroRNA Signatures in Malignant Pleural Mesothelioma Effusions
Kimberly A. Birnie, Cecilia M. Prêle, Arthur W. (Bill) Musk, Nicholas de Klerk, Y. C. Gary Lee, Deirdre Fitzgerald, Richard J. N. Allcock, Philip J. Thompson, Jenette Creaney, Bahareh Badrian, Steven E. Mutsaers
Disease Markers.2019; 2019: 1. CrossRef
Combination of DNA ploidy analysis and miR-21 or miR-24 in screening malignant pleural effusion
Chongmei Liu, Liuyan Huang, Xuechun Zhang, Juan Yang
Interactive CardioVascular and Thoracic Surgery.2018; 26(3): 376. CrossRef
Microarray expression profile and analysis of circular RNA regulatory network in malignant pleural effusion
Yakun Wen, Yong Wang, Zhenchuan Xing, Zongjian Liu, Ziliang Hou
Cell Cycle.2018; 17(24): 2819. CrossRef
Diagnostic value of tumor markers for lung adenocarcinoma-associated malignant pleural effusion: a validation study and meta-analysis
Mei Feng, Jing Zhu, Liqun Liang, Ni Zeng, Yanqiu Wu, Chun Wan, Yongchun Shen, Fuqiang Wen
International Journal of Clinical Oncology.2017; 22(2): 283. CrossRef
miR-134: A Human Cancer Suppressor?
Jing-Yu Pan, Feng Zhang, Cheng-Cao Sun, Shu-Jun Li, Guang Li, Feng-Yun Gong, Tao Bo, Jing He, Rui-Xi Hua, Wei-Dong Hu, Zhan-Peng Yuan, Xin Wang, Qi-Qiang He, De-Jia Li
Molecular Therapy - Nucleic Acids.2017; 6: 140. CrossRef
Molecular mechanisms and clinical applications of miR-22 in regulating malignant progression in human cancer (Review)
Jingyu Wang, Yuan Li, Meiman Ding, Honghe Zhang, Xiaoming Xu, Jinlong Tang
International Journal of Oncology.2017; 50(2): 345. CrossRef
MicroRNA-134 modulates glioma cell U251 proliferation and invasion by targeting KRAS and suppressing the ERK pathway
Yuguang Zhao, Dong Pang, Cui Wang, Shijiang Zhong, Shuang Wang
Tumor Biology.2016; 37(8): 11485. CrossRef
MicroRNA profiling of cisplatin-resistant oral squamous cell carcinoma cell lines enriched with cancer-stem-cell-like and epithelial-mesenchymal transition-type features
Ruma Dey Ghosh, Sangeeta Ghuwalewala, Pijush Das, Sapan Mandloi, Sk Kayum Alam, Jayanta Chakraborty, Sajal Sarkar, Saikat Chakrabarti, Chinmoy Kumar Panda, Susanta Roychoudhury
Scientific Reports.2016;[Epub] CrossRef
Cell‐free microRNAs in blood and other body fluids, as cancer biomarkers
Blanca Ortiz‐Quintero
Cell Proliferation.2016; 49(3): 281. CrossRef
Clinical relevance of circulating cell-free microRNAs in ovarian cancer
Koji Nakamura, Kenjiro Sawada, Akihiko Yoshimura, Yasuto Kinose, Erika Nakatsuka, Tadashi Kimura
Molecular Cancer.2016;[Epub] CrossRef
MicroRNA-432 functions as a tumor suppressor gene through targeting E2F3 and AXL in lung adenocarcinoma
Ling Chen, Guangming Kong, Chuantao Zhang, Hongyan Dong, Cuicui Yang, Guanhua Song, Chengye Guo, Lin Wang, Hongsheng Yu
Oncotarget.2016; 7(15): 20041. CrossRef
Hepatocellular carcinoma and microRNA: New perspectives on therapeutics and diagnostics
Ningning Yang, Nsikak R. Ekanem, Clement A. Sakyi, Sidhartha D. Ray
Advanced Drug Delivery Reviews.2015; 81: 62. CrossRef
Reduced expression of microRNA-134 correlates with malignancy and poor prognosis in human glioma
Jianfeng Zhong, Bing Li
Journal of Clinical Neuroscience.2015; 22(3): 583. CrossRef
2015 update on the diagnosis and management of neoplastic pericardial disease
Chiara Lestuzzi, Massimiliano Berretta, Witold Tomkowski
Expert Review of Cardiovascular Therapy.2015; 13(4): 377. CrossRef
Extracellular microRNAs in bronchoalveolar lavage samples from patients with lung diseases as predictors for lung cancer
Grit Rehbein, Bernd Schmidt, Michael Fleischhacker
Clinica Chimica Acta.2015; 450: 78. CrossRef

16,417 View
138 Download
38 Web of Science
27 Crossref

Case Reports

Multiple Cardiac Metastases from a Nonfunctioning Pancreatic Neuroendocrine Tumor: Yong Hyeok Choi, Hye-Suk Han, Sung-Nam Lim, Sang Yeub Lee, Ji Hae Koo, Ok-Jun Lee, Ki Hyeong Lee, Seung Taik Kim; Cancer Res Treat. 2013;45(2):150-154. Published online June 30, 2013; DOI: https://doi.org/10.4143/crt.2013.45.2.150

Abstract PDF PubReader ePub

Pancreatic neuroendocrine tumors (pNETs) are rare neoplasms, which most commonly metastasize to the liver. However, intrathoracic metastases from pNETs are encountered infrequently. This report describes a case of nonfunctioning pNET with multiple cardiac metastases. A 56-year-old male presented with a palpable abdominal mass that showed progressive enlargement. Findings on computed tomography (CT) of the abdomen revealed two relatively well-marginated inhomogeneous low-attenuation masses, one in the head of the pancreas and the other in the tail. Multiple enhancing masses in the left pericardium with myocardial involvement were observed on chest CT and transthoracic echocardiography. Needle biopsies were performed on the mass in the tail of the pancreas and the left ventricular apical pericardium; histologic examination by hematoxylin and eosin morphology and immunohistochemical staining showed pNET in both. This is the first report of pNET with multiple cardiac metastases to previously undescribed metastatic sites.

Citations

Citations to this article as recorded by

Cardiac Neuroendocrine Tumor Metastases on68Ga-DOTATATE PET/CT: Identification and Prognostic Significance
Hwan Lee, Ahmad S. Alhamshari, Vandan Patel, Abhijit Bhattaru, Chaitanya Rojulpote, Mahesh K. Vidula, Daniel A. Pryma, Paco E. Bravo
Journal of Nuclear Medicine.2024; 65(11): 1745. CrossRef
Atypical Cardiac Location of Melanoma of Unknown Origin
Agnieszka Styczeń, Mariusz Kozak, Marta Karaś-Głodek, Elżbieta Czekajska-Chehab, Andrzej Tomaszewski, Andrzej Wysokiński, Tomasz Zapolski
Medicina.2021; 57(2): 107. CrossRef
Cardiac Metastases in Patients with Neuroendocrine Tumours: Clinical Features, Therapy Outcomes, and Prognostic Implications
Man Liu, Eleni Armeni, Shaunak Navalkissoor, Joseph Davar, Luke Sullivan, Charlotte Leigh, Luke Furtado O’Mahony, Aimee Hayes, Dalvinder Mandair, Jie Chen, Martyn Caplin, Christos Toumpanakis
Neuroendocrinology.2021; 111(10): 907. CrossRef
A concealed carcinoid cardiac metastasis uncovered by comprehensive cardiovascular magnetic resonance-based tissue characterization: a case report
Georgios Georgiopoulos, Panagiota Mitropoulou, Pier Giorgio Masci, Juerg Schwitter, Khan Tina, Voges Inga, Raisi Estabragh Zahra, Minguito Carazo Carlos, Thomson Ross
European Heart Journal - Case Reports.2020; 4(6): 1. CrossRef
A Multimodal Approach to Evaluate for Cardiac Metastasis in a Case of Non-Small Cell Lung Cancer
Nadeem Bilani, Leah Elson, Felipe Martinez, Diego Sadler, Zeina Nahleh, Elizabeth Elimimian, Evan Alley
Case Reports in Oncology.2020; 13(1): 212. CrossRef
Identification of multiple cardiac metastases from nonsmall-cell lung cancer by 18F-FDG PET/CT
Shengming Deng, Bin Zhang, Jihui Li, Shibiao Sang, Wei Zhang
Medicine.2018; 97(49): e12868. CrossRef

12,376 View
67 Download
6 Crossref

Poorly Differentiated Neuroendocrine Carcinoma in a Perigastric Lymph Node from an Unknown Primary Site: Hee Seung Lee, Hye-Suk Han, Sung-Nam Lim, Hyun-Jung Jeon, Ho-chang Lee, Ok-Jun Lee, Hyo Young Yun, Ki Hyeong Lee, Seung Taik Kim; Cancer Res Treat. 2012;44(4):271-274. Published online December 31, 2012; DOI: https://doi.org/10.4143/crt.2012.44.4.271

Abstract PDF PubReader ePub

Neuroendocrine carcinomas from an unknown primary site are uncommon. The authors report on a case of neuroendocrine carcinoma in a perigastric lymph node (LN) with no primary site. A 52-year-old male patient with early gastric adenocarcinoma underwent treatment by endoscopic submucosal dissection, and, six months later, findings on a computed tomographic scan of the abdomen revealed a LN enlargement measuring 2.0 cm in the perigastric region. The patient underwent subtotal gastrectomy and regional LN dissection under a suggestive preoperative diagnosis of gastric adenocarcinoma with LN metastasis. However, microscopically, no residual tumor was found in the stomach, and the perigastric LN showed poorly differentiated neuroendocrine carcinoma (PDNEC). After an extensive workup, no primary site was identified. The patient also received four cycles of etoposide and cisplatin. Despite its extremely rare incidence, this case suggests that PDNEC of an unknown primary site is limited to a single site, and that resection should be considered in combination with chemotherapy.

Citations

Citations to this article as recorded by

A case of laparoscopic lymphadenectomy for adenocarcinoma of unknown primary incidentally detected as a solitary enlarged lymph node along the common hepatic artery
Tomonori Morimoto, Shigeo Hisamori, Hiromitsu Kinoshita, Yosuke Yamada, Yuki Teramoto, Takashi Sakamoto, Keiko Kasahara, Shintaro Okumura, Tatsuto Nishigori, Shigeru Tsunoda, Kazutaka Obama
Surgical Case Reports.2024;[Epub] CrossRef
Synchronous Gastric Adenocarcinoma and Perigastric Lymph Node Metastatic Squamous Cell Carcinoma with Unknown Primary: A Case Report
Bernard K Seshie, Ki Hyun Kim, Hyun Jung Lee, Si Hak Lee, Sun-Hwi Hwang
The Journal of Minimally Invasive Surgery.2020; 23(2): 99. CrossRef
Metastatic Neuroendocrine Carcinoma of Unknown Origin Arising in the Femoral Nerve Sheath
Nicholas Candy, Adam Young, Kieren Allinson, Oliver Carr, Jason McMillen, Rikin Trivedi
World Neurosurgery.2017; 104: 1047.e1. CrossRef
Submucosal small-cell neuroendocrine carcinoma of the larynx detected using 18F-fluorodeoxyglucose positron emission tomography/computed tomography: A case report and review of the literature
HONG-FANG YING, YANG-YANG BAO, SHUI-HONG ZHOU, LIANG CHAI, KUI ZHAO, TING-TING WU
Oncology Letters.2014; 8(3): 1065. CrossRef

11,489 View
49 Download
4 Crossref

Metastatic Renal Cell Carcinoma in a Supraclavicular Lymph Node with No Known Primary: A Case Report: Young-Rak Choi, Hye-Suk Han, Ok-Jun Lee, Sung-Nam Lim, Mi-Jin Kim, Myeong-Ho Yeon, Hyun-Jung Jeon, Ki Hyeong Lee, Seung Taik Kim; Cancer Res Treat. 2012;44(3):215-218. Published online September 30, 2012; DOI: https://doi.org/10.4143/crt.2012.44.3.215

Abstract PDF PubReader ePub

Although metastasis is relatively frequent in cases of renal cell carcinoma (RCC), metastasis in the cervical or supraclavicular lymph node (LN) is relatively rare. Moreover, cases of metastatic RCC with a non-identifiable kidney mass are extremely rare. Here, the authors report a case of metastatic RCC in a supraclavicular LN without a primary kidney lesion. A 69-year-old man presented with a progressively enlarging right supraclavicular mass. Incisional biopsy of the affected supraclavicular LN was performed, and histological examination revealed metastatic RCC. However, no tumor was found in either kidney, despite various examinations. The patient was treated with radiotherapy followed by sunitinib. After three months on sunitinib, a follow-up computed tomography scan revealed that the supraclavicular LN had markedly decreased, and after 20 months, the disease had not progressed. This case suggests that, even when there is no primary kidney lesion, clinicians must consider the possibility of metastatic RCC when evaluating patients with clear cell carcinoma with an unknown primary site.

Citations

Citations to this article as recorded by

The Relevance of the Virchow Node and Virchow Triad in Renal Cancer Diagnosis
Luiza-Roxana Dorobantu-Lungu, Viviana Dinca, Andrei Gegiu, Dan Spataru, Andreea Toma, Luminita Welt, Mihaela Florentina Badea, Constantin Caruntu, Cristian Scheau, Ilinca Savulescu-Fiedler
Clinics and Practice.2025; 15(1): 18. CrossRef
Pure Metastatic Papillary Renal Cell Carcinoma Without Renal Mass: A Case Report and Literature Review
Pay Enes, Ibrahim Hacibey, Serhat Yentur, Salih Sonmez, Atilla Semercioz
International Journal of Clinical and Experimental Medical Sciences.2024; 10(2): 25. CrossRef
Nivolumab rechallenge after severe immune hepatitis in a metastatic renal cell cancer patient with hepatitis B and no detectable primary
Lutfiye Demir, Funda Canaz
Indian Journal of Cancer.2023; 60(1): 114. CrossRef
Extrarenal renal cell carcinoma arising in the kidney proximity but without an identifiable renal primary – an intriguing dilemma: report of three cases and review of the literature
Mehdi Mansoor, Morgan Young‐Speirs, Bing Ren, Geoffrey Gotto, Larissa Merten, Summit Sawhney, Farshid Siadat, Andres M Acosta, Abbas Agaimy, Kiril Trpkov
Histopathology.2022; 81(5): 635. CrossRef
New rising entities in cancer of unknown primary: Is there a real therapeutic benefit?
Elie Rassy, Pauline Parent, Felix Lefort, Stergios Boussios, Giulia Baciarello, Nicholas Pavlidis
Critical Reviews in Oncology/Hematology.2020; 147: 102882. CrossRef
Metastatic renal cell carcinoma of unknown primary site. Clinical follow-up
N. A. Ognerubov, T. S. Antipova, G. E. Gumareva
Journal of Modern Oncology.2020; 22(3): 149. CrossRef
Carcinoma of Unknown Primary Site (CUP) With Metastatic Renal-Cell Carcinoma (mRCC) Histologic and Immunohistochemical Characteristics (CUP-mRCC): Results From Consecutive Patients Treated With Targeted Therapy and Review of Literature
Anders Overby, Lone Duval, Morten Ladekarl, Britt Elmedal Laursen, Frede Donskov
Clinical Genitourinary Cancer.2019; 17(1): e32. CrossRef
Central pancreatectomy in portal annular pancreas for metastatic renal cell carcinoma: a case report
Hiroshi Yamaguchi, Yasutoshi Kimura, Minoru Nagayama, Masafumi Imamura, Shingo Tanaka, Makoto Yoshida, Eiji Yoshida, Hiroki Fujino, Takashi Machiki, Koji Miyanishi, Toru Mizuguchi, Junji Kato, Ichiro Takemasa
World Journal of Surgical Oncology.2019;[Epub] CrossRef
Metastatic renal cell carcinoma with undetectable renal mass presenting as lymphadenopathy
Mohamed Salah Fayaz, Aishah Ebrahim Al-Qaderi, Mustafa Shawki El-Sherify
CEN Case Reports.2017; 6(1): 36. CrossRef
The clinical application of angiostatic therapy in combination with radiotherapy: past, present, future
Lisanne C. Hamming, Ben J. Slotman, Henk M. W. Verheul, Victor L. Thijssen
Angiogenesis.2017; 20(2): 217. CrossRef
Optimal treatment scheduling of ionizing radiation and sunitinib improves the antitumor activity and allows dose reduction
Esther A. Kleibeuker, Matthijs A. ten Hooven, Kitty C. Castricum, Richard Honeywell, Arjan W. Griffioen, Henk M. Verheul, Ben J. Slotman, Victor L. Thijssen
Cancer Medicine.2015; 4(7): 1003. CrossRef
Combining radiotherapy with sunitinib: lessons (to be) learned
Esther A. Kleibeuker, Matthijs A. ten Hooven, Henk M. Verheul, Ben J. Slotman, Victor L. Thijssen
Angiogenesis.2015; 18(4): 385. CrossRef
Sunitinib

Reactions Weekly.2014; 1494(1): 42. CrossRef
To combine or not combine: the role of radiotherapy and targeted agents in the treatment for renal cell carcinoma
Christian Weiss, Björn Schulze, Annette Ottinger, Claus Rödel
World Journal of Urology.2014; 32(1): 59. CrossRef

13,454 View
101 Download
14 Crossref

First
Prev
Page of 1
Next
Last

Search