Cancer Research and Treatment

A Study of Relationship of Atheroembolic Risk Factors with Postoperative Recovery in Renal Function after Partial Nephrectomy in Patients Staged T1-2 Renal Cell Carcinoma during Median 4-Year Follow-up: Sung Han Kim, Kyung Min Kang, Ami Yu, Jung Hoon Lee, Byung Ho Nam, Eun Sik Lee; Cancer Res Treat. 2016;48(1):288-296. Published online April 15, 2015; DOI: https://doi.org/10.4143/crt.2014.297

Purpose
The objective of this study is to evaluate the relationship of atheroembolic risk factors with postoperative recovery of renal function after on-clamp partial nephrectomy (PN) with warm ischemia in patients with staged T1-2 renal cell carcinoma (RCC).
Materials and Methods
A total of 234 patients from 2004 to 2012 were included, and their clinicopathologic and operative parameters, including atheroembolic risk factors were reviewed retrospectively. Renal function, as determined by estimated glomerular filtration rate (eGFR) and measurement of serum creatinine level (Cr) at each scheduled follow-up for a median four years, was compared between the high-risk (HR) group (n=49, ≥ five risk factors) and the low-risk (LR) group (n=185, < five risk factors).
Results
Except for baseline renal function and number of risk factors for atheroembolism, differences in characteristics between groups were comparatively insignificant. At 3 months after the operation, Cr and eGFR differed significantly between the two groups (p < 0.05), but no differences were observed afterward. Significant deterioration from baseline in Cr and eGFR was observed in both groups at 1 month after the operation, with a greater change in the HR group (p < 0.05). From measurement to measurement, significantly faster deterioration in Cr and eGFR was observed in the HR group than in the LR group until 6 months after the operation (Cr: LR, 0.02 mg/dL and HR, 0.13 mg/dL; eGFR: LR, 1.50 mL/min/1.73 m² and HR, 6.38 mL/min/1.73 m²; p < 0.05).
Conclusion
The presence of atheroembolic risk factors may negatively influence postoperative recovery of renal function after PN in patients with localized RCC.

Citations

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Metastatic prostatic carcinoma: Kyung Joon Min, Eun Sik Lee, Hyun Hee Kim, Jong Wook Lee; J Korean Cancer Assoc. 1993;25(3):397-402.

Abstract PDF: No abstract available.

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Prognosis of metastatic renal cell carcinoma: Won Hee Park, Hyeon Hoe Kim, Eun Sik Lee, Chongwook Lee; J Korean Cancer Assoc. 1992;24(1):160-167.

Abstract PDF: No abstract available.

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Urothelial tumors of the upper urinary tract: Eun Sik Lee, Hyeon Hoe Kim, Kyung Joon Min, Moon Soo Park, Chongwook Lee; J Korean Cancer Assoc. 1991;23(4):828-834.

Abstract PDF: No abstract available.

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Continent ileal reservoir after radical cystectomy for bladder tumor: Eun Sik Lee, Chongwook Lee; J Korean Cancer Assoc. 1991;23(2):366-374.

Abstract PDF: No abstract available.

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Mitomycin C vs. bacillus calmette-guerin: comparison of prophylactic efficacy to high risk superficial bladder tumor: Eun Sik Lee, Moon Soo Park, Chongwook Lee; J Korean Cancer Assoc. 1991;23(1):101-106.

Abstract PDF: No abstract available.

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Study on the various factors affecting growth of human renal cell carcinoma cell lines: Eun Sik Lee, Jae Gahb Park, Chongwook Lee; J Korean Cancer Assoc. 1991;23(1):65-75.

Abstract PDF: No abstract available.

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Antitumor Activity of Lymphokine Activated Killer Cells ( LAK ) and Interleukin-2 Activated Tumor Infiltrating Lymphocytes ( TIL ) to the Cell Lines of Human Renal cell carcinom: Chong Wook Lee, Eun Sik Lee, Dae Seog Heo, Jae Gahb Park; J Korean Cancer Assoc. 1990;22(2):286-298.

Abstract PDF: We analysed the antitumor activity of lymphokine activated killer cells (LAK) induced from peripheral bloods of normal, renai cells carcinoma and transitional cell carcinoma patients and interleukin-2 (IL-2) activated tumor infiltrating lymphocytes (TIL) from human renal cell carcinoma and transitional cell carcinoma of the bladder. An establidhed human renal cell carcinoma (Caki-1l and transitiunai cell carcinoma cell lines (T-24) were used as target cell. Cytotoxicity was checked by MTT assay. As a pilot study, concentration of IL-2 produced by KAIST was measured using IL-2 dependent CTLL cell compared with Cetus standard unit and optimun conditions for LAK generation were evaiuated. The concentration of IL-2 was 2 x 10(6) Cetus units/mg. The optimum target cell number was 5 x 10(3) cells in Caki-1 and 2.5 x 10(3) cells in T-24 cell line. Most active LAK cells were induced by 1,000 units,' m1 of IL-2 concentration and 5 days incubation period. The LAK activity of 10 normal adults (group 1), 10 renal celi carcinoma (group 2) and 9 transitional cell carcinoma patients lgroup 3) ta the target cells were compared. More than 50% of target cells were killed when effector; target cell ratio was 10 or more. The killing activities against the T-24 and Caki-1 cell lines were not different in all three groups. The tunwr infiltrating lymphocytes from 10 renal cell and 9 transitional cell carcinomas were activated with 1,000 units/ml of IL-2. TIL was activated in 7 of 19 tumor tissues. TIL from renal cell carcinoma showed good proliferating potential and nonspecific killing activity to the T-24 and Caki-l. The killing activity of TIL appeared to be somewhat stronger than LAK. Adoptive immunotherapy using LAK and TIL cauid provide a good therapeutic modality in the patients with advanced renai cell carcinoma and transitional cell carcinoma of the bladder.

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