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Gastrointestinal cancer
Daily Vigorous Intensity Physical Activity and Its Preventive Effect on Pancreatic Cancer
Sung Keun Park, Ju Young Jung, Chang-Mo Oh, Min-Ho Kim, Eunhee Ha, Yeji Kim, Do Jin Nam, Jae-Hong Ryoo
Cancer Res Treat. 2022;54(3):873-881.   Published online September 27, 2021
DOI: https://doi.org/10.4143/crt.2021.400
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
There has been accumulating evidence for the preventive effect of high physical activity on cancer. However, it is still unclear which level of physical activity is associated with the decreased risk of pancreatic cancer. The purpose of current study is to assess the association between the frequency of vigorous intensity physical activity and the risk of pancreatic cancer.
Materials and Methods
The nationwide retrospective cohort study was conducted using the National Health Information Database. Study participants were 220,357 Koreans who received health check-up in 2009. They were divided into four groups by the weekly frequency of vigorous intensity physical activity longer than 20 minutes (group 1, no vigorous intensity physical activity (reference); group 2, 1-3 days; group 3, 4-5 days and group 4, 6-7 days). Cox proportional hazard model was used to calculate the adjusted hazard ratios (HRs) and 95% confidence interval (CI) for incident pancreatic cancer (adjusted HRs [95% CI]) according to the weekly frequency of vigorous intensity physical activity.
Results
For 4.38 years’ follow-up on average, 377 cases of pancreatic cancer developed. Subjects without incident pancreatic cancer had more favorable metabolic condition and higher physical activity than subjects with incident pancreatic cancer. Adjusted HRs and 95% CI indicated that only group 4 was significantly associated with the decreased risk of pancreatic cancer (group 1, reference; group 2, 1.10 [0.86-1.40]; group 3, 0.75 [0.45-1.25] and group 4, 0.47 [0.25-0.89]).
Conclusion
In this nationwide representative cohort study, near daily vigorous intensity physical activity showed the preventive effect on pancreatic cancer.

Citations

Citations to this article as recorded by  
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    H.J. Lee, J.W. Choi
    Public Health.2024; 229: 73.     CrossRef
  • Physical Activity Decreases Inflammation and Delays the Development of Obesity-Associated Pancreatic Ductal Adenocarcinoma
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    Danilo Bondi, Michele Bevere, Rosanna Piccirillo, Guglielmo Sorci, Valentina Di Felice, Andrea David Re Cecconi, Daniela D'Amico, Tiziana Pietrangelo, Stefania Fulle
    Molecular Genetics and Metabolism.2023; 140(3): 107705.     CrossRef
  • 6,511 View
  • 136 Download
  • 5 Web of Science
  • 5 Crossref
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Geographical Variations and Trends in Major Cancer Incidences throughout Korea during 1999-2013
Young-Joo Won, Kyu-Won Jung, Chang-Mo Oh, Eun-Hye Park, Hyun-Joo Kong, Duk Hyoung Lee, Kang Hyun Lee, The Community of Population-based Regional Cancer Registries
Cancer Res Treat. 2018;50(4):1281-1293.   Published online January 4, 2018
DOI: https://doi.org/10.4143/crt.2017.411
AbstractAbstract PDFPubReaderePub
Purpose
We aimed to describe the temporal trends and district-level geographical variations in cancer incidences throughout Korea during 1999-2013.
Materials and Methods
Data were obtained from the Korean National Cancer Incidence Database. We calculated the age-standardized cumulative cancerincidences according to sex and geographicalregion (metropolitan cities, provinces, and districts) for three 5-year periods (1999-2003, 2004- 2008, and 2009-2013). Each quintile interval contained the same number of regions. Disease maps were created to visualize regional differences in the cancer incidences.
Results
Substantial differences in cancer incidences were observed according to district and cancer type. The largest variations between geographical regions were found for thyroid cancer among both men and women. There was little variation in the incidences of stomach, colorectal, and lung cancer according to geographical region. Substantially elevated incidences of specific cancers were observed in Jeollanam-do (thyroid); Daejeon (colorectum); Jeollanam-do, Gyeongsangbuk-do, and Chungcheongbuk-do (lung); Seocho-gu, Gangnam-gu and Seongnam, Bundang-gu (breast and prostate); Chungcheong and Gyeongsang provinces (stomach); Ulleung-gun and the southern districts of Gyeongsangnam-do and Jeollanam-do (liver); and along the Nakdonggang River (gallbladder and biliary tract).
Conclusion
Mapping regional cancer incidences in Korea allowed us to compare the results according to geographical region. Our results may facilitate the development of infrastructure for systematic cancerincidence monitoring,which could promote the planning and implementation of region-specific cancer management programs.

Citations

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    International Journal of Environmental Research and Public Health.2020; 17(21): 7824.     CrossRef
  • 9,480 View
  • 188 Download
  • 11 Web of Science
  • 11 Crossref
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Nationwide Trends in the Incidence of Melanoma and Non-melanoma Skin Cancers from 1999 to 2014 in South Korea
Chang-Mo Oh, Hyunsoon Cho, Young-Joo Won, Hyun-Joo Kong, Yun Ho Roh, Ki-Heon Jeong, Kyu-Won Jung
Cancer Res Treat. 2018;50(3):729-737.   Published online July 14, 2017
DOI: https://doi.org/10.4143/crt.2017.166
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
This descriptive study was aimed to examine trends in the incidence of melanoma and nonmelanoma in South Korea.
Materials and Methods
The nationwide incidence data for melanoma and non-melanoma skin cancer was obtained from the Korea Central Cancer Registry. Age-standardized rates were calculated and analyzed, using a Joinpoint regression model.
Results
The incidence of basal cell carcinoma has increased dramatically both in men (average annual percentage change [AAPC], 8.0 [95% confidence interval (CI), 6.0 to 10.1]) and women (AAPC, 9.0 [95% CI, 7.5 to 10.4]). Squamous cell carcinoma has also steadily increased both in men (AAPC, 3.3 [95% CI, 2.6 to 4.0]) and women (AAPC, 6.8 [95% CI, 5.3 to 8.4]). Cutaneous melanoma increased continuously from 1999 to 2014 inwomen (AAPC, 3.5 [95% CI, 2.4 to 4.6]), whilst rapidly increasing in men until 2005 (APC, 7.9 [95% CI, 2.4 to 13.7]) after which no increase has been observed (APC, ‒0.2 [95% CI, ‒2.3 to 2.0]).
Conclusion
The incidence rates of melanoma and non-melanoma skin cancer have increased over the past years, with the exception of melanoma in men. Further studies are required to investigate the reasons for the increased incidence of these skin cancers in South Korea.

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    Sun Kim, Seungeun Lee, Eunhye Lee, Hyesol Lim, Ji Shin, Joohee Jung, Sang Kim, Aree Moon
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  • Melanoma signature in Brazil: epidemiology, incidence, mortality, and trend lessons from a continental mixed population country in the past 15 years
    Andréia C. de Melo, Alberto J.A. Wainstein, Antonio C. Buzaid, Luiz C.S. Thuler
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  • 14,961 View
  • 445 Download
  • 47 Web of Science
  • 52 Crossref
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Second Primary Cancer Risk among Kidney Cancer Patients in Korea: A Population-Based Cohort Study
Jae Young Joung, Whi-An Kwon, Jiwon Lim, Chang-Mo Oh, Kyu-Won Jung, Sung Han Kim, Ho Kyung Seo, Weon Seo Park, Jinsoo Chung, Kang Hyun Lee, Young-Joo Won
Cancer Res Treat. 2018;50(1):293-301.   Published online April 19, 2017
DOI: https://doi.org/10.4143/crt.2016.543
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
Secondary primary cancers (SPCs) commonly arise in patients with renal cell carcinoma (RCC). We designed the present study to estimate the SPC incidence in Korean patients with RCC.
Materials and Methods
The study cohort was population-based and consisted of 40,347 individuals from the Korean Central Cancer Registry who were diagnosed with primary renal cancer between 1993 and 2013. Standardized incidence ratios (SIRs) for SPCs were estimated for different ages at diagnosis, latencies, diagnostic periods, and treatments.
Results
For patients with primary RCC, the risk of developing a SPC was higher than the risk of developing cancer in the general population (SIR, 1.13; 95% confidence interval, 1.08 to 1.18). Most cancer types showed higher incidences in patients with RCC than in the general population. However, the relative incidence of gastric cancer as an SPC varied by age. Gastric cancer incidence was elevated in young patients (< 30 years) with RCC, but reduced in older (≥ 30) patients with RCC. Patients with advanced RCC died prematurely, regardless of SPC development. In contrast, those with early-stage RCC survived for longer periods, although SPC development affected their post-RCC survival. After SPC development, women had better survival than men.
Conclusion
In Korean patients with primary RCC, the incidence of SPC was 13% higher than the incidence of cancer in the general population. These findings may play important roles in the conduct of follow-up evaluations and education for patients with RCC.

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Nationwide Statistical Analysis of Lymphoid Malignancies in Korea
Hyewon Lee, Hyeon Jin Park, Eun-Hye Park, Hee Young Ju, Chang-Mo Oh, Hyun-Joo Kong, Kyu-Won Jung, Byung-Kiu Park, Eunyoung Lee, Hyeon-Seok Eom, Young-Joo Won
Cancer Res Treat. 2018;50(1):222-238.   Published online March 30, 2017
DOI: https://doi.org/10.4143/crt.2017.093
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
Regional differences in the incidence of lymphoid malignancies have been reported worldwide, but there has been no large-scale epidemiologic analysis in Korea. The aim of this study was to provide a nationwide population-based statistical analysis of Korean patients with lymphoid malignancies.
Materials and Methods
The Korea Central Cancer Registry analyzed the incidence and survival of patients with lymphoid malignancies from the Korean National Cancer Incidence Database. Diseases were grouped by clinically relevant categories based on the 2008 World Health Organization classification.
Results
Overall 65,948 lymphoid diseases were identified between 1999 and 2012. The incidence of most subtypes increased with age, except for precursor cell neoplasms. Male predominance (male:female ratio=1.28:1) was observed. In 2012, annual age-standardized incidence rates per 100,000 persons of Hodgkin’s lymphoma, mature B-cell neoplasm, mature T/natural killer (NK)–cell neoplasm, and precursor cell neoplasm were 0.46, 6.60, 0.95, and 1.50, respectively, and they increased yearly from 1999. Composite Hodgkin’s and non-Hodgkin’s lymphomas were extremely rare. Survival improvement estimated using 5-year relative survival rate was observed in patients with Hodgkin’s lymphoma (71.1%- 83.0%), diffuse large B-cell lymphoma (49.5%-61.5%), plasma cell neoplasms (20.2%- 36.9%), and lymphoblastic lymphoma/leukemia (41.5%-56.3%) between 1993 and 2012. However, survival rates of T/NK-cell lymphoma (excluding cutaneous T-cell lymphoma) ranged from 40.5%-43.5% during the study period. Survival rates decreased with age in most subtypes.
Conclusion
This report presented the subtype-specific statistical analysis of lymphoid malignancies in the Korean population, showing increasing incidences and survival rates in most subtypes.

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Special Articles
Prediction of Cancer Incidence and Mortality in Korea, 2017
Kyu-Won Jung, Young-Joo Won, Chang-Mo Oh, Hyun-Joo Kong, Duk Hyoung Lee, Kang Hyun Lee
Cancer Res Treat. 2017;49(2):306-312.   Published online March 17, 2017
DOI: https://doi.org/10.4143/crt.2017.130
AbstractAbstract PDFPubReaderePub
Purpose
This study aimed to report on cancer incidence and mortality for the year 2017 in Korea in order to estimate the nation’s current cancer burden.
Materials and Methods
Cancer incidence data from 1999 to 2014 were obtained from the Korea National Cancer Incidence Database, and cancer mortality data from 1993 to 2015 were acquired from Statistics Korea. Cancer incidence and mortality were projected by fitting a linear regression model to observe age-specific cancer rates against observed years, and then multiplying the projected age-specific rates by the age-specific population. The Joinpoint regression model was used to determine at which year the linear trend changed significantly; we only used data of the latest trend.
Results
A total of 221,143 new cancer cases and 80,268 cancer deaths are expected to occur in Korea in 2017. The most common cancer sites are the colorectum, stomach, lung, thyroid, and breast. These five cancers represent half of the overall burden of cancer in Korea. For mortality, the most common sites are the lung, liver, colorectal, stomach, and pancreas.
Conclusion
The incidence rate of all cancers in Korea appears to have decreased mainly because of a decrease in thyroid cancer. These up-to-date estimates of the cancer burden in Korea could be an important resource for planning and evaluation of cancer-control programs.

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Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2014
Kyu-Won Jung, Young-Joo Won, Chang-Mo Oh, Hyun-Joo Kong, Duk Hyoung Lee, Kang Hyun Lee, The Community of Population-Based Regional Cancer Registries
Cancer Res Treat. 2017;49(2):292-305.   Published online March 9, 2017
DOI: https://doi.org/10.4143/crt.2017.118
AbstractAbstract PDFPubReaderePub
Purpose
This study presents the 2014 nationwide cancer statistics in Korea, including cancer incidence, survival, prevalence, and mortality.
Materials and Methods
Cancer incidence data from 1999 to 2014 was obtained from the Korea National Cancer Incidence Database and followed until December 31, 2015. Mortality data from 1983 to 2014 were obtained from Statistics Korea. The prevalence was defined as the number of cancer patients alive on January 1, 2015, among all cancer patients diagnosed since 1999. Crude and age-standardized rates (ASRs) for incidence, mortality, prevalence, and 5-year relative survivals were also calculated.
Results
In 2014, 217,057 and 76,611 Koreans were newly diagnosed and died from cancer respectively. The ASRs for cancer incidence and mortality in 2014 were 270.7 and 85.1 per 100,000, respectively. The all-cancer incidence rate has increased significantly by 3.4% annually from 1999 to 2012, and started to decrease after 2012 (2012-2014; annual percent change, –6.6%). However, overall cancer mortality has decreased 2.7% annually since 2002. The 5-year relative survival rate for patients diagnosed with cancer between 2010 and 2014 was 70.3%, an improvement from the 41.2% for patients diagnosed between 1993 and 1995.
Conclusion
Age-standardized cancer incidence rates have decreased since 2012 and mortality rates have also declined since 2002, while 5-year survival rates have improved remarkably from 1993-1995 to 2010-2014 in Korea.

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  • Cross-national analysis about the difference of histopathological management in Tis and T1 colorectal cancer between Japan and Korea
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  • Development of a risk scoring system for patients with papillary thyroid cancer
    Kyoungjune Pak, Yun Hak Kim, Sunghwan Suh, Tae Sik Goh, Dae Cheon Jeong, Seong Jang Kim, In Joo Kim, Myoung‐Eun Han, Sae‐Ock Oh
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  • Adult height in relation to risk of cancer in a cohort of 22,809,722 Korean adults
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  • Association of Periodontitis with Oral Cancer: A Case-Control Study
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  • Economic burden of lung cancer: A retrospective cohort study in South Korea, 2002-2015
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  • Relationship Between Preferences for Advance Directive Treatments and Decisional Conflicts Among Low-Income, Home-Based Cancer Management Recipients in Korea
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  • Clinical Outcomes of Conversion Surgery after Neoadjuvant Chemotherapy in Patients with Borderline Resectable and Locally Advanced Unresectable Pancreatic Cancer: A Single-Center, Retrospective Analysis
    Changhoon Yoo, Sang Hyun Shin, Kyu-pyo Kim, Jae Ho Jeong, Heung-Moon Chang, Jun Ho Kang, Sang Soo Lee, Do Hyun Park, Tae Jun Song, Dong Wan Seo, Sung Koo Lee, Myung-Hwan Kim, Jin-hong Park, Dae Wook Hwang, Ki Byung Song, Jae Hoon Lee, Baek-Yeol Ryoo, Song
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  • Prevalence of Pressure Injuries Nationwide from 2009 to 2015: Results from the National Inpatient Sample Database in Korea
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  • Prediction of Recurrence With KRAS Mutational Burden Using Ultrasensitive Digital Polymerase Chain Reaction of Radial Resection Margin of Resected Pancreatic Ductal Adenocarcinoma
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  • Evaluation of satisfaction with three different cervical cancer screening modalities: clinician-collected Pap test vs. HPV test by self-sampling vs. HPV test by urine sampling
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    Kyung Hwa Lee, Yong Chan Ahn, Hongryull Pyo, Jae Myoung Noh, Seung Gyu Park, Tae Gyu Kim, Eonju Lee, Heerim Nam, Hyebin Lee, Jong-Mu Sun, Jin Seok Ahn, Myung-Ju Ahn, Keunchil Park
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  • Phase I Dose-Finding Study of OPB-111077, a Novel STAT3 Inhibitor, in Patients with Advanced Hepatocellular Carcinoma
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  • Incidence and Overall Survival of Biliary Tract Cancers in South Korea from 2006 to 2015: Using the National Health Information Database
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  • A retrospective feasibility study of biweekly docetaxel in patients with high-risk metastatic castration-naïve prostate cancer
    Sang Eun Yoon, Youjin Kim, Jangho Cho, Minyong Kang, Hyun Hwan Sung, Hwang Gyun Jeon, Byoung Chang Jeong, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee, Han Yong Choi, Su Jin Lee, Se Hoon Park
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  • Integrative cancer treatment may have a survival benefit in patients with lung cancer
    Kyeore Bae, Eunseok Kim, Ji-Sook Kong, Jeehye Kim, So-jung Park, Hyeong joon Jun, Chong-kwan Cho, Mi Kyung Kim, Hwa-Seung Yoo
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  • Clinical Features and Outcomes of Invasive Breast Cancer: Age-Specific Analysis of a Modern Hospital-Based Registry
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  • The Korean–Advance Directive Model and Factors Associated With Its Completion Among Patients With Hematologic Disorders
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    Jieun Jang, Eun-Jung Cho, Yunji Hwang, Elisabete Weiderpass, Choonghyun Ahn, Jeoungbin Choi, Soung-Hoon Chang, Hai-Rim Shin, Min Kyung Lim, Keun-Young Yoo, Sue K. Park
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  • Clinical and Genetic Characteristics of BRCA1/2 Mutation in Korean Ovarian Cancer Patients: A Multicenter Study and Literature Review
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  • The Health Burden of Cancer Attributable to Obesity in Korea: A Population-Based Cohort Study
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    Kyong-Ah Yoon, Sang Myung Woo, Yun-Hee Kim, Sun-Young Kong, Min Kyoung Lee, Sung-Sik Han, Tae Hyun Kim, Woo Jin Lee, Sang-Jae Park
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  • Effect of Different Types of Mammography Equipment on Screening Outcomes: A Report by the Alliance for Breast Cancer Screening in Korea
    Bo Hwa Choi, Eun Hye Lee, Jae Kwan Jun, Keum Won Kim, Young Mi Park, Hye-Won Kim, You Me Kim, Dong Rock Shin, Hyo Soon Lim, Jeong Seon Park, Hye Jung Kim
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  • Amenorrhea and Menopause in Patients with Breast Cancer after Chemotherapy
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  • Psychometric Evaluation of a Korean Version of the Cancer Survivors' Self-efficacy Scale
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  • Do disinfection byproducts in drinking water have an effect on human cancer risk worldwide? A meta‐analysis
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    Hyun-Suk Jang, Jong-Han Leem, Seong Soo Jeon, Shin-Goo Park, Sangyoon Lee, Yangwon Kang, Go Choi, Hyung Doo Kim, Hyeonwoo Ju, Sung Wook Jang, Youna Won, Hwan-Cheol Kim
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  • Clinical outcomes of early gastric cancer with non-curative resection after pathological evaluation based on the expanded criteria
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  • A psychological intervention programme for patients with breast cancer under chemotherapy and at a high risk of depression: A randomised clinical trial
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  • Necessity of D2 lymph node dissection in older patients ≥ 80 years with gastric cancer
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  • Mapping patterns of locoregional recurrence following contemporary treatment with radiation therapy for breast cancer: A multi-institutional validation study of the ESTRO consensus guideline on clinical target volume
    Jee Suk Chang, Jeongshim Lee, Mison Chun, Kyung Hwan Shin, Won Park, Jong Hoon Lee, Jin Hee Kim, Won Sup Yoon, Ik Jae Lee, Juree Kim, Hye Li Park, Yong Bae Kim
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  • Prevalence of human papillomavirus genotypes and precancerous cervical lesions in a screening population in the Republic of Korea, 2014–2016
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  • Changes in Clinical Characteristics of Patients with an Initial Diagnosis of Prostate Cancer in Korea: 10-Year Trends Reported by a Tertiary Center
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    Hyeong Su Kim, Min-Hee Ryu, Dae Young Zang, Sook Ryun Park, Boram Han, Won Ki Kang, Sun Young Rha, Minkyu Jung, Jin-Soo Kim, Byung Woog Kang, Kyung-Hee Lee, Sang-Young Rho, Jung Han Kim, Kab Choong Kim, Ji Woong Cho, Dae Ro Choi, Hyun Lim, Ho Suk Kang, Ja
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  • Analysis of Motion-dependent Clinical Outcome of Tumor Tracking Stereotactic Body Radiotherapy for Prostate Cancer
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  • The Correlation Between Serum Chemokines and Clinical Outcome in Patients with Advanced Biliary Tract Cancer
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  • Forty‐nine gastric cancer cell lines with integrative genomic profiling for development of c‐MET inhibitor
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Original Articles
Lung Cancer Epidemiology in Korea
Aesun Shin, Chang-Mo Oh, Byung-Woo Kim, Hyeongtaek Woo, Young-Joo Won, Jin-Soo Lee
Cancer Res Treat. 2017;49(3):616-626.   Published online September 23, 2016
DOI: https://doi.org/10.4143/crt.2016.178
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
The current study was undertaken to examine the trends in the lung cancer incidence, mortality, and survival after a diagnosis in Korea.
Materials and Methods
Lung cancer incidence data according to the histologic type and mortality data were obtained from the Korea Central Cancer Registry and the Statistics Korea, respectively. The age-standardized incidence and mortality rates were calculated, and the Joinpoint model and age-period-cohort analyses were used to describe the trends in the rates. The 5-year relative survival rates of lung cancer were also calculated.
Results
Although the number of new lung cancer cases increased between 1999 and 2012, the age-standardized incidence rate decreased by 0.9% per year in men, whereas the incidence in women increased by 1.7% per year over the same time. Until 2010, the most common histologic type in men was squamous cell carcinoma, then adenocarcinoma prevailed thereafter. Since 1999, the most frequent histological type in women was adenocarcinoma. The lung cancer mortality started to decrease in 2002, with a more apparent decline for the younger age groups in both men and women. Overall, the 5-year relative survival rates have improved significantly from 11.2% for men and 14.7% for women among patients diagnosed between 1993 and 1997 to 19.3% for men and 28.2% for women among patients diagnosed between 2008 and 2012, respectively. An improvement in survival rate was observed for all major histology groups.
Conclusion
The epidemiology of lung cancer in Korea has changed over a short time span, with decreasing mortality and improving survival rates. Further study is warranted to determine the cause of these changes.

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Current Trends in the Incidence and Survival Rate of Urological Cancers in Korea
Jae Young Joung, Jiwon Lim, Chang-Mo Oh, Kyu-Won Jung, Hyunsoon Cho, Sung Han Kim, Ho Kyung Seo, Weon Seo Park, Jinsoo Chung, Kang Hyun Lee, Young-Joo Won
Cancer Res Treat. 2017;49(3):607-615.   Published online September 23, 2016
DOI: https://doi.org/10.4143/crt.2016.139
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
This descriptive study assessed the current trends in the incidence of urological cancers and patient survival in Korea.
Materials and Methods
In this nationwide retrospective observational study based on the data from the Korea National Cancer Incidence Database (KNCIDB), this study analyzed the age-standardized incidence rates (ASRs) and annual percentage changes (APCs) of kidney, bladder, prostate, testicular, and penile cancers as well as cancer of the renal pelvis and ureter between 1999 and 2012. The relative survival rates (RSRs) were calculated for urological cancer patients diagnosed between 1993 and 2012 from the KNCIDB data.
Results
Prostate cancer was diagnosed in 66,812 individuals followed by bladder (41,549) and kidney (36,836) cancers. The overall ASR (18.26 per 100,000) increased with age because of the higher ASRs of bladder and prostate cancers in the elderly. The ASR for kidney cancer was highest in the 40-59-year-old group, whereas testicular cancer occurred most frequently before the age of 40. The incidence of most urological cancers increased (overall APC, 6.39%; p < 0.001), except for penile (APC, –2.01%; p=0.05) and bladder (APC, –0.40%; p=0.25) cancers. The overall survival increased steadily (5-year RSR, 66.4% in 1993-1995 vs. 84.2% in 2008-2012; p < 0.001), particularly for prostate (by 34.10%) and kidney (by 16.30%) cancers, but not for renal pelvis and ureter cancers (–7.20%).
Conclusion
The most common urological cancer in Korea was prostate cancer followed by bladder and kidney cancers. The incidence of most urological cancers, except for penile and bladder cancers, increased. Survival also increased, particularly for prostate and kidney cancers.

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Trends and Age-Period-Cohort Effects on the Incidence and Mortality Rate of Cervical Cancer in Korea
Eun-Kyeong Moon, Chang-Mo Oh, Young-Joo Won, Jong-Keun Lee, Kyu-Won Jung, Hyunsoon Cho, Jae Kwan Jun, Myong Cheol Lim, Moran Ki
Cancer Res Treat. 2017;49(2):526-533.   Published online September 1, 2016
DOI: https://doi.org/10.4143/crt.2016.316
AbstractAbstract PDFPubReaderePub
Purpose
This study was conducted to describe the trends and age-period-cohort effects on the incidence and mortality rate of cervical cancer in Korea.
Materials and Methods
The incidence and mortality rate of cervical cancer among ≥ 20-year-old women from 1993 to 2012 were obtained from the Korea Central Cancer Registry and the Korean Statistical Information Service. Age-standardized rates were calculated and Joinpoint regression was used to evaluate the trends in the incidence and mortality rate. Age-period-cohort analysis was performed to investigate the independent effects of age, period and cohort.
Results
The incidence of cervical cancer decreased from 32.8 per 100,000 in 1993 to 15.9 per 100,000 in 2012 (annual percent change [APC], –3.9%; 95% confidence interval [CI], –4.2% to –3.6%). The mortality rate decreased from 5.2 per 100,000 in 1993 to 2.1 per 100,000 in 2012 (APC, –4.8%; 95% CI, –5.1% to –4.4%); however, the incidence and mortality rates among young women (< 30 years old) increased. An age-period-cohort model of the incidence and mortality rate showed decreasing period effects between 1993 and 2008 and decreasing cohort effects between 1928 and 1973, while birth cohorts after 1973 exhibited slight increases in the incidence and mortality rate of cervical cancer.
Conclusion
Recent decreases in the incidence and mortality rate of cervical cancer were due to decreases in the period and cohort effects, which reflect the implementation of a cancer screening program and changes in lifestyle. However, our findings also highlighted an increase in cohort effects on the incidence and mortality rate among young women born after 1973.

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Nationwide Population-Based Incidence and Survival Rates of Malignant Central Nervous System Germ Cell Tumors in Korea, 2005-2012
Seung Hoon Lee, Kyu-Won Jung, Johyun Ha, Chang-Mo Oh, Hyeseon Kim, Hyeon Jin Park, Heon Yoo, Young-Joo Won
Cancer Res Treat. 2017;49(2):494-501.   Published online August 24, 2016
DOI: https://doi.org/10.4143/crt.2016.129
AbstractAbstract PDFPubReaderePub
Purpose
Malignant central nervous system (CNS) germ cell tumors (GCTs), although rare, are thought to occur more frequently among Asians. However, a recent population-based study revealed no differences in GCT incidence between Asians and Caucasians. Therefore, this study was conducted to determine the incidence and survival rates of CNS GCTs using the national cancer incidence database, and to compare these rates to those in the United States and Japan.
Materials and Methods
We extracted CNS GCT patients diagnosed between 2005 and 2012 from the Korea Central Cancer Registry database. Age-standardized rates (ASRs), annual percentage change, and the male-female incidence rate ratios (IRRs) were calculated. To estimate the survival rate, we used data for patients diagnosed between 2005 and 2010 and followed their cases until December 31, 2013.
Results
The ASR for CNS GCT between 2005 and 2012 was 0.179 per 100,000 (95% confidence interval, 0.166 to 0.193), with an overall male-to-female (M:F) IRR of 2.95:1. However, when stratified by site, the M:F IRR was 13.62:1 for tumors of the pineal region and 1.87:1 for those located in nonpineal regions. The most frequent histologic type was germinoma (76.0%), and the most frequent location was the suprasellar region (48.5%). The 5-year survival rate of germinoma patients was 95.3%.
Conclusion
The incidence rate of CNS GCTs in Korea during 2005-2012 was 0.179 per 100,000, which was similar to that of the Asian/Pacific Islander subpopulation in the United States. Moreover, the CNS GCT survival rate in Korea was similar to rates in Japan and the United States.

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Special Articles
Prediction of Cancer Incidence and Mortality in Korea, 2016
Kyu-Won Jung, Young-Joo Won, Chang-Mo Oh, Hyun-Joo Kong, Hyunsoon Cho, Jong-Keun Lee, Duk Hyoung Lee, Kang Hyun Lee
Cancer Res Treat. 2016;48(2):451-457.   Published online March 25, 2016
DOI: https://doi.org/10.4143/crt.2016.092
AbstractAbstract PDFPubReaderePub
Purpose
To estimate of Korea’s current cancer burden, this study aimed to report on projected cancer incidence and mortality rates for the year 2016.
Materials and Methods
Cancer incidence data from 1999 to 2013 were obtained from the Korea National Cancer Incidence Database, and cancer mortality data from 1993 to 2014 were acquired from Statistics Korea. Cancer incidence in 2016 was projected by fitting a linear regression model to observed age-specific cancer incidence rates against observed years, then multiplying the projected age-specific rates by the age-specific population. The Joinpoint regression model was used to determine at which year the linear trend changed significantly.
Results
A total of 254,962 new cancer cases and 75,172 cancer deaths are expected to occur in Korea in 2016. The five leading primary cancer incident sites in 2016 were estimated colorectal, stomach, lung, liver and thyroid cancer in men; thyroid, breast, colorectal, stomach, and lung cancer in women.
Conclusion
Currently cancer is one of the foremost public health concerns in Korea. Although cancer rates are anticipated to decrease the nation’s cancer burden will continue to increase as the population ages.

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Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2013
Chang-Mo Oh, Young-Joo Won, Kyu-Won Jung, Hyun-Joo Kong, Hyunsoon Cho, Jong-Keun Lee, Duk Hyoung Lee, Kang Hyun Lee, The Community of Population-Based Regional Cancer Registries
Cancer Res Treat. 2016;48(2):436-450.   Published online March 3, 2016
DOI: https://doi.org/10.4143/crt.2016.089
AbstractAbstract PDFPubReaderePub
Purpose
This study described the 2013 nationwide cancer statistics in Korea, including cancer incidence, survival, prevalence, and mortality.
Materials and Methods
Cancer incidence data from 1999-2013 were obtained from Korea National Cancer Incidence Database and followed until December 31, 2014. Mortality data from 1983-2013 were obtained from Statistics Korea. The prevalence was defined as the number of cancer patients alive on January 1, 2014 among all cancer patients diagnosed since 1999. Crude, and age-standardized and 5-year relative survival rates were also calculated.
Results
In 2013, a total of 225,343 and 75,334 Koreans were newly diagnosed and died from cancer, respectively. The age-standardized rates for cancer incidence and mortality in 2013 were 290.5 and 87.9 per 100,000, respectively. The age-standardized cancer incidence rate increased 3.1% annually between 1999 and 2013. However, the overall cancer incidence rates have decreased slightly in recent years (2011 to 2013). The age-standardized rate for all-cancer mortality has decreased 2.7% annually since 2002. Overall, the 5-year relative survival rate for people diagnosed with cancer between 2009 and 2013 was 69.4%, which represents an improved survival rate as compared with 41.2% for people diagnosed between 1993 and 1995.
Conclusion
Age-standardized cancer incidence rates have decreased between 2011 and 2013; mortality rates have also declined since 2002, while 5-year survival rates have improved remarkably from 1993-1995 to 2009-2013 in Korea.

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Original Article
Incidence and Survival of Childhood Cancer in Korea
Hyeon Jin Park, Eun-Kyeong Moon, Ju Young Yoon, Chang-Mo Oh, Kyu-Won Jung, Byung Kiu Park, Hee Young Shin, Young-Joo Won
Cancer Res Treat. 2016;48(3):869-882.   Published online January 21, 2016
DOI: https://doi.org/10.4143/crt.2015.290
AbstractAbstract PDFPubReaderePub
Purpose
An epidemiologic study of childhood cancer would provide useful information on cancer etiology and development of management guidelines.
Materials and Methods
Data from the Korea National Cancer Incidence Database were used to examine the incidence and survival of cancer in patients aged 0-14 years. Patients were grouped according to the International Classification of Childhood Cancer, 3rd edition. Age-specific and age-standardized incidences per million and estimated annual percentage change (APC) were calculated by sex and age. Five-year relative survival was calculated for four periods from 1993 to 2011.
Results
The study comprised 15,113 patients with malignant neoplasms. Age-standardized incidence rates for all cancers were 134.9 per million children in 1999-2011 and 144.0 and 124.9 per million for males and females, respectively (M/F ratio, 1.2; p < 0.05). The highest incidences were observed for ‘leukemias, myeloproliferative diseases, and myelodysplastic diseases’ (group I) (46.4), ‘central nervous system neoplasms’ (group III) (18.3), and ‘lymphomas and reticuloendothelial neoplasms’ (group II) (13.4). Age-standardized incidence increased from 117.9 in 1999 to 155.3 in 2011, with an APC of 2.4% (95% confidence interval, 2.1 to 2.7). There was a significant increase of APC in ‘neuroblastoma and other peripheral nervous cell tumors’ (group IV) (5.6%) and ‘other malignant epithelial neoplasms and malignant melanomas’ (group XI) (5.6%). The 5-year relative survival rate for all childhood cancers improved significantly from 56.2% (1993-1995) to 78.2% (2007-2011) (males, 56.7% to 77.7%; females, 55.5% to 78.8%).
Conclusion
This study provides reliable information on incidence and survival trends for childhood cancer in Korea.

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Special Articles
Prediction of Cancer Incidence and Mortality in Korea, 2015
Kyu-Won Jung, Young-Joo Won, Chang-Mo Oh, Hyun-Joo Kong, Hyunsoon Cho, Duk Hyoung Lee, Kang Hyun Lee
Cancer Res Treat. 2015;47(2):142-148.   Published online March 17, 2015
DOI: https://doi.org/10.4143/crt.2015.066
AbstractAbstract PDFPubReaderePub
Purpose
For estimation of Korea’s current cancer burden, this study aimed to report on the projected cancer incidence and mortality rates for the year 2015. Materials and Methods Cancer incidence data from 1999 to 2012 were obtained from the Korea National Cancer Incidence Database, and cancer mortality data from 1993 to 2013 were acquired from Statistics Korea. The cancer incidence in 2015 was projected by fitting a linear regression model to the observed age-specific cancer incidence rates against the observed years and then multiplying the projected age-specific rates by the age-specific population. A similar procedure was used for cancer mortality, except a Joinpoint regression model was used to determine at which year the linear trend changed significantly.
Results
A total of 280,556 new cancer cases and 76,698 cancer deaths are expected to occur in Korea in 2015. The crude incidence rate per 100,000 of all sites combined will likely reach 551.6 and the age-standardized incidence rate, 347.6. The estimated five leading primary cancer incidence sites are the stomach, colorectum, lung, prostate, and liver in men; and thyroid, breast, colorectum, stomach, and lung in women. The projected crude mortality rate of all sites combined and age-standardized rate is 150.8 and 82.4, respectively. Conclusion Cancer is currently one of the foremost public health concerns in Korea, and as the population ages, the nation’s cancer burden will continue to increase.

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Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2012
Kyu-Won Jung, Young-Joo Won, Hyun-Joo Kong, Chang-Mo Oh, Hyunsoon Cho, Duk Hyoung Lee, Kang Hyun Lee
Cancer Res Treat. 2015;47(2):127-141.   Published online March 3, 2015
DOI: https://doi.org/10.4143/crt.2015.060
AbstractAbstract PDFPubReaderePub
Purpose
The aim of this study was to report nationwide cancer statistics in Korea, including incidence, mortality, survival, and prevalence, and their trends. Materials and Methods Incidence data from 1993 to 2012 were obtained from the Korea National Cancer Incidence Database, and vital status was followed through December 31, 2013. Mortality data from 1983 to 2012 were obtained from Statistics Korea. Crude and age-standardized rates for incidence, mortality, and prevalence, and relative survival were calculated. Results A total of 224,177 cancer cases and 73,759 cancer deaths were reported in 2012, and there were 1,234,879 prevalent cases identified in Korea as of January 1, 2013. Over the past 14 years (1999-2012), overall incidence rates have increased by 3.3% per year. The incidence rates of liver and cervical cancers have decreased, while those of thyroid, breast, prostate, and colorectal cancers have increased. Notably, incidence of thyroid cancer increased by 22.3% per year in both sexes and has been the most common cancer since 2009. The mortality for all cancers combined decreased by 2.7% per year from 2002 to 2012. Five-year relative survival rates of patients diagnosed in the last 5 years (2008-2012) have improved by 26.9% compared with those from 1993 to1995. Conclusion Overall cancer mortality rates have declined since 2002 in Korea, while incidence has increased and survival has improved.

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  • Association between Metformin Use and Survival in Nonmetastatic Rectal Cancer Treated with a Curative Resection: A Nationwide Population Study
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  • A randomized, multicenter, phase III study of gemcitabine combined with capecitabine versus gemcitabine alone as first-line chemotherapy for advanced pancreatic cancer in South Korea
    Hee Seung Lee, Moon Jae Chung, Jeong Youp Park, Seungmin Bang, Seung Woo Park, Ho Gak Kim, Myung Hwan Noh, Sang Hyub Lee, Yong-Tae Kim, Hyo Jung Kim, Chang Duck Kim, Dong Ki Lee, Kwang Bum Cho, Chang Min Cho, Jong Ho Moon, Dong Uk Kim, Dae Hwan Kang, Youn
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  • Predicting biochemical recurrence in patients with high-risk prostate cancer using the apparent diffusion coefficient of magnetic resonance imaging
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  • Salvage therapy for acute chemorefractory leukemia by allogeneic stem cell transplantation: the Korean experience
    Shin Hye Yoo, Youngil Koh, Dae-Young Kim, Jung-Hee Lee, Je-Hwan Lee, Kyoo-Hyung Lee, Sung-Soo Yoon, Seonyang Park, Sung-Kyu Park, Dae-Sik Hong, Hyeon Gyu Yi, Chul-Soo Kim, Ji Eun Jang, June-Won Cheong, Joonho Moon, Yoo Hong Min, Sang Kyun Sohn, Inho Kim
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  • Prevalence of and Factors Associated with Sarcopenia in Korean Cancer Survivors: Based on Data Obtained by the Korea National Health and Nutrition Examination Survey (KNHANES) 2008–2011
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  • HER2 Amplification and Cetuximab Efficacy in Patients With Metastatic Colorectal Cancer Harboring Wild-type RAS and BRAF
    Jae Ho Jeong, Jihun Kim, Yong Sang Hong, Dalyong Kim, Jeong Eun Kim, Sun Young Kim, Kyu-pyo Kim, Young-Kwang Yoon, Deokhoon Kim, Sung-Min Chun, Yangsoon Park, Se Jin Jang, Tae Won Kim
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  • Is Male Gender a Prognostic Factor for Papillary Thyroid Microcarcinoma?
    Yi Ho Lee, Yu Mi Lee, Tae Yon Sung, Jong Ho Yoon, Dong Eun Song, Tae Yong Kim, Jung Hwan Baek, Jin Suk Ryu, Ki Wook Chung, Suck Joon Hong
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  • Proportion and clinical features of never-smokers with non-small cell lung cancer
    Jaeyoung Cho, Sun Mi Choi, Jinwoo Lee, Chang-Hoon Lee, Sang-Min Lee, Dong-Wan Kim, Jae-Joon Yim, Young Tae Kim, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Young Sik Park
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  • Preoperative Predictive Factors for Complete Cytoreduction and Survival Outcome in Epithelial Ovarian, Tubal, and Peritoneal Cancer After Neoadjuvant Chemotherapy
    Min-Hyun Baek, Shin-Wha Lee, Jeong-Yeol Park, Chae Chun Rhim, Dae-Yeon Kim, Dae-Shik Suh, Jong-Hyeok Kim, Yong-Man Kim, Young-Tak Kim, Joo-Hyun Nam
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  • Identification of major dietary patterns in Korean adults and their association with cancer risk in the Cancer Screening Examination Cohort
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    European Journal of Gastroenterology & Hepatology.2017; 29(4): 407.     CrossRef
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  • Computational Modeling of complete HOXB13 protein for predicting the functional effect of SNPs and the associated role in hereditary prostate cancer
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    Myong Cheol Lim, Maria Lee, Seung Hyuk Shim, Eun Ji Nam, Jung Yun Lee, Hyun Jung Kim, Yoo-Young Lee, Kwang Beom Lee, Jeong Yeol Park, Yun Hwan Kim, Kyung Do Ki, Yong Jung Song, Hyun Hoon Chung, Sunghoon Kim, Jeong-won Lee, Jae-Weon Kim, Duk-Soo Bae, Jong-
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    Do-Hoon Kim, Hyojin Chae, Irene Jo, Jaeeun Yoo, Hyeyoung Lee, Woori Jang, Joonhong Park, Gun Dong Lee, Dong-Seok Jeon, Keun Ho Lee, Soo Young Hur, Byung Joo Chae, Byung Joo Song, Myungshin Kim, Yonggoo Kim
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  • Effectiveness of the Korean National Cancer Screening Program in Reducing Gastric Cancer Mortality
    Jae Kwan Jun, Kui Son Choi, Hoo-Yeon Lee, Mina Suh, Boyoung Park, Seung Hoon Song, Kyu Won Jung, Chan Wha Lee, Il Ju Choi, Eun-Cheol Park, Dukhyoung Lee
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  • Increased breast cancer mortality only in the lower education group: age-period-cohort effect in breast cancer mortality by educational level in South Korea, 1983-2012
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  • Differences in the survival rates of older patients with colorectal cancers in 2003 and 2009
    Je-Wook Shin, Byung Kwan Park, Min Jung Kim, Bun Kim, Byung Chang Kim, Sung Chan Park, Kyung Su Han, Dae Kyung Sohn, Jae Hwan Oh
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  • Common Causes of Postmenopausal Bleeding in Korean Women: 10-Year Outcomes from a Single Medical Center
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  • Nationwide Population-Based Incidence and Survival Rates of Malignant Central Nervous System Germ Cell Tumors in Korea, 2005-2012
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  • Phase II Study of Irinotecan and Cisplatin Combination Chemotherapy in Metastatic, Unresectable Esophageal Cancer
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  • Current Trends of Lung Cancer Surgery and Demographic and Social Factors Related to Changes in the Trends of Lung Cancer Surgery: An Analysis of the National Database from 2010 to 2014
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    Mi-Ju Kim, Min-Sun Kim, Sung Joo Kim, Soyeon An, Jin Park, Hosub Park, Jae Hoon Lee, Ki-Byung Song, Dae Wook Hwang, Suhwan Chang, Kyu-pyo Kim, Seong-Yun Jeong, Song Cheol Kim, Seung-Mo Hong
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  • Inhibitory Effect of D-chiro-inositol on Both Growth and Recurrence of Breast Tumor from MDA-MB-231 Cancer Cells
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  • Mammea longifolia Planch. and Triana Fruit Extract Induces Cell Death in the Human Colon Cancer Cell Line, SW480, via Mitochondria-Related Apoptosis and Activation of p53
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  • Liquiritin (LT) exhibits suppressive effects against the growth of human cervical cancer cells through activating Caspase-3 in vitro and xenograft mice in vivo
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  • Measurement of Radon Concentration in Selected Houses in Ibadan, Nigeria
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  • Risk factors associated with treatment refusal in lung cancer
    Won Na Suh, Kyoung Ae Kong, Yeji Han, Soo Jung Kim, Su Hwan Lee, Yon Ju Ryu, Jin Hwa Lee, Sung Shine Shim, Yookyung Kim, Jung Hyun Chang
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  • Epigenetic suppression of the anti-aging geneKLOTHOin human prostate cancer cell lines
    Minkyu Seo, Min Su Kim, Ara Jang, Hyun Joo Chung, Yoohun Noh, Do-Hee Kim, Jaehyouk Lee, Kisung Ko, Soon Chul Myung
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  • The Impact of Thyroid Nodule Size and Fine-Needle Aspiration Biopsy Result on the Risk of Malignancy in the Patients Who Underwent Thyroidectomy
    Hwibin Im, Yu-Young Park, Jae-Gu Cho, Seung-Kuk Baek, Soon-Young Kwon, Kwang-Yoon Jung, Jeong-Soo Woo
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  • The association between physical activity and health-related quality of life among breast cancer survivors
    Woo-kyoung Shin, Sihan Song, So-Youn Jung, Eunsook Lee, Zisun Kim, Hyeong-Gon Moon, Dong-Young Noh, Jung Eun Lee
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    Young Duck Shin, Seung-Myoung Son, Young Jin Song, Sung-Su Park, Young Jin Choi
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  • Induction Chemotherapy with Gemcitabine and Cisplatin Followed by Simultaneous Integrated Boost–Intensity Modulated Radiotherapy with Concurrent Gemcitabine for Locally Advanced Unresectable Pancreatic Cancer: Results from a Feasibility Study
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  • Prognostic value of putative cancer stem cell markers (CD24, CD44, CD133, and ALDH1) in human papillary thyroid carcinoma
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  • Post hoc analyses of East Asian patients from the randomized placebo-controlled PREVAIL trial of enzalutamide in patients with chemotherapy-naïve, metastatic castration-resistant prostate cancer
    Choung Soo Kim, Young Deuk Choi, Sang Eun Lee, Hyun Moo Lee, Takeshi Ueda, Junji Yonese, Takashi Fukagai, Edmund Chiong, Weber Lau, Sarang Abhyankar, Ad Theeuwes, Bertrand Tombal, Tomasz M. Beer, Go Kimura
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  • Will a Fibrin Sealant be Effective as a Seroma Reductant and a Hemostatic Agent in Breast Reconstruction Using a Latissimus Dorsi Flap?
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  • Current Trends in the Incidence and Survival Rate of Urological Cancers in Korea
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  • Clinically Significant Unclassified Variants in BRCA1 and BRCA2 Genes among Korean Breast Cancer Patients
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  • Trends in Participation Rates for the National Cancer Screening Program in Korea, 2002-2012
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  • Why Do Some People Choose Opportunistic Rather Than Organized Cancer Screening? The Korean National Health and Nutrition Examination Survey (KNHANES) 2010-2012
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  • A Multicenter Randomized Phase II Study of Docetaxel vs. Docetaxel Plus Cisplatin vs. Docetaxel Plus S-1 as Second-Line Chemotherapy in Metastatic Gastric Cancer Patients Who Had Progressed after Cisplatin Plus Either S-1 or Capecitabine
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  • Lung Cancer Epidemiology in Korea
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  • Real-World Treatment Patterns among Patients with Advanced Gastric Cancer in South Korea
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  • Development of a Community-Based Palliative Care Model for Advance Cancer Patients in Public Health Centers in Busan, Korea
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  • Estimating utility weights and quality-adjusted life year loss for colorectal cancer-related health states in Korea
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  • Mortality differences by surgical volume among patients with stomach cancer: a threshold for a favorable volume-outcome relationship
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    Ji Young Chang, Ki-Nam Shim, Chung Hyun Tae, Ko Eun Lee, Jihyun Lee, Kang Hoon Lee, Chang Mo Moon, Seong-Eun Kim, Hye-Kyung Jung, Sung-Ae Jung, Joo-Ho Lee, Min-Sun Cho
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  • Metastatic Squamous Cell Carcinoma from Lung Adenocarcinoma after Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy
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  • Correlation Between Bowel Preparation and the Adenoma Detection Rate in Screening Colonoscopy
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  • Atypical squamous cells of undetermined significance and low-grade squamous intraepithelial lesion triage in Korean women: Revisiting the 2012 American Society of Colposcopy and Cervical Pathology screening guidelines
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  • A Systematic Review of Interventions with Siblings of Pediatric Cancer Patients
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  • Is MRI of the Liver Needed During Routine Preoperative Workup for Colorectal Cancer?
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  • Effects of sorghum ethyl-acetate extract on PC3M prostate cancer cell tumorigenicity
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  • A retrospective feasibility study of biweekly, reduced-dose docetaxel in Asian patients with castrate-resistant, metastatic prostate cancer
    Hae Su Kim, Ji Yun Lee, Su Jin Lee, Ho Yeong Lim, Hyun Hwan Sung, Hwang Gyun Jeon, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee, Han-Yong Choi, Se Hoon Park
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  • Different features of the histopathological subtypes of ovarian tumors in pre- and postmenopausal women
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  • Luteolin-induced apoptosis through activation of endoplasmic reticulum stress sensors in pheochromocytoma cells
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    Minsun Shim, Yong-Chan Kim, Su Yeon Kye, Keeho Park
    Journal of Korean Medical Science.2016; 31(8): 1231.     CrossRef
  • Performance of Screening Mammography: A Report of the Alliance for Breast Cancer Screening in Korea
    Eun Hye Lee, Keum Won Kim, Young Joong Kim, Dong-Rock Shin, Young Mi Park, Hyo Soon Lim, Jeong Seon Park, Hye-Won Kim, You Me Kim, Hye Jung Kim, Jae Kwan Jun
    Korean Journal of Radiology.2016; 17(4): 489.     CrossRef
  • Identification of an N staging system that predicts oncologic outcome in resected left-sided pancreatic cancer
    Sung Hyun Kim, Ho Kyoung Hwang, Woo Jung Lee, Chang Moo Kang
    Medicine.2016; 95(26): e4035.     CrossRef
  • Association between obesity and local control of advanced rectal cancer after combined surgery and radiotherapy
    Yunseon Choi, Yun-Han Lee, Sung Kwang Park, Heunglae Cho, Ki Jung Ahn
    Radiation Oncology Journal.2016; 34(2): 113.     CrossRef
  • The clinical utilization of radiation therapy in Korea between 2009 and 2013
    Jin-Kyu Kang, Mi-Sook Kim, Won-Il Jang, Young Seok Seo, Hee Jin Kim, Chul Koo Cho, Hyung Jun Yoo, Eun Kyung Paik, Yu Jin Cha, Hyun Jin Song
    Radiation Oncology Journal.2016; 34(2): 88.     CrossRef
  • Relationship between Salt Preference and Gastric Cancer Screening: An Analysis of a Nationwide Survey in Korea
    Ji-Yeon Shin, Jeongseon Kim, Kui Son Choi, Mina Suh, Boyoung Park, Jae Kwan Jun
    Cancer Research and Treatment.2016; 48(3): 1037.     CrossRef
  • Changing Patterns of Primary Treatment in Korean Men with Prostate Cancer Over 10 Years: A Nationwide Population Based Study
    Jinsung Park, Beomseok Suh, Dong Wook Shin, Jun Hyuk Hong, Hanjong Ahn
    Cancer Research and Treatment.2016; 48(3): 899.     CrossRef
  • Effects of hand grip strength on shoulder muscle activity in breast cancer patients
    Tae-Won Yun, Byoung-Hee Lee
    Physical Therapy Rehabilitation Science.2016; 5(2): 95.     CrossRef
  • The Structural Equation Model on Resilience of Breast Cancer Patients Receiving Chemotherapy
    Jeong Ha Yang, Ok Soo Kim
    Journal of Korean Academy of Nursing.2016; 46(3): 327.     CrossRef
  • Gastric Cancer with Peritoneal Tuberculosis: Challenges in Diagnosis and Treatment
    Amer Saeed Alshahrani, In Seob Lee
    Journal of Gastric Cancer.2016; 16(2): 111.     CrossRef
  • Is there a difference in clinicopathological outcomes of renal tumor between young and old patients? A multicenter matched-pair analysis
    Jeong Ho Kim, Yong Hyun Park, Yong June Kim, Seok Ho Kang, Seok Soo Byun, Sung-Hoo Hong
    Scandinavian Journal of Urology.2016; 50(5): 387.     CrossRef
  • Doctors' Ageism towards the Elderly Cancer Patients: Focusing on Disclosure of Cancer Diagnosis and Explanation on Treatment
    Yeonok Lim, Dae Young Zang, Dae Ro Choi, Seok Yun Kang, Young Suk Park, Hyunsook Yoon, Hyunjoo Lee, Yojin Kim, Ilsung Nam, Kyoungwon Choi
    Korean Journal of Health Promotion.2016; 16(2): 101.     CrossRef
  • The Effect of A Salivation Stimulation Method on Xerostomia in Colon Cancer Patients after Surgery
    Anna Kim, Jeong Sook Park
    Asian Oncology Nursing.2016; 16(2): 75.     CrossRef
  • Quality of life changes during adjuvant chemotherapy in patients with colon cancer
    Seo Hee Lee, Taek-Gu Lee, Moo Jun Baek, Jang Jin Kim, Sung-Su Park, Sang-Jeon Lee
    Korean Journal of Clinical Oncology.2016; 12(1): 60.     CrossRef
  • Preventive effect of fermented red ginseng on cisplatin-induced nephrotoxicity mouse
    Ja-Kyoung Hyun, O Jun Kwon, Joo Young Lee, Seong-Soo Roh, Young-Bae Seo
    Journal of Applied Biological Chemistry.2016; 59(2): 113.     CrossRef
  • Prostate‐specific antigen kinetics following hypofractionated stereotactic body radiotherapy versus conventionally fractionated external beam radiotherapy for low‐ and intermediate‐risk prostate cancer
    Seok Ho Lee, Hun Jung Kim, Woo Chul Kim
    Asia-Pacific Journal of Clinical Oncology.2016; 12(4): 388.     CrossRef
  • Sex Disparity in Gastric Cancer: Female Sex is a Poor Prognostic Factor for Advanced Gastric Cancer
    Hae Won Kim, Jie-Hyun Kim, Beom Jin Lim, HyunKi Kim, Hoguen Kim, Jae Jun Park, Young Hoon Youn, Hyojin Park, Sung Hoon Noh, Jong Won Kim, Seung Ho Choi
    Annals of Surgical Oncology.2016; 23(13): 4344.     CrossRef
  • Resection of Diminutive and Small Colorectal Polyps: What Is the Optimal Technique?
    Jun Lee
    Clinical Endoscopy.2016; 49(4): 355.     CrossRef
  • The Role of Laparoscopic Radical Hysterectomy in Early-Stage Adenocarcinoma of the Uterine Cervix
    Jeong-Yeol Park, Daeyeon Kim, Dae-Shik Suh, Jong-Hyeok Kim, Yong-Man Kim, Young-Tak Kim, Joo-Hyun Nam
    Annals of Surgical Oncology.2016; 23(S5): 825.     CrossRef
  • Clinical characteristics and potential aetiologies of non‐B non‐C hepatocellular carcinoma in hepatitis B virus endemic area
    Seung Bum Lee, Kang Mo Kim, Jihyun An, Danbi Lee, Ju Hyun Shim, Young‐Suk Lim, Han Chu Lee, Young‐Hwa Chung, Yung Sang Lee
    Liver International.2016; 36(9): 1351.     CrossRef
  • Association of human papillomavirus type 16 and its genetic variants with cervical lesion in Korea
    Jeong Su Park, Sue Shin, Eui‐Chong Kim, Ji Eun Kim, Yong Beom Kim, Sohee Oh, Eun Youn Roh, Jong Hyun Yoon
    APMIS.2016; 124(11): 950.     CrossRef
  • Bowel Preparation Formulations and Salvage Options for Inadequate Preparation
    Jun Lee
    The Korean Journal of Gastroenterology.2016; 68(2): 61.     CrossRef
  • Gallstones and the Risk of Gallbladder Cancer Mortality: A Cohort Study
    Seungho Ryu, Yoosoo Chang, Kyung Eun Yun, Hyun-Suk Jung, Jun Ho Shin, Hocheol Shin
    American Journal of Gastroenterology.2016; 111(10): 1476.     CrossRef
  • Symptom Severity according to the Presence of Depressive and Anxiety Symptoms among Patients with Head and Neck Cancer
    Hyun-Joo Kim, Ok-Hee Cho, Yang-Sook Yoo
    Korean Journal of Adult Nursing.2016; 28(2): 148.     CrossRef
  • Quantification of epidermal growth factor receptor (EGFR) mutation may be a predictor of EGFR‐tyrosine kinase inhibitor treatment response
    Ha Young Park, Hyung Joo Oh, Ki‐Hyun Kim, Tae‐Ok Kim, Cheol‐Kyu Park, Hong‐Jun Shin, Jung‐Hwan Lim, Yong‐Soo Kwon, In‐Jae Oh, Yu‐Il Kim, Sung‐Chul Lim, Young‐Chul Kim, Yoo‐Duk Choi
    Thoracic Cancer.2016; 7(6): 639.     CrossRef
  • A pilot study of concurrent chemoradiotherapy with gemcitabine and cisplatin in patients with locally advanced biliary tract cancer
    Kyong Joo Lee, Seung Woo Yi, Jihye Cha, Jinsil Seong, Seungmin Bang, Si Young Song, Hee Man Kim, Seung Woo Park
    Cancer Chemotherapy and Pharmacology.2016; 78(4): 841.     CrossRef
  • Recent advances in multiple myeloma: a Korean perspective
    Junshik Hong, Jae Hoon Lee
    The Korean Journal of Internal Medicine.2016; 31(5): 820.     CrossRef
  • The Fruit Hull of Gleditsia sinensis Enhances the Anti‐Tumor Effect of cis‐Diammine Dichloridoplatinum II (Cisplatin)
    Kyun Ha Kim, Chang-Woo Han, Seong Hoon Yoon, Yun Seong Kim, Jong-In Kim, Myungsoo Joo, Jun-Yong Choi, Siyaram Pandey
    Evidence-Based Complementary and Alternative Medicine.2016;[Epub]     CrossRef
  • Surgical and obstetrical outcomes after laparoscopic radical trachelectomy and pelvic lymphadenectomy for early cervical cancer
    So-Eun Yoo, Kyeong A So, Seon-Ah Kim, Mi Kyung Kim, Yoo Kyung Lee, In-Ho Lee, Tae-Jin Kim, Ki Heon Lee
    Obstetrics & Gynecology Science.2016; 59(5): 373.     CrossRef
  • Detecting Asymptomatic Recurrence in Early-Stage Endometrial Cancer
    Jung-Yun Lee, Ji Hee Kim, Jung Won Seo, Hee Seung Kim, Jae-Weon Kim, Noh Hyun Park, Yong-Sang Song
    International Journal of Gynecological Cancer.2016; 26(8): 1434.     CrossRef
  • Preoperative chemoradiotherapy for elderly patients with locally advanced rectal cancer—a real-world outcome study
    Younak Choi, Jee Hyun Kim, Ji-Won Kim, Jin Won Kim, Keun-Wook Lee, Heung-Kwon Oh, Duck-Woo Kim, Sung-Bum Kang, Changhoon Song, Jae-Sung Kim
    Japanese Journal of Clinical Oncology.2016; 46(12): 1108.     CrossRef
  • The number of retrieved lymph nodes needed for accurate staging differs based on the presence of preoperative chemoradiation for rectal cancer
    Jeonghee Han, Gyoung Tae Noh, Shen Ann Yeo, Chinock Cheong, Min Soo Cho, Hyuk Hur, Byung Soh Min, Kang Young Lee, Nam Kyu Kim
    Medicine.2016; 95(38): e4891.     CrossRef
  • Cancer-specific incidence rates of tuberculosis
    Gi Hyeon Seo, Min Jae Kim, Soyoung Seo, Boram Hwang, Eugene Lee, Yujin Yun, Minsun Choi, Moonsuk Kim, Jin Won Kim, Eu Suk Kim, Hong Bin Kim, Kyoung-Ho Song
    Medicine.2016; 95(38): e4919.     CrossRef
  • Dietary Patterns for Women With Triple-negative Breast Cancer and Dense Breasts
    Yukyung Go, Minsung Chung, Yongsoon Park
    Nutrition and Cancer.2016; 68(8): 1281.     CrossRef
  • Cause of Death in Korean Men with Prostate Cancer: an Analysis of Time Trends in a Nationwide Cohort
    Jinsung Park, Beomseok Suh, Dong Wook Shin, Jun Hyuk Hong, Hanjong Ahn
    Journal of Korean Medical Science.2016; 31(11): 1802.     CrossRef
  • Preoperative Body Mass Index May Determine the Prognosis of Advanced Gastric Cancer
    Dong Hwan Jun, Beom Jin Kim, Ji Hoon Park, Jae G. Kim, Kyong-Choun Chi, Joong-Min Park, Mi Kyung Kim, Hyun Kang
    Nutrition and Cancer.2016; 68(8): 1295.     CrossRef
  • Effect of Previous Gastrectomy on the Performance of Postoperative Colonoscopy
    Sunghwan Kim, Jeongmin Choi, Tae Han Kim, Seong-Ho Kong, Yun-Suhk Suh, Jong Pil Im, Hyuk-Joon Lee, Sang Gyun Kim, Seung-Yong Jeong, Joo Sung Kim, Han-Kwang Yang
    Journal of Gastric Cancer.2016; 16(3): 167.     CrossRef
  • Prognostic Factors for Node-Negative Advanced Gastric Cancer after Curative Gastrectomy
    Eun Woo Lee, Woo Yong Lee, Ho-Seok Koo
    Journal of Gastric Cancer.2016; 16(3): 161.     CrossRef
  • Is There a Role for Adjuvant Therapy in R0 Resected Gallbladder Cancer?: A Propensity Score-Matched Analysis
    Se-Il Go, Young Saing Kim, In Gyu Hwang, Eun Young Kim, Sung Yong Oh, Jun Ho Ji, Haa-Na Song, Se Hoon Park, Joon Oh Park, Jung Hun Kang
    Cancer Research and Treatment.2016; 48(4): 1274.     CrossRef
  • Moderating Effects of Optimism and Family Support on the Depression of Family Caregivers of Cancer Patients
    Kyoungwon Choi, Dae Ro Choi, Dae Young Zang, Young Suk Park, Seok Yun Kang, Hyunsook Yoon, Yeon Ok Lim, Yojin Kim, Ilsung Nam, Hyen Joo Lee
    Korean Journal of Health Promotion.2016; 16(3): 192.     CrossRef
  • Effects of a Navigation Program for Patients with Newly Diagnosed Gastric Cancer: A Randomized Controlled Trial
    Yeon Seo Hong, Jeong Yun Park, So Hee Kim, Sun A Kim, Yeon Hee Kim
    Asian Oncology Nursing.2016; 16(3): 132.     CrossRef
  • Analysis of NF-κ B and Clinical Prognostic Factors in Clear Cell Renal Cell Carcinoma
    Young Lee, Jeonghyouk Choi, Dong-Gi Lee, Koo Han Yoo, Gyeong Eun Min, Hyung-Lae Lee, Kyu Yeoun Won, Sung-Jig Lim
    The Korean Journal of Urological Oncology.2016; 14(2): 63.     CrossRef
  • A geographical study of thyroid cancer incidence in north-west England following the Windscale nuclear reactor fire of 1957
    Richard J Q McNally, Richard Wakeford, Peter W James, Nermine O Basta, Robert D Alston, Mark S Pearce, Alex T Elliott
    Journal of Radiological Protection.2016; 36(4): 934.     CrossRef
  • Targeting the Phosphatidylinositol-3-kinase Pathway in Gastric Cancer: Can Omics Improve Outcomes?
    Phu Tran, Cham Nguyen, Samuel J. Klempner
    International Neurourology Journal.2016; 20(Suppl 2): S131.     CrossRef
  • A Comparison of Open, Laparoscopic, and Robotic Surgery in the Treatment of Right-sided Colon Cancer
    Jeonghyun Kang, Yoon Ah Park, Seung Hyuk Baik, Seung-Kook Sohn, Kang Young Lee
    Surgical Laparoscopy, Endoscopy & Percutaneous Techniques.2016; 26(6): 497.     CrossRef
  • Dietary protein and fat intake in relation to risk of colorectal adenoma in Korean
    Sun Young Yang, Young Sun Kim, Jung Eun Lee, Jueun Seol, Ji Hyun Song, Goh Eun Chung, Jeong Yoon Yim, Sun Hee Lim, Joo Sung Kim
    Medicine.2016; 95(49): e5453.     CrossRef
  • Unkindness Experience of Health Care Provider in Patients with Breast Cancer
    Sue-Kyung Sohn, Ick-Jee Kim, Mi-SunKim Kim, Kyeong-Hee Shin, Min-Suk Lee, Eun-Mee Lee
    Journal of East-West Nursing Research.2016; 22(1): 51.     CrossRef
  • Anal Human Papillomavirus Infection among HIV-Infected Men in Korea
    Chang Hun Lee, Sun Hee Lee, Shinwon Lee, Heerim Cho, Kye-Hyung Kim, Jung Eun Lee, Eun ju Jung, Su jin Lee, Eun Jung Kim, Ki Hyung Kim, Eunsoo Moon, Hong Je Cho, Maria Lina Tornesello
    PLOS ONE.2016; 11(8): e0161460.     CrossRef
  • Timing of Surgical Management of Papillary Thyroid Cancer Diagnosed during Pregnancy
    Yoonseok Kim, Changhoon Lee, Eunae Jae, Youngjin Lee, Jueun Jung, Susun Kim, Mihyang Kim, Eunsuk Lee, Chunsuk Park, Jaemook Park, Hyunwoo Jung, Musil Park, Jaejun Lee, Junmo Ahn, Soo Lee
    International Journal of Thyroidology.2016; 9(2): 168.     CrossRef
  • Postoperative radiotherapy appeared to improve the disease free survival rate of patients with extrahepatic bile duct cancer at high risk of loco-regional recurrence
    Mi Young Kim, Jin Hee Kim, Yonghoon Kim, Sang Jun Byun
    Radiation Oncology Journal.2016; 34(4): 297.     CrossRef
  • Health Behaviors and Associated Sociodemographic Factors in Cervical Cancer Survivors Compared with Matched Non-Cancer Controls
    Boyoung Park, Se Ik Kim, Sang-Soo Seo, Sokbom Kang, Sang-Yoon Park, Myong Cheol Lim, Michael Scheurer
    PLOS ONE.2016; 11(8): e0160682.     CrossRef
  • Weight Change and Associated Factors in Long-Term Breast Cancer Survivors
    Hye-Yeon Koo, Young-Gyun Seo, Mi-Hee Cho, Min-Jung Kim, Ho-Chun Choi, William B. Coleman
    PLOS ONE.2016; 11(7): e0159098.     CrossRef
  • Treatment outcomes after adjuvant radiotherapy following surgery for patients with stage I endometrial cancer
    Jiyoung Kim, Kyung-Ja Lee, Kyung-Ran Park, Boram Ha, Yi-Jun Kim, Wonguen Jung, Rena Lee, Seung Cheol Kim, Hye Sung Moon, Woong Ju, Yun Hwan Kim, Jihae Lee
    Radiation Oncology Journal.2016; 34(4): 265.     CrossRef
  • A Lymph Node Staging System for Gastric Cancer: A Hybrid Type Based on Topographic and Numeric Systems
    Yoon Young Choi, Ji Yeong An, Hitoshi Katai, Yasuyuki Seto, Takeo Fukagawa, Yasuhiro Okumura, Dong Wook Kim, Hyoung-Il Kim, Jae-Ho Cheong, Woo Jin Hyung, Sung Hoon Noh, Anthony W.I. Lo
    PLOS ONE.2016; 11(3): e0149555.     CrossRef
  • Physical, Psychological and Social Symptoms, Activity and Education of Children and Adolescents with Acute Lymphoblastic Leukemia Receiving Maintenance Chemotherapy
    Hee Sung Yoon, Kwang Sung Kim, Sun Hee Choi, So Eun Choi, Kyoung A Kim, Kyoung Eon Kim
    Asian Oncology Nursing.2016; 16(4): 169.     CrossRef
  • Acute High-Dose and Chronic Lifetime Exposure to Alcohol Consumption and Differentiated Thyroid Cancer: T-CALOS Korea
    Yunji Hwang, Kyu Eun Lee, Elisabete Weiderpass, Young Joo Park, Young Jun Chai, Hyungju Kwon, Do Joon Park, BeLong Cho, Ho-Chun Choi, Daehee Kang, Sue K. Park, Li Wang
    PLOS ONE.2016; 11(3): e0151562.     CrossRef
  • Pilot Study of a Next-Generation Sequencing-Based Targeted Anticancer Therapy in Refractory Solid Tumors at a Korean Institution
    Hyung Soon Park, Sun Min Lim, Sora Kim, Sangwoo Kim, Hye Ryun Kim, KyuBum Kwack, Min Goo Lee, Joo-Hang Kim, Yong Wha Moon, Masaru Katoh
    PLOS ONE.2016; 11(4): e0154133.     CrossRef
  • Oral Bisphosphonates and Upper Gastrointestinal Cancer Risks in Asians with Osteoporosis: A Nested Case-Control Study Using National Retrospective Cohort Sample Data from Korea
    Sun-Young Jung, Hyun Soon Sohn, Eun-Ja Park, Hae Sun Suh, Ji-Won Park, Jin-Won Kwon, Chi-Ling Chen
    PLOS ONE.2016; 11(3): e0150531.     CrossRef
  • The Delayed Risk Stratification System in the Risk of Differentiated Thyroid Cancer Recurrence
    Aldona Kowalska, Agnieszka Walczyk, Iwona Pałyga, Danuta Gąsior-Perczak, Klaudia Gadawska-Juszczyk, Monika Szymonek, Tomasz Trybek, Katarzyna Lizis-Kolus, Dorota Szyska-Skrobot, Estera Mikina, Stefan Hurej, Janusz Słuszniak, Ryszard Mężyk, Stanisław Góźdź
    PLOS ONE.2016; 11(4): e0153242.     CrossRef
  • UEG Week 2016 Poster Presentations

    United European Gastroenterology Journal.2016; 4(5_suppl): A157.     CrossRef
  • A Comparison of Spatial Pattern Detection Methods for Major Cancer Mortality in Korea
    Jiyu Kim, Myeonggyun Lee, Inkyung Jung
    Asia Pacific Journal of Public Health.2016; 28(6): 539.     CrossRef
  • Survival Analysis of Advanced Non–Small Cell Lung Cancer Patients Treated by Using Wheel Balance Cancer Therapy
    Jongmin Kim, Chong-Kwan Cho, Hwa-Seung Yoo
    Integrative Cancer Therapies.2016; 15(4): 467.     CrossRef
  • Antitumor and apoptosis-inducing effects of α-mangostin extracted from the pericarp of the mangosteen fruit (Garcinia mangostana L.) in YD-15 tongue mucoepidermoid carcinoma cells
    HAE NIM LEE, HYE YEON JANG, HYEONG JIN KIM, SEONG AH SHIN, GANG SIK CHOO, YOUNG SEOK PARK, SANG KI KIM, JI YOUN JUNG
    International Journal of Molecular Medicine.2016; 37(4): 939.     CrossRef
  • Preoperative chemoradiotherapy followed by transanal local excision for T3 distal rectal cancer: A case report
    SEUNG-GU YEO
    Experimental and Therapeutic Medicine.2016; 11(4): 1465.     CrossRef
  • Long non-coding RNA ATB promotes growth and epithelial-mesenchymal transition and predicts poor prognosis in human prostate carcinoma
    SONG XU, XIAO-MING YI, CHAO-PENG TANG, JING-PING GE, ZHENG-YU ZHANG, WEN-QUAN ZHOU
    Oncology Reports.2016; 36(1): 10.     CrossRef
  • Characteristics of and risk factors for colorectal neoplasms in young adults in a screening population
    Seung Eun Lee, Hee Bum Jo, Won Gun Kwack, Yun Jin Jeong, Yeo-Jin Yoon, Hyoun Woo Kang
    World Journal of Gastroenterology.2016; 22(10): 2981.     CrossRef
  • Differential diagnosis of breast masses in South Korean premenopausal women using diffuse optical spectroscopic imaging
    Anaïs Leproux, You Me Kim, Jun Won Min, Christine E. McLaren, Wen-Pin Chen, Thomas D. O’Sullivan, Seung-ha Lee, Phil-Sang Chung, Bruce J. Tromberg
    Journal of Biomedical Optics.2016; 21(7): 074001.     CrossRef
  • Celecoxib and sulindac inhibit TGF-β1-induced epithelial-mesenchymal transition and suppress lung cancer migration and invasion via downregulation of sirtuin 1
    Byong-Ki Cha, Young-Suk Kim, Ki-Eun Hwang, Kyung-Hwa Cho, Seon-Hee Oh, Byoung-Ryun Kim, Hong-Young Jun, Kwon-Ha Yoon, Eun-Taik Jeong, Hak-Ryul Kim
    Oncotarget.2016; 7(35): 57213.     CrossRef
  • Relationship between insulin-like growth factor axis gene polymorphisms and clinical outcome in advanced gastric cancer patients treated with FOLFOX
    Sung Yong Oh, Aesun Shin, Seong-Geun Kim, Jung-Ah Hwang, Seung Hyun Hong, Yeon-Su Lee, Hyuk-Chan Kwon
    Oncotarget.2016; 7(21): 31204.     CrossRef
  • Strategies to improve treatment outcome in gastric cancer: A retrospective analysis of patients from two high-volume hospitals in Korea and China
    Kun Yang, Yoon Young Choi, Wei-Han Zhang, Xin-Zu Chen, Mi Kyung Song, Jinae Lee, Bo Zhang, Zhi-Xin Chen, Hyoung-Il Kim, Jia-Ping Chen, Jae-Ho Cheong, Zong-Guang Zhou, Woo Jin Hyung, Jian-Kun Hu, Sung Hoon Noh
    Oncotarget.2016; 7(28): 44660.     CrossRef
  • Downregulation of osteoprotegerin expression in metastatic colorectal carcinoma predicts recurrent metastasis and poor prognosis
    Ahrim Moon, Sung-Im Do, Hyun-Soo Kim, Youn-Wha Kim
    Oncotarget.2016; 7(48): 79319.     CrossRef
  • The Korean guideline for colorectal cancer screening
    Dae Kyung Sohn, Min Ju Kim, Younhee Park, Mina Suh, Aesun Shin, Hee Young Lee, Jong Pil Im, Hyoen-Min Cho, Sung Pil Hong, Baek-hui Kim, Yongsoo Kim, Jeong Wook Kim, Hyun-Soo Kim, Chung Mo Nam, Dong Il Park, Jun Won Um, Soon Nam Oh, Hwan Sub Lim, Hee Jin C
    Journal of the Korean Medical Association.2015; 58(5): 420.     CrossRef
  • The different role of intratumoral and peritumoral lymphangiogenesis in gastric cancer progression and prognosis
    Kyung Ho Pak, Ara Jo, Hye Ji Choi, Younghee Choi, Hyunki Kim, Jae-Ho Cheong
    BMC Cancer.2015;[Epub]     CrossRef
  • Total and Dietary Calcium Intake and Colorectal Adenoma in Korean Adults
    Ju Eun Seol, Chang Ho Cho, Sung Hi Kim, Jung Eun Lee
    Journal of Cancer Prevention.2015; 20(2): 153.     CrossRef
  • Association of Dietary Vitamin D and Calcium With Genetic Polymorphisms in Colorectal Neoplasia
    Yoon Park, Jeongseon Kim
    Journal of Cancer Prevention.2015; 20(2): 97.     CrossRef
  • The role of surgery in stage IV gastric cancer
    Dong-Seok Han
    Korean Journal of Clinical Oncology.2015; 11(1): 1.     CrossRef
  • Epidemiology of prostate cancer in South Korea
    Hyun Ho Han, Jae Won Park, Joon Chae Na, Byung Ha Chung, Choung-Soo Kim, Woo Jin Ko
    Prostate International.2015; 3(3): 99.     CrossRef
  • Comparison of Quality of Life and Nutritional Status in Gastric Cancer Patients Undergoing Gastrectomies
    Hee-Sook Lim, Gyu-Seok Cho, Yoon-Hyung Park, Soon-Kyung Kim
    Clinical Nutrition Research.2015; 4(3): 153.     CrossRef
  • Evolution of Gastric Cancer Treatment: From the Golden Age of Surgery to an Era of Precision Medicine
    Yoon Young Choi, Sung Hoon Noh, Jae-Ho Cheong
    Yonsei Medical Journal.2015; 56(5): 1177.     CrossRef
  • Identification of occult tumors by whole-specimen mapping in solitary papillary thyroid carcinoma
    Seog Yun Park, Yuh-S Jung, Chang Hwan Ryu, Chang Yoon Lee, You Jin Lee, Eun Kyung Lee, Seok-Ki Kim, Tae Sung Kim, Tae Hyun Kim, Jeyun Jang, Daeyoon Park, Seung Myung Dong, Jae-Goo Kang, Jin Soo Lee, Junsun Ryu
    Endocrine-Related Cancer.2015; 22(4): 679.     CrossRef
  • <i>Helicobacter Pylori</i> Infection and Related Gastrointestinal Diseases
    Chang Seok Bang, Gwang Ho Baik
    The Korean Journal of Medicine.2015; 89(2): 142.     CrossRef
  • Comparison of two different S-1 plus cisplatin dosing schedules as first-line chemotherapy for metastatic and/or recurrent gastric cancer: a multicenter, randomized phase III trial (SOS)
    M.-H. Ryu, E. Baba, K.H. Lee, Y.I. Park, N. Boku, I. Hyodo, B.-H. Nam, T. Esaki, C. Yoo, B.-Y. Ryoo, E.-K. Song, S.-H. Cho, W.K. Kang, S.H. Yang, D.Y. Zang, D.B. Shin, S.R. Park, K. Shinozaki, T. Takano, Y.-K. Kang
    Annals of Oncology.2015; 26(10): 2097.     CrossRef
  • Has the National Cancer Screening Program reduced income inequalities in screening attendance in South Korea?
    Sujin Kim, Soonman Kwon, S. V. Subramanian
    Cancer Causes & Control.2015; 26(11): 1617.     CrossRef
  • Lung Cancer Screening: Update
    Hyae Young Kim
    Journal of the Korean Society of Radiology.2015; 73(3): 137.     CrossRef
  • Laparoscopic Sentinel Node Navigation Surgery for Gastric Cancer
    Keun Won Ryu
    The Journal of Minimally Invasive Surgery.2015; 18(3): 63.     CrossRef
  • It needs adaptation to the 2015 Korean guideline for breast cancer screening
    Jong-Myon Bae
    Journal of the Korean Medical Association.2015; 58(9): 833.     CrossRef
  • Hormone Replacement Therapy and Risk of Breast Cancer in Korean Women: A Quantitative Systematic Review
    Jong-Myon Bae, Eun Hee Kim
    Journal of Preventive Medicine and Public Health.2015; 48(5): 225.     CrossRef
  • Laparoscopic Total Gastrectomy in Elderly Patients (≥70 Years) with Gastric Carcinoma: A Retrospective Study
    Hong Sung Jung, Young Kyu Park, Seong Yeob Ryu, Oh Jeong
    Journal of Gastric Cancer.2015; 15(3): 176.     CrossRef
  • Anti-Cancer Effects of Oldenlandia diffusa extract on WiDr human colorectal adenocarcinoma cells
    Soojin Lee, Huijin Gim, Ji Hwan Shim, Hyun Soo Park, Byung Joo Kim
    Herbal Formula Science.2015; 23(1): 101.     CrossRef
  • Motivos de consulta al servicio de urgencias de los pacientes adultos con enfermedades hemato-oncológicas en un hospital de cuarto nivel de atención
    Rocio Mariño, Sergio Cervera, Lizet Moreno, Oswaldo Sánchez
    Revista Colombiana de Cancerología.2015; 19(4): 204.     CrossRef
  • Educational Needs for Sexual Health and Its Effect on Depression and the Quality of Life in Patients with Prostate Cancer
    Soonyoung Oh, Eunjung Ryu
    Asian Oncology Nursing.2015; 15(3): 163.     CrossRef
  • Factors Associated with Human Papillomavirus Vaccination and Intention among Male and Female College Students
    Seung Yeun Lee, Mi Ah Han, Jong Park, So Yeon Ryu
    Korean Journal of Health Promotion.2015; 15(3): 141.     CrossRef
  • Prostate-specific antigen kinetics after stereotactic body radiotherapy as monotherapy or boost after whole pelvic radiotherapy for localized prostate cancer
    Hun Jung Kim, Jung Hoon Phak, Woo Chul Kim
    Prostate International.2015; 3(4): 118.     CrossRef
  • The Impact of Low Adherence to the Low-iodine Diet on the Efficacy of the Radioactive Iodine Ablation Therapy
    Dal Lae Ju, Young Joo Park, Hee-Young Paik, YoonJu Song
    Clinical Nutrition Research.2015; 4(4): 267.     CrossRef
  • Hyperuricemia as a Novel Risk Factor for Colorectal Adenomatous Polyp
    Jung Won Lee, Jong Pil Im
    The Korean Journal of Gastroenterology.2015; 66(4): 183.     CrossRef
  • Trends in Colorectal Cancer Incidence in Daejeon and Chungcheongnam-do, South Korea (2000-2012)
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Original Article
Age-Period-Cohort Analysis of Thyroid Cancer Incidence in Korea
Chang-Mo Oh, Kyu-Won Jung, Young-Joo Won, Aesun Shin, Hyun-Joo Kong, Jin-Soo Lee
Cancer Res Treat. 2015;47(3):362-369.   Published online December 2, 2014
DOI: https://doi.org/10.4143/crt.2014.110
AbstractAbstract PDFPubReaderePub
Purpose
South Korea has the highest incidence rate of thyroid cancer in the world, and the incidence rate continues to increase. The aim of this study was to determine the age-period-cohort effects on the incidence of thyroid cancer in Korea.
Materials and Methods
Using the Korean National Cancer registry database, age-standardized incidence rates and annual percent changes (APCs) in thyroid cancer according to sex and histologic type were analyzed between 1997 and 2011. Age-period-cohort models were applied using an intrinsic estimator method according to sex.
Results
In both men and women, the incidence of thyroid cancer showed a sharp increase from 1997 through 2011. Among the histologic types, papillary carcinoma showed the greatest increase, with APCs of 25.1% (95% confidence interval [CI], 22.7% to 27.5%) in men and 23.7% (95% CI, 21.9% to 25.5%) in women, whereas anaplastic carcinoma did not show a significant increase in either sex. An increase in overall thyroid cancer incidence over time was observed in all birth cohorts. An age-period-cohort model indicated a steeply increasing period effect, which increased prominently from 1997 to 2011 in both men and women. The age effect showed an inverted U-shaped trend. The cohort effect tended to show a slight increase or remain constant from 1952 to 1977, followed by a decrease.
Conclusion
The period effect can explain the sharp increase in thyroid cancer incidence, strongly suggesting the role of thyroid screening.

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Special Articles
Prediction of Cancer Incidence and Mortality in Korea, 2014
Kyu-Won Jung, Young-Joo Won, Hyun-Joo Kong, Chang-Mo Oh, Duk Hyoung Lee, Jin Soo Lee
Cancer Res Treat. 2014;46(2):124-130.   Published online April 15, 2014
DOI: https://doi.org/10.4143/crt.2014.46.2.124
AbstractAbstract PDFPubReaderePub
Purpose

We studied and reported on cancer incidence and mortality rates as projected for the year 2014 in order to estimate Korea's current cancer burden.

Materials and Methods

Cancer incidence data from 1999 to 2011 were obtained from the Korea National Cancer Incidence Database, and cancer mortality data from 1993 to 2012 were acquired from Statistics Korea. Cancer incidence in 2014 was projected by fitting a linear regression model to observed age-specific cancer incidence rates against observed years, then multiplying the projected age-specific rates by the age-specific population. For cancer mortality, a similar procedure was employed, except that a Joinpoint regression model was used to determine at which year the linear trend changed significantly.

Results

A total of 265,813 new cancer cases and 74,981 cancer deaths are expected to occur in Korea in 2014. Further, the crude incidence rate per 100,000 of all sites combined will likely reach 524.7 and the age-standardized incidence rate, 338.5. Meanwhile, the crude mortality rate of all sites combined and age-standardized rate are projected to be 148.0 and 84.6, respectively. Given the rapid rise in prostate cancer cases, it is anticipated to be the fourth most frequently occurring cancer site in men for the first time.

Conclusion

Cancer has become the most prominent public health concern in Korea, and as the population ages, the nation's cancer burden will continue to increase.

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Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2011
Kyu-Won Jung, Young-Joo Won, Hyun-Joo Kong, Chang-Mo Oh, Duk Hyoung Lee, Jin Soo Lee
Cancer Res Treat. 2014;46(2):109-123.   Published online April 15, 2014
DOI: https://doi.org/10.4143/crt.2014.46.2.109
AbstractAbstract PDFPubReaderePub
Purpose

This study aimed to report nationwide cancer statistics in Korea, including incidence, mortality, survival, and prevalence, and their trends.

Materials and Methods

Incidence data from 1993 to 2011 were obtained from the Korea National Cancer Incidence Database, and vital status was followed through December 31, 2012. Mortality data from 1983 to 2011 were obtained from Statistics Korea. Crude and age-standardized rates for incidence, mortality, and prevalence, and relative survival were calculated.

Results

A total of 218,017 cancer cases and 71,579 cancer deaths were reported to have occurred in 2011, and there were 1,097,253 prevalent cases identified in Korea as of January 1, 2012. Over the past 13 years (1999-2011), overall incidence rates have increased by 3.4% per year. The incidence rates of liver and cervical cancers have decreased, while those of thyroid, breast, prostate, and colorectal cancers have increased. Notably, thyroid cancer increased by 23.3% per year in both sexes, and became the most common cancer since 2009. The mortality for all cancers combined decreased by 2.7% per year from 2002 to 2011. Five-year relative survival rates of patients diagnosed in the last 5 years (2007-2011) have improved by 25.1% compared with those from 1993 to 1995.

Conclusion

Overall cancer mortality rates have declined since 2002 in Korea, while incidence has increased rapidly and survival has improved.

Citations

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