Cancer Research and Treatment

Case Report

F-18 FDG PET-positive Fibrous Dysplasia in a Patient with Intestinal Non-Hodgkin's Lymphoma: Mi Kim, Hyeong Su Kim, Jung Han Kim, Joo Hyun Jang, Kook Jin Chung, Mi Kyung Shin, Hee Sung Hwang, Byung Chun Kim, So Young Jung; Cancer Res Treat. 2009;41(3):171-174. Published online September 28, 2009; DOI: https://doi.org/10.4143/crt.2009.41.3.171

Fibrous dysplasia (FD) is a common benign bone disorder of an unclear etiology. It is known that FD can appear without an increased FDG uptake on F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT). However, there are also several reports that FD showed increased FDG uptake and this mimicked malignant bone involvement on FDG-PET. Herein we describe a case of biopsy-proven FDG-PET positive FD in a patient with intestinal non-Hodgkin's lymphoma (NHL). A 45-year-old woman was diagnosed with intestinal NHL, which was removed by right hemicolectomy. After the operation, the FDG-PET/CT scan showed hypermetabolic activity in the right transverse process of the T10 vertebra. The patient then received a total of 6 cycles of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone) chemotherapy every 3 weeks. After completion of the planned chemotherapy, the 2^nd FDG-PET/CT showed increased FDG uptake (SUVmax=6.0 g/mL) of the previous bone lesion. The MR images revealed a T1-hypointense lesion with sharp borders in the same region, and this showed homogenous contrast enhancement on the fat-suppressed T1-weighted images. After the radiologic studies were carefully reviewed, the bone lesion was assumed to be benign such as FD. We performed bone biopsy and the histological examination confirmed the diagnosis of FD. In conclusion, bone lesions with FDG uptake need to be carefully interpreted when evaluating patients with known malignancy.

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Original Articles

Effect of Adriamycin in Gastric Chief Cell of Hamster: Byung Chun Kim, Doo Jin Baik, Ho Sam Chung; J Korean Cancer Assoc. 1995;27(2):184-195.

Abstract PDF: Adriamycin, an anthracyclin antibiotics isolated from Streptomes peucetius var caesius, inhibits the synthesis of DNA and reaction of DNA dependent DNA polymerase and it has been widely used as an anticancer drug in the treatment of sarcoma, leukemia and solid tumors. Adriamycin has little specificity to the normal and tumor cells and cytotoxicity of the normal cells happens to the patients as cardiotoxicity and bone marrow depression. The authors have demonstrated the effect of adriamycin on the chief cells of hamster, histologically observing the morphological changes of the cell by the use of light and electron microscope. The animais treated with 50 mg per kg of adriamycin were sacrificed at 24 and 48 hours after the drug administration. The animals of control group were administered only water for injection. All animals were starved for 12 hours before sacrificing them. A part of stomach specimens were fixed 10% neutral formalin and prepared for hematoxylin and eosin stain and the other part of specimens which were prefixed in 2% glutaraldehyde-2.5% paraformaldehyde prepared with phosphate buffer and then post-fixed in the 1% osmic acid, were dehydrated and embedded in the Epon 812. Ultrathin sections, 600-800A thickness, were made and double stained with uranyl acetate and lead citrate. And these preparations were observed with light microscope and JEM 100cx-II electron microscope. The results were as follows; 1) Most of lining cells of gastric glands were atrophied and lumens were dilated. Numbers of chief cells were decreased and indistinct cellular boundary, vacuolar degenertion, pyknosis and karyolysis were observed in the less basophilic chief cells. In the fundus of glands, parietal cells and mucous neck cells were also found. 2) Cisternae of rough endoplasmic reticulum were decreased, and fragmented and membrane bound ribosome were detached. Fusion of irregularly shaped zymogen granules and numerous autophagic vacuoles including whorled membranous bodies were observed#. Irregular shaped mitochondria and atrophied Golgi complex were also found in the chief cells of the gastric mu- cosa of the adriamycin treated rats. 3) Consequently, it is suggested that adriamycin would induce the degenerative changes of the organelles of chief cells in gastric mucosa of hamsters.

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A Clinical Analysis of the Small Bowel Tumor: Jun Ho An, Byung Chun Kim, Jae Jung Lee, Joo Seop Kim, Bong Wha Chang; J Korean Cancer Assoc. 1995;27(2):230-238.

Abstract PDF: The small bowel tumor is rare and prognosis is very poor due to nonspecific symptom and delayed diagnosis. The clinical review was made in 17 cases of the small bowel tumor that had been treated from January 1985 to September 1993 at Department of Surgery, College of Medicine, Hallym University. The obtained results are as follows, 1) The most prevalent age group was the 6th decade(47.0%) and the ratio of male to female was 1.42: l. 2) The most common symptom and sign were abdominal pain(52.9%) and abdominal distension(23.5%), respectively. 3) The most frequent site in sma11 bowel was ileum(47.1%), followed by jejunum (35.3%) and duodenum(17.6%). 4) The histopathologic classification was malignancy in 10 cases, benign in 7 cases and the most predominant type was leiomyosarcoma and lipoma, respectively. 5) The most frequent preoperative diagnostic measure was abdominal ultrasonogram(58.8%) and the diagnosis was correct in 9 cases. 6) The most common type of operation technique was segmental resection(64.6%). 7) The postoperative complications deveioped in 4 cases(26.7%). 8) Duration of the median follow up was 10.8 months and 4 cases were impossible to follow up. Among the 5 patients who died, 3 patients were adenocarcinoma and 2 patients were leiomyosarcoma. In conclusion, poor results of small bowel tumors are due to delayed diagnosis. Thus, prompt diagnostic studies should be performed in patient with persietent symptoms and early consideration of exploratory leparotomy may be needed for possibility of malignancy and curative resection.

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