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Cancer Research and Treatment > Volume 42(2); 2010 > Article
Cancer Research and Treatment 2010;42(2): 115-117. doi: http://dx.doi.org/10.4143/crt.2010.42.2.115
A Case of Pure Red Cell Aplasia Associated with Angioimmunoblastic T-cell Lymphoma
Jung Hye Choi, Young Ha Oh, Ile Kyu Park
0Department of Internal Medicine, Hanyang University Collegeof Medicine, Seoul, Korea. jhcmd@hanyang.ac.kr
1Department of Pathology, Hanyang University College ofMedicine, Seoul, Korea.
2Department of Laboratory Medicine, Hanyang UniversityCollege of Medicine, Seoul, Korea.
Pure red cell aplasia is a bone marrow failure characterized by a progressive normocytic anemia and reticulocytopenia without leucopenia and thrombocytopenia. It is associated with various hematologic diseases. However, pure red cell aplasia with angioimmunoblastic T cell lymphoma has rarely been reported. Here we describe a 43-year-old woman with pure red cell aplasia associated with angioimmunoblastic T-cell lymphoma. She had severe anemia (hemoglobin 6.9 g/dL) and a low reticulocyte count (0.2%). Direct and indirect Coombs' tests were positive. A CT scan of the abdomen revealed marked hepatosplenomegaly and small multiple lymphadenopathies. A bone marrow biopsy revealed focal infiltration of abnormal lymphoid cells and absence of red cell precursors. Splenic biopsy was compatible with angioimmunoblastic T-cell lymphoma. Ultimately, diagnosis of pure red cell aplasia associated with angioimmunoblastic T-cell lymphoma was made. After initiating CHOP therapy, the patient achieved complete remission, which was accompanied, shortly thereafter, by a rise in hemoglobin levels which finally returned to normal.
Key words: Red-cell aplasia;Pure;Lymphoma;T-cell
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