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Cancer Research and Treatment > Volume 34(6); 2002 > Article
Cancer Research and Treatment 2002;34(6): 457-460. doi: https://doi.org/10.4143/crt.2002.34.6.457
A Case of Primary Gastric Choriocarcinoma Presenting with Amenorrhea
Seung Hyun Nam, Seock Ah Im, Ki Sun Bae, In Sook Kang, Jung Mi Kwon, Kyung Eun Lee, Hye Sung Moon, Sun Hee Sung, Woon Sup Han, Chu Myong Seong, Soon Nam Lee
1Department of Internal Medicine, College of Medicine, EwhaWomans University, Seoul, Korea. moisa @ewha.ac.krs
2Department of Gynecology, College of Medicine, Ewha WomansUniversity, Seoul, Korea.
3Department of Pathology, College of Medicine, Ewha WomansUniversity, Seoul, Korea.
  Published online: December 31, 2002.
Primary gastric choriocarcinomas are very rare, and their prognosis is extremely poor. A 37-year-old woman presented with amenorrhea, vaginal spotting and severe nausea, which mimicked a pregnancy and gestational trophoblastic disease. The serum level of the beta-subunit of human chorionic gonadotrophin (beta-hCG) was significantly increased. An endoscopic biopsy of the stomach mass showed the features of a choriocarcinoma, with marked anaplasia and necrosis. Immunohistochemical staining for beta-hCG showed positive results in the choriocarcinoma. Chemotherapy for the choriocarcinoma was administered, but she died 8 months following diagnosis.
Key words: Choriocarcinoma;Stomach;Human chorionic gonadotrophin;Chemotherapy
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