Use of GCDFP-15 (BRST-2) as a Specific Immunocytochemical Marker for Diagnosis of Gastric Metastasis of Breast Carcinoma

Park, Keon Woo; Im, Young Hyuck; Lee, Jeeyun; Kim, Eungho; Lee, Hyuk; Song, Bong Geun; Park, Joon Oh; Kim, Kihyun; Jung, Chul Won; Park, Young Suk; Kang, Won Ki; Lee, Mark H; Park, Keunchil

doi:2003.35.5.460

Cancer Research and Treatment > Volume 35(5); 2003 > Article

Case Report

Cancer Research and Treatment 2003;35(5): 460-464. doi: https://doi.org/10.4143/crt.2003.35.5.460

Use of GCDFP-15 (BRST-2) as a Specific Immunocytochemical Marker for Diagnosis of Gastric Metastasis of Breast Carcinoma

Keon Woo Park, Young Hyuck Im, Jeeyun Lee, Eungho Kim, Hyuk Lee, Bong Geun Song, Joon Oh Park, Kihyun Kim, Chul Won Jung, Young Suk Park, Won Ki Kang, Mark H Lee, Keunchil Park

Division of Hematology-Oncology, Department of InternalMedicine, Samsung Medical Center, Sungkyunkwan UniversitySchool of Medicine, Seoul, Korea. imyh@smc.samsung.co.kr

Published online: October 31, 2003.

ABSTRACT

Metastasis of breast cancer to the stomach is relatively uncommon and typically occurs in patients with disseminated diseases. This may cause difficulty in differentiating it from primary gastric carcinoma. The correct diagnosis of the primary source is important, since the treatment and prognosis of metastatic breast cancer is quite different from those of metastatic gastric cancer. Immunohistochemical staining with GCDFP-15 (gross cystic disease fluid protein-15) can be used to differentiate primary gastric carcinoma and gastric metastasis from breast cancer. We report two cases of gastric metastasis of breast cancer by describing their clinical course, illustrating the histologic findings, and showing the results of immunohistochemical staining with GCDFP-15.

Key words: Breast neoplasm;Gastrointestinal metastases;Gross cystic disease fluid protein-15