KCA
Articles
- Page Path
- HOME > J Korean Cancer Assoc > Accepted articles > Article
-
Original Article
- Secondary Cancer Risk in Breast Cancer with and without Radiotherapy: The Observational Health Data Sciences and Informatics (OHDSI) Cohort Study
-
Seok Kim1
, Dachung Boo2
, Sooyoung Yoo1, Borham Kim1, Kyubo Kim3, Kwangsoo Kim4,5, Eunhye Song6, Junmo Kim7, Hyun Gee Ryoo8,9, Jin Chul Paeng9, In Young Choi10, SooJeong Ko10, Ie Ryung Yoo11, Rae Woong Park12
, Ho-Young Lee1,8
-
DOI: https://doi.org/10.4143/crt.2024.968 [Accepted]
Published online: June 5, 2025
1Office of eHealth Research and Business, Seoul National University Bundang Hospital, Seongnam, Korea
2Department of Biomedical Systems Informatics, Yonsei University College of Medicine Institute for Innovation in Digital Healthcare, Seoul, Korea
3Department of Radiation Oncology, Seoul National University Bundang Hospital, Seongnam, Korea
4Department of Transdisciplinary Medicine, Institute of Convergence Medicine with Innovation Technology, Seoul National University Hospital, Seoul, Korea
5Innovative Medical Technology Research Institute, Seoul National University Hospital, Seoul, Korea
6Department of Data Science Research, Innovative Medical Technology Research Institute, Seoul National University Hospital, Seoul, Korea
7Interdisciplinary Program in Bioengineering, Seoul National University, Seoul, Korea
8Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
9Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea
10Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, Korea
11Division of Nuclear Medicine, Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
12Department of Biomedical Informatics, School of Medicine, Ajou University, Suwon, Korea
2Department of Biomedical Systems Informatics, Yonsei University College of Medicine Institute for Innovation in Digital Healthcare, Seoul, Korea
3Department of Radiation Oncology, Seoul National University Bundang Hospital, Seongnam, Korea
4Department of Transdisciplinary Medicine, Institute of Convergence Medicine with Innovation Technology, Seoul National University Hospital, Seoul, Korea
5Innovative Medical Technology Research Institute, Seoul National University Hospital, Seoul, Korea
6Department of Data Science Research, Innovative Medical Technology Research Institute, Seoul National University Hospital, Seoul, Korea
7Interdisciplinary Program in Bioengineering, Seoul National University, Seoul, Korea
8Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
9Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea
10Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, Korea
11Division of Nuclear Medicine, Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
12Department of Biomedical Informatics, School of Medicine, Ajou University, Suwon, Korea
-
Corresponding author:
Rae Woong Park
Tel: 82-31-219-5342
Email: veritas@ajou.ac.kr
Ho-Young Lee
Tel: 82-31-787-2938
Email: debobkr@snubh.org
- Seok Kim and Dachung Boo contributed equally to this work.
Received: 8 October 2024 • Accepted: 25 May 2025
- 104 Views
- 11 Download
- 0 Crossref
- 0 Scopus
Abstract
Purpose
Radiotherapy is used to reduce the risk of breast cancer recurrence after surgery, but it is a potential cause of secondary cancer. We validated the risk of secondary cancer in primary breast cancer who received radiotherapy compared with those who did not from a matched cohort using a large-scale observational study of the Observational Health Data Sciences and Informatics (OHDSI) data network.
Materials and Methods
A retrospective comparative cohort study using propensity score-matched cohorts was performed using two Observational Medical Outcome Partnership common data model databases, from tertiary general hospitals in South Korea. Among female patients who underwent surgery after the diagnosis of breast cancer, the risk of secondary primary malignant occurrence after 1:1 matching was analyzed.
Results
Among 27,078 patients with breast cancer, there was no significant difference in the risk of secondary cancer following radiotherapy in 4,268 patients after 1:1 propensity-score matching. Further, there were no significant differences in the sensitivity analysis according to age, latency period, and number of radiation treatments.
Conclusion
There was no difference in the risk of secondary cancer in the patients diagnosed with breast cancer depending on whether or not radiotherapy was performed after surgery. In the future, it is necessary to analyze including data generated during cancer treatment.
Cite
