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Original Article
- Association of Pro-inflammatory Cytokines with Gastric Cancer Risk: A Case-Cohort Study
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Seungju Baek1
, Eunjung Park2
, Eun Young Park1,3
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DOI: https://doi.org/10.4143/crt.2024.718 [Accepted]
Published online: November 19, 2024
1Graduate School of Public Health, Korea University, Seoul, Korea
2Department of Cancer Control and Population Health, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Korea
3Department of Preventive Medicine, Korea University College of Medicine, Seoul, Korea
2Department of Cancer Control and Population Health, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Korea
3Department of Preventive Medicine, Korea University College of Medicine, Seoul, Korea
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Corresponding author:
Eun Young Park
Tel: 82-2-2286-1411 Fax: 82-2-927-7220 Email: eunyoungpark2022@gmail.com
- Seungju Baek and Eunjung Park contributed equally to this work.
Received: 29 July 2024 • Accepted: 18 November 2024
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Abstract
Purpose
This study aimed to assess the association between inflammatory cytokines and the risk of gastric cancer (GC).
Materials and Methods
We conducted a case-cohort study using Korean National Cancer Center Community (KNCCC) cohort data to investigate the associations between pro-inflammatory, anti-inflammatory cytokines, inflammatory mediators, and GC risk in the Korean general population (GC cases: n=159, subcohort: n=822). Serum levels of inflammatory cytokines were measured using Quantikine® ELISA and analyzed using a Cox proportional hazards regression model.
Results
Compared to those with the lowest serum interleukin 6 (IL-6) levels, the risk of GC significantly increased in the second (HR: 3.48 [1.73-6.99]), third (HR: 3.74 [1.91-7.29], and fourth quartiles (HR: 3.79 [1.93-7.48]). Elevated levels of interleukin 1β (IL-1β) (HR: 1.57 [1.12-2.21]) and interferon gamma (IFN-γ) (HR: 2.49 [1.73-3.58]) were also associated with an increased risk of GC.
Conclusion
The findings of this study indicate associations between pro-inflammatory cytokines (IL-6, IL-1β, and IFN-γ) and the risk of GC, suggesting that regulating these cytokine levels may aid in GC prevention.
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