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Cancer Research and Treatment > Accepted Articles
doi: https://doi.org/10.4143/crt.2022.894    [Accepted]
Clinicopathological Analysis and Treatment of Adult Patients with Inflammatory Myofibroblastic Tumor: A 15-Year Single- Center Study
Xin Liu1,2 , Chengcheng Gong2,3 , Jieyun Zhang2,4, Wanjing Feng2,4, Yanjing Guo1,2, Youzhou Sang1,2, Chunmeng Wang2,5, Yong Chen2,5, Jian Wang2,6, Yu Lin2,6, Xiaowei Zhang2,4 , Zhiguo Luo2,4
1Department of Head & Neck tumors and Neuroendocrine tumors, Fudan University Shanghai Cancer Center, Shanghai, China
2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
3Department of Breast and Urological Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China
4Department of Gastrointestinal Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China
5Department of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, Shanghai, China
6Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China
Correspondence  Xiaowei Zhang ,Email: dongfangzhizizhxw@aliyun.com
Zhiguo Luo ,Email: luozhiguo88@aliyun.com
Received: July 26, 2022;  Accepted: March 2, 2023.  Published online: March 3, 2023.
*Xin Liu and Chengcheng Gong contributed equally to this work.
ABSTRACT
Purpose
Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal malignancy that occurs primarily in children and adolescents. The clinical and pathological features of IMT in adult patients are not well understood.
Materials and Methods
We retrospectively searched for records of adult patients with IMT at Fudan University Shanghai Cancer Center from 2006 to 2021. Clinicopathological data, treatments, and outcomes were collected and analyzed.
Results
Thirty adult patients with IMT, mostly women (60.0%), were included. The median age of the patients was 38 (21–77). The most common primary site was abdominopelvic region (53.3%), followed by lungs (20.0%). Seven patients had an abdominal epithelioid inflammatory myofibroblast sarcoma (EIMS). The positivity rate of anaplastic lymphoma kinase (ALK) was 81.5% (22/27). Sixteen patients with advanced ALK-positive disease received crizotinib, with an ORR of 81.3% and a disease control rate of 87.5%. The median PFS was 20.8 months. EIMS was associated with more aggressive behavior; however, the prognosis was similar to that of non-EIMS patients after treatment with an ALK inhibitor. At a median follow-up time of 30 months (95%CI 13.6–46.4), the 5-year overall survival was 77% (95% CI 66–88%) in all patients.
Conclusion
Adult IMTs appeared more aggressive, with a higher incidence of recurrence and metastases, and patients with EIMS had more aggressive cases. Treatment with ALK inhibitors resulted in a high ORR and a durable response, which suggested that ALK inhibitors could be used as a first-line treatment option in adult patients with ALK-positive advanced IMT.
Key words: Inflammatory myofibroblastic tumor, Adults, Anaplastic lymphoma kinase, Prognosis
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