The Role of HPV E6 and E7 Oncoproteins in HPV-associated Cervical Carcinogenesis

Eun-Kyoung Yim; Jong-Sup Park

doi:10.4143/crt.2005.37.6.319

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Review Article The Role of HPV E6 and E7 Oncoproteins in HPV-associated Cervical Carcinogenesis: Eun-Kyoung Yim, Ph.D., Jong-Sup Park, M.D., Ph.D.; Cancer Research and Treatment : Official Journal of Korean Cancer Association 2005;37(6):319-324.
DOI: https://doi.org/10.4143/crt.2005.37.6.319
Published online: December 31, 2005

Department of Obstetrics and Gynecology, The Catholic University of Korea College of Medicine, Seoul, Korea.

Correspondence: Jong-Sup Park, Department of Obstetrics and Gynecology, The Catholic University of Korea College of Medicine, 505 Banpo-dong, Seocho-gu, Seoul 137-701, Korea. (Tel) 82-2-590-2596, (Fax) 82-2-595-8774, jspark@catholic.ac.kr

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Abstract

Cervical cancer is one of the leading world causes of cancer morbidity and mortality in woman, with more than 98% related to a human papillomavirus (HPV) infection origin. Infection with specific subtypes of HPV has been strongly implicated in cervical carcinogenesis. The identification and functional verification of host proteins associated with HPV E6 and E7 oncoproteins may provide useful information in understanding cervical carcinogenesis and the development of cervical cancer-specific markers. The advent of functional genomics and proteomics has provided hope of discovering novel biological markers for use in the screening, early diagnosis, prognostication and prediction of response to therapy. Herein, we review the studies where the profiles of host proteins associated with HPV E6 and E7 oncoproteins in cervical cancer were generated.
Key words: Cervix neoplasms, HPV, E6, E7, Genomics, Proteomics

INTRODUCTION

Human papillomavirus (HPV) is the most prevalent sexually transmitted infection in the world, occurring at some point in up to 75% of sexually active women. Although HPV infection is widespread, few people even know they are infected as the symptoms are seldom noticeable. It is even less well known that nearly all cervical cancers (99.7%) are directly linked to previous infection with one or more of the oncogenic types of HPV (1). It is estimated that for every 1 million women infected, 10% (about 100,000) will develop precancerous changes in their cervical tissue. Of these, about 8% will develop early cancer limited to the whole epithelial layer of the uterine cervix (carcinoma in situ; CIS), and a few will develop invasive cancer unless the precancerous lesions are detected and treated, with such cases having been found to carry the oncogenic HPVs (e.g., types 16 and 18) that cause cervical cancer. HPVs have circular, double-stranded DNA genomes that are approximately 8 kb in size and encode eight genes, of which E6 and E7 have transforming properties. These proteins have pleiotropic functions, such as transmembrane signaling, regulation of the cell cycle, transformation of established cell lines, immortalization of primary cell line and regulation of chromosomal stability. The viral E6 and E7 oncoproteins are necessary for malignant conversion. The abilities of high-risk HPV E6 and E7 proteins to associate with the tumor suppressors p53 and pRB, respectively, have been suggested as a mechanism by which these viral proteins induce tumors (Fig. 1). The E6 protein consists of 158 amino acid residues and contains two zinc-finger binding motifs (2). The E6 protein is thought to promote cell proliferation by stimulating degradation of the tumor suppressor p53 protein via the formation of a trimeric complex comprising E6, p53 and the cellular ubiquitination enzyme E6-AP. E6-stimulated degradation interferes with such biological functions of p53; thus perturbing the control of cell cycle progression, leading finally to increased tumor cell growth (3). Although it is commonly accepted that the ability of high-risk type HPV E6 to target p53 for degradation contributes to virus-induced cellular transformation, it is also clear that the E6 protein has oncogenic activities that are independent of p53.

The E7 proteins encoded by the high-risk type HPVs, such as HPV 16 and HPV 18, bind Rb with a much higher affinity compared to those encoded by the low-risk type HPVs, such as HPV 6 and HPV 11. E7 binds to a region of the Rb protein commonly referred to as the 'pocket domains' (4). The 'pocket domain' sequences of Rb are essential for its tumor suppressor function, with many naturally occurring loss-of-function mutations of Rb appearing to cluster in these 'pocket domains'. One of the major biochemical functions of Rb is to bind E2F-family transcription factors and repress the expressions of replication enzyme genes (5). The ability to repress the expressions of replication enzyme genes correlates with the tumor suppression function of Rb. E7 disrupts the interaction between Rb and E2F, resulting in the release of E2F factors in their transcriptionally active forms (6). This E7-mediated conversion of E2Fs to their activator forms stimulates replication and cell-division, which is consistent with the observation that keratinocytes constitutively expressing E7 remain replication- competent, even after differentiation (7). Therefore, complex formation between the products of oncogenes and tumor suppressor genes is believed to be important in the cellular transformation that leads to the disruption of the normal physiological functions of the specific tumor suppressor gene products.

Cervical cancer-specific biomarkers, as yet, have not been well characterized. The diagnosis of cervical cancer is based on histological examinations, with the prognosis assessed based on the clinical features, such as the stage of the disease at diagnosis. Host proteins associated with HPV E6 and E7 oncoproteins should contain fundamental information about the development and progression of HPV-associated cervical carcinogenesis. Utilization of this information for discovering biomarkers, and/or therapeutic targets could be possible if a tool can be developed to rapidly analyze and display changes in protein expression under different conditions for neoplastic cell subpopulations. Therefore, the search for proteins associated with a given cancer is a major challenge.

HOST PROTEINS ASSOCIATED WITH HPV E6 ONCOPROTEIN

The E6 oncoproteins of high risk HPV interfere with the function of the cellular tumor-suppressor protein p53 through the induction of increased proteasome-dependent p53 degradation. High risk HPV E6 proteins target the cellular E3 ubiquitin ligase E6AP to p53, resulting in the transfer of ubiquitin peptides from E6AP to p53, which marks p53 for degradation by the 26S proteasome. Low risk and cutaneous epithelia-infecting HPV E6 proteins are unable to target the cellular p53 protein for degradation through the proteasome pathway. Although E6-induced loss of p53 is an important element of E6-induced cellular transformation, recent studies have identified a number of additional cellular targets of E6 that may also play an important role. These included the following (8, 9): proteins involved in the regulation of transcription and DNA replication, such as p300/CBP, Gps2, IRF-3, hMcm7, E6TP1 and ADA3; proteins, involved in apoptosis and immune evasion, such as Bak, TNF receptor 1 (TNF R1), FADD and c-Myc,; proteins involved with epithelial organization and differentiation, such as paxillin, E6BP/ERC-55, zyxin and fibulin-1; proteins involved in cell-cell adhesion, polarity and proliferation control, which contain a PDZ-binding motif, such as hDLG, hScrib, PKN, MAGI-1, MAGI-2, MAGI-3 or MUPP1; and proteins involved in DNA repair, such as XRCC1 and 6-O-methylguanine-DNA methyltransferase (MGMT) (Table 1).

In this article, we described the global pattern of protein expression in human adenocarcinoma cell lines stably expressing HPV E6 gene, compared with those of control cells, using a proteomics analysis. An interesting study in comparative proteomics showed the expression of proteins in response to transfection by E6. The prominent function of HPV E6 is the proteolytic inactivation of certain pro-apoptotic factors, such as p53, Bak or Bax, through the ubiquitin-proteasome pathway (10, 11). The Bcl-2 family of proteins is a critical death regulator of mitochondrial integrity and of mitochondria-initiated apoptosis. Bak plays a major role in the apoptosis of several types of cells. The findings of increased levels of Bcl-2 and decreased Bak expression indicates a change in the balance of anti-apoptotic and pro-apoptotic molecules, with a shift in favor of the former. Although Bcl-2 appears to bind poorly to Bak, the over-expression of Bcl-2 is shown to suppress the death function of Bak (12). Therefore, the imbalance between Bcl-2 and Bak is believed to play a role in promoting growth in E6-infected cells. TRAF-interacting protein (I-TRAF) has been shown to be up-regulated by E6. I-TRAF, a novel signal transducer of the TNFR superfamily, inhibits the induction of NF-κB activation mediated by TNFR6, which indirectly interacts with TRAF2 via TRADD. However, I-TRAF was unable to inhibit the activation of NF-κB by IL-1R, which is mediated by TRAF6 (13), suggesting a negative effect of I-TRAF on NF-κB activation was specific to a TRAF2- mediated pathway. E6 may suppress the function of I-TRAF as a negative regulator of NF-κB activation. Cellular damage or stress results from two fundamental cellular responses: apoptosis, a precisely programmed form of cell death, and stress response, or the expression of heat shock protein (HSP), which protects cells and mediates an accelerated recovery following damage. HSPs are multi functional molecular chaperons relating to cellular homeostasis. Primary, HSPs are expressed in response to cellular stresses, which may also include carcinogenesis. E6 induced stronger up-regulation of HSP60, HSP70 and HSP90-β proteins in our experiment. There has been a report that the expressions of HSP40, HSP60 and HSP70, but not that of HSP90, were increased with increasing severity of the cervical lesion, suggestive of stress responses from the progression from an HPV infection to cervical cancer.

Many proteins involved in cell cycle progression are expressed, including E2F5 and CDK5 (cyclin-dependent kinase5). Proteins involved in G1/S progression are decreased, and were thought to be concerned with cyclin-dependent kinase regulation. Transformed cells expressing E6 lose the G1 checkpoint activity at a very early point, presumably due to the degradation of p53. The G2 checkpoint is initially unaffected, but there is increased chromosomal instability in E6-expressing cells over time, which is probably caused by the observed attenuation of the G2 checkpoint function (14). This may be caused by E6 altering the cyclin/cdk complexes, or may relate to the ablation of a p53-regulated G2/M checkpoint. The up- regulated proteins have been studied further for their diagnostic potential.

In our previous work, we looked for p53-independent HPV E6 interacting proteins, using a yeast two-hybrid screening, which resulted in the identification of p73; a homologue protein of p53. The functional inactivation of p73, by both high- and low-risk HPV E6, could play an important role in the malignant transformation and benign condyloma formation of the cervix (15).

Recently, we found a novel interaction between HPV E6 and BARD1 (BRCA1-associated ring domain 1), which was described as a crucial partner of the breast and ovarian tumor suppressor BRCA1 (16). We also demonstrated the existence of BARD1 as a p53 tumor co-suppressor, which inactivated the E6 oncoprotein.

HOST PROTEINS ASSOCIATED WITH HPV E7 ONCOPROTEIN

HPV E7 proteins interact with the so-called 'pRb-associated pocket proteins', including the retinoblastoma protein pRb, which are negative cell-cycle regulators involved in the G1/S and G2/M transitions. The interaction between high-risk E7 and pRb results in enhanced phosphorylation and degradation. pRb destruction leads to the release of E2F family of transcription factors and the subsequent activation of genes promoting cell proliferation. However, the stimulatory effect of E7 upon cell proliferation not only depends on its association with pRb, since E7 targets the function of a plethora of cell cycle regulators, including cyclin A, E and cyclin-dependent kinase inhibitor p21^Cip1 and p27^kip1 together with the metabolic regulators, acid-α-glucosidase and M2 pyruvate kinase. HPV E7 also interferes with the activity of a variety of cellular transcription factors, such as AP-1, p48, interferon regulatory factor-1 (IRF-1), forkhead transcription factor MPP2, TATA- box binding protein (TBP) and TATA-box binding protein- associated factor (TAF110), as well as with the Mi2 histone deacetylase activity. Also, E7 interacts with the S4 subunit of the 26S proteasome, a human homolog of the Drosophila tumor suppressor protein Tid56 (hTid-1), insulin-like growth factor binding protein (IGFBP-3) and histone H1 kinase (Table 2) (17, 18).

In a proteomic study using E7-transfected C33A cell lines, cytoskeletal proteins, such as actin and myosin V, were down-regulated by E7 (19). Tumor suppressor integrase interactor 1 protein (INI), ING1, and a novel protein, DJ579F20.2.1, (similar to transcriptional repressor CTCF) were suppressed by E7. E7 was also found to down-regulate chaperones, such as protein disulfide isomerase (PDI) A3. INI is a member of the ATP-dependent SWI/SNF chromatin remodeling complex, also known as tumor suppressor hSNF5/INI, which is mutated in sporadic and hereditary malignant rhabdoid tumors (20), causing G0-G1 cell cycle arrest (20). It was recently reported that the SWI/SNF complex plays an important role in p53-regulated cell cycle control (21), suggesting that the E7-induced down-regulation of hSNF5/INI may contribute to oncogenesis. ING1 is also suppressed by E7, and is a candidate tumor suppressor gene, which contributes to the process of malignant transformation and progression (22). ING1 is involved in DNA repair, apoptosis and chromatin remodeling, and is known to share several biological functions with p53, including cell cycle arrest, DNA repair and apoptosis, and is down-regulated in various cancers, such as breast and gastric cancer (22). However, the relationship between ING1 and the HPV oncoprotein remains to be reported. The mechanism by which E7 inhibits the expression of ING1 should also be elucidated. PDI is an enzyme that catalyzes the formation and isomerization of disulfide bonds, which has peptide binding and chaperone activity for cell adhesion, and is also involved in cell-cell interaction and gene expression. This report demonstrates that E7 can evade immune surveillance and resist apoptosis by suppressing or inducing various factors, such as immune- regulatory, cell signaling and cell cycle regulatory factors.

In HaCaT keratinocytes, E7 was found to down-regulate cytoplasmic actin and the leukocyte elastase inhibitor (LEI) (23). Actin plays an essential role in regulating cell structure during reorganization of cells via specific association with tight junctions. Neutrophil elastase is a protease involved in tissue destruction and inflammation, which characterizes numerous diseases, including hereditary emphysema, chronic obstructive pulmonary disease, cystic fibrosis, adult respiratory distress syndrome, ischemic-reperfusion injury and rheumatoid arthritis (24). Thus, elastase has been the object of extensive research in the development of potent inhibitors targeting its destructive and pro-inflammatory actions (24). This data suggests E7 may be involved in the modulation of elastase activity due to the down-regulation of LEI expression. Chaperone-related proteins, such as HSP60 and cytosolic chaperonin-containing T-complex polypeptide 1 (CCT), were up-regulated. HSP60 is known to be highly expressed in various cancers (25), is presumed may interact with a variety of cellular proteins and has a role in cervical carcinogenesis (25). CCT is a molecular chaperone that plays an important role in the folding of proteins in eukaryotic cytosol. Actin, tubulin and several other proteins are known to be folded by CCT. CCT expression is strongly up-regulated during cell growth, especially from the G1/S transition to the early S phase. CCT is expected to play important roles in the growth of cancer cells by assisting the folding of tubulin andother proteins (26). Ku70BP was up-regulated by E7 in 2-DE, with Ku70 and Ku80 essential for DNA double-strand break repair. It has been suggested that Ku70BP amplification and overexpression may be involved in the function of Ku70 in the DNA-PK complex implicated in the maintenance of genome stability and reduction of mutation frequency (27). E7-induced up-regulation of Ku70BP as been assumed to contribute to the functioning of Ku70, which plays roles in double-strand DNA break repair and maintenance of telomeres. Livin inhibitor-of-apoptosis, a novel human inhibitor of apoptosis protein (IAP) family members, termed 'livin', was induced by E7. The mRNA for livin was undetectable in most normal adult tissues, but was present in developmental tissues and several cancer cell lines. Livin was expressed in the nucleus and in a filamentous pattern throughout the cytoplasm. Disruption of livin may provide a strategy for the induction of apoptosis in certain cancer cells (28).

These results suggest that the infection of the E7 oncogene into epithelial cells can evade immune surveillance or resist against apoptosis by inducing or binding to various factors, such as chaperone, cell signaling and cell cycle regulatory factors.

CONCLUSIONS

Cervical cancer is a worldwide public health problem among women, especially in emerging nations. To improve the control of cervical cancer, new adjuvant diagnostic and therapeutic strategies are required. Advances in immunology, genomics and proteomics have accelerated our understanding of the genetic and cellular basis of many cancer types. Cervical cancer is a member of the virus-related neoplasms, with its initiation and promotion associated with persistent infection of oncogenic HPV.

The application of functional genomics and proteomics to query cervical cancer tissue specimens has yielded novel cancer biomarkers, but these require further validation. The integration of molecular and proteomic biotechnology with immunology has also yielded promising findings that may translate into clinically relevant biological assays. The studies of host proteins associated with HPV E6 and E7 oncoproteins continue to display potential future usage in the management of cervical cancer. Subsequent scientific investigations will probably yield new diagnostic and prognostic tools for cervical cancer, provide insights into its underlying biology and contribute to the development of novel management strategies.

Proteomics is now widely accepted as a useful tool in the development of molecular diagnosis and the identification of disease biomarkers in the post-genomic era. Proteomics also promises lower R&D costs, with the opportunities of new revenue streams through the identification of new drug targets in the treatment of various cancers. This review identifies the key technologies that will enable pharmaceutical companies to develop new niche products, improve drug attrition rates, increase the speed of clinical development and target new drug markets.

NOTES

This work was supported by the Korea Science and Engineering Fund through the Cancer Metastasis Research Center (CMRC) at Yonsei University (R11-2000-082-02007-0 (2004)).

REFERENCES

1. Walboomers JM, Jacobs MV, Manos MM, Bosch FX, Kummer JA, Shah KV, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol. 1999;189:12–19. PMID: 10451482Article PubMed
2. Lipari F, McGibbon GA, Wardrop E, Cordingley MG. Purification and biophysical characterization of a minimal functional domain and of an N-terminal Zn²⁺-binding fragment from the human papillomavirus type 16 E6 protein. Biochemistry. 2001;40:1196–1204. PMID: 11170444Article PubMed
3. Crook T, Tidy JA, Vousden KH. Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation. Cell. 1991;67:547–556. PMID: 1657399Article PubMed
4. Jones DL, Munger K. Interactions of the human papillomavirus E7 protein with cell cycle regulators. Semin Cancer Biol. 1996;7:327–337. PMID: 9284525Article PubMed
5. Lipinski MM, Jacks T. The retinoblastoma gene family in differentiation and development. Oncogene. 1999;18:7873–7882. PMID: 10630640Article PubMed
6. Chellappan S, Kraus VB, Kroger B, Munger K, Howley PM, Phelps WC, et al. Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product. Proc Natl Acad Sci USA. 1992;89:4549–4553. PMID: 1316611Article PubMed PMC
7. Cheng S, Schmidt-Grimminger DC, Murant T, Broker TR, Chow LT. Differentiation-dependent up-regulation of the human papillomavirus E7 gene reactivates cellular DNA replication in suprabasal differentiated keratinocytes. Genes Dev. 1995;9:2335–2349. PMID: 7557386Article PubMed
8. Filippova M, Parkhurst L, Duerksen-Hughes PJ. The human papillomavirus 16 E6 protein binds to Fas-associated death domain and protects cells from Fas-triggered apoptosis. J Biol Chem. 2004;279:25729–25744. PMID: 15073179Article PubMed
9. Yim EK, Meoyng J, Namakoong SE, Um SJ, Park JS. Genomic and proteomic expression patterns in HPV-16 E6 gene transfected stable human carcinoma cell lines. DNA Cell Biol. 2004;23:826–835. PMID: 15684709Article PubMed
10. Scheffner M, Werness BA, Huibregtse JM, Levine AJ, Howley PM. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell. 1990;63:1129–1136. PMID: 2175676Article PubMed
11. Degenhardt K, Sundararajan R, Lindsten T, Thompson C, White E. Bax and Bak independently promote cytochrome C release from mitochondria. J Biol Chem. 2002;277:14127–14134. PMID: 11836241Article PubMed
12. Cheng EH, Wei MC, Weiler S, Flavell RA, Mak TW, Lindsten T, et al. BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol Cell. 2001;8:705–711. PMID: 11583631Article PubMed
13. Cao Z, Xiong J, Takeuchi M, Kurama T, Goeddel DV. TRAF6 is a signal transducer for interleukin-1. Nature. 1996;383:443–446. PMID: 8837778Article PubMed
14. Kaufmann WK, Schwartz JL, Hurt JC, Byrd LL, Galloway DA, Levedakou E, et al. Inactivation of G2 checkpoint function and chromosomal destabilization are linked in human fibroblasts expressing human papillomavirus type 16 E6. Cell Growth Differ. 1997;8:1105–1114. PMID: 9342189PubMed
15. Park JS, Kim EJ, Lee JY, Sin HS, Namkoong SE, Um SJ. Functional inactivation of p73, a homolog of p53 tumor suppressor protein, by the human papillomavirus E6 proteins. Int J Cancer. 2001;91:822–827. PMID: 11275986Article PubMed
16. Yim EK, Um SJ, Park JS. Interaction of HPV E6 oncoprotein with the novel protein, BARD1 (BRCA1-associated ring domain 1) and its biological role. 2005. In: 22nd Intl. Papillomavirus Conference;
17. Park JS, Kim EJ, Kwon HJ, Hwang ES, Namkoong SE, Um SJ. Inactivation of interferon regulatory factor-1 tumor suppressor protein by HPV E7 oncoprotein; implication for the E7-mediated immune evasion mechanism in cervical carcinogenesis. J Biol Chem. 2000;275:6764–6769. PMID: 10702232Article PubMed
18. Barnard P, McMillan NA. The human papillomavirus E7 oncoprotein abrogates signaling mediated by interferon-alpha. Virology. 1999;259:305–313. PMID: 10388655Article PubMed
19. Lee KA, Shim JH, Kho CW, Park SG, Park BC, Kim JW, et al. Protein profiling and identification of modulators regulated by the E7 oncogene in the C33A cell line by proteomics and genomics. Proteomics. 2004;4:839–848. PMID: 14997504Article PubMed
20. Versteege I, Medjkane S, Rouillard D, Delattre O. A key role of the hSNF5/INI1 tumour suppressor in the control of the G1-S transition of the cell cycle. Oncogene. 2002;21:6403–6412. PMID: 12226744Article PubMed
21. Lee D, Kim JW, Seo T, Hwang SG, Choi EJ, Choe J. SWI/SNF complex interacts with tumor suppressor p53 and is necessary for the activation of p53-mediated transcription. J Biol Chem. 2002;277:22330–22337. PMID: 11950834Article PubMed
22. Tokunaga E, Maehara Y, Oki E, Kitamura K, Kakeji Y, Ohno S, et al. Diminished expression of ING1 mRNA and the correlation with p53 expression in breast cancers. Cancer Lett. 2000;152:15–22. PMID: 10754201Article PubMed
23. Lee KA, Kang JW, Shim JH, Kho CW, Park SG, Lee HG, et al. Protein profiling and identification of modulators regulated by human papillomavirus 16 E7 oncogene in HaCaT keratinocytes by proteomics. Gynecol Oncol. 2005;99:142–152. PMID: 16038965Article PubMed
24. Tremblay GM, Janelle MF, Bourbonnais Y. Anti-inflammatory activity of neutrophil elastase inhibitors. Curr Opin Investig Drugs. 2003;4:556–565. PubMed
25. Kimura E, Enns RE, Thiebaut F, Howell SB. Regulation of HSP60 mRNA expression in a human ovarian carcinoma cell line. Cancer Chemother Pharmacol. 1993;32:279–285. PMID: 8100743Article PubMed
26. Yokota S, Yanagi H, Yura T, Kubota H. Cytosolic chaperonin is up-regulated during cell growth Preferential expression and binding to tubulin at G(1)/S transition through early S phase. J Biol Chem. 1999;274:37070–37078. PMID: 10601265Article PubMed
27. Song K, Jung D, Jung Y, Lee SG, Lee I. Interaction of human Ku70 with TRF2. FEBS Lett. 2000;481:81–85. PMID: 10984620Article PubMed
28. Kasof GM, Gomes BC. Livin, a novel inhibitor of apoptosis protein family member. J Biol Chem. 2001;276:3238–3246. PMID: 11024045Article PubMed

Fig. 1

HPV E6 and E7 binding to P53, with Rb interfering with the normal functions of the tumor suppressors.

Table 1

Cellular binding partners for HPV E6

Table 2

Cellular binding partners for HPV E7

Figure & Data

REFERENCES

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Biology of the Cell.2024;[Epub] CrossRef
Exploring the Relationship between Ovarian Cancer and Genital Microbiota: A Systematic Review and Meta-Analysis
Vito Andrea Capozzi, Giosuè Giordano Incognito, Elisa Scarpelli, Marco Palumbo, Cinzia Lucia Randazzo, Alessandra Pino, Marco La Verde, Carlo Ronsini, Gaetano Riemma, Michela Gaiano, Paola Romeo, Vittorio Palmara, Roberto Berretta, Stefano Cianci
Journal of Personalized Medicine.2024; 14(4): 351. CrossRef
Virus-like Particles for Disease Diagnosis and Drug Delivery Applications
Rishav Sharma, Rishabha Malviya
Current Nanoscience.2024; 20(5): 613. CrossRef
Biplex quantitative PCR to detect transcriptionally active human papillomavirus 16 from patient saliva
Fiona Deutsch, Dayna Sais, Ni Keatinge, Meredith Hill, Ngoc Ha Tran, Michael Elliott, Nham Tran
BMC Cancer.2024;[Epub] CrossRef
Biochemical and toxicity evaluation of Retama sphaerocarpa extracts and in-silico investigation of phenolic compounds as potential inhibitors against HPV16 E6 oncoprotein
Soumia Moujane, Ismail Bouadid, Aziz Bouymajane, Filali Zegzouti Younes, Mohamed Benlyas, Bouachrine Mohammed, Francesco Cacciola, Roberto Laganà Vinci, Alessia Tropea, Luigi Mondello, Ammar B. Altemimi, Mohamed Eddouks, Benaissa Moualij
Fitoterapia.2024; 175: 105923. CrossRef
Viruses in glioblastoma: an update on evidence and clinical trials
Bavani Gunasegaran, Caroline L. Ashley, Felix Marsh-Wakefield, Gilles J. Guillemin, Benjamin Heng
BJC Reports.2024;[Epub] CrossRef
Ubiquitin-specific protease 7 inhibitors reveal a differentiated mechanism of p53-driven anti-cancer activity
Alan S. Futran, Tao Lu, Katherine Amberg-Johnson, Jiayi Xu, Xiaoxiao Yang, Saidi He, Sarah Boyce, Jeffrey A. Bell, Robert Pelletier, Takao Suzuki, Xianhai Huang, Heng Qian, Liping Fang, Li Xing, Zhaowu Xu, Stephen E. Kurtz, Jeffrey W. Tyner, Wayne Tang, T
iScience.2024; 27(5): 109693. CrossRef
Emerging biomarkers and molecular targets for precision medicine in cervical cancer
Pankaj Garg, Madhu Krishna, Ayalur Raghu Subbalakshmi, Sravani Ramisetty, Atish Mohanty, Prakash Kulkarni, David Horne, Ravi Salgia, Sharad S. Singhal
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2024; 1879(3): 189106. CrossRef
Unfurling the functional association between long intergenic noncoding RNAs (lincRNAs) and HPV16-related cervical cancer pathogenesis through weighted gene co-expression network analysis of differentially expressed lincRNAs and coding genes
Abarna Sinha, Sahana Ghosh, Abhisikta Ghosh, Arnab Ghosh, Sonia Mathai, Jaydip Bhaumik, Asima Mukhopadhyay, Arindam Maitra, Nidhan K Biswas, Sharmila Sengupta
Carcinogenesis.2024; 45(7): 451. CrossRef
Two Lineages of Papillomaviruses Identified from Caracals (Caracal caracal) in South Africa
Simona Kraberger, Laurel E. K. Serieys, Gabriella R. M. Leighton, Matthew D. De Koch, John S. Munday, Jacqueline M. Bishop, Arvind Varsani
Viruses.2024; 16(5): 701. CrossRef
Molecular Typing of Human Leukocyte Antigen-Class I (HLA-A, HLA-B) & Human Leukocyte Antigen-Class II (HLA-DR) in Carcinoma Cervix and Its Association with Staging
Sumanta Das, Mukul Singh, Anjali Sharma, R. Naveen Kumar, Adil Aziz Khan
Indian Journal of Gynecologic Oncology.2024;[Epub] CrossRef
Tumor-Derived Antigenic Peptides as Potential Cancer Vaccines
Stanislav Sotirov, Ivan Dimitrov
International Journal of Molecular Sciences.2024; 25(9): 4934. CrossRef
CRL4-DCAF1 Ubiquitin Ligase Dependent Functions of HIV Viral Protein R and Viral Protein X
Ashley Dobransky, Mary Root, Nicholas Hafner, Matty Marcum, H. John Sharifi
Viruses.2024; 16(8): 1313. CrossRef
Impact of human papillomavirus types on uterine cervical neoplasia
Ayumi Taguchi, Daisuke Yoshimoto, Misako Kusakabe, Satoshi Baba, Akira Kawata, Yuichiro Miyamoto, Mayuyo Mori, Kenbun Sone, Yasushi Hirota, Yutaka Osuga
Journal of Obstetrics and Gynaecology Research.2024; 50(8): 1283. CrossRef
Quantification of HPV16 E7 Oncoproteins in Urine Specimens from Women with Cervical Intraepithelial Neoplasia
Daiki Makioka, Mikio Inada, Masayuki Awano, Ema Saito, Takuya Shinoda, Satoko Abe, Teruki Yoshimura, Martin Müller, Toshiyuki Sasagawa, Etsuro Ito
Microorganisms.2024; 12(6): 1205. CrossRef
Assessing bias in the causal role of HPV in oral cancer: A systematic review and meta‐analysis
Gagandeep Kaur, Tami Yap, Rishi Ramani, Michael McCullough, Ankur Singh
Oral Diseases.2024; 30(8): 5379. CrossRef
Current status and future directions for the development of human papillomavirus vaccines
Rui Wang, Hongpeng Huang, Chulin Yu, Xuefeng Li, Yang Wang, Liangzhi Xie
Frontiers in Immunology.2024;[Epub] CrossRef
Exosome‐based therapy and targeted PROTAC delivery: A new nanomedicine frontier for HPV‐mediated cervical cancer treatment
Nobendu Mukerjee, Swastika Maitra, Arabinda Ghosh
Clinical and Translational Discovery.2024;[Epub] CrossRef
Human papillomavirus‐16 E6‐positive cervical cancer attenuated by potent 2‐(4‐biphenylyl)‐N‐(1‐ethyl‐4‐piperidinyl) acetamide second‐generation analogs with improved binding affinity
Ashish Kumar
Biotechnology and Applied Biochemistry.2024; 71(6): 1428. CrossRef
Transforming growth factor-β micro-environment mediated immune cell functions in cervical cancer
Jayapradha Gnanagurusamy, Sneha Krishnamoorthy, Sridhar Muthusami
International Immunopharmacology.2024; 140: 112837. CrossRef
Harnessing virulence factor-derived peptides for innovative oral cancer treatment
Karthikeyan Kandaswamy, Ajay Guru
Natural Product Research.2024; : 1. CrossRef
Oncoviral Infections and Small Extracellular Vesicles
Łukasz Ważny, Theresa L. Whiteside, Monika Pietrowska
Viruses.2024; 16(8): 1291. CrossRef
Therapeutic Strategies in Advanced Cervical Cancer Detection, Prevention and Treatment
Xolisiwe Sebutsoe, Nrateng Tsotetsi, Zodwa Jantjies, Portia Pheladi Raphela-Choma, Mpho Choene, lesetja R Motadi
OncoTargets and Therapy.2024; Volume 17: 785. CrossRef
Bovine papillomavirus gene expression and inflammatory pathway activation vary between equine sarcoid tumour subtypes
Nicholas J. Parkinson, Abby Ward, Alexandra J. Malbon, Richard J.M. Reardon, Padraig G. Kelly
Veterinary Immunology and Immunopathology.2024; 277: 110838. CrossRef
Small non-coding RNAs as diagnostic, prognostic and predictive biomarkers of gynecological cancers: an update
Marios A. Diamantopoulos, Panagiotis G. Adamopoulos, Andreas Scorilas
Expert Review of Molecular Diagnostics.2024; 24(11): 979. CrossRef
The role of transforming growth factor β in cervical carcinogenesis
Kleber Paiva Trugilo, Guilherme Cesar Martelossi Cebinelli, Eliza Pizarro Castilha, Mariane Ricciardi da Silva, Fernanda Costa Brandão Berti, Karen Brajão de Oliveira
Cytokine & Growth Factor Reviews.2024; 80: 12. CrossRef
A Self-Amplifying Human Papillomavirus 16 Vaccine Candidate Delivered by Tobacco Mosaic Virus-Like Particles
Sweta Karan, Jessica Fernanda Affonso De Oliveira, Miguel A. Moreno-Gonzalez, Nicole F. Steinmetz
ACS Applied Bio Materials.2024; 7(11): 7675. CrossRef
A State‐of‐the‐Art Review on the Recent Advances in Exosomes in Oncogenic Virus
Fatemeh Ebrahimi, Ali Modaresi Movahedi, Mohammad Sabbaghian, Vahdat Poortahmasebi
Health Science Reports.2024;[Epub] CrossRef
miRNAs Dysregulated in Human Papillomavirus-Associated Benign Prostatic Lesions and Prostate Cancer
Sandra Viridiana Salgado-Hernández, Lucero Martínez-Retamoza, Rodolfo Ocadiz-Delgado, Salvador Pérez-Mora, Gladys Edith Cedeño-Arboleda, María del Consuelo Gómez-García, Patricio Gariglio, David Guillermo Pérez-Ishiwara
Cancers.2024; 17(1): 26. CrossRef
Association between mutant E6 and E7 Human Papilloma Virus Type 16 oncogenes with cyclin D1 expression in cervical cancer: Observational study in Bali
I Nyoman Bayu Mahendra, I Nyoman Gede Budiana, I Gede Mega Putra, Anom Suardika, Anak Agung Gede Putra Wiradnyana, Alisza Novrita Sari
F1000Research.2023; 12: 257. CrossRef
Human papillomavirus infection, cervical cancer and the less explored role of trace elements
Anne Boyina Sravani, Vivek Ghate, Shaila Lewis
Biological Trace Element Research.2023; 201(3): 1026. CrossRef
Viral subversion of the cell polarity regulator Scribble
Airah Javorsky, Patrick O. Humbert, Marc Kvansakul
Biochemical Society Transactions.2023;[Epub] CrossRef
High nuclear expression of DNMT1 in correlation with inactivation of TET1 portray worst prognosis among the cervical carcinoma patients: clinical implications
Priyanka Dutta, Mukta Basu, Anup Roy, Ranajit Kumar Mandal, Chinmay Kumar Panda
Journal of Molecular Histology.2023; 54(1): 89. CrossRef
p15INK4B is an alternative marker of senescent tumor cells in colorectal cancer
Soon Sang Park, Young-Kyoung Lee, So Hyun Park, Su Bin Lim, Yong Won Choi, Jun Sang Shin, Young Hwa Kim, Jang-Hee Kim, Tae Jun Park
Heliyon.2023; 9(2): e13170. CrossRef
Evaluation of the proteomic landscape of HPV E7‑induced alterations in human keratinocytes reveal therapeutically relevant pathways for cervical cancer
Sivasangkary Gandhi, Muhammad Fazril Mohamad Razif, Shatrah Othman, Sajib Chakraborty, Nurshamimi Nor Rashid
Molecular Medicine Reports.2023;[Epub] CrossRef
Immune Environment and Immunotherapy in Endometrial Carcinoma and Cervical Tumors
Alexandra Lainé, Andrea M. Gonzalez-Lopez, Uzma Hasan, Ryotaro Ohkuma, Isabelle Ray-Coquard
Cancers.2023; 15(7): 2042. CrossRef
Drug repurposing for viral cancers: A paradigm of machine learning, deep learning, and virtual screening‐based approaches
Faheem Ahmed, In Suk Kang, Kyung Hwan Kim, Arun Asif, Chethikkattuveli Salih Abdul Rahim, Anupama Samantasinghar, Fida Hussain Memon, Kyung Hyun Choi
Journal of Medical Virology.2023;[Epub] CrossRef
Protein–DNA Interactions Regulate Human Papillomavirus DNA Replication, Transcription, and Oncogenesis
Roxanne Evande, Anshul Rana, Esther E. Biswas-Fiss, Subhasis B. Biswas
International Journal of Molecular Sciences.2023; 24(10): 8493. CrossRef
Histopathologic and molecular characterization of Erethizon dorsatum papillomavirus 1 and Erethizon dorsatum papillomavirus 2 infection in North American porcupines (Erethizon dorsatum)
Zoe E. Mack, Leonardo C. Caserta, Randall W. Renshaw, Shotaro Nakagun, Rhea S. Gerdes, Diego G. Diel, Sara E. Childs-Sanford, Jeanine Peters-Kennedy
Veterinary Pathology.2023; 60(6): 898. CrossRef
Whole-Genome Doubling as a source of cancer: how, when, where, and why?
Natalia Sanz-Gómez, María González-Álvarez, Javier De Las Rivas, Guillermo de Cárcer
Frontiers in Cell and Developmental Biology.2023;[Epub] CrossRef
Retrospective Phylodynamic and Phylogeographic Analysis of the Human Papillomavirus 16 E6 Gene in the Mediterranean Region
Oussama Souiai, Ameni Sallemi
Bioinformatics and Biology Insights.2023;[Epub] CrossRef
MicroRNAs as Potential Biomarkers in Gynecological Cancers
Joanna Miśkiewicz, Aleksandra Mielczarek-Palacz, Joanna Magdalena Gola
Biomedicines.2023; 11(6): 1704. CrossRef
Impact of Dietary Quality on Genital Oncogenic Human Papillomavirus Infection in Women
Hui-Yi Lin, Qiufan Fu, Tung-sung Tseng, Xiaodan Zhu, Krzysztof Reiss, L Joseph Su, Michael E Hagensee
The Journal of Infectious Diseases.2023; 228(10): 1385. CrossRef
Prevalence of P16 Immunohistochemistry Positive Staining and Its Correlation to Clinical and Radiological Staging of Squamous Cell Carcinoma of the Cervix
Hossam H. El Sokkary, Eman Sheta
The Journal of Obstetrics and Gynecology of India.2023; 73(S1): 142. CrossRef
HPV-associated cancers: insights into the mechanistic scenario and latest updates
Anirban Goutam Mukherjee, Uddesh Ramesh Wanjari, Abilash Valsala Gopalakrishnan, Rama Jayaraj, Ramkumar Katturajan, Sandra Kannampuzha, Reshma Murali, Arunraj Namachivayam, Sabina Evan Prince, Balachandar Vellingiri, Abhijit Dey, Kaviyarasi Renu
Medical Oncology.2023;[Epub] CrossRef
Genome editing mRNA nanotherapies inhibit cervical cancer progression and regulate the immunosuppressive microenvironment for adoptive T-cell therapy
Kaijian Ling, Yin Dou, Neng Yang, Li Deng, Yanzhou Wang, Yudi Li, Leiyan Yang, Cheng Chen, Lupin Jiang, Qingchun Deng, Chenwen Li, Zhiqing Liang, Jianxiang Zhang
Journal of Controlled Release.2023; 360: 496. CrossRef
Viral manipulation of cell polarity signalling
Airah Javorsky, Patrick O. Humbert, Marc Kvansakul
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research.2023; 1870(7): 119536. CrossRef
The Undefinable Links: Unraveling the Mysterious Relationships Between Viruses and the Human
Yuening Li
Highlights in Science, Engineering and Technology.2023; 54: 397. CrossRef
Herpes Simplex Virus, Human Papillomavirus, and Cervical Cancer: Overview, Relationship, and Treatment Implications
Daniel Sausen, Oren Shechter, Elisa Gallo, Harel Dahari, Ronen Borenstein
Cancers.2023; 15(14): 3692. CrossRef
The potential role of the microbiota in prostate cancer pathogenesis and treatment
Nicolò Pernigoni, Christina Guo, Lewis Gallagher, Wei Yuan, Manuel Colucci, Martina Troiani, Lei Liu, Luisa Maraccani, Ilaria Guccini, Denis Migliorini, Johann de Bono, Andrea Alimonti
Nature Reviews Urology.2023; 20(12): 706. CrossRef
Clinicopathologic and Molecular Characterization of Anorectal Neuroendocrine Carcinomas Reveals Human Papillomavirus, p53, and c-Myc as Alternative Mechanisms of Carcinogenesis
Allison J. Cox, William E. Crowe, Qi Yang, Bin Zhang, Zoltán N. Oltvai, Xiaoyan Liao
Modern Pathology.2023; 36(11): 100295. CrossRef
An updated systemic review and meta-analysis on human papillomavirus in breast carcinogenesis
Usman Ayub Awan, Aamer Ali Khattak, Noman Ahmed, Xingyi Guo, Sohail Akhtar, Shehrish Kamran, Zhao Yongjing, Jianbo Liu, Suliman Khan
Frontiers in Oncology.2023;[Epub] CrossRef
Role of MLH1 and MSH2 deficiency in the development of tumorigenesis and chemo-tolerance of cervical Carcinoma: Clinical implications
Priyanka Dutta, Debolina Pal, Anup Roy, Ranajit Kumar Mandal, Chinmay Kumar Panda
Gene.2023; 888: 147746. CrossRef
Detection of High-Grade Cervical Intraepithelial Neoplasia by Electrical Impedance Spectroscopy in Women Diagnosed with Low-Grade Cervical Intraepithelial Neoplasia in Cytology
Georgios Panagakis, Ioannis K. Papapanagiotou, Charalampos Theofanakis, Paraskevi Tsetsa, Adamantia Kontogeorgi, Nikolaos Thomakos, Alexandros Rodolakis, Dimitrios Haidopoulos
Life.2023; 13(11): 2139. CrossRef
MULTİPL SKLEROZ HASTALARINDA SERVİKAL DİSPLAZİ RİSKİ
Özlem Kayacık Günday, Gökçe Zeytin Demiral, Şerafettin Baysal, Tacettin Sevim, Selin Yoldaş, Berkay Çelebi, Ensar Çam
Kocatepe Tıp Dergisi.2023; 24(4): 493. CrossRef
p16/Ki67 dual stain triage versus cytology in primary human papillomavirus‐based cervical cancer screening with limited genotyping
Martyna Trzeszcz, Maciej Mazurec, Robert Jach, Karolina Mazurec, Izabela Kotkowska‐Szeps, Magdalena Kania, Mariola Wantuchowicz, Jolanta Wasowska, Monika Duczek‐Polakiewicz, Patrycja Rozmus, Joanna Streb, Agnieszka Halon
Journal of Medical Virology.2023;[Epub] CrossRef
From Diagnosis to Treatment: Exploring the Latest Management Trends in Cervical Intraepithelial Neoplasia
Saloni Gupta, Nikhilesh Nagtode, Vaibhav Chandra, Kavita Gomase
Cureus.2023;[Epub] CrossRef
Regulatory Effect of Ficus carica Latex on Cell Cycle Progression in Human Papillomavirus-Positive Cervical Cancer Cell Lines: Insights from Gene Expression Analysis
Muharrem Cakir, Ugur Bilge, Arshia Ghanbari, G. Ashrafi
Pharmaceuticals.2023; 16(12): 1723. CrossRef
Leveraging innovative therapies with an evolving understanding of the molecular pathogenesis of penile squamous cell carcinoma
Ali Hajiran, Taylor Bracco, Logan Zemp, Philippe E. Spiess
Urologic Oncology: Seminars and Original Investigations.2022; 40(5): 173. CrossRef
Antioxidant and Cytotoxic Activities of Exopolysaccharides from Alcaligenes faecalis Species Isolated from the Marine Environment of Mauritius
Aadil Ahmad Aullybux, Daneshwar Puchooa, Theeshan Bahorun, Rajesh Jeewon, Xuesong Wen, Poona Matin
Journal of Polymers and the Environment.2022; 30(4): 1462. CrossRef
Molecular landscape of vulvovaginal squamous cell carcinoma: new insights into molecular mechanisms of HPV-associated and HPV-independent squamous cell carcinoma
Abeer M. Salama, Amir Momeni-Boroujeni, Chad Vanderbilt, Marc Ladanyi, Robert Soslow
Modern Pathology.2022; 35(2): 274. CrossRef
Haemophilus pittmaniae and Leptotrichia spp. Constitute a Multi-Marker Signature in a Cohort of Human Papillomavirus-Positive Head and Neck Cancer Patients
Jean-Luc C. Mougeot, Micaela F. Beckman, Holden C. Langdon, Rajesh V. Lalla, Michael T. Brennan, Farah K. Bahrani Mougeot
Frontiers in Microbiology.2022;[Epub] CrossRef
Therapeutic DNA Vaccines against HPV-Related Malignancies: Promising Leads from Clinical Trials
Jianming Tang, Mingzhu Li, Chao Zhao, Danhua Shen, Lei Liu, Xiujun Zhang, Lihui Wei
Viruses.2022; 14(2): 239. CrossRef
Modelling Chlamydia and HPV co-infection in patient-derived ectocervix organoids reveals distinct cellular reprogramming
Stefanie Koster, Rajendra Kumar Gurumurthy, Naveen Kumar, Pon Ganish Prakash, Jayabhuvaneshwari Dhanraj, Sofia Bayer, Hilmar Berger, Shilpa Mary Kurian, Marina Drabkina, Hans-Joachim Mollenkopf, Christian Goosmann, Volker Brinkmann, Zachary Nagel, Mandy M
Nature Communications.2022;[Epub] CrossRef
Peptide-Based Nanovaccines in the Treatment of Cervical Cancer: A Review of Recent Advances
Jiahui Zhang, Jingyi Fan, Mariusz Skwarczynski, Rachel J Stephenson, Istvan Toth, Waleed M Hussein
International Journal of Nanomedicine.2022; Volume 17: 869. CrossRef
Cancer Therapy With TCR-Engineered T Cells: Current Strategies, Challenges, and Prospects
Paul Shafer, Lauren M. Kelly, Valentina Hoyos
Frontiers in Immunology.2022;[Epub] CrossRef
Human Papillomavirus E6/E7 oncogene transcripts as biomarkers for the early detection of cervical cancer
Sadhana M Gupta, Himangi Warke, Hemangi Chaudhari, Padmaja Mavani, Rajshree D. Katke, Shilpa C. Kerkar, Jayanti Mania‐Pramanik
Journal of Medical Virology.2022; 94(7): 3368. CrossRef
Targeting metabolism: A potential strategy for hematological cancer therapy
Xue Tang, Fen Chen, Li-Chun Xie, Si-Xi Liu, Hui-Rong Mai
World Journal of Clinical Cases.2022; 10(10): 2990. CrossRef
Head and Neck Cancer Susceptibility and Metabolism in Fanconi Anemia
Tafadzwa Chihanga, Sara Vicente-Muñoz, Sonya Ruiz-Torres, Bidisha Pal, Mathieu Sertorio, Paul R. Andreassen, Ruby Khoury, Parinda Mehta, Stella M. Davies, Andrew N. Lane, Lindsey E. Romick-Rosendale, Susanne I. Wells
Cancers.2022; 14(8): 2040. CrossRef
Current and future direction in treatment of HPV-related cervical disease
Niloofar Khairkhah, Azam Bolhassani, Reza Najafipour
Journal of Molecular Medicine.2022; 100(6): 829. CrossRef
Parent Attitudes regarding Orthodontists’ Role as Potential Administrators of Human Papilloma Virus (HPV) Vaccines
Gloria Lee, Jessica Begley, Kavita Ahluwalia, Jaffer A Shariff, Sunil Wadhwa, Christine O’Hea, Gaetano Isola
International Journal of Dentistry.2022; 2022: 1. CrossRef
Graphene Quantum Dots – Hydrothermal Green Synthesis, Material Characterization and Prospects for Cervical Cancer Diagnosis Applications: A Review
Raghavv Raghavender Suresh, Arockia Jayalatha Kulandaisamy, Noel Nesakumar, Saisubramanian Nagarajan, Jung Heon Lee, John Bosco Balaguru Rayappan
ChemistrySelect.2022;[Epub] CrossRef
Interplay between cellular metabolism and DNA viruses
Milad Zandi, Somayeh Shokri, Shahab Mahmoudvand, Ahmad Hosseinzadeh Adli, Ramin Mohammadi, Azita Haddadi
Journal of Medical Virology.2022; 94(11): 5163. CrossRef
Breast Cancer Risk and Human Papillomavirus Infection: A Bradford Hill Criteria Based Evaluation
Muhammad Usman, Yasir Hameed, Mukhtiar Ahmad, Jalil Ur Rehman, Hamad Ahmed, Muhammad Safdar Hussain, Rizwan Asif, Muhammad Ghulam Murtaza, Muhammad Tayyab Jawad, Muhammad Junaid Iqbal
Infectious Disorders - Drug Targets.2022;[Epub] CrossRef
Sensor detection in gynaecological medicine
Michael Thompson, Soha Ahmadi, Katharina Davoudian, Brian De La Franier, Navina Lotay, Marcus Q. Bernardini
Sensors & Diagnostics.2022; 1(5): 877. CrossRef
Cervical cancer screening, treatment and prophylaxis in Brazil: Current and future perspectives for cervical cancer elimination
Flávia M. Corrêa, Arn Migowski, Liz M. de Almeida, Marcelo A. Soares
Frontiers in Medicine.2022;[Epub] CrossRef
HPV-mediated Cervical Cancer: A Systematic Review on Immunological Basis, Molecular Biology, and Immune Evasion Mechanisms
Ramar Vanajothi, Natarajan Srikanth, Rajendran Vijayakumar, Manikandan Palanisamy, Sundaresan Bhavaniramya, Kumpati Premkumar
Current Drug Targets.2022; 23(8): 782. CrossRef
Potential role of human papillomavirus proteins associated with the development of cancer
Dhanvee Balaji, Iyshwarya Bhaskar Kalarani, Vajagathali Mohammed, Ramakrishnan Veerabathiran
VirusDisease.2022; 33(3): 322. CrossRef
Proton-induced DNA damage promotes integration of foreign plasmid DNA into human genome
Meghri Katerji, Antonella Bertucci, Valery Filippov, Marcelo Vazquez, Xin Chen, Penelope J. Duerksen-Hughes
Frontiers in Oncology.2022;[Epub] CrossRef
Anti-cancer properties of Caulerpa racemosa by altering expression of Bcl-2, BAX, cleaved caspase 3 and apoptosis in HeLa cancer cell culture
Happy Kurnia Permatasari, Defny Silvia Wewengkang, Nur Iedha Tertiana, Farida Zharfani Muslim, Muhammad Yusuf, Shintya Octaviana Baliulina, Vanessa Pradna Adyana Daud, Aurielle Annalicia Setiawan, Fahrul Nurkolis
Frontiers in Oncology.2022;[Epub] CrossRef
Does Lactobacillus Exert a Protective Effect on the Development of Cervical and Endometrial Cancer in Women?
Karolina Frąszczak, Bartłomiej Barczyński, Adrianna Kondracka
Cancers.2022; 14(19): 4909. CrossRef
Cervical cancer screening: Past, present and outlook
Radomir Živadinović, Aleksandra Petrić, Aleksandar Živadinović, Sonja Pop-Trajković, Lazar Živadinović, Dušan Simić
Glasnik javnog zdravlja.2022; 96(3): 333. CrossRef
HPV-18 E7 Interacts with Elk-1 Leading to Elevation of the Transcriptional Activity of Elk-1 in Cervical Cancer
Sung-Ho Go, Seung Bae Rho, Dong-Wha Yang, Boh-Ram Kim, Chang Hoon Lee, Seung-Hoon Lee
Biomolecules & Therapeutics.2022; 30(6): 593. CrossRef
A Reverse Structure-based Design of HPV E7 Inhibitor
Wan Chein Tan, Shatrah Othman, See Khai Lim, Nurshamimi Nor Rashid, Choon Han Heh
Current Computer-Aided Drug Design.2022; 18(4): 318. CrossRef
Investigation of Curcumin-Loaded OA400 Nanoparticle’s Effect on the Expression of E6 and E7 Human Papilloma-Virus Oncogenes and P53 and Rb Factors in HeLa Cell Line
Rezvaneh Vahedian Sadeghi, Masoud Parsania, Majid Sadeghizadeh, Setareh Haghighat
Iranian Journal of Pharmaceutical Research.2022;[Epub] CrossRef
Enhancing the Effect of Nucleic Acid Vaccines in the Treatment of HPV-Related Cancers: An Overview of Delivery Systems
Ingrid Andrêssa de Moura, Anna Jéssica Duarte Silva, Larissa Silva de Macêdo, Maria da Conceição Viana Invenção, Mylenna Máyra Gois de Sousa, Antonio Carlos de Freitas
Pathogens.2022; 11(12): 1444. CrossRef
Effects of Human Papilloma Virus E6/E7 Oncoproteins on Genomic Structure in Head and Neck Squamous Cell Carcinoma
Matthew Uzelac, Armon Barakchi, Varsha Beldona, Daniel John, Jaideep Chakladar, Wei Tse Li, Weg M. Ongkeko
Cancers.2022; 14(24): 6190. CrossRef
Towards Novel Gene and Cell Therapy Approaches for Cervical Cancer
Robert Polten, Ivana Kutle, Jens Hachenberg, Rüdiger Klapdor, Michael Morgan, Axel Schambach
Cancers.2022; 15(1): 263. CrossRef
The Presence of Human Papillomavirus and Epstein-Barr Virus Infection in Gastric Cancer: A Systematic Study
Abolfazl Jafari-Sales, Afsoon Shariat, Hossein Bannazadeh Baghi, Behzad Baradaran, Behboud Jafari
Oncologie.2022; 24(3): 413. CrossRef
Immunology of HPV-mediated cervical cancer: current understanding
Babban Jee, Renu Yadav, Sangeeta Pankaj, Shivendra Kumar Shahi
International Reviews of Immunology.2021; 40(5): 359. CrossRef
The role of human papillomavirus in the pathogenesis of sinonasal inverted papilloma: a narrative review
Rohit Gupta, Peter L. Rady, Andrew G. Sikora, Stephen K. Tyring
Reviews in Medical Virology.2021;[Epub] CrossRef
The role of HPV gene expression and selected cellular MiRNAs in lung cancer development
Bashdar Mahmud Hussen, Gelavizh Ahmadi, Havva Marzban, Maryam Ebadi Fard Azar, Saba Sorayyayi, Romina Karampour, Javid Sadri Nahand, Hazha Jamal Hidayat, Mohsen Moghoofei
Microbial Pathogenesis.2021; 150: 104692. CrossRef
Adjunctive testing by cytology, p16/Ki‐67 dual‐stained cytology or HPV16/18 E6 oncoprotein for the management of HPV16/18 screen‐positive women
Leticia Torres‐Ibarra, Attila T. Lorincz, Cosette M. Wheeler, Jack Cuzick, Rubí Hernández‐López, Donna Spiegelman, Leith León‐Maldonado, Berenice Rivera‐Paredez, Pablo Méndez‐Hernández, Eduardo Lazcano‐Ponce, Jorge Salmerón
International Journal of Cancer.2021; 148(9): 2264. CrossRef
EGFR Protein Expression Relates with Tumor Histology, Methylation Status of EGFR and HPV16 E6 Viral Load in Oropharyngeal Carcinoma
Yo Suzuki, Yuki Fukumura, Miki Asahina, Mitsuhisa Fujimaki, Shinichi Ohba, Fumihiko Matsumoto, Isao Kurahayashi, Takashi Yao, Katsuhisa Ikeda
Head and Neck Pathology.2021; 15(3): 743. CrossRef
An internal class III PDZ binding motif in HPV16 E6* protein is required for Dlg degradation activity
Wareerat Umnajvijit, Jariya Sangthong, Fabien Loison, Kulthida Vaeteewoottacharn, Mathurose Ponglikitmongkol
Biochimica et Biophysica Acta (BBA) - General Subjects.2021; 1865(5): 129850. CrossRef
Microbiota Effects on Carcinogenesis: Initiation, Promotion, and Progression
Lacey R. Lopez, Rachel M. Bleich, Janelle C. Arthur
Annual Review of Medicine.2021; 72(1): 243. CrossRef
Ovulatory Follicular Fluid Facilitates the Full Transformation Process for the Development of High-Grade Serous Carcinoma
Che-Fang Hsu, Pao-Chu Chen, Vaishnavi Seenan, Dah-Ching Ding, Tang-Yuan Chu
Cancers.2021; 13(3): 468. CrossRef
Is There a Carcinogenic Risk Attached to Vitamin B12 Deficient Diets and What Should We Do About It? Reviewing the Facts
Alexandra K. Loedin, Dave Speijer
Molecular Nutrition & Food Research.2021;[Epub] CrossRef
Virus-like particles: preparation, immunogenicity and their roles as nanovaccines and drug nanocarriers
Saghi Nooraei, Howra Bahrulolum, Zakieh Sadat Hoseini, Camellia Katalani, Abbas Hajizade, Andrew J. Easton, Gholamreza Ahmadian
Journal of Nanobiotechnology.2021;[Epub] CrossRef
Focus on HPV Infection and the Molecular Mechanisms of Oral Carcinogenesis
Luigi Santacroce, Michele Di Cosola, Lucrezia Bottalico, Skender Topi, Ioannis Alexandros Charitos, Andrea Ballini, Francesco Inchingolo, Angela Pia Cazzolla, Gianna Dipalma
Viruses.2021; 13(4): 559. CrossRef
An Emerging Anti-p16 Antibody-BC42 Clone as an Alternative to the Current E6H4 for Use in the Female Genital Tract Pathological Diagnosis: Our Experience and a Review on p16ink4a Functional Significance, Role in Daily-Practice Diagnosis, Prognostic Potent
Giuseppe Angelico, Angela Santoro, Frediano Inzani, Patrizia Straccia, Saveria Spadola, Damiano Arciuolo, Michele Valente, Nicoletta D’Alessandris, Roberta Benvenuto, Antonio Travaglino, Antonio Raffone, Gian Franco Zannoni
Diagnostics.2021; 11(4): 713. CrossRef
Dynamic crosstalk within the tumor microenvironment of uterine cervical carcinoma: baseline network, iatrogenic alterations, and translational implications
Rosalba De Nola, Vera Loizzi, Ettore Cicinelli, Gennaro Cormio
Critical Reviews in Oncology/Hematology.2021; 162: 103343. CrossRef
Meet the Insidious Players: Review of Viral Infections in Head and Neck Cancer Etiology with an Update on Clinical Trials
Lejla Mahmutović, Esma Bilajac, Altijana Hromić-Jahjefendić
Microorganisms.2021; 9(5): 1001. CrossRef
Degradation of p53 by HPV16-E6 variants isolated from cervical cancer specimens of Moroccan women
Khaoula HADAMI, Charles SABY, Nadia DAKKA, Guillaume COLLIN, Mohammed ATTALEB, Meriem KHYATTI, Abdelkarim FILALI-MALTOUF, Hamid MORJANI, Mohammed EL MZIBRI
Gene.2021; 791: 145709. CrossRef
The potential applications of T cell receptor (TCR)-like antibody in cervical cancer immunotherapy
Sylvia Annabel Dass, Rehasri Selva Rajan, Gee Jun Tye, Venugopal Balakrishnan
Human Vaccines & Immunotherapeutics.2021; 17(9): 2981. CrossRef
UVB Inhibits Proliferation, Cell Cycle and Induces Apoptosis via p53, E2F1 and Microtubules System in Cervical Cancer Cell Lines
Angelica Judith Granados-López, Eduardo Manzanares-Acuña, Yamilé López-Hernández, Julio Enrique Castañeda-Delgado, Ixamail Fraire-Soto, Claudia Araceli Reyes-Estrada, Rosalinda Gutiérrez-Hernández, Jesús Adrián López
International Journal of Molecular Sciences.2021; 22(10): 5197. CrossRef
Novel Affibody Molecules Targeting the HPV16 E6 Oncoprotein Inhibited the Proliferation of Cervical Cancer Cells
Jinshun Zhu, Saidu Kamara, Qi Wang, Yanru Guo, Qingfeng Li, Linlin Wang, Jingjing Chen, Qianqian Du, Wangqi Du, Shao Chen, Shanli Zhu, Jun Chen, Maoping Chu, Lifang Zhang
Frontiers in Cell and Developmental Biology.2021;[Epub] CrossRef
Recent Progress in Electrochemical Detection of Human Papillomavirus (HPV) via Graphene‐Based Nanosensors
Seyyed Mojtaba Mousavi, Gity Behbudi, Seyyed Alireza Hashemi, Aziz Babapoor, Wei-Hung Chiang, Seeram Ramakrishna, Mohammed Muzibur Rahman, Chin Wei Lai, Ahmad Gholami, Navid Omidifar, Khadije Yousefi, Bruno C. Janegitz
Journal of Sensors.2021;[Epub] CrossRef
Antioxidants Associated With Oncogenic Human Papillomavirus Infection in Women
Hui-Yi Lin, Qiufan Fu, Yu-Hsiang Kao, Tung-sung Tseng, Krzysztof Reiss, Jennifer E Cameron, Martin J Ronis, Joseph Su, Navya Nair, Hsiao-Man Chang, Michael E Hagensee
The Journal of Infectious Diseases.2021; 224(9): 1520. CrossRef
The Microbiome and Gynecologic Cancer: Current Evidence and Future Opportunities
Laura M. Chambers, Parker Bussies, Roberto Vargas, Emily Esakov, Surabhi Tewari, Ofer Reizes, Chad Michener
Current Oncology Reports.2021;[Epub] CrossRef
Interpretations on the Interaction between Protein Tyrosine Phosphatase and E7 Oncoproteins of High and Low-Risk HPV: A Computational Perception
Murali Aarthy, Sanjeev Kumar Singh
ACS Omega.2021; 6(25): 16472. CrossRef
Validation of Potential Protein Markers Predicting Chemoradioresistance in Early Cervical Cancer by Immunohistochemistry
Soo Young Jeong, Joon-Yong Chung, Sun-Ju Byeon, Chul Jung Kim, Yoo-Young Lee, Tae-Joong Kim, Jeong-Won Lee, Byoung-Gie Kim, Ye Lin Chae, So Young Oh, Chel Hun Choi
Frontiers in Oncology.2021;[Epub] CrossRef
Viral load and interaction of HPV oncoprotein E6 and E7 with host cellular markers in the progression of cervical cancer
Bilal Ahmad Mir, P. F. Rahaman, Arif Ahmad
AIMS Molecular Science.2021; 8(3): 184. CrossRef
Integrin alpha 6 as a stemness driver is a novel promising target for HPV (+) head and neck squamous cell carcinoma
Jin Seol An, Jung Hwa Moon, Chayeon Kim, Joo Kyung No, Young Gyu Eun, Young Chang Lim
Experimental Cell Research.2021; 407(2): 112815. CrossRef
Reduced MAGI3 level by HPV18E6 contributes to Wnt/β‐catenin signaling activation and cervical cancer progression
Zhuoli Yang, Hua Liu, Ran Song, Wenxiu Lu, Haibo Wang, Siyu Gu, Xuedi Cao, Yibin Chen, Jihuan Liang, Qiong Qin, Xiaomei Yang, Duiping Feng, Junqi He
FEBS Open Bio.2021; 11(11): 3051. CrossRef
An Integrated View of Virus-Triggered Cellular Plasticity Using Boolean Networks
Jenny Paola Alfaro-García, María Camila Granados-Alzate, Miguel Vicente-Manzanares, Juan Carlos Gallego-Gómez
Cells.2021; 10(11): 2863. CrossRef
Role of interleukin-17 in human papillomavirus infection and associated malignancies
Utkarsha Sahu, Prashant Khare
Microbial Pathogenesis.2021; 161: 105294. CrossRef
FNDC3B and BPGM Are Involved in Human Papillomavirus-Mediated Carcinogenesis of Cervical Cancer
Luhan Zhang, Hong Yu, Tian Deng, Li Ling, Juan Wen, Mingfen Lv, Rongying Ou, Qiaozhi Wang, Yunsheng Xu
Frontiers in Oncology.2021;[Epub] CrossRef
Investigating host-virus interaction mechanism and phylogenetic analysis of viral proteins involved in the pathogenesis
Ahmad Abu Turab Naqvi, Farah Anjum, Alaa Shafie, Sufian Badar, Abdelbaset Mohamed Elasbali, Dharmendra Kumar Yadav, Md. Imtaiyaz Hassan, Timir Tripathi
PLOS ONE.2021; 16(12): e0261497. CrossRef
Potential anticancer effect of aspirin and 2'‑hydroxy‑2,3,5'‑trimethoxychalcone‑linked polymeric micelles against cervical cancer through apoptosis
Kang Lee, Suji Baek, Myeong Yoon, Ji Park, Bok Hong, Sang Lee, Seung Oh, Seung Kwon, Ruda Lee, Dae Lee, Kang-Seo Park, Byung Moon
Oncology Letters.2021;[Epub] CrossRef
HPVE6-USP46 Mediated Cdt2 Stabilization Reduces Set8 Mediated H4K20-Methylation to Induce Gene Expression Changes
Shashi Kiran, Briana Wilson, Shekhar Saha, Julia Ann Graff, Anindya Dutta
Cancers.2021; 14(1): 30. CrossRef
Translatable gene therapy for lung cancer using Crispr CAS9—an exploratory review
Jishnu Nair, Abhishek Nair, Soundaram Veerappan, Dwaipayan Sen
Cancer Gene Therapy.2020; 27(3-4): 116. CrossRef
Cancer signaling by plasmonic quantum probes
Ayushi Agarwal, Krishnan Venkatakrishnan, Bo Tan
Applied Materials Today.2020; 18: 100465. CrossRef
Multistate Markov Model to Predict the Prognosis of High-Risk Human Papillomavirus-Related Cervical Lesions
Ayumi Taguchi, Konan Hara, Jun Tomio, Kei Kawana, Tomoki Tanaka, Satoshi Baba, Akira Kawata, Satoko Eguchi, Tetsushi Tsuruga, Mayuyo Mori, Katsuyuki Adachi, Takeshi Nagamatsu, Katsutoshi Oda, Toshiharu Yasugi, Yutaka Osuga, Tomoyuki Fujii
Cancers.2020; 12(2): 270. CrossRef
Early-stage cervical cancer diagnosis based on an ultra-sensitive electrochemical DNA nanobiosensor for HPV-18 detection in real samples
Pegah Mahmoodi, Majid Rezayi, Elisa Rasouli, Amir Avan, Mehrdad Gholami, Majid Ghayour Mobarhan, Ehsan Karimi, Yatima Alias
Journal of Nanobiotechnology.2020;[Epub] CrossRef
Cervical Cancer Screening: Past, Present, and Future
Sarah L. Bedell, Lena S. Goldstein, Amelia R. Goldstein, Andrew T. Goldstein
Sexual Medicine Reviews.2020; 8(1): 28. CrossRef
Potential oncogenic roles of mutant-p53-derived exosomes in the tumor–host interaction of head and neck cancers
Etti Ester Azulay, Tomer Cooks, Moshe Elkabets
Cancer Immunology, Immunotherapy.2020; 69(2): 285. CrossRef
Extracellular Vesicles from Human Papilloma Virus-Infected Cervical Cancer Cells Enhance HIV-1 Replication in Differentiated U1 Cell Line
Sabina Ranjit, Sunitha Kodidela, Namita Sinha, Subhash Chauhan, Santosh Kumar
Viruses.2020; 12(2): 239. CrossRef
Preparation, Characterization and Diagnostic Valuation of Two Novel Anti-HPV16 E7 Oncoprotein Monoclonal Antibodies
Renjian Hu, Zhen Dong, Kui Zhang, Guangzhao Pan, Chongyang Li, Hongjuan Cui
Viruses.2020; 12(3): 333. CrossRef
Cell Cycle Profiling Reveals Protein Oscillation, Phosphorylation, and Localization Dynamics
Patrick Herr, Johan Boström, Eric Rullman, Sean G. Rudd, Mattias Vesterlund, Janne Lehtiö, Thomas Helleday, Gianluca Maddalo, Mikael Altun
Molecular & Cellular Proteomics.2020; 19(4): 608. CrossRef
HPV Infection Significantly Accelerates Glycogen Metabolism in Cervical Cells with Large Nuclei: Raman Microscopic Study with Subcellular Resolution
Katarzyna Sitarz, Krzysztof Czamara, Joanna Bialecka, Malgorzata Klimek, Barbara Zawilinska, Slawa Szostek, Agnieszka Kaczor
International Journal of Molecular Sciences.2020; 21(8): 2667. CrossRef
Cyclin-dependent kinases and CDK inhibitors in virus-associated cancers
Shaian Tavakolian, Hossein Goudarzi, Ebrahim Faghihloo
Infectious Agents and Cancer.2020;[Epub] CrossRef
Oncolytic Newcastle disease virus delivered by Mesenchymal stem cells-engineered system enhances the therapeutic effects altering tumor microenvironment
Mohsen Keshavarz, Mir Saeed Ebrahimzadeh, Seyed Mohammad Miri, Hassan Dianat-Moghadam, Seyedeh Sara Ghorbanhosseini, Seyed Reza Mohebbi, Hossein Keyvani, Amir Ghaemi
Virology Journal.2020;[Epub] CrossRef
Virus-Specific T Cells for the Treatment of Malignancies—Then, Now, and the Future
Sandhya Sharma, Wingchi K Leung, Helen E Heslop
Current Stem Cell Reports.2020; 6(2): 17. CrossRef
The Relationship between Estrogen-Related Signaling and Human Papillomavirus Positive Cancers
Claire D. James, Iain M. Morgan, Molly L. Bristol
Pathogens.2020; 9(5): 403. CrossRef
Combination Vaccination With Tetanus Toxoid and Enhanced Tumor-Cell Based Vaccine Against Cervical Cancer in a Mouse Model
Donia Alson, Scott C. Schuyler, Bo-Xin Yan, Karthika Samimuthu, Jiantai Timothy Qiu
Frontiers in Immunology.2020;[Epub] CrossRef
HPV‐related methylation‐based reclassification and risk stratification of cervical cancer
Si Yang, Ying Wu, Shuqian Wang, Peng Xu, Yujiao Deng, Meng Wang, Kang Liu, Tian Tian, Yuyao Zhu, Na Li, Linghui Zhou, Zhijun Dai, Huafeng Kang
Molecular Oncology.2020; 14(9): 2124. CrossRef
Anti-tumor activities of probiotics in cervical cancer
Moghaddaseh Jahanshahi, Parisa Maleki Dana, Bita Badehnoosh, Zatollah Asemi, Jamal Hallajzadeh, Mohammad Ali Mansournia, Bahman Yousefi, Bahram Moazzami, Shahla Chaichian
Journal of Ovarian Research.2020;[Epub] CrossRef
Dysregulation of Stemness Pathways in HPV Mediated Cervical Malignant Transformation Identifies Potential Oncotherapy Targets
Megha Budhwani, Samuel W. Lukowski, Sandro V. Porceddu, Ian H. Frazer, Janin Chandra
Frontiers in Cellular and Infection Microbiology.2020;[Epub] CrossRef
Bee venom inhibits the proliferation and migration of cervical-cancer cells in an HPV E6/E7-dependent manner
Da-Hyun Kim, Hyun-Woo Lee, Hyun-Woo Park, Han-Woong Lee, Kyung-Hee Chun
BMB Reports.2020; 53(8): 419. CrossRef
The association between HPV gene expression, inflammatory agents and cellular genes involved in EMT in lung cancer tissue
Marzieh Rezaei, Shayan Mostafaei, Amir Aghaei, Nayyerehalsadat Hosseini, Hassan Darabi, Majid Nouri, Ashkan Etemadi, Andrew O’. Neill, Javid Sadri Nahand, Hamed Mirzaei, Seamas C. Donnelly, Mohammad Doroudian, Mohsen Moghoofei
BMC Cancer.2020;[Epub] CrossRef
The role of viruses in adenocarcinoma development
Mohsen Nakhaie, Javad Charostad, Gholam Abbas Kaydani, Ebrahim Faghihloo
Infection, Genetics and Evolution.2020; 86: 104603. CrossRef
Use of Cap Analysis Gene Expression to detect human papillomavirus promoter activity patterns at different disease stages
Ayumi Taguchi, Kazunori Nagasaka, Charles Plessy, Hiroe Nakamura, Yoshiko Kawata, Sachi Kato, Kosuke Hashimoto, Takeshi Nagamatsu, Katsutoshi Oda, Iwao Kukimoto, Kei Kawana, Piero Carninci, Yutaka Osuga, Tomoyuki Fujii
Scientific Reports.2020;[Epub] CrossRef
Potential therapeutic and pharmacological effects of Wogonin: an updated review
Do Luong Huynh, Tran Hoang Ngau, Nguyen Hoai Nguyen, Gia-Buu Tran, Cuong Thach Nguyen
Molecular Biology Reports.2020; 47(12): 9779. CrossRef
The Molecular and Pathophysiological Functions of Members of the LNX/PDZRN E3 Ubiquitin Ligase Family
Jeongkwan Hong, Minho Won, Hyunju Ro
Molecules.2020; 25(24): 5938. CrossRef
Investigating the aetiology of adverse events following HPV vaccination with systems vaccinology
Joan Campbell-Tofte, Aristidis Vrahatis, Knud Josefsen, Jesper Mehlsen, Kaj Winther
Cellular and Molecular Life Sciences.2019; 76(1): 67. CrossRef
DNA methyltransferases in virus‐associated cancers
Javad Charostad, Akram Astani, Hossein Goudarzi, Ebrahim Faghihloo
Reviews in Medical Virology.2019;[Epub] CrossRef
Identification and characterization of an alternative cancer-derived PD-L1 splice variant
Nadia B. Hassounah, Venkat S. Malladi, Yi Huang, Samuel S. Freeman, Ellen M. Beauchamp, Shohei Koyama, Nicholas Souders, Sunil Martin, Glenn Dranoff, Kwok-Kin Wong, Chandra S. Pedamallu, Peter S. Hammerman, Esra A. Akbay
Cancer Immunology, Immunotherapy.2019; 68(3): 407. CrossRef
What is the potential of p53 isoforms as a predictive biomarker in the treatment of cancer?
Liam Hayman, Wajeeh Raza Chaudhry, Victor V. Revin, Nikolai Zhelev, Jean-Christophe Bourdon
Expert Review of Molecular Diagnostics.2019; 19(2): 149. CrossRef
Transforming properties of ovine papillomaviruses E6 and E7 oncogenes
Gessica Tore, Gian Mario Dore, Carla Cacciotto, Rosita Accardi, Antonio G. Anfossi, Luisa Bogliolo, Marco Pittau, Salvatore Pirino, Tiziana Cubeddu, Massimo Tommasino, Alberto Alberti
Veterinary Microbiology.2019; 230: 14. CrossRef
Human papilloma virus and breast cancer: the role of inflammation and viral expressed proteins
Niloofar Khodabandehlou, Shayan Mostafaei, Ashkan Etemadi, Amir Ghasemi, Mehrdad Payandeh, Shima Hadifar, Amir Hossein Norooznezhad, Anoshirvan Kazemnejad, Mohsen Moghoofei
BMC Cancer.2019;[Epub] CrossRef
HPVE6/E7,hTERT, andKi67mRNA RT-qPCR Assay for Detecting High-Grade Cervical Lesion with Microscope Slides
Geehyuk Kim, Jemberu Taye, Kwangmin Yu, Sunyoung Park, Jungho Kim, Sunghyun Kim, Dongsup Lee, Hye-young Wang, Kwang Hwa Park, Hyeyoung Lee
Analytical Cellular Pathology.2019; 2019: 1. CrossRef
A high-risk papillomavirus 18 E7 affibody-enabled in vivo imaging and targeted therapy of cervical cancer
Ledan Wang, Wangqi Du, Shanli Zhu, Pengfei Jiang, Lifang Zhang
Applied Microbiology and Biotechnology.2019; 103(7): 3049. CrossRef
HOXC6 promotes cervical cancer progression via regulation of Bcl‐2
Yongsheng Wang, Cong Wang, Na Liu, Jun Hou, Wenjing Xiao, Hui Wang
The FASEB Journal.2019; 33(3): 3901. CrossRef
Meta‐analysis of the accuracy of p16 or p16/Ki‐67 immunocytochemistry versus HPV testing for the detection of CIN2+/CIN3+ in triage of women with minor abnormal cytology
Eliana Peeters, Nicolas Wentzensen, Christine Bergeron, Marc Arbyn
Cancer Cytopathology.2019; 127(3): 169. CrossRef
Long non-coding RNA FAM83H-AS1 is regulated by human papillomavirus 16 E6 independently of p53 in cervical cancer cells
Jamie A. Barr, Karen E. Hayes, Tayvia Brownmiller, Abby D. Harold, Rajaganapathi Jagannathan, Paul R. Lockman, Saleem Khan, Ivan Martinez
Scientific Reports.2019;[Epub] CrossRef
Pongapin and Karanjin, furanoflavanoids of Pongamia pinnata, induce G2/M arrest and apoptosis in cervical cancer cells by differential reactive oxygen species modulation, DNA damage, and nuclear factor kappa‐light‐chain‐enhancer of activated B cell signal
Rituparna Roy, Debolina Pal, Subhayan Sur, Suvra Mandal, Prosenjit Saha, Chinmay Kumar Panda
Phytotherapy Research.2019; 33(4): 1084. CrossRef
Effect of Multiple Vaccinations with Tumor Cell-Based Vaccine with Codon-Modified GM-CSF on Tumor Growth in a Mouse Model
Jiantai Qiu, Donia Alson, Ta-Hsien Lee, Ching-Chou Tsai, Ting-Wei Yu, Yu-Sing Chen, Ya-Fang Cheng, Chu-Chi Lin, Scott Schuyler
Cancers.2019; 11(3): 368. CrossRef
Flax seed oil reduced tumor growth, modulated immune responses and decreased HPV E6 and E7 oncoprotein expression in a murine model of ectopic cervical cancer
Rashmi Deshpande, Prerna Raina, Kavita Shinde, Prakash Mansara, Manjiri Karandikar, Ruchika Kaul-Ghanekar
Prostaglandins & Other Lipid Mediators.2019; 143: 106332. CrossRef
The free energy landscape of the oncogene protein E7 of human papillomavirus type 16 reveals a complex interplay between ordered and disordered regions
Predrag Kukic, Giuseppe Mattia Lo Piccolo, Marcela O. Nogueira, Dmitri I. Svergun, Michele Vendruscolo, Isabella C. Felli, Roberta Pierattelli
Scientific Reports.2019;[Epub] CrossRef
Immune Signature-Based Subtypes of Cervical Squamous Cell Carcinoma Tightly Associated with Human Papillomavirus Type 16 Expression, Molecular Features, and Clinical Outcome
Xiaofan Lu, Liyun Jiang, Liya Zhang, Yue Zhu, Wenjun Hu, Jiashuo Wang, Xinjia Ruan, Zhengbao Xu, Xiaowei Meng, Jun Gao, Xiaoping Su, Fangrong Yan
Neoplasia.2019; 21(6): 591. CrossRef
How to Steer and Control ERK and the ERK Signaling Cascade Exemplified by Looking at Cardiac Insufficiency
Tim Breitenbach, Kristina Lorenz, Thomas Dandekar
International Journal of Molecular Sciences.2019; 20(9): 2179. CrossRef
Dietary Polyphenols, Resveratrol and Pterostilbene Exhibit Antitumor Activity on an HPV E6-Positive Cervical Cancer Model: An in vitro and in vivo Analysis
Kaushiki Chatterjee, Sumit Mukherjee, Jonathan Vanmanen, Probal Banerjee, Jimmie E. Fata
Frontiers in Oncology.2019;[Epub] CrossRef
Human papilloma virus DNA-biomarker analysis for cervical cancer: Signal enhancement by gold nanoparticle-coupled tetravalent streptavidin-biotin strategy
Qingfeng Lv, Yongmei Wang, Cuijin Su, Thangavel Lakshmipriya, Subash C.B. Gopinath, Kannaiyan Pandian, Veeradasan Perumal, Ying Liu
International Journal of Biological Macromolecules.2019; 134: 354. CrossRef
RNA-seq analysis in equine papillomavirus type 2-positive carcinomas identifies affected pathways and potential cancer markers as well as viral gene expression and splicing events
Anna Sophie Ramsauer, Jakub Kubacki, Claude Favrot, Mathias Ackermann, Cornel Fraefel, Kurt Tobler
Journal of General Virology .2019; 100(6): 985. CrossRef
Different expression of GSK3β and pS9GSK3β depending on phenotype of cervical cancer: possible association of GSK3β with squamous cell carcinoma and pS9GSK3β with adenocarcinoma
Kwanghee Ahn, Sojung Kweon, Dae Woon Kim, Hojung Lee
Obstetrics & Gynecology Science.2019; 62(3): 157. CrossRef
Delivery of microRNAs by Extracellular Vesicles in Viral Infections: Could the News be Packaged?
Fabio Seiti Yamada Yoshikawa, Franciane Mouradian Emidio Teixeira, Maria Notomi Sato, Luanda Mara da Silva Oliveira
Cells.2019; 8(6): 611. CrossRef
The high-risk HPV oncogene E7 upregulates miR-182 expression through the TGF-β/Smad pathway in cervical cancer
Jiao Chen, Yan Deng, Liangfei Ao, Yi Song, Yan Xu, Chi Chiu Wang, Kwong Wai Choy, Kwok Hung Tony Chung, Quan Du, Yi Sui, Tao Yang, Jing Yang, Hu Li, Chang Zou, Tao Tang
Cancer Letters.2019; 460: 75. CrossRef
A unique insert in the genomes of high-risk human papillomaviruses with a predicted dual role in conferring oncogenic risk
Noam Auslander, Yuri I. Wolf, Svetlana A. Shabalina, Eugene V. Koonin
F1000Research.2019; 8: 1000. CrossRef
Papillomavirus DNA not detected in canine lobular orbital adenoma and normal conjunctival tissue
Elizabeth A. F. Schaefer, Shirley Chu, Jacqueline W. Pearce, Jeffrey N. Bryan, Brian K. Flesner
BMC Veterinary Research.2019;[Epub] CrossRef
Phenotype-based discovery of a HeLa-specific cytotoxic molecule that downregulates HPV-mediated signaling pathwaysviaoxidative damage
Sanghee Lee, Wansang Cho, Sungyoul Hong, Sihyeong Yi, Heejun Kim, Soo Yeon Baek, Hankum Park, Jinjoo Jung, Young Kee Shin, Seung Bum Park
Organic & Biomolecular Chemistry.2019; 17(31): 7388. CrossRef
High Incidence of Human Papillomavirus Types 16 and 18 in Cervical Carcinoma Patients in a Tertiary Care Unit, Jabalpur, MP, India
Shyamji Rawat, Sulekha Yadav, Pranjil Mandloi, Chinkal Panihar, P. V. Barde
Indian Journal of Gynecologic Oncology.2019;[Epub] CrossRef
Advances in technologies for cervical cancer detection in low-resource settings
Kathryn A. Kundrod, Chelsey A. Smith, Brady Hunt, Richard A. Schwarz, Kathleen Schmeler, Rebecca Richards-Kortum
Expert Review of Molecular Diagnostics.2019; 19(8): 695. CrossRef
Papillomavirus Immune Evasion Strategies Target the Infected Cell and the Local Immune System
Chenhao Zhou, Zewen Kelvin Tuong, Ian Hector Frazer
Frontiers in Oncology.2019;[Epub] CrossRef
Identification of potential binding pocket on viral oncoprotein HPV16 E6: a promising anti-cancer target for small molecule drug discovery
Srikanth Kolluru, Rosemary Momoh, Lydia Lin, Jayapal Reddy Mallareddy, John L. Krstenansky
BMC Molecular and Cell Biology.2019;[Epub] CrossRef
The DNA deaminase APOBEC3B interacts with the cell-cycle protein CDK4 and disrupts CDK4-mediated nuclear import of Cyclin D1
Jennifer L. McCann, Madeline M. Klein, Evelyn M. Leland, Emily K. Law, William L. Brown, Daniel J. Salamango, Reuben S. Harris
Journal of Biological Chemistry.2019; 294(32): 12099. CrossRef
LncRNA SRA1 is down-regulated in HPV-negative cervical squamous cell carcinoma and regulates cancer cell behaviors
Yunyong Liu, Mengdan Li, Huihui Yu, Haozhe Piao
Bioscience Reports.2019;[Epub] CrossRef
Diagnosis and management of vulvar cancer: A review
Andrea Tan, Amy K. Bieber, Jennifer A. Stein, Miriam K. Pomeranz
Journal of the American Academy of Dermatology.2019; 81(6): 1387. CrossRef
Transcription factor homeobox D9 is involved in the malignant phenotype of cervical cancer through direct binding to the human papillomavirus oncogene promoter
Nobumaru Hirao, Takashi Iwata, Kohsei Tanaka, Hiroshi Nishio, Masaru Nakamura, Tohru Morisada, Kenji Morii, Natsuki Maruyama, Yuki Katoh, Tomonori Yaguchi, Shigeki Ohta, Iwao Kukimoto, Daisuke Aoki, Yutaka Kawakami
Gynecologic Oncology.2019; 155(2): 340. CrossRef
Phase 1 Safety and Immunogenicity Trial of Recombinant Lactococcus lactis Expressing Human Papillomavirus Type 16 E6 Oncoprotein Vaccine
Sedigheh Taghinezhad-S, Amir Hossein Mohseni, Hossein Keyvani, Mohammad Reza Razavi
Molecular Therapy - Methods & Clinical Development.2019; 15: 40. CrossRef
Cloning and expression of the L1 immunogenic protein of human papillomavirus genotype 16 by using Lactobacillus expression system
Masumeh Haj Hodaei, Rudabeh Behzadi Anduhjerdi, Jalil Fallah Mehrabadi, Davoud Esmaeili
Gene Reports.2019; 17: 100521. CrossRef
Relationship between p16 expression and prognosis in different anatomic subsites of OSCC
Yanhong Ni, Xiaoxin Zhang, Yunxia Wan, Kai Dun Tang, Yin Xiao, Yue Jing, Yuxian Song, Xiaofeng Huang, Chamindie Punyadeera, Qingang Hu
Cancer Biomarkers.2019; 26(3): 375. CrossRef
A unique insert in the genomes of high-risk human papillomaviruses with a predicted dual role in conferring oncogenic risk
Noam Auslander, Yuri I. Wolf, Svetlana A. Shabalina, Eugene V. Koonin
F1000Research.2019; 8: 1000. CrossRef
A Current Update on Human Papillomavirus-Associated Head and Neck Cancers
Ebenezer Tumban
Viruses.2019; 11(10): 922. CrossRef
Current Perspectives in Human Papilloma Virus: Where We are and What We Need?
B.S Anjali Devi, Venugopal Reddy Bovilla, SubbaRao V. Madhunapantula
Biomedical and Pharmacology Journal.2019; 12(04): 1683. CrossRef
Plant viral and bacteriophage delivery of nucleic acid therapeutics
Patricia Lam, Nicole F. Steinmetz
WIREs Nanomedicine and Nanobiotechnology.2018;[Epub] CrossRef
Prevalence of human papillomavirus in benign and malignant laryngeal lesions in Egyptian patients: Cross‐sectional study
P. Milad, H. Kassamy, A. Askoura, S. Abuelela, R. Salem, D. Ragab
Clinical Otolaryngology.2018; 43(1): 312. CrossRef
Human papillomavirus E7 induces p63 expression to modulate DNA damage response
Sahar Eldakhakhny, Qing Zhou, Emma J. Crosbie, Berna S. Sayan
Cell Death & Disease.2018;[Epub] CrossRef
ViFi: accurate detection of viral integration and mRNA fusion reveals indiscriminate and unregulated transcription in proximal genomic regions in cervical cancer
Nam-phuong D Nguyen, Viraj Deshpande, Jens Luebeck, Paul S Mischel, Vineet Bafna
Nucleic Acids Research.2018; 46(7): 3309. CrossRef
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Use of protein-based biomarkers of exfoliated cervical cells for primary screening of cervical cancer
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Archives of Pharmacal Research.2018; 41(4): 438. CrossRef
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Journal of Cellular Biochemistry.2018; 119(6): 4397. CrossRef
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Journal of Biosciences.2018; 43(2): 249. CrossRef
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Oncogene.2018; 37(48): 6275. CrossRef
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Frontiers in Oncology.2018;[Epub] CrossRef
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Journal of Medical Microbiology.2018; 67(10): 1509. CrossRef
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New Journal of Chemistry.2018; 42(21): 17339. CrossRef
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Biological implications and therapeutic significance of DNA methylation regulated genes in cervical cancer
Samatha Bhat, Shama Prasada Kabekkodu, Ashish Noronha, Kapaettu Satyamoorthy
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Human papillomavirus integration pattern and demographic, clinical, and survival characteristics of patients with oropharyngeal squamous cell carcinoma
Ming Yann Lim, Kristina R. Dahlstrom, Erich M. Sturgis, Guojun Li
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Journal of the American Society of Cytopathology.2016; 5(4): 221. CrossRef
Loss of histone variant macroH2A2 expression associates with progression of anal neoplasm
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Journal of Clinical Pathology.2016; 69(7): 627. CrossRef
Targeting HPV‐infected cervical cancer cells with PEGylated liposomes encapsulating siRNA and the role of siRNA complexation with polyethylenimine
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Oncotarget.2016; 7(32): 51854. CrossRef
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Expert Review of Vaccines.2015; 14(7): 1031. CrossRef
NGS-based approach to determine the presence of HPV and their sites of integration in human cancer genome
P Chandrani, V Kulkarni, P Iyer, P Upadhyay, R Chaubal, P Das, R Mulherkar, R Singh, A Dutt
British Journal of Cancer.2015; 112(12): 1958. CrossRef
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Virology Journal.2011;[Epub] CrossRef

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The Role of HPV E6 and E7 Oncoproteins in HPV-associated Cervical Carcinogenesis

Cancer Res Treat. 2005;37(6):319-324. Published online December 31, 2005

DOI: https://doi.org/10.4143/crt.2005.37.6.319

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Abstract
INTRODUCTION
HOST PROTEINS ASSOCIATED WITH HPV E6 ONCOPROTEIN
HOST PROTEINS ASSOCIATED WITH HPV E7 ONCOPROTEIN
CONCLUSIONS
NOTES
REFERENCES

The Role of HPV E6 and E7 Oncoproteins in HPV-associated Cervical Carcinogenesis

Fig. 1 HPV E6 and E7 binding to P53, with Rb interfering with the normal functions of the tumor suppressors.

Fig. 1

The Role of HPV E6 and E7 Oncoproteins in HPV-associated Cervical Carcinogenesis

Table 1

Cellular binding partners for HPV E6

Table 2

Cellular binding partners for HPV E7

Table 1 Cellular binding partners for HPV E6

Table 2 Cellular binding partners for HPV E7