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Cancer Research and Treatment > Epub ahead of print
doi: https://doi.org/10.4143/crt.2022.264    [Epub ahead of print]
Five-Year Overall Survival and Prognostic Factors in Patients with Lung Cancer: Results from the Korean Association of Lung Cancer Registry (KALC-R) 2015
Da Som Jeon1 , Ho Cheol Kim1 , Se Hee Kim2, Tae-Jung Kim3, Hong Kwan Kim4, Mi Hyung Moon5, Kyongmin Sarah Beck6, Yang-Gun Suh7, Changhoon Song8, Jin Seok Ahn9, Jeong Eun Lee10, Jeong Uk Lim11, Jae Hyun Jeon12, Kyu-Won Jung13, Chi Young Jung14, Jeong Su Cho15, Yoo-Duk Choi16, Seung-Sik Hwang17, Chang-Min Choi1,18 , Korean Association for Lung Cancer, Korea Central Cancer Registry
1Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
2Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
3Department of Hospital Pathology, Yeouido St. Mary’s hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
4Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
5Department of Thoracic and Cardiovascular Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
6Department of Radiology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
7Proton Therapy Center, Research Institute and Hospital, National Cancer Center, Goyang, Korea
8Department of Radiation Oncology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea
9Department of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
10Division of Pulmonology, Chungnam National University College of Medicine, Daejeon, Korea
11Division of Pulmonary, Allergy and Critical Care Medicine, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
12Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea
13Division of Cancer Registration and Surveillance, National Cancer Control Institute, National Cancer Center, Goyang, Korea
14Department of Pulmonary, Daegu Catholic University Medical Center, Daegu Catholic University School of Medicine, Daegu, Korea
15Department of Thoracic and Cardiovascular Surgery, Pusan National University Hospital, Busan, Korea
16Department of Pathology, Chonnam National University Medical School, Gwangju, Korea
17Department of Public Health Science, Graduate School of Public Healthy, Seoul National University, Seoul, Korea
18Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Correspondence  Chang-Min Choi ,Tel: 82-2-3010-5902, Fax: 82-2-3010-5902, Email: ccm@amc.seoul.kr
Received: April 25, 2022;  Accepted: June 16, 2022.  Published online: June 20, 2022.
*Da Som Jeon and Ho Cheol Kim contributed equally to this work.
ABSTRACT
Purpose
This study aimed to provide the clinical characteristics, prognostic factors, and 5-year relative survival rates of lung cancer diagnosed in 2015.
Materials and Methods
The demographic risk factors of lung cancer were calculated using the KALC-R (Korean Association of Lung Cancer Registry) cohort in 2015, with survival follow-up until December 31, 2020. The 5-year relative survival rates were estimated using Ederer II methods, and the general population data used the death rate adjusted for sex and age published by the Korea Statistical Information Service from 2015 to 2020.
Results
We enrolled 2,657 patients with lung cancer who were diagnosed in South Korea in 2015. Of all patients, 2,098 (79.0%) were diagnosed with non–small cell lung cancer (NSCLC) and 345 (13.0%) were diagnosed with small cell lung cancer (SCLC), respectively. Old age, poor performance status, and advanced clinical stage were independent risk factors for both NSCLC and SCLC. In addition, the 5-year relative survival rate declined with advanced stage in both NSCLC (82%, 59%, 16%, 10% as the stage progressed) and SCLC (16%, 4% as the stage progressed). In patients with stage IV adenocarcinoma, the 5-year relative survival rate was higher in the presence of epidermal growth factor receptor (EGFR) mutation (19% vs. 11%) or anaplastic lymphoma kinase (ALK) translocation (38% vs. 11%).
Conclusion
In this Korean nationwide survey, the 5-year relative survival rates of NSCLC were 82% at stage I, 59% at stage II, 16% at stage III, and 10% at stage IV, and the 5-year relative survival rates of SCLC were 16% in cases with limited disease, and 4% in cases with extensive disease.
Key words: Lung neoplasms, Epidemiology, Korea, Relative survival rate
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