Prognostication of the Last Days of Life

Masanori Mori; Tatsuya Morita; Eduardo Bruera; David Hui

doi:10.4143/crt.2021.1573

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Review Article Prognostication of the Last Days of Life: Masanori Mori¹, Tatsuya Morita¹, Eduardo Bruera², David Hui²; Cancer Research and Treatment 2022;54(3):631-643.
DOI: https://doi.org/10.4143/crt.2021.1573
Published online: March 30, 2022

¹Palliative and Supportive Care Division, Seirei Mikatahara General Hospital, Hamamatsu, Japan

²Department of Palliative Care, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Correspondence: Masanori Mori, Division of Palliative and Supportive Care, Seirei Mikatahara Hospital, 3453 Mikatahara-cho, Kita-ku, Hamamatsu 433-8558, Japan,
Tel: 81-53-436-1251 Fax: 81-53-438-0652 E-mail: masanori.mori@sis.seirei.or.jp

• Received: December 11, 2021 • Accepted: March 26, 2022

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Abstract

Accurate prediction of impending death (i.e., last few days of life) is essential for terminally-ill cancer patients and their families. International guidelines state that clinicians should identify patients with impending death, communicate the prognosis with patients and families, help them with their end-of-life decision-making, and provide sufficient symptom palliation. Over the past decade, several national and international studies have been conducted that systematically investigated signs and symptoms of impending death as well as how to communicate such a prognosis effectively with patients and families. In this article, we summarize the current evidence on prognostication and communication regarding the last days of life of patients with cancer, and future directions of clinical research.
Key words: Prognostication, Impending death, Communication

Introduction

Accurate prediction of impending death (i.e., last few days of life) is essential for terminally-ill cancer patients [1,2]. It can help patients, families, and clinicians clarify goals of care, promote shared decision-making, avoid unnecessary investigations and aggressive care, ensure goal-concordant care, and allow patients and families to complete unfinished business and achieve a good death [1–4]. International guidelines state that clinicians should identify patients with impending death, communicate the prognosis with patients and families, help them with their end-of-life (EOL) decision-making, and provide sufficient symptom palliation [1]. Over the past decade, several national and international studies have been conducted that systematically investigated signs and symptoms of impending death as well as how to communicate such a prognosis effectively with patients and families [5–15]. In this article, we review important findings on prognostication and communication regarding the last days of life of patients with cancer.

Prognostication of Impending Death

1. General consideration

One of the early studies was a prospective observational study at a palliative care unit (PCU). Morita et al. [16] revealed that the proportion of patients with decreased consciousness increased over the last week of life, and that the median time from the onset of death rattle, respiration with mandibular movement (RMM), peripheral cyanosis, and pulselessness of the radial artery to death was 23, 2.5, 1.0, and 1.0 hours respectively. In 2013, an international Delphi study provided expert consensus on various categories for prediction of the last hours or days of life, such as changes related to “breathing”, “skin”, and “consciousness/cognition” [5].

2. Clinician prediction of survival

Clinician prediction of survival (CPS) is an easy and quick way of prognostication. CPS has three question formats: temporal, probabilistic, and surprise questions [17]. With the temporal approach, a clinician is asked, “How long will this patient live?” The answer is provided as a specific time frame such as “3 days.” This is the most common approach for prognostication in daily practice. The accuracy of temporal approach is traditionally defined as a predicted survival rate of within ±33% of actual survival [18–21]. This approach often results in overestimation and has a 20% to 30% rate of accuracy, even among palliative care specialists [19].

With the probabilistic approach, a clinician is asked, “What is the approximate probability that this patient will be alive (0%–100%)?” An estimation of the probability of survival is considered to be accurate if either the patient died and the clinician endorsed a survival probability ≤ 30%, or the patient survived and the clinician selected a survival probability ≥ 70% [19].

Previous studies involving advanced cancer patients admitted to acute PCUs (median survival, 8 to 14 days) showed that 24-hour and 48-hour probabilistic CPS was consistently more accurate than temporal CPS [19,22]. In addition, while nurses were not more accurate than physicians in estimating survival using temporal CPS, they were largely more accurate than physicians in estimating survival using 24-hour and 48-hour probabilistic CPS [19,22].

With respect to changes in accuracy over time, Selby et al. [23] explored the accuracy of temporal CPS using time-based prognostic categories, and found that CPS of < 24 hours and one to 7 days were significantly more likely to be accurate than CPS of longer intervals. Hui et al. [24] investigated the accuracy of temporal CPS with time-based categories (0–14 days, 15–42 days, and ≥ 43 days), and reported that CPS was as accurate as prognostic tools such as Palliative Prognostic (PaP) Score and Palliative Prognostic Index among advanced cancer patients with a median overall survival of 10 days. Focusing on the last 2 weeks of life, Perez-Cruz et al. [22] showed that while the accuracy of temporal CPS was relatively stable over time, that of 24-hour and 48-hour probabilistic CPS significantly decreased as patients approached death.

A surprise question (SQ), “would I be surprised if this patient died in [specific timeframe]?”, is a simple and feasible screening tool to identify patients at their EOL [25,26]. In addition to SQ estimating 1-year mortality, those of various other timeframes have been proposed (e.g., 30, 7, 3, and 1 day(s)) [12,25–27]. In secondary analyses of the East-Asian cross-cultural collaborative Study to Elucidate the Dying process (EASED) study, Ikari et al. [12,28] showed that among 1,411 advanced cancer patients with Palliative Performance Scale (PPS) ≤ 20, the sensitivity and negative predictive value (NPV) of 3-day SQ were 94.3% and 83.6%, respectively, and those of 1-day SQ were 82.0% and 91.0%, respectively. These findings indicate that both 3-day and 1-day SQs can be useful screening tools to identify patients facing impending death. In another study, Kim et al. [29] examined the accuracy of 7-day SQ in 130 patients admitted to PCUs in South Korea, and reported a sensitivity of 47%, specificity of 89%, positive predictive value (PPV) of 35%, and NPV of 93%, with an overall accuracy of 84% (C-index 0.66).

3. Physical signs

In the 2010s, two multicenter, prospective, observational studies were conducted to investigate the dying process. The first was the Investigating the Process of Dying (IPOD) study that enrolled 357 consecutive patients with advanced cancer who were admitted to two acute palliative care units (APCUs) in the United States and Brazil [6,7]. The IPOD study systematically examined the diagnostic performance of comprehensive signs and symptoms for the prediction of death within 3 days. The authors identified “early signs” and “late signs” of impending death (Table 1). The early signs (i.e., decreased level of consciousness, PPS ≤ 20%, and dysphagia of liquids) appeared at a high frequency and more than 3 days before death, and showed a low specificity and positive likelihood ratio (LR) for impending death. In contrast, late signs occurred mostly in the last 3 days of life and at a lower frequency, but showed a very high specificity and positive LR for death within 3 days.

The other study was EASED, an East-Asian, multicenter cohort study conducted at PCUs in Japan, South Korea, and Taiwan. One of its correlative studies used Japanese data from 22 sites, and investigated the diagnostic performance of 15 clinical signs after patients’ performance status had declined to PPS ≤ 20% (n=1,396) [11]. The authors confirmed that the physical signs were divided into early and late signs, consistent with the findings of the IPOD study (Table 1).

4. Vital signs

Although vital signs in patients with advanced cancer can vary over time and may fluctuate due to acute complications, they show some characteristic changes in the last days of life. The IPOD study showed that, overall, blood pressure and oxygen saturation gradually decrease, body temperature increases, and heart rate and respiratory rate remain mostly constant, during the last 3 days of life [10]. Several prognostic tools for impending death include vital signs, such as Objective Palliative Prognostic Score (OPPS) [30], Prognosis in Palliative care Study predictor (PiPS) models [31], and Objective Prognostic Index for advanced cancer (OPI-AC) [32], all of which include heart rate as a variable in the prediction of days of survival. However, as a large proportion of patients have normal vital signs in the last days of life (40% to 80% of patients during the last 3 days of life), vital signs alone should not be overly relied on in the prediction of impending death [10]. Rather, they can be deemed supplemental to other signs of impending death for predicting death within the next 3 days. In practice, marked deterioration of vital signs often occurs in the last minutes/hours of life and may serve as a predictor of death within the same day.

5. Physiological parameters

Several laboratory abnormalities have been shown to indicate poor survival. For example, leukocytosis, neutrophilia, low lymphocyte percentage, thrombocytopenia, hyperkalemia, elevated urea, creatinine, alanine transaminase, alkaline phosphatase, lactic dehydrogenase, total bilirubin, C-reactive protein (CRP), and hypoalbuminemia are in part included in several prognostic tools which can identify patients with days of survival, such as PaP Score, Objective Prognostic Scale (OPS), OPPS, PiPS model, and OPI-AC [30–34]. Recently, Nagasako et al. [35] reported that Glasgow Prognostic Score indicating elevated CRP and hypoalbuminemia optimized with concomitant thrombocytopenia was significantly correlated with 3-day mortality, and had a specificity of 97.5% and high positive LR > 5.

Among objective and physiological measures with a prognostic value is the phase angle, a marker of cellular membrane integrity and hydration. The phase angle is measured by bioelectric impedance analysis. It typically ranges from 4 to 9 in healthy individuals, and is known to be lower in patients with shorter survival [36–38]. A prospective study involving 204 APCU patients with advanced cancer and a median survival of 10 days revealed that the phase angle was not significantly correlated with survival in the entire group, but remained a significant prognostic factor in a non-edematous subgroup [39]. Specifically, a phase angle ≤ 3° had a sensitivity of 50%, specificity of 90%, and overall accuracy of 86% (95% confidence interval, 77% to 93%) for 3-day survival in patients without edema. Further studies are needed to validate these findings.

6. Symptoms

Patients with advanced cancer suffer from multiple symptoms throughout the disease trajectory. Acute complications in the last weeks to days of life may contribute to an increased symptom burden [40]. Indeed, the intensity of certain symptoms, such as fatigue, anorexia, drowsiness, and dyspnea, often worsens in the last weeks to days of life [41]. The EASED study indicated that patients whose symptoms (i.e., dyspnea, fatigue, dry mouth, and drowsiness) worsened during the first week of admission to PCUs had shorter survival (median survival, 15 to 21 days) than those whose symptoms improved (median survival, 23 to 31 days) or remained stable (median survival, 27 to 29 days) (p < 0.001) [42].

The IPOD study demonstrated that certain symptoms (e.g., anorexia, drowsiness, fatigue, dyspnea, and insomnia) continued to worsen over the last week of life, even under specialist palliative care [8]. Indeed, fatigue (or poor performance status), anorexia, dyspnea, and/or delirium are incorporated in various prognostic scales, and their presence indicates a poorer prognosis [31,33,43].

7. Diagnostic models

(1) First diagnostic model: the IPOD model

Hui et al. [44] proposed a diagnostic model consisting of two signs (PPS and drooping of nasolabial folds) to predict death within 3 days by utilizing recursive partitioning analysis (Fig. 1). The 3-day mortality rates of patients with PPS ≤ 20% and drooping of nasolabial folds present, PPS ≤ 20% and drooping of nasolabial folds absent, PPS of 30 to 60%, and PPS ≥ 70% were 94, 42, 16, and 3%, respectively (accuracy, 81%).

(2) Second diagnostic model: the prediction of 3-day impending death-decision tree (P3did-DT)

The prediction of impending death becomes especially relevant and important for patients who are considered close to death based on clinical signs, such as decreased activities and oral intake [6]. Although accurate prediction of impending death among patients who started to show such “early signs” remains challenging, it would help clinicians urgently expedite EOL decision-making [6]. Using Japanese data of the EASED study, Mori et al. [11] proposed another diagnostic model to predict death within 3 days by utilizing recursive partitioning analysis (prediction of 3-day impending death-decision tree [P3did-DT]) (Fig. 2). P3did-DT was based on three variables and had four terminal leaves: urinary output (u/o) ≤ 200 mL/day and decreased response to verbal stimuli, u/o ≤ 200 mL/day and no decreased response to verbal stimuli, u/o > 200 mL/day and Richmond Agitation-Sedation Scale (RASS) ≤ −2, and u/o > 200 mL/day and RASS ≥ −1. The 3-day mortality rates were 80.3%, 53.3%, 39.9%, and 20.6%, respectively (accuracy, 68.3%).

(3) A system-based prediction score: the P3did-score

In addition to P3did-DT, EASED investigators developed P3did-score by categorizing 10 representative signs into four systems: nervous (decreased level of consciousness as indicated by RASS ≤ −2), cardiovascular (peripheral cyanosis, pulselessness of radial artery, and decreased u/o), respiratory (apnea, Cheyne-Stokes breathing, and RMM), and musculoskeletal (inability to close eyelids, hyperextension of the neck, and drooping of nasolabial folds) systems. If any sign was present within each system, a score of 1 was given to the system without a weight being assigned (i.e., each system would have a score of 0 or 1). The total score was calculated by adding the score of each system, which ranges from 0 to 4 with a higher score indicating the presence of clinical signs in more systems (P3did-score) (Table 2). Overall, 79.6, 62.9, 47.2, 32.8, and 17.4% of patients with P3did-scores of 4, 3, 2, 1, and 0, respectively, died within 3 days [11].

Of note, P3did-DT and P3did-score were derived from patients with PPS ≤ 20%, while the IPOD model was derived from unselected PCU patients, which may explain their different performance. All these models require external validation.

8. Sudden unexpected death

Although a majority of patients with advanced cancer show a gradual and predictable functional decline through a terminal phase to death, a small proportion in the palliative care setting may die suddenly and/or unexpectedly [45]. So far, four major definitions of sudden unexpected death have been utilized in the palliative care literature: rapid decline death (i.e., a sudden death preceded by functional decline over 1–2 days) [46], surprise death (i.e., the primary responsible physicians answered “yes” to the question, “Were you surprised by the timing of death?”) [9], unexpected death (i.e., a death that occurred earlier than the physician had anticipated) [9], and performance status–defined sudden death (i.e., a death that occurred within 1 week of functional status assessment with an Australia-modified Karnofsky performance status ≥ 50) [47]. Using these four definitions, Ito et al. [13] prospectively followed 1,896 PCU patients, and found that the incidence of rapid decline death was the highest (30-day cumulative incidence: 16.8%), followed by surprise death (9.6%), unexpected death (9.0%) [46,48], and performance status–defined sudden death (6.4%) [13]. These findings were generally consistent with the IPOD study, which found that approximately 10% of PCU deaths were unexpected by physicians and nurses based on the “surprise” and “unexpected death” questions [9]. In EOL discussions and decision-making, clinicians should bear in mind that approximately 1 to 2 in 10 patients might experience unexpected deterioration and death.

Communication of Impending Death

1. Communication with patients

Effective communication with patients, shared decision-making, and family involvement are among the essential elements of quality EOL care [49,50]. The NICE guideline on the care of adults in the last days of life also recommends that clinicians disclose the impending death to patients, clarify goals of care, and facilitate EOL decision-making [1]. However, these are challenging, as most cancer patients become uncommunicative due to the development of delirium and acute complications, medications with sedative effects, and/or the natural dying process [8,51–55].

In addition, whether to disclose the nature of impending death to patients varies widely across cultures. In Asia, for example, non/partial-disclosure and family-centered decision-making remain the cultural norm [56–62]. In the EASED study analyzing data of 2,138 advanced cancer patients admitted to PCUs and deceased during the hospitalization, Yamaguchi et al. [14] reported that markedly fewer Japanese (4.8%) and South Korean (19.6%) patients were informed of their impending death, whereas 66.4% of Taiwanese were informed. In contrast, over 90% of families were informed of their loved one’s impending death in all three countries, indicating a varying degree of family-centered EOL decision-making in East Asia. Thus, it is vital to establish the communication needs of each patient before prognostic disclosure, and explore whether the patient has any cultural, religious, social, or spiritual preferences for shared decision-making [1,61].

2. Communication with families

During patients’ last days of life, it is essential to help families prepare for their loved one’s death cognitively, emotionally, and practically, so that they can make any necessary arrangements. Studies involving bereaved families of cancer patients have indicated the need for improved communication with families of imminently dying patients. A bereaved family survey involving 22 hospitals in seven European and South American countries showed that although 87% of families were told of their relative’s dying, only 63% were informed about what to expect during the dying phase [63]. A bereaved family survey in Japan also revealed that nearly a third of bereaved families perceived some need to improve clinicians’ explanation about impending death [15]. Determinants of the family-perceived need for improvements in the explanation included the following: not receiving an explicit explanation about physical signs of impending death; not receiving an explanation of how long the patient and family could talk; receiving an excessive warning of impending death; and having a feeling of uncertainty caused by vague explanations about future changes.

When explaining signs of impending death to families, caution needs to be taken as family caregivers may perceive some signs as distressing to patients. For example, in a cross-sectional survey of bereaved families of cancer patients in 95 PCUs, up to two-thirds of families reported high distress levels related to death rattle, and higher distress levels were associated with unawareness about death rattle being a natural phenomenon and their fear and distressing interpretations of death rattle [64]. In another study to explore appropriate physicians’ behaviors on death pronouncement, compassion-enhanced behaviors which included reassuring families that the patient did not experience pain associated with RMM resulted in higher physician compassion scores, greater trust in a physician, and less negative emotions among families [65].

Lack of timely explanation about impending death could leave families unprepared for their loved one’s death, resulting in a sense of having unfinished business. Even among families of cancer patients who spent the last days of life in PCUs, over a quarter reported some unfinished business [66]. Moreover, families with unfinished business had significantly higher depression and grief scores after bereavement compared with those without it. Furthermore, even if families do not explicitly talk about death with their loved one, they could act in preparation for their loved one’s death. A bereaved family survey showed that the majority of families acted in such a way, and those who acted more were less likely to suffer depression and complicated grief [67].

While uncertainty is unavoidable in prognostication [17], addressing it compassionately and discussing what can be done may help most patients and families maintain hope [68]. The goals of prognostic discussions include improving illness understanding, promoting prognostic awareness towards acceptance, and ultimately decision-making [69]. There are many different frameworks for approaching these sensitive discussions, and they typically involve finding the right time and setting for the discussion, exploring patients/families’ understanding, acknowledging the uncertainty, communicating information in a clear, honest, empathic manner, responding to emotions, and providing follow-up [70]. Based on the aforementioned literature and anecdotal evidence, we propose several specific strategies when discussing impending death with patients and families (Table 3).

Clinical Implications of Prognostication

Upon the recognition that a patient may be in the last days of life, and before he or she loses communication capacity, clinicians need to adopt an urgent and effective interdisciplinary approach to clarify goals of care, ensure compassionate communication and shared decision-making, address any unfinished business, and support their last wishes.

Predictors of impending death to focus on when informing of impending death may depend on the needs of patients, families, and clinicians. For example, when an inpatient’s family wants to know if they can safely leave the room for one night to rest at home and return the next day to accompany the patient again, the absence of signs of impending death and/or tools with high sensitivity and NPV would be helpful (e.g., 1-day SQ, P3did-score of 0). In contrast, if a patient and/or family wants to spend the last hours to days of life in a private room, or if clinicians consider softening visit restrictions in the COVID-19 pandemic, and wish to know when death is absolutely imminent, identifying late signs with high specificity and PPV would be informative.

Recognition of impending death may also prompt clinicians to reconsider if the current symptom management is in line with the patient’s individual goals. Individuals have their own preferences toward the balance between symptom relief and maintenance of communication capacity in the last days of life [71]. Thus, while managing severe distress such as dyspnea, agitation, and refractory suffering, clinicians should bear in mind the uniqueness of patients’ preferences when titrating medications with sedative effects (e.g., opioids, antipsychotics, benzodiazepines) [52,53,72–75].

Lastly, signs of impending death represent the last chance for both patients and families to complete unfinished business and share their appreciation, forgiveness, and good-byes (i.e., “last words”). Clinicians can help patients and/or families understand the situation, arrange the environment appropriately (e.g., transfer to a private room, softening of visit restrictions), and help them share their words and feelings with each other either explicitly or implicitly when appropriate [76]. The recognition and compassionate communication of impending death, and effective approach may help provide truly value-based, goal-concordant care in the last days of life.

Future Directions

Despite the increasing number of studies on impending death, a number of unanswered questions remain. Among the most important questions in the prognostication of impending death is “why should we prognosticate?”. Table 4 summarizes unanswered questions and future directions in prognostication of impending death. Future studies should help clinicians better prognosticate impending death, effectively communicate with patients and families, and improve clinically important outcomes.

Conclusion

Various signs, symptoms, and tools have been reported for use to predict the impending death of advanced cancer patients. Future efforts should be made to clarify aims of prognostication, establish diagnostic performance of various tools, and develop individualized communication strategies as well as appropriate outcome measurements. Ultimately, impact studies should be conducted to confirm that accurate prognostication and effective communication can actually improve clinically important outcomes of patients and families in the last days of life.

NOTES

Author Contributions

Conceived and designed the analysis: Mori M, Morita T, Bruera E, Hui D.

Collected the data: Mori M, Hui D.

Contributed data or analysis tools: Mori M, Morita T, Bruera E, Hui D.

Wrote the paper: Mori M, Morita T, Bruera E, Hui D.

Final approval: Mori M, Morita T, Bruera E, Hui D.

Conflicts of Interest

Conflict of interest relevant to this article was not reported.

Acknowledgements

We would like to thank all the IPOD and EASED investigators. We appreciate Grant-in-Aid from the Japan Hospice Palliative Care Foundation and JSPS KAKENHI (JP16K15418, 18H02736). DH was supported in part by grants from the National Cancer Institute (R01CA214960; R01CA225701; R01CA231471).

Fig. 1

A diagnostic model for impending death based on the IPOD study. Late signs included in this recursive partitioning model were: death rattle, respiration with mandibular movement, peripheral cyanosis, Cheyne-Stokes breathing, pulselessness of radial artery, decreased response to verbal stimuli, decreased response to visual stimuli, nonreactive pupils, drooping of nasolabial fold, hyperextension of neck, inability to close eyelids, grunting of vocal cords, and upper gastrointestinal bleed. APCU, acute palliative care unit; IPOD, Investigating the Process of Dying; PPS, Palliative Performance Scale. Reference: Hui et al. Cancer. 2015;121:3914-21 [44].

Fig. 2

A diagnostic model for impending death among patients with PPS ≤ 20% based on the EASED study (P3did-DT). A recursive partitioning model for impending death within 3 days in cancer patients who developed PPS ≤ 20% during admission at palliative care units. The entire dataset of 15 clinical signs of 1,396 patients were used for analyses. Clinical signs included in this model were: decreased level of consciousness (RASS ≤ −2), dysphagia of liquids, death rattle, respiration with mandibular movement, peripheral cyanosis, Cheyne-Stokes breathing, pulselessness of radial artery, decreased response to verbal stimuli, decreased response to visual stimuli, apnea periods, drooping of nasolabial fold, hyperextension of neck, inability to close eyelids, grunting of vocal cords, and decreased urine output. EASED, East-Asian cross-cultural collaborative Study to Elucidate the Dying process; P3did-DT, prediction of 3-day impending death-decision tree; PPS, Palliative Performance Scale; RASS, Richmond Agitation-Sedation Scale. Reference: Mori et al. Cancer Med. 2021;10:7988-95 [11].

Table 1

Frequency and diagnostic performance of impending death signs at different timing and settings

	Onset^a), median (95% CI, day)	Frequency^b) in the last 3 days of death (%)	Sensitivity (%)(95% CI)	Specificity (%)(95% CI)	Positive LR (%)(95% CI)	Negative LR (%)(95% CI)
Clinical signs of advanced cancer patients on admission to acute palliative care units (IPOD study)^c)
Early signs
Dysphagia of liquids	7 (5.5–13)	90	40.9 (40.1–41.7)	78.8 (78.3–79.2)	1.9 (1.9–2)	0.75 (0.74–0.76)
RASS ≤ −2	7 (5.5–9.5)	90	50.5 (49.9–51.1)	89.3 (88.9–89.7)	4.9 (4.7–5)	0.6 (0.5–0.6)
PPS ≤ 20%	4 (3.5–6)	93	64 (63.4–64.7)	81.3 (80.9–81.7)	3.5 (3.4–3.6)	0.44 (0.43–0.45)
Late signs
Nonreactive pupils	2.0 (1.5–3)	38	15.3 (14.9–15.7)	99 (98.8–99.1)	16.7 (14.9–18.6)	0.86 (0.85–0.86)
Pulselessness of radial artery	1 (0.5–1)	38	11.3 (10.9–11.8)	99.3 (99.2–99.5)	15.6 (13.7–17.4)	0.89 (0.89–0.9)
Urine output over last 12 hr < 100 mL	1.5 (1–2.5)	72	24.2 (23.2–25.1)	98.2 (98–98.5)	15.2 (13.4–17.1)	0.77 (0.76–0.78)
Inability to close eyelids	1.5 (1–1.5)	57	21.4 (20.9–21.8)	97.9 (97.7–98.1)	13.6 (11.7–15.5)	0.8 (0.8–0.81)
Cheyne-Stokes breathing	2 (1–2)	41	14.1 (13.6–14.5)	98.5 (98.4–98.7)	12.4 (10.8–13.9)	0.9 (0.9–0.9)
Grunting of vocal cords	1.5 (1–2)	54	19.5 (19–19.9)	97.9 (97.7–98.1)	11.8 (10.3–13.4)	0.82 (0.82–0.83)
Respiration with mandibular movement	1.5 (1–2)	56	22 (21.5–22.4)	97.5 (97.3–97.6)	10 (9.1–10.9)	0.8 (0.8–0.81)
Death rattle	1.5 (1–2)	66	22.4 (21.8–22.9)	97.1 (96.9–97.3)	9 (8.1–9.8)	0.8 (0.79–0.81)
Drooping of nasolabial fold	2.5 (1.5–3)	78	33.7 (33.2–34.3)	95.5 (95.3–95.8)	8.3 (7.7–8.9)	0.69 (0.69–0.7)
Decreased response to verbal stimuli	2.0 (1.5–4)	69	30 (29.4–30.5)	96 (95.8–96.3)	8.3 (7.7–9)	0.73 (0.72–0.74)
Hyperextension of neck	2.5 (2–3)	46	21.2 (20.6–21.7)	96.7 (96.5–96.9)	7.3 (6.7–8)	0.82 (0.81–0.82)
Decreased response to visual stimuli	3.0 (2–4)	70	31.9 (31.4–32.4)	94.9 (94.6–95.1)	6.7 (6.3–7.1)	0.72 (0.71–0.72)
Peripheral cyanosis	4 (2–4.5)	59	26.7 (26.1–27.3)	94.9 (94.7–95.2)	5.7 (5.4–6.1)	0.77 (0.77–0.78)
Apnea periods	1.5 (1.5–2.5)	46	17.6 (17.1–18)	95.3 (95.1–95.6)	4.5 (3.7–5.2)	0.86 (0.86–0.87)
Clinical signs of advanced cancer patients with PPS ≤ 20% at inpatient hospices/palliative care units (EASED study)^d)
Physical signs
Decreased level of consciousness (RASS ≤ −2)	3 (2–7)	80.4	73.9 (71.8–76.0)	52.3 (48.7–55.9)	1.55 (1.44–1.67)	0.50 (0.45–0.55)
Dysphagia of liquids	3 (2–8)	75.0	80.5 (78.4–82.6)	33.8 (30.0–37.7)	1.22 (1.15–1.29)	0.58 (0.50–0.66)
Decreased response to verbal stimuli	2 (1–5)	25.1	40.4 (38.0–42.8)	82.1 (79.5–84.7)	2.26 (1.96–2.59)	0.73 (0.70–0.76)
Decreased response to visual stimuli	2 (1–5)	39.8	53.6 (51.1–56.1)	71.6 (68.3–74.9)	1.89 (1.69–2.12)	0.65 (0.61–0.69)
Apnea periods	2 (1–5)	17.4	26.1 (23.7–28.4)	86.7 (84.2–89.2)	1.96 (1.63–2.35)	0.85 (0.82–0.88)
Cheyne-Stokes breathing	2 (1–5)	6.6	10.1 (8.5–11.7)	95.4 (93.9–96.9)	2.19 (1.60–3.01)	0.94 (0.92–0.96)
Peripheral cyanosis	2 (1–4)	22.3	30.2 (27.8–32.5)	88.1 (85.8–90.4)	2.54 (2.12–3.05)	0.79 (0.77–0.82)
Pulselessness of radial artery	1 (1–2)	6.8	11.0 (9.5–12.5)	97.7 (96.5–98.8)	4.67 (2.88–7.59)	0.91 (0.90–0.93)
Respiration with mandibular movement	1 (1–2)	6.1	11.1 (9.6–12.6)	98.8 (98.2–99.5)	9.27 (5.45–15.78)	0.90 (0.89–0.92)
Drooping of nasolabial folds	2 (1–5)	16.2	23.7 (21.4–25.9)	86.1 (83.3–88.8)	1.70 (1.41–2.05)	0.89 (0.86–0.92)
Hyperextension of neck	2 (1–5)	6.6	9.5 (7.9–11.1)	95.7 (94.2–97.2)	2.23 (1.60–3.12)	0.95 (0.93–0.96)
Inability to close eyelids	2 (1–4)	9.0	13.3 (11.5–15.1)	94.5 (92.8–96.1)	2.40 (1.80–3.22)	0.92 (0.90–0.94)
Grunting of vocal cords	2 (1–3)	4.5	9.2 (7.8–10.6)	97.7 (96.8–98.5)	3.96 (2.82–5.55)	0.93 (0.92–0.94)
Urine output over last 24 hr ≤ 200 mL	2 (1–4)	23.9	34.2 (31.9–36.5)	89.1 (87.0–91.1)	3.13 (2.62–3.73)	0.74 (0.71–0.77)
Death rattle	3 (2–8)	24.4	30.0 (27.5–32.5)	76.5 (73.2–79.8)	1.28 (1.11–1.47)	0.92 (0.87–0.96)

CI, confidence interval; EASED, East-Asian cross-cultural collaborative Study to Elucidate the Dying process; IPOD, Investigating the Process of Dying; LR, likelihood ratio; PPS, Palliative Performance Scale; RASS, Richmond Agitation-Sedation Scale.

^a) Onset from death backwards,

^b) Any occurrence of the sign of interest within the last 3 days of life among patients with PPS ≤ 20% and who died in the palliative care units,

^c) Reference: Hui et al. Oncologist. 2014;19:681–7 [6], Hui et al. Cancer. 2015;121:960–7 [7],

^d) Reference: Mori et al. Cancer Med. 2021;10:7988–95 [11].

Table 2

The proportion of patients who died within 3 days based on the P3did-score (EASED study)

	P3did-score (0–4) (%)
	0	1	2	3	4
Death ≤ 1 day	4.3	10.8	20.1	32.3	48.9
Death ≤ 2 days	10.9	22.6	35.3	51.4	70.1
Death ≤ 3 days	17.4	32.8	47.2	62.9	79.6

The P3did-score is the sum of 4 systems: nervous (decreased level of consciousness as indicated by RASS ≤ −2), cardiovascular (peripheral cyanosis, pulselessness of radial artery, and decreased u/o), respiratory (apnea, Cheyne-Stokes breathing, and respiration with mandibular movement), and musculoskeletal (inability to close eyelids, hyperextension of the neck, and drooping of nasolabial folds) systems. If any sign is present within each system, a score of 1 is given to the system, with the total score ranging from 0–4, and a higher score signifying a greater likelihood of death within 3 days. Reference: Mori M, et al. Cancer Med. 2021;10:7988–95 [11]. EASED, East-Asian cross-cultural collaborative Study to Elucidate the Dying process; P3did, prediction of 3-day impending death; RASS, Richmond Agitation-Sedation Scale; u/o, urinary output.

Table 3

Recommended care strategies when communicating impending death

No.	Strategy
1	Recognize impending death without delay based on relevant signs, symptoms, and tools.
2	Prevent and treat distressing signs and symptoms both pharmacologically and non-pharmacologically based on the patient’s goals.
3	Explore informational needs of both the patient and family.
4	Discuss achievable goals, prepare for the future, and pace explanation with the level of preparedness of the patient and family.
5	Avoid saying that clinicians could do nothing further for the patient.
6	Reassure the patient and family that he/she would remain comfortable despite the presence of signs of impending death.
7	Find a balance between detailed explanation and excessive warning.
8	Address how long the patient and family could talk in the remaining time.
9	Coordinate the appropriate timing for what the patient and family wish to do.
10	Help the patient and family act in preparation for death and receive goal-concordant care.

Table 4

Unanswered questions and future directions in prognostication of impending death

Unanswered question	Explanation and example
Aims and important outcomes of prognostication
1. What are the aims of prognostication of impending death?	The ultimate goal of prognostication of impending death is to improve patient outcomes in their last days of life. However, impact studies are lacking. Investigators should start with why, and clarify the aims of prognostication. For example, do accurate prognostication and timely communication help patients and families complete unfinished business, spend the last days of life in their preferred place surrounded by their loved ones, and achieve a good death? Can prognostication help clinicians clarify patients’ goals, optimize medical treatment and care, and provide goal-concordant care in the last days of life? Or for advanced cancer patients under observation at home for COVID-19, can the timely detection of early signs of impending death or changes in vital signs by remote censoring help facilitate urgent hospitalization to prevent further deterioration? With such specific aims in mind, investigators can better develop and test prognostic tools as well as communication strategies in various settings.
2. What are the clinically important outcomes?	In addition to the pursuit of accuracy of prognostic tools, clinically important outcomes of prognostication should be established. Outcome measurements may include, but are not limited to, goal-concordant care, aggressive end-of-life care, completion of unfinished business, patients’ and families’ satisfaction with care, preferred place of death, quality of dying, and a good death. These need to be clarified and validated if necessary.
Development of better prognostic tools
3. Validation of prognostic models	There are several prognostic models based on data from IPOD and ESAED studies. However, external validation is needed, and testing of how these models perform in a real-world setting is necessary.
4. Which prognostic tools should be used in which clinical settings?	How to define and assess signs of impending death needs to be standardized. While many signs, symptoms, and tools have been suggested to inform of impending death, how to use them efficiently in settings where high sensitivity or specificity is desirable is not well-understood. Furthermore, the accuracy of clinicians’ prediction of survival in the presence of impending death needs to be compared with existing signs and tools.
5. What are novel biomedical makers for the prediction of impending death?	Regardless of tumor sites, most cancer patients follow a typical, natural dying process. By investigating physiological signs in patients’ serum, electrophysiology, and imaging studies, novel biomedical markers to predict impending death may be identified.
6. Is continuous monitoring of physiological signs helpful in predicting impending death?	Previous studies involved relatively infrequent assessment of clinical signs (e.g., once or twice daily), and could not identify subtle changes of vital signs and other physiologic signs sufficiently. The use of continuous monitoring may allow real-time prognostication. It may also help clinicians provide more timely symptom management and effective communication with patients and families, especially in settings with less resources such as during the night time and in home or nursing home settings.
7. Can artificial intelligence help predict impending death?	Electronic medical records provide rich quantitative and qualitative data related to various signs and symptoms of impending death. Natural language processing of the medical record would help identify the point when a patient enters the dying phase before clinicians recognize it. Continuous image recognition by a bedside monitor that observes patients’ movement and facial expressions would also identify impending death without delay. This might also help clinicians remotely identify signs of impending death, and could be widely used in the era of the COVID-19 pandemic.
Communication of impending death
8. What are intra and inter-country differences in patients’ and families’ preferences for, and clinicians practice of, communication of impending death?	Patients’ and families’ perceptions, beliefs, and preferences regarding communication of impending death, as well as clinicians’ beliefs and practice patterns can vary widely across countries and within a country. Cross-cultural surveys involving western and eastern countries and regions may also clarify similarities and differences in communication of impending death.
9. What contributes to the variable practice in communication of impending death with patients, and how can clinicians support patients without explicit prognostic disclosure?	While there are marked cross-cultural differences in communication of impending death with patients, reasons behind such differences are largely unknown. Cross-cultural qualitative studies may provide a deep understanding of different perceptions and practice patterns. In particular, better understanding of why, when, and how patients wish to be informed of their impending death may help clinicians develop individualized communication strategies.
10. What is the best practice of explaining impending death to patients with various degrees of readiness?	Unlike explanation of longer life expectancy, the best way to communicate days of prognosis, either explicitly or implicitly, while tailoring to patients’ readiness and preferences has not been fully elucidated. When, how, and to whom such communication should be initiated need to be elucidated. However, there is no one-size-fits-all approach. Sequential process may be required to realize effective communication and decision-making.
Impact studies
11. Is a comprehensive care pathway including individualized communication strategies effective and safe, and what are the mechanisms of action?	Communication and decision-making are part of a more comprehensive care pathway for patients during the last days of life. A mixed-method, randomized controlled trial could help confirm the feasibility, effectiveness, and safety of such a care pathway and their mechanisms of action. A real-world implementation and dissemination of such care pathways may help provide quality care for imminently dying patients

COVID-19, coronavirus disease 2019; EASED, East-Asian cross-cultural collaborative Study to Elucidate the Dying process; IPOD, Investigating the Process of Dying.

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Prognostication of the Last Days of Life

Cancer Res Treat. 2022;54(3):631-643. Published online March 30, 2022

DOI: https://doi.org/10.4143/crt.2021.1573

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Abstract
Introduction
Prognostication of Impending Death
Communication of Impending Death
Clinical Implications of Prognostication
Future Directions
Conclusion
NOTES
REFERENCES

Prognostication of the Last Days of Life

Fig. 1 A diagnostic model for impending death based on the IPOD study. Late signs included in this recursive partitioning model were: death rattle, respiration with mandibular movement, peripheral cyanosis, Cheyne-Stokes breathing, pulselessness of radial artery, decreased response to verbal stimuli, decreased response to visual stimuli, nonreactive pupils, drooping of nasolabial fold, hyperextension of neck, inability to close eyelids, grunting of vocal cords, and upper gastrointestinal bleed. APCU, acute palliative care unit; IPOD, Investigating the Process of Dying; PPS, Palliative Performance Scale. Reference: Hui et al. Cancer. 2015;121:3914-21 [44].

Fig. 2 A diagnostic model for impending death among patients with PPS ≤ 20% based on the EASED study (P3did-DT). A recursive partitioning model for impending death within 3 days in cancer patients who developed PPS ≤ 20% during admission at palliative care units. The entire dataset of 15 clinical signs of 1,396 patients were used for analyses. Clinical signs included in this model were: decreased level of consciousness (RASS ≤ −2), dysphagia of liquids, death rattle, respiration with mandibular movement, peripheral cyanosis, Cheyne-Stokes breathing, pulselessness of radial artery, decreased response to verbal stimuli, decreased response to visual stimuli, apnea periods, drooping of nasolabial fold, hyperextension of neck, inability to close eyelids, grunting of vocal cords, and decreased urine output. EASED, East-Asian cross-cultural collaborative Study to Elucidate the Dying process; P3did-DT, prediction of 3-day impending death-decision tree; PPS, Palliative Performance Scale; RASS, Richmond Agitation-Sedation Scale. Reference: Mori et al. Cancer Med. 2021;10:7988-95 [11].

Fig. 1

Fig. 2

Prognostication of the Last Days of Life

Table 1

Frequency and diagnostic performance of impending death signs at different timing and settings

	Onset^a), median (95% CI, day)	Frequency^b) in the last 3 days of death (%)	Sensitivity (%)(95% CI)	Specificity (%)(95% CI)	Positive LR (%)(95% CI)	Negative LR (%)(95% CI)
Clinical signs of advanced cancer patients on admission to acute palliative care units (IPOD study)^c)
Early signs
Dysphagia of liquids	7 (5.5–13)	90	40.9 (40.1–41.7)	78.8 (78.3–79.2)	1.9 (1.9–2)	0.75 (0.74–0.76)
RASS ≤ −2	7 (5.5–9.5)	90	50.5 (49.9–51.1)	89.3 (88.9–89.7)	4.9 (4.7–5)	0.6 (0.5–0.6)
PPS ≤ 20%	4 (3.5–6)	93	64 (63.4–64.7)	81.3 (80.9–81.7)	3.5 (3.4–3.6)	0.44 (0.43–0.45)
Late signs
Nonreactive pupils	2.0 (1.5–3)	38	15.3 (14.9–15.7)	99 (98.8–99.1)	16.7 (14.9–18.6)	0.86 (0.85–0.86)
Pulselessness of radial artery	1 (0.5–1)	38	11.3 (10.9–11.8)	99.3 (99.2–99.5)	15.6 (13.7–17.4)	0.89 (0.89–0.9)
Urine output over last 12 hr < 100 mL	1.5 (1–2.5)	72	24.2 (23.2–25.1)	98.2 (98–98.5)	15.2 (13.4–17.1)	0.77 (0.76–0.78)
Inability to close eyelids	1.5 (1–1.5)	57	21.4 (20.9–21.8)	97.9 (97.7–98.1)	13.6 (11.7–15.5)	0.8 (0.8–0.81)
Cheyne-Stokes breathing	2 (1–2)	41	14.1 (13.6–14.5)	98.5 (98.4–98.7)	12.4 (10.8–13.9)	0.9 (0.9–0.9)
Grunting of vocal cords	1.5 (1–2)	54	19.5 (19–19.9)	97.9 (97.7–98.1)	11.8 (10.3–13.4)	0.82 (0.82–0.83)
Respiration with mandibular movement	1.5 (1–2)	56	22 (21.5–22.4)	97.5 (97.3–97.6)	10 (9.1–10.9)	0.8 (0.8–0.81)
Death rattle	1.5 (1–2)	66	22.4 (21.8–22.9)	97.1 (96.9–97.3)	9 (8.1–9.8)	0.8 (0.79–0.81)
Drooping of nasolabial fold	2.5 (1.5–3)	78	33.7 (33.2–34.3)	95.5 (95.3–95.8)	8.3 (7.7–8.9)	0.69 (0.69–0.7)
Decreased response to verbal stimuli	2.0 (1.5–4)	69	30 (29.4–30.5)	96 (95.8–96.3)	8.3 (7.7–9)	0.73 (0.72–0.74)
Hyperextension of neck	2.5 (2–3)	46	21.2 (20.6–21.7)	96.7 (96.5–96.9)	7.3 (6.7–8)	0.82 (0.81–0.82)
Decreased response to visual stimuli	3.0 (2–4)	70	31.9 (31.4–32.4)	94.9 (94.6–95.1)	6.7 (6.3–7.1)	0.72 (0.71–0.72)
Peripheral cyanosis	4 (2–4.5)	59	26.7 (26.1–27.3)	94.9 (94.7–95.2)	5.7 (5.4–6.1)	0.77 (0.77–0.78)
Apnea periods	1.5 (1.5–2.5)	46	17.6 (17.1–18)	95.3 (95.1–95.6)	4.5 (3.7–5.2)	0.86 (0.86–0.87)
Clinical signs of advanced cancer patients with PPS ≤ 20% at inpatient hospices/palliative care units (EASED study)^d)
Physical signs
Decreased level of consciousness (RASS ≤ −2)	3 (2–7)	80.4	73.9 (71.8–76.0)	52.3 (48.7–55.9)	1.55 (1.44–1.67)	0.50 (0.45–0.55)
Dysphagia of liquids	3 (2–8)	75.0	80.5 (78.4–82.6)	33.8 (30.0–37.7)	1.22 (1.15–1.29)	0.58 (0.50–0.66)
Decreased response to verbal stimuli	2 (1–5)	25.1	40.4 (38.0–42.8)	82.1 (79.5–84.7)	2.26 (1.96–2.59)	0.73 (0.70–0.76)
Decreased response to visual stimuli	2 (1–5)	39.8	53.6 (51.1–56.1)	71.6 (68.3–74.9)	1.89 (1.69–2.12)	0.65 (0.61–0.69)
Apnea periods	2 (1–5)	17.4	26.1 (23.7–28.4)	86.7 (84.2–89.2)	1.96 (1.63–2.35)	0.85 (0.82–0.88)
Cheyne-Stokes breathing	2 (1–5)	6.6	10.1 (8.5–11.7)	95.4 (93.9–96.9)	2.19 (1.60–3.01)	0.94 (0.92–0.96)
Peripheral cyanosis	2 (1–4)	22.3	30.2 (27.8–32.5)	88.1 (85.8–90.4)	2.54 (2.12–3.05)	0.79 (0.77–0.82)
Pulselessness of radial artery	1 (1–2)	6.8	11.0 (9.5–12.5)	97.7 (96.5–98.8)	4.67 (2.88–7.59)	0.91 (0.90–0.93)
Respiration with mandibular movement	1 (1–2)	6.1	11.1 (9.6–12.6)	98.8 (98.2–99.5)	9.27 (5.45–15.78)	0.90 (0.89–0.92)
Drooping of nasolabial folds	2 (1–5)	16.2	23.7 (21.4–25.9)	86.1 (83.3–88.8)	1.70 (1.41–2.05)	0.89 (0.86–0.92)
Hyperextension of neck	2 (1–5)	6.6	9.5 (7.9–11.1)	95.7 (94.2–97.2)	2.23 (1.60–3.12)	0.95 (0.93–0.96)
Inability to close eyelids	2 (1–4)	9.0	13.3 (11.5–15.1)	94.5 (92.8–96.1)	2.40 (1.80–3.22)	0.92 (0.90–0.94)
Grunting of vocal cords	2 (1–3)	4.5	9.2 (7.8–10.6)	97.7 (96.8–98.5)	3.96 (2.82–5.55)	0.93 (0.92–0.94)
Urine output over last 24 hr ≤ 200 mL	2 (1–4)	23.9	34.2 (31.9–36.5)	89.1 (87.0–91.1)	3.13 (2.62–3.73)	0.74 (0.71–0.77)
Death rattle	3 (2–8)	24.4	30.0 (27.5–32.5)	76.5 (73.2–79.8)	1.28 (1.11–1.47)	0.92 (0.87–0.96)

^a)Onset from death backwards,

^b)Any occurrence of the sign of interest within the last 3 days of life among patients with PPS ≤ 20% and who died in the palliative care units,

^c)Reference: Hui et al. Oncologist. 2014;19:681–7 [6], Hui et al. Cancer. 2015;121:960–7 [7],

^d)Reference: Mori et al. Cancer Med. 2021;10:7988–95 [11].

Table 2

The proportion of patients who died within 3 days based on the P3did-score (EASED study)

	P3did-score (0–4) (%)
	0	1	2	3	4
Death ≤ 1 day	4.3	10.8	20.1	32.3	48.9
Death ≤ 2 days	10.9	22.6	35.3	51.4	70.1
Death ≤ 3 days	17.4	32.8	47.2	62.9	79.6

Table 3

Recommended care strategies when communicating impending death

No.	Strategy
1	Recognize impending death without delay based on relevant signs, symptoms, and tools.
2	Prevent and treat distressing signs and symptoms both pharmacologically and non-pharmacologically based on the patient’s goals.
3	Explore informational needs of both the patient and family.
4	Discuss achievable goals, prepare for the future, and pace explanation with the level of preparedness of the patient and family.
5	Avoid saying that clinicians could do nothing further for the patient.
6	Reassure the patient and family that he/she would remain comfortable despite the presence of signs of impending death.
7	Find a balance between detailed explanation and excessive warning.
8	Address how long the patient and family could talk in the remaining time.
9	Coordinate the appropriate timing for what the patient and family wish to do.
10	Help the patient and family act in preparation for death and receive goal-concordant care.

Table 4

Unanswered questions and future directions in prognostication of impending death

Unanswered question	Explanation and example
Aims and important outcomes of prognostication
1. What are the aims of prognostication of impending death?	The ultimate goal of prognostication of impending death is to improve patient outcomes in their last days of life. However, impact studies are lacking. Investigators should start with why, and clarify the aims of prognostication. For example, do accurate prognostication and timely communication help patients and families complete unfinished business, spend the last days of life in their preferred place surrounded by their loved ones, and achieve a good death? Can prognostication help clinicians clarify patients’ goals, optimize medical treatment and care, and provide goal-concordant care in the last days of life? Or for advanced cancer patients under observation at home for COVID-19, can the timely detection of early signs of impending death or changes in vital signs by remote censoring help facilitate urgent hospitalization to prevent further deterioration? With such specific aims in mind, investigators can better develop and test prognostic tools as well as communication strategies in various settings.
2. What are the clinically important outcomes?	In addition to the pursuit of accuracy of prognostic tools, clinically important outcomes of prognostication should be established. Outcome measurements may include, but are not limited to, goal-concordant care, aggressive end-of-life care, completion of unfinished business, patients’ and families’ satisfaction with care, preferred place of death, quality of dying, and a good death. These need to be clarified and validated if necessary.
Development of better prognostic tools
3. Validation of prognostic models	There are several prognostic models based on data from IPOD and ESAED studies. However, external validation is needed, and testing of how these models perform in a real-world setting is necessary.
4. Which prognostic tools should be used in which clinical settings?	How to define and assess signs of impending death needs to be standardized. While many signs, symptoms, and tools have been suggested to inform of impending death, how to use them efficiently in settings where high sensitivity or specificity is desirable is not well-understood. Furthermore, the accuracy of clinicians’ prediction of survival in the presence of impending death needs to be compared with existing signs and tools.
5. What are novel biomedical makers for the prediction of impending death?	Regardless of tumor sites, most cancer patients follow a typical, natural dying process. By investigating physiological signs in patients’ serum, electrophysiology, and imaging studies, novel biomedical markers to predict impending death may be identified.
6. Is continuous monitoring of physiological signs helpful in predicting impending death?	Previous studies involved relatively infrequent assessment of clinical signs (e.g., once or twice daily), and could not identify subtle changes of vital signs and other physiologic signs sufficiently. The use of continuous monitoring may allow real-time prognostication. It may also help clinicians provide more timely symptom management and effective communication with patients and families, especially in settings with less resources such as during the night time and in home or nursing home settings.
7. Can artificial intelligence help predict impending death?	Electronic medical records provide rich quantitative and qualitative data related to various signs and symptoms of impending death. Natural language processing of the medical record would help identify the point when a patient enters the dying phase before clinicians recognize it. Continuous image recognition by a bedside monitor that observes patients’ movement and facial expressions would also identify impending death without delay. This might also help clinicians remotely identify signs of impending death, and could be widely used in the era of the COVID-19 pandemic.
Communication of impending death
8. What are intra and inter-country differences in patients’ and families’ preferences for, and clinicians practice of, communication of impending death?	Patients’ and families’ perceptions, beliefs, and preferences regarding communication of impending death, as well as clinicians’ beliefs and practice patterns can vary widely across countries and within a country. Cross-cultural surveys involving western and eastern countries and regions may also clarify similarities and differences in communication of impending death.
9. What contributes to the variable practice in communication of impending death with patients, and how can clinicians support patients without explicit prognostic disclosure?	While there are marked cross-cultural differences in communication of impending death with patients, reasons behind such differences are largely unknown. Cross-cultural qualitative studies may provide a deep understanding of different perceptions and practice patterns. In particular, better understanding of why, when, and how patients wish to be informed of their impending death may help clinicians develop individualized communication strategies.
10. What is the best practice of explaining impending death to patients with various degrees of readiness?	Unlike explanation of longer life expectancy, the best way to communicate days of prognosis, either explicitly or implicitly, while tailoring to patients’ readiness and preferences has not been fully elucidated. When, how, and to whom such communication should be initiated need to be elucidated. However, there is no one-size-fits-all approach. Sequential process may be required to realize effective communication and decision-making.
Impact studies
11. Is a comprehensive care pathway including individualized communication strategies effective and safe, and what are the mechanisms of action?	Communication and decision-making are part of a more comprehensive care pathway for patients during the last days of life. A mixed-method, randomized controlled trial could help confirm the feasibility, effectiveness, and safety of such a care pathway and their mechanisms of action. A real-world implementation and dissemination of such care pathways may help provide quality care for imminently dying patients

COVID-19, coronavirus disease 2019; EASED, East-Asian cross-cultural collaborative Study to Elucidate the Dying process; IPOD, Investigating the Process of Dying.

Table 1 Frequency and diagnostic performance of impending death signs at different timing and settings

Onset from death backwards,

Any occurrence of the sign of interest within the last 3 days of life among patients with PPS ≤ 20% and who died in the palliative care units,

Reference: Hui et al. Oncologist. 2014;19:681–7 [6], Hui et al. Cancer. 2015;121:960–7 [7],

Reference: Mori et al. Cancer Med. 2021;10:7988–95 [11].

Table 2 The proportion of patients who died within 3 days based on the P3did-score (EASED study)

Table 3 Recommended care strategies when communicating impending death

Table 4 Unanswered questions and future directions in prognostication of impending death

COVID-19, coronavirus disease 2019; EASED, East-Asian cross-cultural collaborative Study to Elucidate the Dying process; IPOD, Investigating the Process of Dying.