Department of Head Neck and Thyroid, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China
Copyright © 2020 by the Korean Cancer Association
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NPC survivor (n=83) | Sporadic oral SCC (n=1,158) | p-value | |
---|---|---|---|
Age (yr) | |||
≥ 60 | 46 | 632 | 0.881 |
< 60 | 37 | 526 | |
Sex | |||
Male | 67 | 891 | 0.428 |
Female | 16 | 267 | |
Drinker | |||
Yes | 8 | 200 | 0.072 |
No | 75 | 958 | |
Smoker | |||
Yes | 11 | 323 | 0.004 |
No | 72 | 835 | |
Tumor site | |||
Tongue | 54 | 486 | 0.004 |
Mouth floor | 6 | 312 | |
Buccal | 13 | 203 | |
Lower gingiva | 10 | 157 | |
Tumor stage | |||
T1+T2 | 59 | 736 | 0.167 |
T3+T4 | 24 | 422 | |
Disease stage | |||
I+Ⅱ | 51 | 633 | 0.230 |
Ⅲ+Ⅳ | 32 | 525 | |
Node stage | |||
N0 | 55 | 789 | 0.724 |
N+ | 28 | 369 | |
Differentiation | |||
Well | 47 | 554 | 0.133 |
Moderate | 23 | 377 | |
Poor | 13 | 167 | |
Unknown | 0 | 60 | |
Perineural invasion | |||
Positive | 23 | 130 | < 0.001 |
Negative | 60 | 949 | |
Unknown | 0 | 79 | |
Lymphovascular invasion | |||
Positive | 16 | 153 | < 0.001 |
Negative | 67 | 955 | |
Unknown | 0 | 50 | |
Treatment | |||
S | 15 | 145 | 0.235 |
S+R | 30 | 369 | |
S+R+C | 38 | 612 |
NPC survivor (n=83) | Matched group (n=166) | p-value | |
---|---|---|---|
Age (yr) | |||
≥ 60 | 46 | 88 | 0.719 |
< 60 | 37 | 78 | |
Sex | |||
Male | 67 | 134 | > 0.99 |
Female | 16 | 32 | |
Drinker | |||
Yes | 8 | 25 | 0.234 |
No | 75 | 141 | |
Smoker | |||
Yes | 11 | 22 | > 0.99 |
No | 72 | 144 | |
Tumor site | |||
Tongue | 54 | 108 | > 0.99 |
Mouth floor | 6 | 12 | |
Buccal | 13 | 26 | |
Lower gingiva | 10 | 20 | |
Tumor stage | |||
T1+T2 | 59 | 118 | > 0.99 |
T3+T4 | 24 | 48 | |
Disease stage | |||
Ⅰ+Ⅱ | 51 | 102 | > 0.99 |
Ⅲ+Ⅳ | 32 | 64 | |
Node stage | |||
N0 | 55 | 110 | > 0.99 |
N+ | 28 | 56 | |
Differentiation | |||
Well | 47 | 92 | 0.891 |
Moderate | 23 | 44 | |
Poor | 13 | 30 | |
Perineural invasion | |||
Positive | 23 | 46 | > 0.99 |
Negative | 60 | 120 | |
Lymphovascular invasion | |||
Positive | 16 | 32 | > 0.99 |
Negative | 67 | 134 | |
Treatment | |||
S | 15 | 22 | 0.601 |
S+R | 30 | 64 | |
S+R+C | 38 | 80 |
Variable | Univariate Log-rank test | Cox model |
|
---|---|---|---|
HR (95% CI) | p-value | ||
Age (≥ 60 yr vs. < 60 yr) | 0.358 | - | - |
Sex (male vs. female) | 0.288 | - | - |
Drinker (yes vs. no) | 0.112 | - | - |
Smoker (yes vs. no) | 0.025 | 1.963 (1.275-4.002) | 0.031 |
Tumor site (tongue vs. others) | 0.034 | 2.111 (0.687-8.244) | 0.657 |
Tumor stage (T1+T2 vs. T3+T4) | 0.096 | - | - |
Node stage (N0 vs. N+) | 0.044 | 3.013 (0.846-6.897) | 0.273 |
Disease stage (Ⅰ+Ⅱ vs. Ⅲ+Ⅳ) | 0.008 | 3.482 (1.852-10.336) | < 0.001 |
Differentiation (well vs. moderate+poor) | 0.017 | 2.541 (1.344-6.579) | 0.005 |
Perineural invasion (yes vs. no) | 0.324 | - | - |
Lymphovascular invasion (yes vs. no) | 0.119 | - | - |
Treatment (surgery alone vs. others) | 0.613 | - | - |
Variable | Univariate Log-rank test | Cox model |
|
---|---|---|---|
HR (95% CI) | p-value | ||
Age (≥ 60 yr vs. < 60 yr) | 0.147 | - | - |
Sex (male vs. female) | 0.638 | - | - |
Drinker (yes vs. no) | 0.241 | - | - |
Smoker (yes vs. no) | 0.013 | 1.951 (0.847-3.003) | 0.287 |
Tumor site (tongue vs. others) | 0.378 | - | - |
Tumor stage (T1+T2 vs. T3+T4) | 0.016 | 2.631 (0.411-6.387) | 0.612 |
Node stage (N0 vs. N+) | 0.188 | - | - |
Disease stage (Ⅰ+Ⅱ vs. Ⅲ+Ⅳ) | 0.007 | 4.021 (1.637-13.554) | < 0.001 |
Differentiation (well vs. moderate+poor) | 0.087 | - | - |
Perineural invasion (yes vs. no) | 0.016 | 2.002 (1.174-3.982) | 0.011 |
Lymphovascular invasion (yes vs. no) | 0.325 | - | - |
Treatment (surgery alone vs. others) | 0.023 | 1.988 (1.164-3.863) | 0.013 |
NPC, nasopharyngeal carcinoma; SCC, squamous cell carcinoma; S, surgery; R, radiotherapy; C, chemotherapy.
NPC, nasopharyngeal carcinoma; S, surgery; R, radiotherapy; C, chemotherapy.
NPC, nasopharyngeal carcinoma; HR, hazard ratio; CI, confidence interval.
HR, hazard ratio; CI, confidence interval.