1State Key Laboratory of Molecular Oncology, Department of Etiology & Carcinogenesis, Beijing Key Laboratory for Carcinogenesis and Cancer Prevention, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
2Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Copyright © 2019 by the Korean Cancer Association
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Characteristic |
Leukopenia |
Diarrhea |
Dermatitis |
||||||
---|---|---|---|---|---|---|---|---|---|
Grade 0-1 | Grade ≥ 2 | p-valuea) | Grade 0-1 | Grade ≥ 2 | p-valuea) | Grade 0-1 | Grade ≥ 2 | p-valuea) | |
Sex | |||||||||
Male | 165 (64.2) | 56 (51.9) | 0.028 | 117 (57.4) | 104 (64.6) | 0.160 | 178 (60.1) | 43 (62.3) | 0.738 |
Female | 92 (35.8) | 52 (48.1) | 87 (42.6) | 57 (35.4) | 118 (39.9) | 26 (37.7) | |||
Age (yr) | |||||||||
≤ 56 | 134 (52.1) | 64 (59.3) | 0.213 | 118 (57.8) | 80 (49.7) | 0.121 | 160 (54.1) | 38 (55.1) | 0.878 |
> 56 | 123 (47.9) | 44 (40.7) | 86 (42.2) | 81 (50.3) | 136 (45.9) | 31 (44.9) | |||
Clinical stage | |||||||||
II | 109 (42.4) | 40 (37.0) | 0.340 | 88 (43.1) | 61 (37.9) | 0.311 | 123 (41.6) | 26 (37.7) | 0.556 |
III | 148 (57.6) | 68 (63.0) | 116 (56.9) | 100 (62.1) | 173 (58.4) | 43 (62.3) | |||
Tumor grade | |||||||||
Poor | 11 (4.3) | 5 (4.6) | 0.848 | 8 (3.9) | 8 (5.0) | 0.687 | 14 (4.7) | 2 (2.9) | 0.780 |
Moderate | 220 (85.6) | 90 (83.3) | 172 (84.3) | 138 (85.7) | 251 (84.8) | 59 (85.5) | |||
Well | 26 (10.1) | 13 (12.1) | 24 (11.8) | 15 (9.3) | 31 (10.5) | 8 (11.6) | |||
KPS | |||||||||
90-100 | 109 (42.4) | 42 (38.9) | 0.223 | 78 (38.2) | 73 (45.3) | 0.315 | 125 (42.2) | 26 (37.7) | 0.689 |
80 | 131 (51.0) | 53 (49.1) | 110 (53.9) | 74 (46.0) | 146 (49.3) | 38 (55.1) | |||
70 | 17 (6.6) | 13 (12.0) | 16 (7.9) | 14 (8.7) | 25 (8.5) | 5 (7.2) | |||
Surgery | |||||||||
Dixon | 201 (78.2) | 83 (76.9) | 0.776 | 129 (63.2) | 155 (96.3) | < 0.001 | 240 (81.1) | 44 (63.8) | 0.002 |
Mile’s | 56 (21.8) | 25 (23.1) | 75 (36.8) | 6 (3.7) | 56 (18.9) | 25 (36.2) | |||
Tumor location | |||||||||
Distance from anal < 5 cm | 95 (37.0) | 34 (31.5) | 0.317 | 94 (46.1) | 35 (21.7) | < 0.001 | 92 (31.1) | 37 (53.6) | < 0.001 |
Distance from anal ≥ 5 cm | 162 (63.0) | 74 (68.5) | 110 (53.9) | 126 (78.3) | 204 (68.9) | 32 (46.4) |
Characteristic | Total | Alive | Death | p-valuea) |
---|---|---|---|---|
Sex | ||||
Male | 198 (60.6) | 156 (58.6) | 42 (68.9) | 0.175 |
Female | 129 (39.4) | 110 (41.4) | 19 (31.1) | |
Age (yr) | ||||
≤ 56 | 175 (53.5) | 145 (54.5) | 30 (49.2) | 0.547 |
> 56 | 152 (46.5) | 121 (45.5) | 31 (50.8) | |
Clinical stage | ||||
II | 140 (42.8) | 124 (46.6) | 16 (26.2) | 0.002 |
III | 187 (57.2) | 142 (53.4) | 45 (73.8) | |
Tumor grade | ||||
Poor | 14 (4.3) | 12 (4.5) | 2 (3.3) | 0.189 |
Moderate | 280 (85.6) | 230 (86.5) | 50 (82.0) | |
Well | 33 (10.1) | 24 (9.0) | 9 (14.7) | |
KPS | ||||
90-100 | 137 (41.9) | 114 (42.9) | 23 (37.7) | 0.089 |
80 | 171 (52.3) | 140 (52.6) | 31 (50.8) | |
70 | 19 (5.8) | 12 (4.5) | 7 (11.5) | |
Surgery | ||||
Dixon | 254 (77.7) | 208 (78.2) | 46 (75.4) | 0.534 |
Mile’s | 73 (22.3) | 58 (21.8) | 15 (24.6) | |
Tumor location | ||||
Distance from anal < 5 cm | 113 (34.6) | 89 (33.5) | 24 (39.3) | 0.349 |
Distance from anal ≥ 5 cm | 214 (65.4) | 177 (66.5) | 37 (60.7) |
Genotype |
No. (%) |
OR (95% CI)a) | p-value | |
---|---|---|---|---|
Grade 0-1 diarrhea | Grade ≥ 2 diarrhea | |||
rs12513549 | ||||
GG | 88 (43.4) | 85 (53.1) | 1.00 (reference) | |
GT | 93 (45.8) | 62 (38.8) | 0.69 (0.42-1.12) | 0.136 |
TT | 22 (10.8) | 13 (8.1) | 0.49 (0.20-1.14) | 0.101 |
GT+TT | 115 (56.6) | 75 (46.9) | 0.63 (0.39-1.00) | 0.053 |
rs33013 | ||||
AA | 57 (27.9) | 52 (32.3) | 1.00 (reference) | |
AG | 105 (51.5) | 88 (54.7) | 0.88 (0.52-1.49) | 0.641 |
GG | 42 (20.6) | 21 (13.0) | 0.38 (0.17-0.83) | 0.017 |
AG+GG | 147 (72.1) | 109 (67.7) | 0.74 (0.44-1.22) | 0.239 |
rs6151627 | ||||
AA | 125 (61.3) | 84 (52.2) | 1.00 (reference) | |
AG | 73 (35.8) | 66 (41.0) | 1.38 (0.85-2.25) | 0.192 |
GG | 6 (2.9) | 11 (6.8) | 2.99 (0.97-10.49) | 0.067 |
AG+GG | 79 (38.7) | 77 (47.8) | 1.50 (0.94-2.40) | 0.088 |
Genotype |
No. (%) |
OR (95% CI)a) | p-value | |
---|---|---|---|---|
Grade 0-1 dermatitis | Grade ≥ 2 dermatitis | |||
rs1233255 | ||||
AA | 221 (74.9) | 60 (87.0) | 1.00 (reference) | |
AC | 70 (23.7) | 8 (11.6) | 0.41 (0.17-0.86) | 0.028 |
CC | 4 (1.4) | 1 (1.4) | 0.56 (0.03-4.44) | 0.627 |
Genotype | Alive | Death |
Univariate analysis |
Multivariate analysis |
||
---|---|---|---|---|---|---|
HR (95% CI)a) | p-value | HR (95% CI)b) | p-value | |||
rs4920657 | ||||||
TT | 156 (58.6) | 43 (70.5) | 1.00 (reference) | 1.00 (reference) | ||
TA | 90 (33.9) | 16 (26.2) | 0.66 (0.37-1.17) | 0.158 | 0.57 (0.32-1.03) | 0.063 |
AA | 20 (7.5) | 2 (3.3) | 0.42 (0.10-1.72) | 0.227 | 0.33 (0.08-1.38) | 0.129 |
TA+AA | 110 (41.4) | 18 (29.5) | 0.62 (0.36-1.08) | 0.090 | 0.54 (0.31-0.94) | 0.029 |
rs5743030 | ||||||
GG | 202 (76.5) | 54 (90.0) | 1.00 (reference) | 1.00 (reference) | ||
GA | 59 (22.3) | 6 (10.0) | 0.41 (0.18-0.96) | 0.040 | 0.38 (0.16-0.89) | 0.025 |
AA | 3 (1.2) | 0 | - | 0.996 | 0.38 (0.16-0.89) | 0.969 |
GA+AA | 62 (23.5) | 6 (10.0) | 0.40 (0.17-0.92) | 0.031 | 0.36 (0.15-0.85) | 0.019 |
rs5743100 | ||||||
GG | 194 (74.3) | 52 (85.2) | 1.00 (reference) | 1.00 (reference) | ||
GT | 64 (24.5) | 9 (14.8) | 0.55 (0.27-1.12) | 0.100 | 0.53 (0.26-1.08) | 0.080 |
TT | 3 (1.2) | 0 | - | 0.997 | - | 0.968 |
GT+TT | 67 (25.7) | 9 (14.8) | 0.53 (0.26-1.08) | 0.080 | 0.50 (0.25-1.03) | 0.060 |
SNP, single nucleotide polymorphism; HR, hazard ratio; CI, confidence interval.
a) Univariate analysis: calculated by Cox regression model without adjustment,
b) Multivariate analysis: calculated by Cox regression model, adjusted by sex, age, Karnofsky Performance Score, clinical stage, tumor grade, surgical procedure and tumor location.
Characteristic | Leukopenia |
Diarrhea |
Dermatitis |
||||||
---|---|---|---|---|---|---|---|---|---|
Grade 0-1 | Grade ≥ 2 | p-value |
Grade 0-1 | Grade ≥ 2 | p-value |
Grade 0-1 | Grade ≥ 2 | p-value |
|
Sex | |||||||||
Male | 165 (64.2) | 56 (51.9) | 0.028 | 117 (57.4) | 104 (64.6) | 0.160 | 178 (60.1) | 43 (62.3) | 0.738 |
Female | 92 (35.8) | 52 (48.1) | 87 (42.6) | 57 (35.4) | 118 (39.9) | 26 (37.7) | |||
Age (yr) | |||||||||
≤ 56 | 134 (52.1) | 64 (59.3) | 0.213 | 118 (57.8) | 80 (49.7) | 0.121 | 160 (54.1) | 38 (55.1) | 0.878 |
> 56 | 123 (47.9) | 44 (40.7) | 86 (42.2) | 81 (50.3) | 136 (45.9) | 31 (44.9) | |||
Clinical stage | |||||||||
II | 109 (42.4) | 40 (37.0) | 0.340 | 88 (43.1) | 61 (37.9) | 0.311 | 123 (41.6) | 26 (37.7) | 0.556 |
III | 148 (57.6) | 68 (63.0) | 116 (56.9) | 100 (62.1) | 173 (58.4) | 43 (62.3) | |||
Tumor grade | |||||||||
Poor | 11 (4.3) | 5 (4.6) | 0.848 | 8 (3.9) | 8 (5.0) | 0.687 | 14 (4.7) | 2 (2.9) | 0.780 |
Moderate | 220 (85.6) | 90 (83.3) | 172 (84.3) | 138 (85.7) | 251 (84.8) | 59 (85.5) | |||
Well | 26 (10.1) | 13 (12.1) | 24 (11.8) | 15 (9.3) | 31 (10.5) | 8 (11.6) | |||
KPS | |||||||||
90-100 | 109 (42.4) | 42 (38.9) | 0.223 | 78 (38.2) | 73 (45.3) | 0.315 | 125 (42.2) | 26 (37.7) | 0.689 |
80 | 131 (51.0) | 53 (49.1) | 110 (53.9) | 74 (46.0) | 146 (49.3) | 38 (55.1) | |||
70 | 17 (6.6) | 13 (12.0) | 16 (7.9) | 14 (8.7) | 25 (8.5) | 5 (7.2) | |||
Surgery | |||||||||
Dixon | 201 (78.2) | 83 (76.9) | 0.776 | 129 (63.2) | 155 (96.3) | < 0.001 | 240 (81.1) | 44 (63.8) | 0.002 |
Mile’s | 56 (21.8) | 25 (23.1) | 75 (36.8) | 6 (3.7) | 56 (18.9) | 25 (36.2) | |||
Tumor location | |||||||||
Distance from anal < 5 cm | 95 (37.0) | 34 (31.5) | 0.317 | 94 (46.1) | 35 (21.7) | < 0.001 | 92 (31.1) | 37 (53.6) | < 0.001 |
Distance from anal ≥ 5 cm | 162 (63.0) | 74 (68.5) | 110 (53.9) | 126 (78.3) | 204 (68.9) | 32 (46.4) |
Characteristic | Total | Alive | Death | p-value |
---|---|---|---|---|
Sex | ||||
Male | 198 (60.6) | 156 (58.6) | 42 (68.9) | 0.175 |
Female | 129 (39.4) | 110 (41.4) | 19 (31.1) | |
Age (yr) | ||||
≤ 56 | 175 (53.5) | 145 (54.5) | 30 (49.2) | 0.547 |
> 56 | 152 (46.5) | 121 (45.5) | 31 (50.8) | |
Clinical stage | ||||
II | 140 (42.8) | 124 (46.6) | 16 (26.2) | 0.002 |
III | 187 (57.2) | 142 (53.4) | 45 (73.8) | |
Tumor grade | ||||
Poor | 14 (4.3) | 12 (4.5) | 2 (3.3) | 0.189 |
Moderate | 280 (85.6) | 230 (86.5) | 50 (82.0) | |
Well | 33 (10.1) | 24 (9.0) | 9 (14.7) | |
KPS | ||||
90-100 | 137 (41.9) | 114 (42.9) | 23 (37.7) | 0.089 |
80 | 171 (52.3) | 140 (52.6) | 31 (50.8) | |
70 | 19 (5.8) | 12 (4.5) | 7 (11.5) | |
Surgery | ||||
Dixon | 254 (77.7) | 208 (78.2) | 46 (75.4) | 0.534 |
Mile’s | 73 (22.3) | 58 (21.8) | 15 (24.6) | |
Tumor location | ||||
Distance from anal < 5 cm | 113 (34.6) | 89 (33.5) | 24 (39.3) | 0.349 |
Distance from anal ≥ 5 cm | 214 (65.4) | 177 (66.5) | 37 (60.7) |
Genotype | No. (%) |
OR (95% CI) |
p-value | |
---|---|---|---|---|
Grade 0-1 diarrhea | Grade ≥ 2 diarrhea | |||
rs12513549 | ||||
GG | 88 (43.4) | 85 (53.1) | 1.00 (reference) | |
GT | 93 (45.8) | 62 (38.8) | 0.69 (0.42-1.12) | 0.136 |
TT | 22 (10.8) | 13 (8.1) | 0.49 (0.20-1.14) | 0.101 |
GT+TT | 115 (56.6) | 75 (46.9) | 0.63 (0.39-1.00) | 0.053 |
rs33013 | ||||
AA | 57 (27.9) | 52 (32.3) | 1.00 (reference) | |
AG | 105 (51.5) | 88 (54.7) | 0.88 (0.52-1.49) | 0.641 |
GG | 42 (20.6) | 21 (13.0) | 0.38 (0.17-0.83) | 0.017 |
AG+GG | 147 (72.1) | 109 (67.7) | 0.74 (0.44-1.22) | 0.239 |
rs6151627 | ||||
AA | 125 (61.3) | 84 (52.2) | 1.00 (reference) | |
AG | 73 (35.8) | 66 (41.0) | 1.38 (0.85-2.25) | 0.192 |
GG | 6 (2.9) | 11 (6.8) | 2.99 (0.97-10.49) | 0.067 |
AG+GG | 79 (38.7) | 77 (47.8) | 1.50 (0.94-2.40) | 0.088 |
Genotype | No. (%) |
OR (95% CI) |
p-value | |
---|---|---|---|---|
Grade 0-1 dermatitis | Grade ≥ 2 dermatitis | |||
rs1233255 | ||||
AA | 221 (74.9) | 60 (87.0) | 1.00 (reference) | |
AC | 70 (23.7) | 8 (11.6) | 0.41 (0.17-0.86) | 0.028 |
CC | 4 (1.4) | 1 (1.4) | 0.56 (0.03-4.44) | 0.627 |
Genotype | Alive | Death | Univariate analysis |
Multivariate analysis |
||
---|---|---|---|---|---|---|
HR (95% CI) |
p-value | HR (95% CI) |
p-value | |||
rs4920657 | ||||||
TT | 156 (58.6) | 43 (70.5) | 1.00 (reference) | 1.00 (reference) | ||
TA | 90 (33.9) | 16 (26.2) | 0.66 (0.37-1.17) | 0.158 | 0.57 (0.32-1.03) | 0.063 |
AA | 20 (7.5) | 2 (3.3) | 0.42 (0.10-1.72) | 0.227 | 0.33 (0.08-1.38) | 0.129 |
TA+AA | 110 (41.4) | 18 (29.5) | 0.62 (0.36-1.08) | 0.090 | 0.54 (0.31-0.94) | 0.029 |
rs5743030 | ||||||
GG | 202 (76.5) | 54 (90.0) | 1.00 (reference) | 1.00 (reference) | ||
GA | 59 (22.3) | 6 (10.0) | 0.41 (0.18-0.96) | 0.040 | 0.38 (0.16-0.89) | 0.025 |
AA | 3 (1.2) | 0 | - | 0.996 | 0.38 (0.16-0.89) | 0.969 |
GA+AA | 62 (23.5) | 6 (10.0) | 0.40 (0.17-0.92) | 0.031 | 0.36 (0.15-0.85) | 0.019 |
rs5743100 | ||||||
GG | 194 (74.3) | 52 (85.2) | 1.00 (reference) | 1.00 (reference) | ||
GT | 64 (24.5) | 9 (14.8) | 0.55 (0.27-1.12) | 0.100 | 0.53 (0.26-1.08) | 0.080 |
TT | 3 (1.2) | 0 | - | 0.997 | - | 0.968 |
GT+TT | 67 (25.7) | 9 (14.8) | 0.53 (0.26-1.08) | 0.080 | 0.50 (0.25-1.03) | 0.060 |
Values are presented as number (%). KPS, Karnofsky Performance Score. On the basis of chi-square test or Fisher exact test.
Values are presented as number (%). KPS, Karnofsky Performance Score. Log-rank test.
SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence interval. Calculated by logistic regression model and adjusted for sex, age, clinical stage, tumor grade, Karnofsky Performance Score, surgical procedure, and tumor location.
OR, odds ratio; CI, confidence interval. Calculated by logistic regression model and adjusted for sex, age, clinical stage, tumor grade, Karnofsky Performance Score, surgical procedure, and tumor location.
SNP, single nucleotide polymorphism; HR, hazard ratio; CI, confidence interval. Univariate analysis: calculated by Cox regression model without adjustment, Multivariate analysis: calculated by Cox regression model, adjusted by sex, age, Karnofsky Performance Score, clinical stage, tumor grade, surgical procedure and tumor location.