1Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
2Department of Pathology, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Korea
3Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
4Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
5Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
6Department of Pathology, Department of Pathology, Inha University Hospital, Inha University School of Medicine, Incheon, Korea
7Department of Pathology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
8Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
9Department of Pathology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea
10Department of Pathology, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, Korea
11Department of Pathology, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea
12Department of Pathology, Inje University Ilsan Paik Hospital, Inje Univeristy College of Medicine, Goyang, Korea
13Department of Pathology, Dong-A University Hospital, Dong-A University College of Medicine, Busan, Korea
14Department of Pathology, Chonbuk National University Hospital, Chonbuk National University Medical School, Jeonju, Korea
15Department of Pathology, Inje University Busan Paik Hospital,Inje University College of Medicine, Busan, Korea
16Department of Pathology, Soon Chun Hyang University Hospital, Soon Chun Hyang University College of Medicine, Seoul, Korea
17Department of Pathology, Inje University Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea
18Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
19Department of Pathology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea
20Division of Statistics in Institute of ifestyle Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea
Copyright © 2015 by the Korean Cancer Association
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WHO, World Health Organization; WDET, well-differentiated endocrine tumor; WDEC, well-differentiated endocrine carcinoma; PDEC, poorly-differentiated endocrine carcinoma; MEEC, mixed exo-endocrine carcinoma; NET G1, neuroendocrine tumor grade 1; NET G2, neuroendocrine tumor grade 2; NEC, neuroendocrine carcinoma.
Glucagon-I | Glucagon-II | PYY | |
---|---|---|---|
Glucagon-I | 1.00000 | - | - |
Glucagon-II | 0.77165a) | 1.00000 | - |
PYY | 0.42458a) | 0.42876a) | 1.00000 |
Clinicopahtological parameter | No. of cases with available information (%) | Total | |
---|---|---|---|
Histologic classification (2000 WHO) | WDET | 1,620 (93.37) | 1,732 |
WDEC | 57 (3.29) | ||
PDEC | 45 (2.59) | ||
MEEC | 10 (0.58) | ||
Grade (2010 WHO) | NET G1 | 906 (87.28) | 1,038 |
NET G2 | 66 (6.36) | ||
NEC | 66 (6.36) | ||
Extent | Mucosa-submucosa | 1,582 (92.62) | 1,708 |
Proper muscle | 33 (1.93) | ||
Subserosa | 44 (2.58) | ||
Serosa | 12 (0.70) | ||
Adjacent organ invasion | 4 (0.23) | ||
Distant metastasis | 33 (1.93) | ||
Size (mm) | 1-4 | 547 (38.31) | 1,428 |
5-9 | 604 (42.30) | ||
10-14 | 150 (10.50) | ||
15-20 | 52 (3.64) | ||
> 20 | 75 (5.25) |
Glucagon-I | Glucagon-II | PYY | |
---|---|---|---|
Glucagon-I | 1.00000 | - | - |
Glucagon-II | 0.77165 |
1.00000 | - |
PYY | 0.42458 |
0.42876 |
1.00000 |
Clinicopathologic parameter | No. of cases | Non–L-cell type | L-Cell type | p-value | |
---|---|---|---|---|---|
Grade | NET G1 | 113 (64.42) | 4 (3.54) | 109 (96.46) | < 0.0001 |
NET G2 | 21 (12.88) | 1 (4.76) | 20 (95.24) | ||
NEC | 29 (17.79) | 17 (58.62) | 12 (41.38) | ||
Total | 163 (100) | 22 (13.50) | 141 (86.50) | ||
Extent | Mucosa/submucosa | 90 (63.38) | 3 (3.33) | 87 (96.67) | < 0.0001 |
Proper muscle | 13 (9.15) | 2 (15.39) | 11 (84.61) | ||
Subserosa | 24 (16.90) | 8 (33.33) | 16 (66.67) | ||
Serosa | 6 (4.23) | 3 (50.00) | 3 (50.00) | ||
Adjacent organ | 2 (1.41) | 1 (50.00) | 1 (50.00) | ||
Distant metastasis | 7 (4.93) | 3 (42.86) | 4 (57.14) | ||
Total | 142 (100) | 20 (14.08) | 122 (85.92) | ||
Size | 141 (100) | 33.6905±26.0809 | 12.4417±12.5830 | < 0.0001 | |
LN metastasis | Positive | 49 (76.56) | 16 (32.65) | 33 (67.35) | 0.1453 |
Negative | 15 (23.44) | 2 (13.33) | 13 (86.67) | ||
Total | 64 (100) | 18 (28.13) | 46 (71.87) |
WHO, World Health Organization; WDET, well-differentiated endocrine tumor; WDEC, well-differentiated endocrine carcinoma; PDEC, poorly-differentiated endocrine carcinoma; MEEC, mixed exo-endocrine carcinoma; NET G1, neuroendocrine tumor grade 1; NET G2, neuroendocrine tumor grade 2; NEC, neuroendocrine carcinoma.
Pearson correlation coefficient.
Values are presented as number (%) or mean±standard deviation. n, number of cases with available data; NET G1, neuroendocrine tumor grade 1; NET G2, neuroendocrine tumor grade 2; NEC, neuroendocrine carcinoma (G3); LN, lymph node.