Primary testicular non-Hodgkin's Lymphoma is very rare. It may be the systemic manifestation of nodular lymphoma. The most common symptom of primary testicular lymphoma is the painless enlargement of testis. It frequently involves Waldeyer's ring, skin and central nervous system. The combination chemotherapy and CNS prophlylaxis may be needed in the treatment of early stage primary testicular non-Hodgkin's lymphoma. We are reporting a case of primary testicular non-Hodgkin's 1ymphoma stage I, which relapsed in central nervous system during combination chemotherapy.