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HOME > J Korean Cancer Assoc > Volume 28(5); 1996 > Article
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A Case of Synchronous Triple Primary Cancers in Larynx , Esophageu , and Stomach
Gyo Seon Kwun, Kyung Tae Kim, Yong Cho Kim, Ju Byeung Sung, Young Wo Lee, Eun Jung Jang, Baek Yeol Ryoo, Tae You Kim, Young Hyuck Im, Yoon Koo Kang, Seung sook Lee, Jim Oh Lee, Tae Woong Kang
Journal of the Korean Cancer Association 1996;28(5): 888-897.
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Multiple primary cancers can occur in up to 20% of primary aerodigestive tract cancer patients. The multiplicity of cancer in aerodigestive tract suggests that the exposure to common carcinogen may be the cause of multiplicity(field cancerization). Continuous alcohol drinking and smoking are considered to be the major factors in development of multiple cancers. Also, high frequency of genetic alterations in multiple primary cancer patients implys that the genetic instability such as replication error or mutation of tumor suppressor gene may play a role in the development of multiple primary cancers. We report a case of a 61 year-old man who had triple synchronous cancers in larynx, esophagus, and stomach. He was a heavy smoker of 30-pack-years and a heavy drinker. Pathological examination showed squamous cell carcinoma of larynx and esophagus, and adenocarrinoma of stomach, respectively.

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    A Case of Synchronous Triple Primary Cancers in Larynx , Esophageu , and Stomach
    J Korean Cancer Assoc. 1996;28(5):888-897.
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