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J Korean Cancer Assoc > Volume 28(2); 1996 > Article
Journal of the Korean Cancer Association 1996;28(2): 247-253.
유방암에서 Matrix-metalloproteinase- 9 ( MMP- 9 ) 의 발현
라선영, 김세중, 정현철, 김주항, 노재경, 이경식, 김병수
Expression of Matrix-metalloproteinase- 9 ( MMP- 9 ) in Breast Cancer
Sun Young Rha, Se Joong Kim, Hyun Cheol Chung, Joo Hang Kim, Jae Kyung Roh, Kyung Shik Lee, Byung Soo Kim
The degradation of the basement membrane by matrix-metalloproteinase(MMP) and serine protease is a critical point in tumor invasion and metastasis. We measured the activity of MMP-9 from 28 normal, 12 benign, and 126 breast cancer tissues using gelatin zymography with an image analysis system. Inactive MMP-9 was expressed in 17.5% of the cancer patients compared to 2.5% in 40 non-cancerous tissues(p=0.008). The active form of MMP-9(82kD) was expressed only in T2-T4 stages. During the early phase of breast cancer (DCIS and Tl stage) progression, only the production of inactive MMP-9 was increased. However, as the cancer grew or invaded skin(T2-T4), or with lymphovascular permeation, both production and activation of MMP-9 were increased. In conclusion, MMP-9 productian was the main cause of increased MMP-9 activity during the ear1y phase, while both production and activation were increased in the late phase of breast cancer.
Key words: Breast cancer, Invasion, Zymography, MMP-9
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