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J Korean Cancer Assoc > Volume 27(6); 1995 > Article
Journal of the Korean Cancer Association 1995;27(6): 929-936.
췌장암 및 담도암에서 담즙정체 해소전후의 혈청 CA 19-9 치의 변화
김현각, 이창희, 류백렬, 정숙향, 김유철, 김창민, 이진오, 강태웅, 도영수, 이병희
The Significance of Serum CA 19-9 Level Change after Biliary Drainage Procedures in Pancreatic and Biliary Tract Cancer
Hyun Kag Kim, Chang Hee Lee, Baek Yeol Ryoo, Sook Hyang Jung, You Cheoul Kim, Chang Min Kim, Jhin Oh Lee, Taik Koo Yun, Young Soo Do, Byung Hee Lee
Although CA 19-9 has been widely used as a tumor marker for the diagnosis of pancreatobiliary cancers, the pattern of CA l9-9 level change after biliary drainage has not been well characterized. Because biliary drainage procedures are frequently employed for the temporary or palliative measures in biliary obstruction, the precise understanding on the change of CA 19-9 level after biliary drainage may be very helpful for the follow-up evaluation of those cases. We prospectively analyzed the serum CA 19-9 level before and after percutaeous transhepatic biliary drainage (PTBD) and biliary stent in patients with pancreatic, biliary tract cancer and common bile duct stone. Serum CA 19-9 level was initially measured by radioimmunoassay in 69 patients with be nign and malignant pancreatobiliary diseases. In 22 of 69 patients, PTBD and/or the insertion of biliary stent were performed and serial checks of CA 19-9 levels were followed. The elevation of serum CA 19-9 level was highly associated with pancreatobiliary cancers, especially in the cases with biliary obstruction, and in the CBD stones complicated with acute cholangitis. The serum CA 19-9 levels in most cases were significantly decreased by PTBD. There was the trend that the decrease after PTBD in biliary tract cancer was more prominent than that of pancreatic cancer. The elevation of serum CA 19-9 level was highly associated with the presence of biliary obstruction in pancreatobiliary cancers. Because the biliary drainage procedures significantly decrease serum CA 19-9 level, this can not be used for the marker of cancer pragression after biliary drainage procedures.
Key words: Tumor marker, CA 19-9, Biliary drainage, Pancreatic cancer, Biliary tract cancer
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