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J Korean Cancer Assoc > Volume 27(5); 1995 > Article
Journal of the Korean Cancer Association 1995;27(5): 869-879.
다발성골수종 56 예의 임상적 분석 및 치료 결과
정진우, 김정희, 김시영, 윤휘중, 조경삼
A Clinical Study on Multiple Myelom
Jin Woo Jung, Jeong Hee Kim, Si Young Kim, Hwi Joong Yoon, Kyung Sam Cho
Clinical findings and results were analysed in 56 cases diagnosed as multiple myeloma between October 1981 and June l994 at Kyung Hee University Hospital. The resuts were as followings: 1) The incidence reached a peak during 7th decade and male to female ratio was 1.2:l. 2) The chief complaints at initial presentation were bone pain(50%), pathologic fracture (14%) and anemia(14%), 3) Hematologic findings showed anemia in 77%, leukopenia in 25% and thrombocytopenia in 23%. ESR was elevated in 91% of patients. Hypercalcemia was noted in l3% and renal failure in 29%. 4) X-ray findings showed pathologic fracture in 39%, osteolytic lesion in 70% and osteo-porosis in 32% but normal finding was found in 5% of patients. 5) Clinical stage was stage I in 8%, stage II in 19% and stage III in 73% of patients. Fifteen of sixteen patients with renal insufficiency were in stage III. 6) Serum protein electrophoresis showed a M-peak in 89%. Mean M-protein concentration was 4.55 g/dl. M-protein was IgG in 57%, IgA in 24%, IgD in 2% and light chain only in 17% . Kappa to lambda ratio was 1.4: l. 7) Varisnt forms of multiple myeloma were 2 cases of nonsecretory myeloma, 1 case of solitary plasmacytoma and 1 case of plasma cell leukemia. 8) Response rate to primary chemotherapy was 37% for MP regimen and 60% for M2 regimen. There was statistically significant survival difference between responders and non-responders(p<0.01). The overall median survival of patients was 76 weeks.
Key words: Multiple myeloma, Clinical study
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