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J Korean Cancer Assoc > Volume 27(5); 1995 > Article
Journal of the Korean Cancer Association 1995;27(5): 783-790.
Bromodeoxyuridine 표지에 의한 인체 상피세포암의 세포역동학 연구
성진실, 이정운, 정은지, 김영태, 김재욱, 김남규, 홍성준, 최은창, 이원상, 권오헌, 김귀언
Cell Kinetics Studies of Human Epithelial Cancers with Bromodeoxyuridine Labeling
Jin Sil Seong, Jung Woon Lee, Eun Ji Chung, Yung Tae Kim, Jae Wook Kim, Nam Kyu Kim, Sung Joon Hong, Eun Chan Choi, Won Sang Lee, Oh Hun Kwon, Gwi Eon Kim
Cell kinetic parameters of labeling index (LI), duration of S-phase (Ts), and potential doubling time (Tpot) were analyzed following infusion of bromodeoxyuridine (BUdR) in 33 patients with various epithelial cancers. Twelve uterine cervical cancers, 9 rectal cancers, 7 head and neck caneers, and 5 bladder cancers were included. Biopsies were taken about 4-6 h after 200 mg/m(2) BUdR infusion and the samples were anaiyzed with bivariate DNA /BUdR flow cytometry. The distribution of cell kinetic parameters for the 33 epithelial cancers showed a large range of values for each parameter. The median LI, Ts, and Tpot were 4.5%, 10.8 h, and 242.3 h, respectively. Eight among 33 patients (24.2%) showed aneuploidy. In aneuploid tumors the distribution of LI, Ts, and Tpot was in relatively small range. Aneupliod tumors appeared to show higher LI and shorter Tpot than those in diploid tumors. In diploid tumors, the poesibility of normal cell contamination could not be ruled out. The results of this study would be a basis for future trial to predict which ones would show tumor clonogen repopulation during radiotherapy so that benefit from altered fractionated radiotherapy.
Key words: Cell kinetics, BUdR, Flow cytometry, Epithelial eancer
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